Staff Profile
Dr Laura Maringele
Lecturer (Genome Instability)
- Telephone: +44 (0) 191 2088146
- Address: Newcastle University Biosciences Institute
M2.022A, 2nd floor Cookson Building
Medical School
Newcastle University
Framlington Place
Newcastle upon Tyne
NE2 4HH
Teaching
Postgraduate Teaching
Telomeres in ageing and cancer
Publications
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Articles
- Robertson CM, Xue Y, Chowdhury S, Maringele L. A CDK-Dependent Phosphorylation of a Novel Domain of Rif1 Regulates its Function during Telomere Damage and Other Types of Stress. Molecular and Cellular Biology 2023, 43(5), 185-199.
- Raykov V, Marvin ME, Louis EJ, Maringele L. Telomere Dysfunction Triggers Palindrome Formation Independently of Double-Strand Break Repair Mechanisms. Genetics 2016, 203(4), 1659-1668.
- Xue Y, Marvin ME, Ivanova IG, Lydall D, Louis EJ, Maringele L. Rif1 and Exo1 regulate the genomic instability following telomere losses. Aging Cell 2016, 15(3), 553-562.
- Ivanova I, Maringele L. Polymerases ε and ∂ repair dysfunctional telomeres facilitated by salt. Nucleic Acids Research 2016, 44(8), 3728-3738.
- Addinall SG, Holstein EM, Lawless C, Yu M, Chapman K, Banks AP, Ngo HP, Maringele L, Taschuk M, Young A, Ciesiolka A, Lister AL, Wipat A, Wilkinson DJ, Lydall D. Quantitative Fitness Analysis Shows That NMD Proteins and Many Other Protein Complexes Suppress or Enhance Distinct Telomere Cap Defects. PLoS Genetics 2011, 7(4), e1001362.
- Deshpande AM, Ivanova IG, Raykov V, Xue Y, Maringele L. Polymerase Epsilon Is Required To Maintain Replicative Senescence. Molecular and Cellular Biology 2011, 31(8), 1637-1645.
- Xue Y, Rushton MD, Maringele L. A Novel Checkpoint and RPA Inhibitory Pathway Regulated by Rif1. PLoS Genetics 2011, 7(12), e1002417.
- LeBel C, Rosonina E, Sealey DCF, Pryde F, Lydall D, Maringele L, Harrington LA. Telomere Maintenance and Survival in Saccharomyces cerevisiae in the Absence of Telomerase and RAD52. Genetics 2009, 182(3), 671-684.
- Zubko MK, Maringele L, Foster SS, Lydall D. Detecting repair intermediates in vivo: Effects of DNA damage response genes on single-stranded DNA accumulation at uncapped telomeres in budding yeast. Methods in Enzymology 2006, 409, 285-300.
- Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D. A Genome-Wide Screen Identifies the Evolutionarily Conserved KEOPS Complex as a Telomere Regulator. Cell 2006, 124(6), 1155-1168.
- Maringele L, Lydall D. The PAL-mechanism of Chromosome Maintenance: Causes and Consequences. Cell Cycle 2005, 4(6), 747-751.
- Maringele L, Lydall D. Telomerase- and recombination-independent immortalization of budding yeast. Genes and Development 2004, 18(21), 2663-2675.
- Maringele L, Lydall D. EXO1 Plays a Role in Generating Type I and Type II Survivors in Budding Yeast. Genetics 2004, 166(4), 1641-1649.
- Maringele L, Lydall D. EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Δ mutants. Genes & Development 2002, 16(15), 1919-1933.
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Book Chapter
- Maringele L, Lydall D. Pulsed Field Gel Electrophoresis of Budding Yeast Chromosomes. In: Xiao, W, ed. Yeast Protocols. Totawa, New Jersey: Humana Press, 2005, pp.65-74.