Staff Profile

Introduction

I am a scientist who applies physics to quantify pathological processes in human organs and tissues (such as the liver, skeletal muscle, the knee, the heart and the pancreas) to allow early detection of disease, and to provide sensitive biomarkers to use in longitudinal studies of therapy. 

My work as a principal investigator concentrates on creating and clinically validating methods of accelerating quantitative MRI to reduce costs and improve the patient experience. You can read more about these activities on the "Research" tab and in research papers from my group available here and here.

I collaborate with other principal investigators to design, develop and implement quantitative methods and apply them to clinical research questions or genuine importance.

My methods for quantifying the amount of fat stored in the liver and pancreas are playing a key role in Newcastle research to reverse type 2 diabetes through very low calorie diets (available here). 

I have developed and led the physics behind a multicentre trial to prove that MRI is a more sensitive way of tracking disease progression, compared to conventional functional measurements (available here).

Recent work has also included using quantitative MRI to track the effectiveness of anti-inflammatory treatments in juvenile idiopathic arthritis.

I have also collaborated to use quantitative MRI to identify and quantify early sub-clinical changes in cardiac function through the use of strain and torsion measurements, and assessments of cardiac energetics. I have applied these to situations including:

(i) showing the unusual pathological mechanisms of limb girdle muscular dystrophy 2I on the heart, published in European Journal of Heart Failure (available here). 

(ii) the detection of subclinical differences in physically active and inactive women of different ages, published in Circulation: Cardiovascular Imaging (available here).     

(iii) the early detection of cardiac impairment in mitochondrial disease which cannot be detected by conventional ultrasound, published in European Journal of Cardiology, Cardiovascular Imaging (available here). 

Background

I first trained in Magnetic Resonance Physics at the Department of Chemical Engineering, University of Cambridge under Dr Mike Johns, presenting a Ph.D. thesis entitled "Emulsion characterisation using magnetic resonance methods".

As a result of this work, I developed an interest in applying magnetic resonance methods to problems of human disease. In January 2004 I took up a post-doctoral position at the Department of Radiology, University of Cambridge.

In February 2006, I moved to the Newcastle Magnetic Resonance Centre to lead the development of MR physics method across a range of metabolic and genetic dieases, and collaborating with a large number of internationally-renowned clinical groups at the University. With further appointments as a Senior Staff Scientist in 2009, Lecturer in 2012 and Senior Lecturer in 2016 I have combined this with leading my own independent MR physics research, which will provide the next generation of quantitative MR methods for clinical research.  

Qualifications

M.A. (Hons), M.Eng. (Hons), Ph.D. (Cantab)

Positions Held

Reader in Magnetic Resonance Physics, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, from August 2020

Senior Lecturer in Magnetic Resonance Physics, Institute of Cellular Medicine, Newcastle University, from August 2016 to July 2020

Lecturer in Magnetic Resonance Physics (Grade G), Institute of Cellular Medicine, Newcastle University, from August 2012 to July 2016

Senior Staff Scientist (Grade G) in Magnetic Resonance Physics, Institute of Cellular Medicine, Newcastle University, March 2009-July 2012 

Research Associate in Magnetic Resonance Physics,  Institute of Cellular Medicine, Newcastle University, Feb 2006 to Feb 2009

Research Associate in Magnetic Resonance Physics, Radiology, University of Cambridge, Jan 2004 to Feb 2006

Research Fellow, Hughes Hall, University of Cambridge, Jan 2004 to Feb 2006

Memberships

Member of the International Society for Magnetic Resonance in Medicine

Honours and Awards

Danckwerts-Pergammon prize for best Ph.D. dissertation, Department of Chemical Engineering, University of Cambridge

Languages

French, German

My Google Scholar Page can be found at https://scholar.google.co.uk/citations?user=14q5fz4AAAAJ .  

Reducing the cost and patient burden of MRI in clinical trials: acceleration of quantitative MRI using novel reconstruction techniques.

MRI is not just a powerful tool for radiologists to visualise diseased tissue, but rather it can be used to accurately measure the disease state of tissue or the function of an organ, and this has informed my research over the last decade. Applications include tracking disease progression in muscular dystrophy, or examining the lipid content of the liver and pancreas and type 2 diabetes.

However, MRI examinations typically require the patient to lie still for many minutes at a time, and a whole examination can take an hour or more. This is a lot for a patient to tolerate within the contect of other visits in a clinical trial protocol and MRI scanning time is costly (~£500/hr in the UK). There are now active trials in Duchenne muscular dystrophy, a muscle wasting disease that affects young boys as young as 4-5 years old, who find it particularly challenging to keep still in the scanner. 

My research as Principal Investigator, funded by the MRC, is to develop and validate highly accelerated MRI measurements by acquiring less data and using a new reconstruction technique. To date, I have demonstrated that we can speed up the scanning by a factor of 5 times to measure the progressing disease in muscular dystrophy.

The clinical validation work was published in the leading international journal Radiology, available here. The technical exploration of how to find the most robust method for doing this was published in Magnetic Resonance in Medicine and is available here.

My present activity as part of this grant is to validate similar accelerations in the heart, and in the liver and pancreas of patients with type 2 diabetes. 

Quantitative MRI for clinical trials

My main research interests involve finding new ways to quantify early functional impairment or tissue change in diseases, preferably before the disease becauses overt or symptomatic. These measures permit the tissue or organ state to be tracked across time.

Examples of this include the early detection of cardiac disease in neuromuscular diseases and diabetes, and the tracking of liver and pancreas stored lipid in response to very low calorie diets

Postgraduate Supervision

I place great importance on the supervision and training of research students, both clinical and non-clinical, and other post-doctoral workers. I supervise 4 MD and 3 PhD students, with informal but substantial supervision of 2 further PhD students. Evidence of success in this supervisory activity is shown by the timely submission of theses for these students at the appropriate stage (2 PhD and 1 MD) and the successful award of the one PhD and one MD examined to date.

In addition, I have run two four-month research placements for NHS Medical Physics Trainees and three undergraduate research projects. 

Esteem Indicators

Grant reviewer for the Wellcome Trust, Canada Research Chairs program 2012, MRC MRC Experimental Medicine call, 2008 and British Renal Society research awards.

External PhD examiner for University of Cambridge and Universite de Paris Sud.

internal chair of examiners for Newcastle University. 

Reviewer for journals: Heart, Circulation: Cardiovascular Imaging, Journal of Toxicology, Journal of Neurology, Neurosurgery and Psychiatry, NMR in Biomedicine, Magnetic Resonance in Medicine, Journal of Magnetic Resonance Imaging, Neuromuscular Disorders, Journal of Biomedical Research.

Funding

POSTGRADUATE TEACHING

Although my career is mostly research focussed, high quality teaching should flow naturally from research and I contribute teaching to the following courses: 

(1) MSc Clinical Science (Medical Physics)

I provide teaching, examination and assessment for the following modules, which are targetted at the training needs of prospective NHS Medical Physicists, whether or not they intend to specialise in Imaging with Non-Ionising Radiation in the first year (MPY8001, MSC8001) and to those who wish to take specialist modules in their 2nd and 3rd years (MPY8011, MPY8012, MSC8004).

MPY8001 : Introduction to Medical Physics

I am the theme lead for this 1st year course, which is taken by all medical physicist trainees. It considers the physical origins of the magnetic resonance effect, considers the different types of echo and the encoding of these echoes to produce images. Later contributions to the course include basic sequences, quality assurance and an introduction to clinical MRI.

MPY8011 : Imaging with non-ionising radiation 1

Teaching topics include Parallel Imaging, Physics of Image Artefacts* and the hands-on practical, Linking Theory to Practice*

MPY8012 : Imaging with non-ionising radiation 2

Teaching topics include Magnetic Resonance Angiography

(2) MRes contributions

I provide lectures and/or seminar materials for the following MRes modules where quantitative MRI can play an important part:

CVR8007 “Diagnostic Approaches and Current Treatment of Cardiovascular Disorders”

MMB8037 “Cardiovascular Science in Health and Disease”

MMB8035 “Diabetes”  

(3) FRCR Part 1 

I provide teaching in MR Physics to specialist trainees in Radiology in the North East towards the FRCR Part 1 examination.

RESEARCH PROJECTS FOR BSc BIOMEDICAL SCIENCES AND MSc MEDICAL SCIENCES

I regularly supervise final year BSc research projects for students reading Biomedical Sciences and dissertation projects for those reading the MSc in Medical Sciences. It is important that the students have a genuine immersive research experience, and that as far as possible they are able to co-author a publication while working in my group. Previous projects have included:

"Accelerating magnetic resonance imaging in type 2 diabetes and muscular dystrophy" - 2014

"Investigating Magnetic Resonance Imaging as a Method of Measuring Organ Lipid Infiltration in Type 2 Diabetes" - 2013

"Effect of age and physical activity on muscle and cardiac metabolism" - 2011

"White matter lesions and their relationship to autonomic dysfunction in primary biliary cirrhosis"- 2008  

UNDERGRADUATE TUTORING

 I am a Personal Tutor to undergraduates reading the BSc/MSci in Biomedical Sciences, being responsible for providing personal induction advice and meeting regularly with them to provide academic and pastoral support throughout their course.  

PROPOSING PhD PROJECTS/VACATION PROJECTS

While I am willing to be contacted about proposals for PhD projects/vacation projects, it should be noted that deadlines for funding are early and often very competitive. 

• Jabbar A, Ingoe L, Junejo S, Carey P, Addison C, Thomas H, Parikh JD, Austin D, Hollingsworth KG, Stocken DD, Pearce SHS, Greenwood JP, Zaman A, Razvi S. Effect of levothyroxine on left ventricular ejection fraction in patients with subclinical hypothyroidism and acute myocardial infarction: a randomized clinical trial. JAMA: The Journal of the American Medical Association 2020, 324(3), 249-258.
• Steele H, Gomez-Duran A, Pyle A, Hopton S, Newman J, Stefanetti RJ, Charman SJ, Parikh JD, He L, Viscomi C, Jakovljevic DG, Hollingsworth KG, Robinson AJ, Taylor RW, Bottolo L, Horvath R, Chinnery PF. Metabolic effects of bezafibrate in mitochondrial disease. EMBO Molecular Medicine 2020, 12(3), e11589.
• Lean MEJ, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Welsh P, Kean S, Ford I, McConnachie A, Messow CM, Sattar N, Taylor R. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes & Endocrinology 2019, 7(5), 344-355.
• Lean MEJ, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Stefanetti R, Trenell MI, Welsh P, Kean S, Ford I, McConnachie A, Sattar N, Taylor R. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. The Lancet 2018, 391(10120), 541-551.
• Murphy AP, Morrow J, Dahlqvist JR, Stijkovic T, Willis TA, Sinclair CDJ, Wastling S, Yousry T, Hanna MS, James MK, Mayhew A, Eagle M, Lee LE, Hogrel JY, Carlier PG, Thornton JS, Vissing J, Hollingsworth KG, Straub V. Natural history of limb girdle musclar dystrophy R9 over 6 years: searching for trial endpoints. Annals of Clinical and Translational Neurology 2019, 6(6), 1033-1045.
• Taylor R, Al-Mrabeh A, Zhyzhneuskaya S, Peters C, Barnes AC, Aribisala BS, Hollingsworth KG, Mathers JC, Sattar N, Lean MEJ. Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery. Cell Metabolism 2018, 28(4), 547-556.
• Mann, LW, Higgins, DM, Peters, CN, Cassidy, S, Hodson, KK, Coombs, A, Taylor, R, Hollingsworth KG. Accelerating MR Imaging Liver Steatosis Measurement Using Combined Compressed Sensing and Parallel Imaging: A Quantitative Evaluation. Radiology 2016, 278(1), 247-256.
• Loughran T, Higgins DM, McCallum M, Coombs A, Straub V, Hollingsworth KG. Improving highly accelerated fat fraction measurements for clinical trials in muscular dystrophy: origin and quantitative effect of R2* changes. Radiology 2015, 275(2), 570-578.
• Wu ZE, Fraser K, Kruger MC, Sequeira IR, Yip W, Lu LW, Plank LD, Murphy R, Cooper GJS, Martin J-C, Hollingsworth KG, Poppitt SD. Untargeted metabolomics reveals plasma metabolites predictive of ectopic fat in pancreas and liver as assessed by magnetic resonance imaging: the TOFI_Asia study. International Journal of Obesity 2021, 45, 1844-1854.
• Hollingsworth KG, Higgins DM, McCallum M, Ward L, Coombs A, Straub V. Investigating the quantitative fidelity of prospectively undersampled chemical shift imaging in muscular dystrophy with compressed sensing and parallel imaging reconstruction. Magnetic Resonance in Medicine 2014, 72(6), 1610-1619.
• Nathania M, Hollingsworth KG, Bates M, Eggett C, Trenell MI, Velicki L, Seferovic PM, MacGowan GA, Turnbull DM, Jakovljevic DG. Impact of age on the association between cardiac high-energy phosphate metabolism and cardiac power in women. Heart 2018, 104(2), 111-118.
• Burakiewicz J, Sinclair CDJ, Fischer D, Walter GA, Kan HE, Hollingsworth KG. Quantifying fat replacement of muscle by quantitative MRI in muscular dystrophy. Journal of Neurology 2017, 264(10), 2053-2067.
• Houghton D, Thoma C, Hallsworth K, Cassidy S, Hardy T, Burt AD, Tiniakos D, Hollingsworth KG, Taylor R, Day CP, McPherson S, Anstee QM, Trenell MI. Exercise Reduces Liver Lipids and Visceral Adiposity in Patients With Nonalcoholic Steatohepatitis in a Randomized Controlled Trial. Clinical Gastroenterology and Hepatology 2017, 15(1), 96-102.e3.
• Taylor R, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Sattar N, Welsh P, Peters C, Zhyzhneuskaya S, Hollingsworth KG, AlMrabeh A, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Kean S, Ford I, McConachie A, Lean MEJ. Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia 2018, 61(3), 589-598.
• Parikh JD, Kakarla J, Keavney B, O'Sullivan JJ, Ford GA, Blamire AM, Hollingsworth KG, Coats L. 4D flow MRI assessment of right atrial flow patterns in the normal heart - influence of caval vein arrangement and implications for the patent foramen ovale. PLoS One 2017, 12(3), e0173046.
• Steven S, Hollingsworth KG, Al-Mrabeh A, Avery L, Aribisala B, Caslake M, Taylor R. Very-Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders. Diabetes Care 2016, 39(5), 808-815.
• Steven S, Hollingsworth KG, Small PK, Woodcock SA, Pucci A, Aribisala B, Al-Mrabeh A, Daly AK, Batterham RL, Taylor R. Weight Loss Decreases Excess Pancreatic Triacylglycerol Specifically in Type 2 Diabetes. Diabetes Care 2016, 39(1), 158-165.
• Houghton D, Hallsworth K, Thoma C, Cassidy S, Hardy T, Heaps S, Hollingsworth KG, Taylor R, Day CP, Masson S, McPherson S, Anstee QM, Trenell MI. Effects of Exercise on Liver Fat and Metabolism in Alcohol Drinkers. Clinical Gastroenterology and Hepatology 2017, 15(10), 1596-1603.e3.
• Parikh JD, Hollingsworth KG, Wallace D, Blamire AM, MacGowan GA. Left ventricular functional, structural and energetic effects of normal aging: Comparison with hypertension. Plos One 2017, 12(5), e0177404.
• Al-Mrabeh A, Hollingsworth KG, Steven S, Taylor R. Morphology of the pancreas in type 2 diabetes: effect of weight loss with or without normalisation of insulin secretory capacity. Diabetologia 2016, 59(8), 1753–1759.
• Steven S, Hollingsworth KG, Small PK, Woodcock SA, Pucci A, Aribasala B, Al-Mrabeh A, Batterham RL, Taylor R. Calorie restriction and not glucagon-like peptide-1 explains the acute improvement in glucose control after gastric bypass in Type 2 diabetes. Diabetic Medicine 2016, 33(12), 1723-1731.
• Jakovljevic DG, Papakonstantinou L, Blamire AM, MacGowan GA, Taylor R, Hollingsworth KG, Trenell MI. Effect of physical activity on age-related changes in cardiac function and performance in women. Circulation: Cardiovascular Imaging 2014, 8(1), e002086.
• Cassidy S, Thoma C, Hallsworth K, Parikh J, Hollingsworth KG, Taylor R, Jakovljevic DG, Trenell MI. High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial. Diabetologia 2016, 59(1), 56-66.
• Macauley M, Hollingsworth KG, Smith FE, Thelwall PE, Al-Mrabeh A, Schweizer A, Foley JE, Taylor R. Effect of Vildagliptin on Hepatic Steatosis. Journal of Clinical Endocrinology & Metabolism 2015, 100(4), 1578-1585.
• Macauley M, Smith FE, Thelwall PE, Hollingsworth KG, Taylor R. Diurnal variation in skeletal muscle and liver glycogen in humans with normal health and Type 2 diabetes. Clinical Science 2015, 128(10), 707-713.
• Hollingsworth KG. Quantitative MRI in muscular dystrophy: An indispensable trial endpoint?. Neurology 2014, 83(11), 956-957.
• Madathil A, Hollingsworth KG, Blamire AM, Razvi S, Newton JL, Taylor R, Weaver JU. Levothyroxine Improves Abnormal Cardiac Bioenergetics in Subclinical Hypothyroidism: A Cardiac Magnetic Resonance Spectroscopic Study. Journal of Clinical Endocrinology and Metabolism 2015, 100(4), E607-E610.
• Hallsworth K, Thoma C, Hollingsworth KG, Cassidy S, Anstee QM, Day CP, Trenell MI. Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: A randomised controlled trial. Clinical Science 2015, 129(12), 1097-1105.
• Macauley M, Percival K, Thelwall PE, Hollingsworth KG, Taylor R. Altered Volume, Morphology and Composition of the Pancreas in Type 2 Diabetes. PLOS One 2015, 10(5), e0126825.
• Willis TA, Hollingsworth KG, Coombs A, Sveen M-L, Andersen S, Stojkovic T, Eagle M, Mayhew A, Loureiro de Sousa P, Dewar L, Morrow JM, Sinclair CDJ, Thornton JS, Bushby K, Lochmuller H, Hanna MG, Hogrel J-Y, Carlier PG, Vissing J, Straub V. Quantitative Magnetic Resonance Imaging in Limb-Girdle Muscular Dystrophy 2I: A Multinational Cross-Sectional Study. PLoS ONE 2014, 9, e90377.
• Payne BAI, Hollingsworth KG, Baxter J, Wilkins E, Lee V, Price DA, Trenell M, Chinnery PF. In Vivo Mitochondrial Function in HIV-Infected Persons Treated with Contemporary Anti-Retroviral Therapy: A Magnetic Resonance Spectroscopy Study. PLoS One 2014, 9(1), e84678.
• Hussain R, Vogt SJ, Honari A, Hollingsworth KG, Sederman AJ, Mitchell J, Johns ML. Interfacial Tension Measurements Using MRI Drop Shape Analysis. Langmuir 2014, 30(6), 1566-1572.
• Hollingsworth KG, Willis TA, Bates MG, Dixon BJ, Lochmüller H, Bushby K, Bourke J, MacGowan GA, Straub V. Subepicardial dysfunction leads to global left ventricular systolic impairment in patients with limb girdle muscular dystrophy 2I. European Journal of Heart Failure 2013, 15(9), 986-994.
• Cassidy S, Hallsworth K, Thoma C, MacGowan GA, Hollingsworth KG, Day CP, Taylor R, Jakovljevic DG, Trenell MI. Cardiac structure and function are altered in type 2 diabetes and Non-alcoholic fatty liver disease and associate with glycemic control. Cardiovascular Diabetology 2015, 14, 23.
• Sinha A, Hollingsworth K, Ball S, Cheetham T. Impaired quality of life in growth hormone-deficient adults is independent of the altered skeletal muscle oxidative metabolism found in conditions with peripheral fatigue. Clinical Endocrinology 2013, 80(1), 107-114.
• Willis TA, Hollingsworth KG, Coombs A, Sveen ML, Andersen S, Stojkovic T, Eagle M, Mayhew A, de Sousa PL, Dewar L, Morrow JM, Sinclair CDJ, Thornton JS, Bushby K, Lochmuller H, Hanna MG, Hogrel JY, Carlier PG, Vissing J, Straub V. Quantitative Muscle MRI as an Assessment Tool for Monitoring Disease Progression in LGMD2I: A Multicentre Longitudinal Study. PLoS ONE 2013, 8(8), e70993.
• Bates MG, Newman JH, Jakovljevic DG, Hollingsworth KG, Alston CL, Zalewski P, Klawe JJ, Blamire AM, Macgowan GA, Keavney BD, Bourke JP, Schaefer A, McFarland R, Newton JL, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Defining cardiac adaptations and safety of endurance training in patients with m.3243A>g-related mitochondrial disease. International Journal of Cardiology 2013, 168(4), 3599-3608.
• Hallsworth K, Hollingsworth KG, Thoma C, Jakovljevic DG, MacGowan GA, Anstee QM, Taylor R, Day CP, Trenell MI. Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease. Journal of Hepatology 2013, 58(4), 757-762.
• Sinha A, Hollingsworth K, Ball S, Cheetham T. Improving the Vitamin D status of Vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle. Journal of Clinical Endocrinology and Metabolism 2013, 98(3), E509-E513.
• Hollingsworth KG, Garrood P, Eagle M, Bushby K, Straub V. Magnetic resonance imaging in duchenne muscular dystrophy: Longitudinal assessment of natural history over 18 months. Muscle & Nerve 2013, 48(4), 586-588.
• Wood CL, Tinnion RJ, Korada SM, Cheetham TD, Relton CL, Cooke RJ, Pearce MS, Hollingsworth KG, Trenell MI, Embleton ND. Growth and metabolic outcome in adolescents born preterm (GROWMORE): follow-up protocol for the Newcastle preterm birth growth study (PTBGS). BMC Pediatrics 2013, 13, 213.
• Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011, 54(10), 2506-2514.
• Hollingsworth KG, Newton JL, Robinson L, Taylor R, Blamire AM, Jones DEJ. Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis. Journal of Hepatology 2010, 53(1), 155-161.
• Hollingsworth KG, Hodgson T, MacGowan GA, Blamire AM, Newton JL. Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging. Journal of Internal Medicine 2012, 271(3), 264-270.
• Jones DEJ, Hollingsworth KG, Taylor R, Blamire AM, Newton JL. Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome. Journal of Internal Medicine 2010, 267(4), 394-401.
• Hollingsworth KG, Blamire AM, Keavney BD, MacGowan GA. Left ventricular torsion, energetics, and diastolic function in normal human aging. American Journal of Physiology: Heart and Circulatory Physiology 2012, 302(4), H885-H892.
• Hollingsworth KG, Macgowan GA, Morris L, Bates MG, Taylor R, Jones DE, Newton JL, Blamire AM. Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study. Journal of Applied Physiology 2012, 112(12), 2043-2048.
• Bates MG, Hollingsworth KG, Newman J, Jakovljevic DG, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodeling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. European Heart Journal - Cardiovascular Imaging 2013, 14(7), 650-658.
• Hollingsworth KG, Gorman GS, Trenell MI, McFarland R, Taylor RW, Turnbull DM, Macgowan GA, Blamire AM, Chinnery PF. Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation load. Neuromuscular Disorders 2012, 22(7), 592-596.
• Lim EL, Hollingsworth KG, Smith FE, Thelwall PE, Taylor R. Effects of raising muscle glycogen synthesis rate on skeletal muscle ATP turnover rate in type 2 diabetes. American Journal of Physiology: Endocrinology and Metabolism 2011, 301(6), E1155.
• Jones DEJ, Hollingsworth KG, Jakovljevic DG, Fattakhova G, Pairman J, Blamire AM, Trenell MI. Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: A case control study. European Journal of Clinical Investigation 2012, 42(2), 186-194.
• Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, Day CP, Trenell MI. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut 2011, 60(9), 1278-1283.
• Lim EL, Hollingsworth KG, Smith F, Thelwall P, Taylor R. Inhibition of lipolysis in type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates. Clinical Science 2011, 121(4), 169-177.
• Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Fasting Successfully Treats Early Diabetes Type 2. Forschende Komplementaermedizin 2011, 18(6), 359-360.
• Hollingsworth KG, Jones DEJ, Taylor R, Blamire AM, Newton JL. Impaired cardiovascular response to standing in Chronic Fatigue Syndrome. European Journal of Clinical Investigation 2010, 40(7), 608-615.
• Hollingsworth KG, Jones DEJ, Taylor R, Frith J, Blamire AM, Newton JL. Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline. Liver International 2010, 30(6), 878-885.
• Jones DEJ, Hollingsworth K, Fattakhova G, MacGowan G, Taylor R, Blamire A, Newton JL. Impaired cardiovascular function in primary biliary cirrhosis. American Journal of Physiology: Gastrointestinal and Liver Physiology 2010, 298(5), G764-G773.
• Reilich P, Horvath R, Krause S, Schramm N, Turnbull DM, Trenell M, Hollingsworth KG, Gorman GS, Hans VH, Reimann J, MacMillan A, Turner L, Schollen A, Witte G, Czermin B, Holinski-Feder E, Walter MC, Schoser B, Lochmuller H. The phenotypic spectrum of neutral lipid storage myopathy due to mutations in the PNPLA2 gene. Journal of Neurology 2011, 258(11), 1987-1997.
• Lim EL, Hollingsworth KG, Thelwall PE, Taylor R. Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy. NMR in Biomedicine 2010, 23(8), 952-957.
• Wang K, Hollingsworth K, Sims AJ, Blamire AM, Murray A. Evaluation of semi-automated border detection algorithms for the left ventricular endocardium from magnetic resonance images. In: Computing in Cardiology. 2010, Belfast, UK: IEEE.
• Hollingsworth KG, Jones DE, Aribisala BS, Thelwall PE, Taylor R, Newton JL, Blamire AM. Globus pallidus magnetisation transfer ratio, T1 and T2 in primary biliary cirrhosis: relationship with disease stage and age. Journal of Magnetic Resonance Imaging 2009, 29(4), 780-784.
• Garrood P, Hollingsworth KG, Eagle M, Aribisala BS, Birchall D, Bushby K, Straub V. MR Imaging in Duchenne Muscular Dystrophy: Quantification of T-1-Weighted Signal, Contrast Uptake, and the Effects of Exercise. Journal of Magnetic Resonance Imaging 2009, 30(5), 1130-1138.
• Hollingsworth KG, Newton JL, Taylor R, McDonald C, Palmer JM, Blamire AM, Jones DEJ. Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis. Clinical Gastroenterology and Hepatology 2008, 6(9), 1041-1048.
• Yu-Wai-Man P, Trenell MI, Hollingsworth KG, Griffiths PG, Chinnery PF. OPA1 mutations impair mitochondrial function in both pure and complicated dominant optic atrophy. Brain 2011, 134(4), e164.
• Kinali M, Arechavala-Gomeza V, Cirak S, Glover A, Guglieri M, Feng L, Hollingsworth KG, Hunt D, Jungbluth H, Roper HP, Quinlivan RM, Gosalakkal JA, Jayawant S, Nadeau A, Hughes-Carre L, Manzur AY, Mercuri E, Morgan JE, Straub V, Bushby K, Sewry C, Rutherford M, Muntoni F. Muscle histology vs MRI in Duchenne muscular dystrophy. Neurology 2011, 76(4), 346-353.
• Newton JL, Hollingsworth KG, Taylor R, El-Sharkawy AM, Khan ZU, Pearce R, Sutcliffe K, Okonkwo O, Davidson A, Burt J, Blamire AM, Jones DEJ. Cognitive impairment in primary biliary cirrhosis: Symptom impact and potential etiology. Hepatology 2008, 48(2), 541-549.
• Trenell MI, Hollingsworth KG, Lim EL, Taylor R. Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes. Diabetes Care 2008, 31(8), 1644-1649.
• Trenell MI, Hollingsworth KG, Lim EL, Taylor R. Walking improves lipid oxidation independent of changes in mitochondrial ATP synthesis in people with Type 2 diabetes. Diabetes Care 2008, 31(8), 1644-1649.
• Zahra MA, Hollingsworth KG, Sala E, Lomas DJ, Tan LT. Dynamic contrast-enhanced MRI as a predictor of tumour response to radiotherapy. Lancet Oncology 2007, 8(1), 63-74.
• Zahra MA, Hollingsworth KG, Sala E, Lomas DJ, Brenton JD, Arends MJ, Crawford RAF, Tan LT. Correlating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) with changes in tumour volume, as a predictor of radiation response in cervix cancer. In: 3rd International Conference on Translational Research and Pre-Clinical Strategies in Radiation Oncology (ICTR 2006). 2006, Lugano, Switzerland: Radiotherapy and Oncology: Elsevier.
• Hollingsworth KG, Johns ML. Droplet migration in emulsion systems measured using MR methods. Journal of Colloid and Interface Science 2006, 296(2), 700-709.
• Hollingsworth KG, Lomas DJ. Influence of perfusion on hepatic MR diffusion measurement. NMR in Biomedicine 2006, 19(2), 231-235.
• Hollingsworth KG, Abubacker MZ, Joubert I, Allison MED, Lomas DJ. Low-carbohydrate diet induced reduction of hepatic lipid content observed with a rapid non-invasive MRI technique. British Journal of Radiology 2006, 79(945), 712-715.
• Hollingsworth KG, Johns ML. Spatially resolved emulsion droplet sizing using inverse Abel transforms. Journal of Magnetic Resonance 2005, 176(1), 71-78.
• Hindmarsh JP, Hollingsworth KG, Wilson DI, Johns ML. An NMR study of the freezing of emulsion-containing drops. Journal of Colloid and Interface Science 2004, 275(1), 165-171.
• Sederman AJ, Hollingsworth KG, Johns ML, Gladden LF. Development and application of rotationally compensated RARE. Journal of Magnetic Resonance 2004, 171(1), 118-123.
• Hollingsworth KG, Sederman AJ, Buckley C, Gladden LF, Johns ML. Fast emulsion droplet sizing using NMR self-diffusion measurements. Journal of Colloid and Interface Science 2004, 274(1), 244-250.
• Barnes EC, Hollingsworth KG, Wilson DI, Johns ML. Magnetic resonance studies of liquid-soft solid mixing by extrusion. Chemical Engineering Research & Design 2004, 82(A10), 1360-1366.
• Hollingsworth KG, Johns ML. Rheo-nuclear magnetic resonance of emulsion systems. Journal of Rheology 2004, 48(4), 787-803.
• Buckley C, Hollingsworth KG, Sederman AJ, Holland DJ, Johns ML, Gladden LF. Applications of fast diffusion measurement using Difftrain. Journal of Magnetic Resonance 2003, 161(1), 112-117.
• Hollingsworth KG, Johns ML. Measurement of emulsion droplet sizes using PFG NMR and regularization methods. Journal of Colloid and Interface Science 2003, 258(2), 383-389.
• Al-Mrabeh A, Hollingsworth KG, Steven S, Tiniakos D, Taylor R. Quantification of intrapancreatic fat in type 2 diabetes by MRI. PLOS One 2017, 12(4), e0174660.
• Parikh J, Hollingsworth KG, Wallace D, Blamire AM, MacGowan GA. Normal age-related changes in left ventricular function: Role of afterload and subendocardial dysfunction. International Journal of Cardiology 2016, 223, 306-312.
• Hollingsworth KG, Weber M-A. Advanced and quantitative magnetic resonance imaging techniques. In: Neuromuscular Imaging. Springer New York, 2013, pp.35-53.
• Wood CL, Cheetham TD, Hollingsworth KG, Guglieri M, Ailins-Sahun Y, Punniyakodi S, Mayhew A, Straub V. Observational study of clinical outcomes for testosterone treatment of pubertal delay in Duchenne muscular dystrophy. BMC Pediatrics 2019, 19(1), 131.
• Neal MA, Pippard BJ, Hollingsworth KG, Maunder A, Dutta P, Simpson AJ, Blamire AM, Wild JM, Thelwall PE. Optimized and accelerated ¹⁹F-MRI of inhaled perfluoropropane to assess regional pulmonary ventilation. Magnetic Resonance in Medicine 2019, 82(4), 1301-1311.
• Houghton D, Zalewski P, Hallsworth K, Cassidy S, Thoma C, Avery L, Slomko J, Hardy T, Burt AD, Tiniakos D, Hollingsworth KG, Taylor R, Day CP, Masson S, McPherson S, Anstee QM, Newton JL, Trenell MI. The degree of hepatic steatosis associates with impaired cardiac and autonomic function. Journal of Hepatology 2019, 70(6), 1203-1213.
• Dodds RM, Davies K, Granic A, Hollingsworth KG, Warren C, Gorman G, Turnbull DM, Sayer AA. Mitochondrial respiratory chain function and content are preserved in the skeletal muscle of active very old men and women. Experimental Gerontology 2018, 113, 80-85.
• Sithamparanathan S, Rocha MC, Parikh JD, Rygiel KA, Falkous G, Grady JP, Hollingsworth KG, Trenell MI, Taylor RW, Turnbull DM, Gorman GS, Corris PA. Skeletal muscle mitochondrial oxidative phosphorylation function in idiopathic pulmonary arterial hypertension: in vivo and in vitro study. Pulmonary Circulation 2018, 8(2), 1-5.
• Al-Mrabeh A, Zhyzhneuskaya SV, Peters C, Barnes AC, Melhem S, Jesuthasan A, Aribasala B, Hollingsworth KG, Lietz G, Mathers JC, Sattar N, Lean MEJ, Taylor R. Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss. Cell Metabolism 2020, 31(2), 233-249.
• Yarnall AJ, Granic A, Waite S, Hollingsworth KG, Warren C, Vincent AE, Turnbull DM, Taylor RW, Dodds RM, Sayer AA. The feasibility of muscle mitochondrial respiratory chain phenotyping across the cognitive spectrum in Parkinson’s disease. Experimental Gerontology 2020, 138, 110997.
• Zhyzhneuskaya SV, Al-Mrabeh A, Peters C, Barnes AC, Aribisala B, Hollingsworth KG, McConnachie A, Sattar N, Lean MEJ, Taylor R. Time course of normalisation of functional beta cell capacity in DiRECT after weight loss in type 2 diabetes. Diabetes Care 2020, 43(4), 813-820.
• Bennett JL, Wood A, Smith N, Mistry R, Allen K, Jandial S, Tuckett JD, Gowdy SC, Foster HE, McErlane F, Hollingsworth KG. Can quantitative MRI be used in the clinical setting to quantify the impact of intra-articular glucocorticoid injection on synovial disease activity in juvenile idiopathic arthritis?. Pediatric Rheumatology 2019, 17(1), 74.
• Wood CL, Hollingsworth KG, Hughes E, Punniyakodi S, Muni-Lofra R, Mayhew A, Mitchell RT, Guglieri M, Cheetham TD, Straub V. Pubertal induction in adolescents with DMD is associated with high satisfaction, gonadotropin release and increased muscle contractile surface area. European Journal of Endocrinology 2021, 184(1), 67-79.
• Pippard BJ, Neal MA, Maunder AM, Hollingsworth KG, Biancardi A, Lawson RA, Fisher H, Matthews JNS, Simpson AJ, Wild JM, Thelwall PE. Reproducibility of ¹⁹F-MR ventilation imaging in healthy volunteers. Magnetic Resonance in Medicine 2021, 85(6), 3343-3352.
• Doorenweerd N, de Rover M, Marini-Bettolo C, Hollingsworth KG, Niks EH, Hendriksen JGM, Kan HE, Straub V. Resting-state functional MRI shows altered default-mode network functional connectivity in Duchenne muscular dystrophy patients. Brain Imaging and Behavior 2021, 15, 2297-2307.
• Al-Mrabeh A, Hollingsworth KG, Shaw JAM, McConnachie A, Sattar N, Lean MEJ, Taylor R. 2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial. The Lancet: Diabetes & Endocrinology 2020, 8(12), 939-948.
• Al-Mrabeh A, Hollingsworth KG, Shaw JAM, McConnachie A, Sattar N, Lean MEJ, Taylor R. 2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial. The Lancet Diabetes and Endocrinology 2020, 8(12), 939-948.
• Lu LW, Silvestre MP, Sequeira IR, Plank LD, Foster M, Middleditch N, Acevedo-Fani A, Hollingsworth KG, Poppitt SD. A higher-protein nut-based snack product suppresses glycaemia and decreases glycaemic response to co-ingested carbohydrate in an overweight prediabetic Asian Chinese cohort: The Tu Ora postprandial RCT. Journal of Nutritional Science 2021, 10, e30.
• Wibowo PG, Charman SJ, Okwose NC, Velicki L, Popovic D, Hollingsworth KG, Macgowan GA, Jakovljevic DG. Association between cardiac high-energy phosphate metabolism and whole body metabolism in healthy female adults. Physiological Research 2021, 70(3), 393-399.
• Al-Mrabeh A, Peters C, Hollingsworth KG, Taylor R. Measurement of intraorgan fat and hepatic output of triglycerides in human type 2 diabetes by magnetic resonance and Intralipid infusion techniques. STAR Protocols 2021, 2(1), 100355.
• Sequeira IR, Woodhead JST, Chan A, D'Souza RF, Wan J, Hollingsworth KG, Plank LD, Cohen P, Poppitt SD, Merry TL. Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes. Biochimica et Biophysica Acta - General Subjects 2021, 1865(11), 129991.
• Jesuthasan A, Zhyzhneuskaya S, Peters C, Barnes AC, Hollingsworth KG, Sattar N, Lean MEJ, Taylor R, Al-Mrabeh AH. Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss. Diabetologia 2021, 65, 226-233.