Staff Profile

My research is focussed mainly on in vitro models of the human aerodigestive tract as an alternative to animal models. I'm interested in mucus function, drug delivery and dietary interventions.

I'm also interested in the commercialisation and translation of research, and helped set up Aelius Biotech which i'm still involved in: www.aeliusbiotech.co.uk

Always interested in collaborations, and am more likely to pick up emails here: peter.chater@aeliusbiotech.co.uk

• Articles

  • Houghton D, Shannon OM, Chater PI, Wilcox MD, Pearson J, Stanforth K, Jordan C, Avery L, Blain AP, Joel A, Jeffers R, Nolan R, Nelson A, Stewart CJ, Malcomson FC. White kidney bean extract as a nutraceutical: Effects on gut microbiota, alpha-amylase inhibition, and user experiences. Gut Microbiome 2023, 4, e8.
  • Wilcox MD, Cherry P, Chater PI, Yang X, Zulali M, Okello EJ, Seal CJ, Pearson JP. The effect of seaweed enriched bread on carbohydrate digestion and the release of glucose from food. Journal of Functional Foods 2021, 87, 104747.
  • Crouch LI, Liberato MV, Urbanowicz PA, Basle A, Lamb CA, Stewart CJ, Cooke K, Doona M, Needham S, Brady RR, Berrington JE, Madunic K, Wuhrer M, Chater P, Pearson JP, Glowacki R, Martens EC, Zhang F, Linhardt RJ, Spencer DIR, Bolam DN. Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown. Nature Communications 2020, 11(1), 4017.
  • Arriola NDA, Chater PI, Wilcox MD, Lucinic L, Rocchettic G, Dalminad M, Pearson JP, Amboni RDdeMC. Encapsulation of stevia rebaudiana Bertoni aqueous crude extracts by ionic gelation – Effects of alginate blends and gelling solutions on the polyphenolic profile. Food Chemistry 2019, 275, 123-134.
  • Houghton d, Wilcox MD, Brownlee IA, Chater PI, Seal CJ, Pearson JP. Acceptability of alginate enriched bread and its effect on fat digestion in humans. Food Hydrocolloids 2019, 93, 395-401.
  • Gill S, Chater PI, Wilcox MD, Pearson JP, Brownlee IA. The impact of dietary fibres on the physiological processes of the large intestine. Bioactive Carbohydrates and Dietary Fibre 2018, 16, 62-74.
  • Chater PI, Wilcox MD, Pearson JP. Efficacy and safety concerns over the use of mucus modulating agents for drug delivery using nanoscale systems. Advanced Drug Delivery Reviews 2018, 124, 184-192.
  • Prufert F, Bonengel S, Kollner S, Griesser J, Wilcox MD, Chater PI, Pearson JP, Bernkop-Schnurch A. ζ potential changing nanoparticles as cystic fibrosis transmembrane conductance regulator gene delivery system: An in vitro evaluation. Nanomedicine 2017, 12(22), 2713-2724.
  • Chater PI, Wilcox M, Cherry P, Herford A, Mustar S, Wheater H, Brownlee I, Seal C, Pearson J. Inhibitory activity of extracts of Hebridean brown seaweeds on lipase activity. Journal of Applied Phycology 2016, 28(2), 1303-1313.
  • Wilcox MD, Van Rooij LK, Chater PI, de Sousa IP, Pearson JP. The effect of nanoparticle permeation on the bulk rheological properties of mucus from the small intestine. European Journal of Pharmaceutics and Biopharmaceutics 2015, 96, 484-487.
  • Houghton D, Wilcox MD, Chater PI, Brownlee IA, Seal CJ, Pearson JP. Biological activity of alginate and its effect on pancreatic lipase inhibition as a potential treatment for obesity. Food Hydrocolloids 2015, 49, 18-24.
  • Chater PI, Wilcox MD, Brownlee IA, Pearson JP. Alginate as a protease inhibitor in vitro and in a model gut system; selective inhibition of pepsin but not trypsin. Carbohydrate Polymers 2015, 131, 142-151.
  • Houghton D, Wilcox MD, Brownlee IA, Chater P, Seal CJ, Pearson JP. Method for quantifying alginate and determining release from a food vehicle in gastrointestinal digesta. Food Chemistry 2014, 151, 352-357.
  • Balasubramaniam V, Mustar S, Mustafa Khalid N, Abd Rashed A, Mohd Noh MF, Wilcox MD, Chater PI, Brownlee IA, Pearson JP. Inhibitory activities of three Malaysian edible seaweeds on lipase and α-amylase. Journal of Applied Phycology 2013, 25(5), 1405-1412.
  • Ali MS, Parikh S, Chater P, Pearson JP. Bile acids in laryngopharyngeal refluxate: Will they enhance or attenuate the action of pepsin?. The Laryngoscope 2013, 123(2), 434-439.

• Conference Proceedings (inc. Abstracts)

  • Houghton D, Chater P, Wilcox M, Brownlee I, Trenell MI, Seal C, Pearson J. Alginate enriched bread attenuates circulating lipids and non-alcoholic fatty liver disease. In: 50th Annual Meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
  • Chater PI, Wilcox M, Brownlee I, Pearson JP. A synthetic model gut system to study macronutrient digestion in vitro. In: Proceedings of the Nutrition Society: Summer Meeting 2014. 2015, Cambridge University Press.

• Letter

  • Dettmar PW, Woodcock AD, Wilcox MD, Chater PI, Pearson JP. Letter: studies of salivary pepsin in patients with gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics 2019, 49(9), 1248-1249.

• Reviews

  • Althuwaybi A, Alamer A, McDonnell MJ, Brennan M, Rutherford RM, Wilcox M, Chater P, Pearson J, Ward C. A clinical review of the potential role of microaspiration and a dysregulated aerodigestive microbiome in lung disease. Annals of Esophagus 2023, 6, 7.
  • Brownlee IA, Gill S, Wilcox MW, Pearson JP, Chater PI. Starch digestion in the upper gastrointestinal tract of humans. Starch 2018, 70(9-10), 1700111.
  • Brownlee IA, Chater PI, Pearson JP, Wilcox MD. Dietary fibre and weight loss: Where are we now?. Food Hydrocolloids 2017, 68, 186-191.
  • Pearson JP, Chater PI, Wilcox MD. The properties of the mucus barrier, a unique gel - how can nanoparticles cross it?. Therapeutic Delivery 2016, 7(4), 229-244.
  • Chater PI, Wilcox MD, Houghton D, Pearson JP. The role of seaweed bioactives in the control of digestion: implications for obesity treatments. Food & Function 2015, 6(11), 3420-3427.
  • Chater PI, Wilcox MD, Pearson JP, Brownlee IA. The impact of dietary fibres on the physiological processes governing small intestinal digestive processes. Bioactive Carbohydrates and Dietary Fibre 2015, 6(2), 117-132.