Staff Profile

Dr Carmen Martin-Ruiz received her PhD in Human Physiology from the University of Paris VII. Her first post-doc was with the MRC Unit at Newcastle General Hospital as part of an international network researching nicotinic receptors role in Alzheimer’s and Parkinson’s disease but also in the context of schizophrenia, autism and vascular dementia. Later her research widened onto cell senescence and ageing and in 2006, within the Newcastle 85 cohort study, she was in charge of the assessment of an extensive panel of blood-derived biomarkers to look at how different health trajectories associate with biological factors such as cell senescence, inflammation and immunosenescence. She then became part of the Newcastle NIHR Biomedical Research Centre as manager of the Biomarker Lab where research is performed onto molecular markers of ageing that can be used to inform clinicians when assessing specific interventions and their impacts on a varied range of age-related diseases.

Area of expertise

• Biomarkers research
• Screening and validation
• Ageing and age-related disease biomarkers

• King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor JP, Thomas AJ. Peripheral inflammation in mild cognitive impairment with possible and probable Lewy body disease and Alzheimer’s disease. International Psychogeriatrics 2019, 31(4), 551-560.
• Mendonca N, Jagger C, Granic A, Martin-Ruiz C, Mathers JC, Seal CJ, Hill TR. Plasma Vitamin B12, Supplementation and Mortality. The Journals of Gerontology: Series A 2019, 74(1), 138-138.
• Bateson M, Aviv A, Bendix L, Benetos A, Ben-Shlomo Y, Bojesen SE, Cooper C, Cooper R, Deary IJ, Hagg S, Harris SE, Kark JD, Kronenberg F, Kuh D, Labat C, Martin-Ruiz CM, Meyer C, Nordestgaard BG, Penninx BWJH, Pepper GV, Revesz D, Said MA, Starr JM, Syddall H, Thomson WM, Van Der Harst P, Whooley M, Von Zglinicki T, Willeit P, Zhan Y, Nettle D. Smoking does not accelerate leucocyte telomere attrition: A meta-analysis of 18 longitudinal cohorts. Royal Society Open Science 2019, 6(6), 190420.
• Aas M, Elvsåshagen T, Westlye LT, Kaufmann T, Athanasiu L, Djurovic S, Melle I, van der Meer D, Martin-Ruiz C, Steen NE, Agartz I, Andreassen OA. Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational Psychiatry 2019, 9(1), 97.
• Mendonça N, Jagger C, Granic A, Martin-Ruiz C, Mathers JC, Seal CJ, Hill TR. Elevated total homocysteine in all participants and plasma vitamin B12 concentrations in women are associated with all-cause and cardiovascular mortality in the very old: The Newcastle 85+ Study. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences 2018, 73(9), 1258-1264.
• King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor J-P, Thomas AJ. Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias. Journal of Neurology, Neurosurgery and Psychiatry 2018, 89(4), 339-345.
• Harris SE, Riggio V, Evenden L, Gilchrist T, McCafferty S, Murphy L, Wrobel N, Taylor AM, Corley J, Pattie A, Cox SR, Martin-Ruiz C, Prendergast J, Starr JM, Marioni RE, Deary IJ. Age-related gene expression changes and transcriptome wide association study of physical and cognitive aging traits in the Lothian Birth Cohort 1936. Aging 2017, 9(12), 2489-2503.
• Nettle D, Andrews C, Reichert S, Bedford T, Kolenda C, Parker C, Martin-Ruiz C, Monaghan P, Bateson M. Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling. Scientific Reports 2017, 7, 40794.
• Granic A, Davies K, Martin-Ruiz C, Jagger C, Kirkwood TBL, von Zglinicki T, Sayer AA. Grip strength and inflammatory biomarker profiles in very old adults. Age and Ageing 2017, 46(6), 976-982.
• Mendonca N, Granic A, Mathers JC, Martin-Ruiz C, Wesnes KA, Seal CJ, Jagger C, Hill TR. Homocysteine, Tryptophan, and Cognition in the Very Old. Journal of the American Medical Directors Association 2017, 18(10), 895-896.
• Mendonca N, Granic A, Mathers JC, Martin-Ruiz C, Wesnes KA, Seal CJ, Jagger C, Hill TR. One-Carbon Metabolism Biomarkers and Cognitive Decline in the Very Old: The Newcastle 85+ Study. Journal of the American Medical Directors Association 2017, 18(9), 806.e19-806.e27.
• McAleese KE, Walker L, Graham S, Moya ELJ, Johnson M, Erskine D, Colloby SJ, Dey M, Martin-Ruiz C, Taylor J-P, Thomas AJ, McKeith IG, De Carli C, Attems J. Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease. Acta Neuropathologica 2017, 134(3), 459-473.
• Nettle D, Andrews C, Reichert S, Bedford T, Gott A, Parker C, Kolenda C, Martin-Ruiz C, Monaghan P, Bateson M. Brood size moderates associations between relative size, telomere length, and immune development in European starling nestlings. Ecology and Evolution 2016, 6(22), 8138-8148.
• Wyatt N, Hogarth L, Turner D, Patterson M, Jamieson D, Black F, Hutton C, Mulvenna P, Simmons T, Bradshaw A, Kolenda C, Parker C, Martin-Ruiz C, Greystoke A. Circulating Biomarkers of Frailty Are Associated with a Poor Prognosis in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC). In: IASLC 17th World Conference on Lung Cancer. 2016, Vienna, Austria: Elsevier.
• Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, Kirkwood T, von Zglinicki T. CMV-seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians - results from the Newcastle 85+ study. Aging Cell 2016, 15(2), 389-392.
• Mendonça NMP, Mathers JC, Adamson AJ, Martin-Ruiz C, Seal CJ, Jagger C, Hill TR. Intakes of Folate and Vitamin B12 and Biomarkers of Status in the Very Old: The Newcastle 85+ Study. Nutrients 2016, 8(10), 604.
• Harris SE, Marioni RE, Martin-Ruiz C, Pattie A, Gow AJ, Cox SR, Corley J, von Zglinicki T, Starr JM, Deary IJ. Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921. Mechanisms of Ageing and Development 2016, 154, 43-48.
• Hill TR, Granic A, Davies K, Collerton J, Martin-Ruiz C, Siervo M, Mathers JC, Adamson AJ, Francis RM, Pearce SH, Razvi S, Kirkwood TBL, Jagger C. Serum 25-hydroxyvitamin D concentration and its determinants in the very old: The Newcastle 85+ study. Osteoporosis International 2016, 27(3), 1199-1208.
• Pearce SHS, Razvi S, Yadegarfar ME, Martin-Ruiz C, Kingston A, Collerton J, Visser TJ, Kirkwood TB, Jagger C. Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+Study. Journal of Clinical Endocrinology & Metabolism 2016, 101(11), 4385-4394.
• Granic A, Aspray T, Hill T, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Kirkwood TB, Mathers JC, Jagger C. 25-hydroxyvitamin D and increased all-cause mortality in very old women: the Newcastle 85+ study. Journal of Internal Medicine 2015, 277(4), 456-467.
• Mitnitski A, Collerton J, Martin-Ruiz C, Jagger C, von Zglinicki T, Rockwood K, Kirkwood TBL. Age-related frailty and its association with biological markers of ageing. BMC Medicine 2015, 13, 161.
• Kunadian V, Veerasamy M, Sinclair H, Batty J, Sharifpour M, Lima J, Neely D, Martin-Ruiz C, Saretzki G. Association of Telomere Length and Telomerase Activity with Clinical Parameters in Older Patients Undergoing Invasive Management Of non-ST Elevation Acute Coronary Syndrome. In: BCS annual conference. 2015, Manchester, UK: BMJ Group.
• Arai Y, Martin-Ruiz CM, Takayama M, Abe Y, Takebayashi T, Koyasu S, Suematsu M, Hirose N, von Zglinicki T. Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians. EBioMedicine 2015, 2(10), 1549-1558.
• Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, Harst PD, Bekaert S, De Meyer T, Roos G, Svenson U, Codd V, Samani NJ, Mcglynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, Von Zglinicki T. Is Southern blotting necessary to measure telomere length reproducibly? Authors' Response to: Commentary: The reliability of telomere length measurements. International Journal of Epidemiology 2015, 44(5), 1686-1687.
• Hoffmann J, Shmeleva EV, Boag SE, Fiser K, Bagnall A, Murali S, Dimmick I, Pircher H, Martin-Ruiz C, Egred M, Keavney B, von Zglinicki T, Das R, Todryk S, Spyridopoulos I. Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients. Circulation Research 2015, 116(1), 87-98.
• Walker L, McAleese KE, Thomas AJ, Johnson M, Martin-Ruiz C, Parker C, Colloby SJ, Jellinger K, Attems J. Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes. Acta Neuropathologica 2015, 129(5), 729-748.
• Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, vanderHarst P, Bekaert S, deMeyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, von Zglinicki T. Reproducibility of telomere length assessment: an international collaborative study. International Journal of Epidemiology 2015, 44(5), 1673-1683.
• Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, Van der Harst P, Bekaert S, De Meyer T, Roos G, Svenson U, Codd V, Samani NJ, Mcglynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, Von Zglinicki T. Reproducibility of telomere length assessment: Authors' Response to Damjan Krstajic and Ljubomir Buturovic. International Journal of Epidemiology 2015, 44(5), 1739-1741.
• Masca NGD, Hensor EMA, Cornelius VR, Buffa FM, Marriott HM, Eales JM, Messenger MP, Anderson AE, Boot C, Bunce C, Goldin RD, Harris J, Hinchliffe RF, Junaid H, Kingston S, Martin-Ruiz C, Nelson CP, Peacock J, Seed PT, Shinkins B, Staples KJ, Toombs J, Wright AKA, Dawn Teare M. RIPOSTE: a framework for improving the design and analysis of laboratory-based research. eLife 2015, 4(MAY), 1-45.
• Granic A, Hill TR, Kirkwood TBL, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Saxby BK, Wesnes KA, Collerton D, Mathers JC, Jagger C. Serum 25-hydroxyvitamin D and cognitive decline in the very old: The Newcastle 85+ study. European Journal of Neurology 2015, 22(1), 106-e7.
• Collerton J, Gautrey HE, van Otterdijk SD, Davies K, Martin-Ruiz C, von Zglinicki T, Kirkwood TBL, Jagger C, Mathers JC, Strathdee G. Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+Study. Biogerontology 2014, 15(4), 317-328.
• Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels P, Sayer AA, Barbieri M, Bekaert S, Bischoff C, Brooks-Wilson A, Chen W, Cooper C, Christensen K, De Meyer T, Deary I, Der G, Roux AD, Fitzpatrick A, Hajat A, Halaschek-Wiener J, Harris S, Hunt SC, Jagger C, Jeon HS, Kaplan R, Kimura M, Lansdorp P, Li CY, Maeda T, Mangino M, Nawrot TS, Nilsson P, Nordfjall K, Paolisso G, Ren F, Riabowol K, Robertson T, Roos G, Staessen JA, Spector T, Tang N, Unryn B, van der Harst P, Woo J, Xing C, Yadegarfar ME, Park JY, Young N, Kuh D, von Zglinicki T, Ben-Shlomo Y, Halcyon Study Team. Gender and telomere length: Systematic review and meta-analysis. Experimental Gerontology 2014, 51, 15-27.
• Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels P, Sayer AA, Barbieri M, Bekaert S, Bischoff C, Brooks-Wilson A, Chen W, Cooper C, Christensen K, DeMeyer T, Deary I, Der G, DiezRoux A, Fitzpatrick A, Hajat A, Halaschek-Wiener J, Harris S, Hunt SC, Jagger C, Jeon HS, Kaplan R, Kimura M, Lansdorp P, Li C, Maeda T, Mangino M, Nawrot TS, Nilsson P, Nordfjall K, Paolisso G, Ren F, Riabowol K, Robertson T, Roos G, Staessen JA, Spector T, Tang N, Unryn B, van der Harst P, Woo J, Xing C, Yadegarfar ME, Park JY, Young N, Kuh D, von Zglinicki T, Ben-Shlomo Y. Gender and telomere length: systematic review and meta-analysis. Experimental Gerontology 2014, 51, 15-27.
• Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, Tan Q, Kamatani Y, Bennet AM, Tamm R, Trompet S, Guobjartsson DF, Flachsbart F, Rose G, Viktorin A, Fischer K, Nygaard M, Cordell HJ, Crocco P, Van den Akker EB, Bohringer S, Helmer Q, Nelson CP, Saunders GI, Alver M, Andersen-Ranberg K, Breen ME, van der Breggen R, Caliebe A, Capri M, Cevenini E, Collerton JC, Dato S, Davies K, Ford I, Gampe J, Garagnani P, de Geus EJC, Harrow J, van Heemst D, Heijmans BT, Heinsen FA, Hottenga JJ, Hofman A, Jeune B, Jonsson PV, Lathrop M, Lechner D, Martin-Ruiz C, Mcnerlan SE, Mihailov E, Montesanto A, Mooijaart SP, Murphy A, Nohr EA, Paternoster L, Postmus I, Rivadeneira F, Ross OA, Salvioli S, Sattar N, Schreiber S, Stefansson H, Stott DJ, Tiemeier H, Uitterlinden AG, Westendorp RGJ, Willemsen G, Samani NJ, Galan P, Sorensen TIA, Boomsma DI, Jukema JW, Rea IM, Passarino G, de Craen AJM, Christensen K, Nebel A, Stefansson K, Metspalu A, Magnusson P, Blanche H, Christiansen L, Kirkwood TBL, van Duijn CM, Franceschi C, Houwing-Duistermaat JJ, Slagboom PE. Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics 2014, 23(16), 4420-4432.
• Baylis D, Ntani G, Edwards MH, Syddall HE, Bartlett DB, Dennison EM, Martin-Ruiz C, von Zglinicki T, Kuh D, Lord JM, Aihie Sayer A, Cooper C. Inflammation, telomere length, and grip strength: a 10-year longitudinal study. Calcified Tissue International 2014, 95(1), 54-63.
• Wiley L, Ashok D, Martin-Ruiz C, Talbot DCS, Collerton J, Kingston A, Davies K, Chinnery PF, Catt M, Jagger C, Kirkwood TBL, von Zglinicki T. Reactive Oxygen Species Production and Mitochondrial Dysfunction in White Blood Cells Are Not Valid Biomarkers of Ageing in the Very Old. PLoS ONE 2014, 9(3), e91005.
• Collerton J, Kingston A, Yousaf F, Davies K, Kenny A, Neely D, Martin-Ruiz C, MacGowan G, Robinson L, Kirkwood TBL, Keavney B. Utility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+Study. BMC Cardiovascular Disorders 2014, 14, 128.
• Granic A, Kirkwood T, Davies K, Collerton J, Hill T, Martin-Ruiz C, vonZglinicki T, Aspray T, Mathers JC, Jagger C. 25-hydroxyvitamin D and increased risk of all-cause mortality in very old women: The Newcastle 85+ study. In: UK Molecular Epidemiology Group (MEG) Winter Meeting on The Future of Epidemiology: Biomarkers meet Populations. 2013, Newcastle University: Oxford University Press.
• Nelson G, Wordsworth J, Wang CF, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T. A senescent cell bystander effect: senescence-induced senescence. Aging Cell 2012, 11(2), 345-349.
• Pearce MS, Mann KD, Martin-Ruiz C, Parker L, White M, von Zglinicki T, Adams J. Childhood Growth, IQ and Education as Predictors of White Blood Cell Telomere Length at Age 49-51 Years: The Newcastle Thousand Families Study. PLoS One 2012, 7(7), e40116.
• Collerton J, Martin-Ruiz C, Davies K, Catt M, Jagger C, von Zglinicki T, Kirkwood T. Frailty and biomarkers of inflammation, immunoscience and cellular ageing in the Newcastle 85+ Study. In: GSA 65th Annual Scientific Meeting. 2012, San Diego, California, USA: Oxford University Press.
• Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, Parker C, Dunn M, Catt M, Jagger C, von Zglinicki T, Kirkwood TB. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study. Mechanisms of Ageing and Development 2012, 133(6), 456-466.
• Hoffmann J, Fiser K, Weaver J, Dimmick I, Loeher M, Pircher H, Martin-Ruiz C, Veerasamy M, Keavney B, von Zglinicki T, Spyridopoulos I. High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction. PLoS one 2012, 7(10), e47155.
• Harris SE, Martin-Ruiz C, vonZglinicki T, Starr JM, Deary IJ. Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936. Neurobiology of Aging 2012, 33(7), 1486.e3-1486.e8.
• Martin Ruiz C, Jagger C, Kingston A, Collerton J, Catt M, Davies K, Dunn M, Hilkens C, Keavney B, Pearce S, den Elzen W, Talbot D, Wiley L, Bond J, Mathers J, Eccles M, Robinson L, James O, Kirkwood T, von Zglinicki T. Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study. Mechanisms of Ageing and Development 2011, 132(10), 496-502.
• Jagger C, Collerton JC, Davies K, Kingston A, Robinson LA, Eccles MP, von Zglinicki T, Martin-Ruiz C, James OFW, Kirkwood TBL, Bond J. Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs. BMC Geriatrics 2011, 11, 21.
• Den Elzen WPJ, Martin-Ruiz C, von Zglinicki T, Westendorp RGJ, Kirkwood TBL, Gussekloo J. Telomere length and anaemia in old age: results from the Newcastle 85-plus Study* and the Leiden 85-plus Study. Age and Ageing 2011, 40(4), 494-500.
• Kirkwood T, Martin-Ruiz C, Jagger C, Collerton J, Kingston A, von Zglinicki T. Biomarkers of ageing and their relationship to disability and cognition [abstract]. Gerontologist 2010, 50, 375.
• Domínguez-Garrido E, Martínez-Redondo D, Martín-Ruiz C, Gómez-Durán A, Ruiz-Pesini E, Madero P, Tamparillas M, Montoya J, von Zglinicki T, Díez-Sánchez C, López-Pérez M. Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations. Biogerontology 2009, 10(4), 435-442.
• Wang CF, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009, 8(3), 311-323.
• Collerton J, Davies K, Jagger C, Kingston A, Bond J, Eccles M, Robinson L, Martin-Ruiz C, Von Zglinicki T, James O, Kirkwood T. Health and disease in 85 year olds: Baseline findings from the Newcastle 85+ cohort study. British Medical Journal 2009, 339, b4904.
• Hapangama DK, Turner MA, Drury JA, Quenby S, Hart A, Maddick M, Martin-Ruiz C, von Zglinicki T. Sustained replication in endometrium of women with endometriosis occurs without evoking a DNA damage response. Human Reproduction 2009, 24(3), 687-696.
• Hapangama DK, Turner MA, Drury JA, Martin-Ruiz C, von Zglinicki T, Farquharson RG, Quenby S. Endometrial telomerase shows specific expression patterns in different types of reproductive failure. Reproductive BioMedicine Online 2008, 17(3), 416-424.
• Hapangama DK, Turner MA, Drury JA, Quenby S, Saretzki G, Martin-Ruiz C, Von Zglinicki T. Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length. Human Reproduction 2008, 23(7), 1511-1519.
• Pearce MS, Adams JM, Martin-Ruiz CM, White M, von Zglinicki TW. Growth and white blood cell telomere length at age 50: the Newcastle Thousand Families Study. In: 5th International Congress on Developmental Origins of Health & Disease. 2007, Perth, Western Australia: Early Human Development: Elsevier Ireland.
• Adams JM, Martin-Ruiz CM, Pearce MS, White M, Parker L, von Zglinicki TW. No association between socio-economic status and white blood cell telomere length. Aging Cell 2007, 6(1), 125-128.
• Ksiazek K, Passos JF, Olijslagers S, Saretzki G, Martin-Ruiz C, von Zglinicki T. Premature senescence of mesothelial cells is associated with non-telomeric DNA damage. Biochemical and Biophysical Research Communications 2007, 362(3), 707-711.
• Collerton J, Martin-Ruiz C, Kenny A, Barrass K, Von Zglinicki T, Kirkwood T, Keavney B, Bond J, Eccles M, Jagger C, James O, Robinson L. Telomere length is associated with left ventricular function in the oldest old: The Newcastle 85+ study. European Heart Journal 2007, 28(2), 172-176.
• Collerton J, Barrass K, Bond J, Eccles M, Jagger C, James O, Martin-Ruiz C, Robinson L, Von Zglinicki T, Kirkwood T. The Newcastle 85+ study: Biological, clinical and psychosocial factors associated with healthy ageing: Study protocol. BMC Geriatrics 2007, 7(14).
• Collerton J, Martin-Ruiz C, Kenny M, Barrass K, von Zglinicki T, Kirkwood T, Keavney B. White blood cell telomere length is associated with left ventricular function in the oldest old: The newcastle 85+study. Heart 2007, 93, A25-A26.
• Getliffe KM, Martin Ruiz C, Passos JF, Von Zglinicki T, Nwokolo CU. Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients. European Journal of Gastroenterology and Hepatology 2006, 18(2), 133-141.
• Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, De Ponte M, Koo A, Forse RA, Chinnappan D, Martin-Ruiz C, Von Zglinicki T, Kirkland JL. Fat depot-specific characteristics are retained in strains derived from single human preadipocytes. Diabetes 2006, 55(9), 2571-2578.
• Martin-Ruiz C, Dickinson HO, Keys B, Rowan E, Kenny RA, von Zglinicki T. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Annals of Neurology 2006, 60(2), 174-180.
• Getliffe KM, Al Dulaimi D, Martin-Ruiz C, Holder RL, Von Zglinicki T, Morris A, Nwokolo CU. Lymphocyte telomere dynamics and telomerase activity in inflammatory bowel disease: Effect of drugs and smoking. Alimentary Pharmacology and Therapeutics 2005, 21(2), 121-131.
• Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RGJ. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: A population-based study. Aging Cell 2005, 4(6), 287-290.
• von Zglinicki T, Martin-Ruiz CM. Telomeres as biomarkers for ageing and age-related diseases. Current Molecular Medicine 2005, 5(2), 197-203.
• Von Zglinicki T, Martin-Ruiz CM, Saretzki G. Telomeres, cell senescence and human ageing. Signal Transduction 2005, 5(3), 103-114.
• Martin-Ruiz CM, Lee M, Perry RH, Baumann M, Court JA, Perry EK. Molecular analysis of nicotinic receptor expression in autism. Molecular Brain Research 2004, 123(1-2), 81-90.
• Adams J, White M, Pearce MS, Martin-Ruiz C, Parker L, von Zglinicki T. Socio-economic position, health behaviours and telomere length at age 50: a prospective cohort study. In: 4th European Congress of Biogerontology. 2004, Newcastle upon Tyne, UK.
• Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, Von Zglinicki T. Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span. Journal of Biological Chemistry 2004, 279(17), 17826-17833.
• Martin-Ruiz CM, Haroutunian VH, Long P, Young AH, Davis KL, Perry EK, Court JA. Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia. Biological Psychiatry 2003, 54(11), 1222-1233.
• Graham AJ, Martin-Ruiz CM, Teaktong T, Ray MA, Court J. Human brain nicotinic receptors, their distribution and participation in neuropsychiatric disorders. Current Drug Targets 2002, 1, 387-397.
• Graham A, Court JA, Martin-Ruiz CM, Jaros E, Perry R, Volsen SG, Bose S, Evans N, Ince P, Kuryatov A, Lindstrom J, Gotti C, Perry EK. Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum. Neuroscience 2002, 113(3), 493-507.
• Lee M, Martin-Ruiz C, Graham A, Court J, Jaros E, Perry R, Iversen P, Bauman M, Perry E. Nicotinic receptor abnormalities in the cerebellar cortex in autism. Brain 2002, 125(7), 1483-1495.
• Martin-Ruiz C, Lawrence S, Piggott M, Kuryatov A, Lindstrom J, Gotti C, Cookson MR, Perry RH, Jaros E, Perry EK, Court JA. Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression. Neuroscience Letters 2002, 335(2), 134-138.
• Perry EK, Lee MLW, Martin-Ruiz CM, Court JA, Volsen SG, Merrit J, Folly E, Iversen PE, Bauman ML, Perry RH, Wenk GL. Cholinergic activity in autism: Abnormalities in the cerebral cortex and basal forebrain. American Journal of Psychiatry 2001, 158(7), 1058-1066.
• Court J, Martin-Ruiz C, Piggott M, Spurden D, Griffiths M, Perry E. Nicotinic receptor abnormalities in Alzheimer's disease. Biological Psychiatry 2001, 49(3), 175-184.
• Perry EK, Martin-Ruiz CM, Court JA. Nicotinic receptor subtypes in human brain related to aging and dementia. In: Alcohol: 10th Congress of the International Society for Biomedical Research on Alcholism (ISBRA). 2001, Yokohama, Japan: Elsevier Inc.
• Martin-Ruiz CM, Piggott M, Gotti C, Lindstrom J, Mendelow AD, Siddique MS, Perry RH, Perry EK, Court JA. Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease. Neuropharmacology 2000, 39(13), 2830-2839.
• Martin-Ruiz CM, Lee M, Court J, Iversen P, Merrit J, Folly E, et al. Cholinergic activities in autism: nicotinic and muscarinic receptor abnormalities in the cerebral cortex. Soc Neurosci Abstracts 2000, 26, 1403.
• Perry E, Martin-Ruiz C, Lee M, Griffiths M, Johnson M, Piggott M, Haroutunian V, Buxbaum JD, Nasland J, Davis K, Gotti C, Clementi F, Tzartos S, Cohen O, Soreq H, Jaros E, Perry R, Ballard C, McKeith I, Court J. Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases. European Journal of Pharmacology 2000, 393(1-3), 215-222.
• Martin-Ruiz C, Court J, Lee M, Piggott M, Johnson M, Ballard C, Kalaria R, Perry R, Perry E. Nicotinic receptors in dementia of Alzheimer, lewy body and vascular types. Acta Neurologica Scandinavica, Supplement 2000, 102(176), 34-41.
• Court JA, Martin-Ruiz C, Graham A, Perry E. Nicotinic receptors in human brain: Topography and pathology. Journal of Chemical Neuroanatomy 2000, 20(3-4), 281-298.
• Martin-Ruiz CM, Court JA, Molnar E, Lee M, Gotti C, Perry EK. Alpha4 but not alpha3 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease. Fundamental and Clinical Pharmacology 1999, 13(Suppl.1), 143.
• Perry EK, Lee M, Martin-Ruiz CM, et al. Cholinergic component of vascular dementia. Alzheimer's Reports 1999, 2(Suppl), 576.
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