Staff Profile
Dr Alison Day
Lecturer in Microbiology
- Email: a.m.day@ncl.ac.uk
- Address: School of Medicine,
Faculty of Medical Sciences,
Newcastle upon Tyne
NE2 4HH
Publications
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Articles
- Cao M, Day AM, Galler M, Latimer HR, Byrne DP, Foy TW, Dwyer E, Bennett E, Palmer J, Morgan BA, Eyers PA, Veal EA. A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms. Molecular Cell 2023, 83(17), 3140-3154.e7.
- Ahmed Y, Ikeh MAC, MacCallum DM, Day AM, Waldron K, Quinn J. Blocking Polyphosphate Mobilization Inhibits Pho4 Activation and Virulence in the Pathogen Candida albicans. mBio 2022, e00342-22.
- Herrero-de-Dios C, Day AM, Tillmann AT, Kastora SL, Stead D, Salgado PS, Quinn J, Brown AJP. Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates Its Nitrosative-Stress-Specific Outputs. mBio 2018, 9(2), e02229-17.
- Rzechonek DA, Day AM, Quinn J, Mironczuk AM. Influence of ylHog1 MAPK kinase on Yarrowia lipolytica stress response and erythritol production. Scientific Reports 2018, 8(1), 14735.
- Day AM, NcNiff MM, da Silva Dantas A, Gow NAR, Quinn J. Hog1 Regulates Stress Tolerance and Virulence in the Emerging Fungal Pathogen Candida auris. mSphere 2018, 3(5), e00506-18.
- Day AM, Herrero-de-Dios CM, MacCallum DM, Brown AJP, Quinn J. Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen. Scientific Reports 2017, 7, 14340.
- Day AM, Smith DA, Ikeh MAC, Haider M, Herrero-de-Dios CM, Brown AJP, Morgan BAM, Erwig LP, MacCallum DM, Quinn J. Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation. PLoS Pathogens 2017, 13(1), e1006131.
- Ikeh MA, Kastora SL, Day AM, Herrero-de-Dios CM, Tarrant E, Waldron KJ, Banks AP, Bain JM, Lydall D, Veal EA, MacCallum DM, Erwig LP, Brown AJ, Quinn J. Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis. Molecular Biology of the Cell 2016, 27(17), 2784-2801.
- Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ-L, Shanley DP, Veal EA. Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed. Free Radicals in Biology and Medicine 2016, 95, 333-348.
- Cuskin F, Baslé A, Ladevèze S, Day AM, Gilbert HJ, Davies GJ, Potocki-Véronèse G, Lowe EC. The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan. Journal of Biological Chemistry 2015, 290(41), 25023-25033.
- Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN. Glycan complexity dictates microbial resource allocation in the large intestine. Nature Communications 2015, 6, 7481.
- Brown JD, Day AM, Taylor SR, Tomalin LE, Morgan BA, Veal EA. A Peroxiredoxin Promotes H2O2 Signaling and Oxidative Stress Resistance by Oxidizing a Thioredoxin Family Protein. Cell Reports 2013, 5(5), 1425-1435.
- Day AM, Brown JD, Taylor SR, Rand JD, Morgan BA, Veal EA. Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival. Molecular Cell 2012, 45(3), 398-408.
- Day AM, Veal EA. Hydrogen Peroxide-sensitive Cysteines in the Sty1 MAPK Regulate the Transcriptional Response to Oxidative Stress. Journal of Biological Chemistry 2010, 285(10), 7505-7516.
- Veal EA, Day AM, Morgan BA. Hydrogen Peroxide Sensing and Signaling. Molecular Cell 2007, 26(1), 1-14.
- Bozonet SM, Findlay VJ, Day AM, Cameron J, Veal EA, Morgan BA. Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide. Journal of Biological Chemistry 2005, 280(24), 23319-23327.
- Veal EA, Findlay VJ, Day AM, Bozonet SM, Evans JM, Quinn J, Morgan BA. A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase. Molecular Cell 2004, 15(1), 129-139.
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Editorial
- Veal EA, Day AM. Hydrogen peroxide as a signaling molecule. Antioxidants and Redox Signaling 2011, 15(1), 147-151.
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Reviews
- Day AM, Quinn J. Stress-Activated Protein Kinases in Human Fungal Pathogens. Frontiers in Cellular and Infection Microbiology 2019, 9(261).
- Dantas AS, Day A, Ikeh M, Kos I, Achan B, Quinn J. Oxidative stress responses in the human fungal pathogen, Candida albicans. Biomolecules 2015, 5(1), 142-165.
- Veal EA, Tomalin LE, Morgan BA, Day AM. The fission yeast Schizosaccharomyces pombe as a model to understand how peroxiredoxins influence cell responses to hydrogen peroxide. Biochemistry Society Transactions 2014, 42(4), 909-916.