Staff Profile

NIHR Academic Clinical Fellow in Trauma and Orthopaedic Surgery in the Translational and Clinical Research Institute and a member of the Sarcoma Research Group at Newcastle Centre for Cancer, with research interests in the basic science of musculoskeletal oncology, fluorescence guided surgery, and the development of novel targeted imaging agents for sarcoma.

Co-Investigator of SarcoSIGHT - A randomised controlled trial of fluorescence guided sarcoma surgery versus standard of care:

https://fundingawards.nihr.ac.uk/award/NIHR134276

ORCID: https://orcid.org/0000-0003-3339-8791

Academic Supervisor: Mr Kenneth Rankin

My research investigates the basic science of sarcoma biology with a translational application to tumour surgery. My role within the Sarcoma Research Group involves studying the mechanisms of indocyanine green (ICG) cellular uptake to help guide its clinical use for near infrared (NIR) fluorescence guided surgery. I am also collaborating with Dr James Knight’s research group at the School of Natural and Environmental Sciences on the development of an MT1-MMP targeted antibody conjugate for image guided sarcoma surgery.

Research Projects:

• Investigating the mechanisms of preferential tumour uptake of indocyanine green in sarcoma cell lines and tissue
• Development of a targeted dual-modality (PET/NIRF) radioimmunoconjugate for image-guided sarcoma surgery
• Optimising immunofluorescence imaging techniques for the evaluation of histological specimens following fluorescence guided surgery
• Evaluating the role of MT1-MMP in sarcoma cell invasion using CRISPR Cas9

Research Fellowships undertaken at:

The Oxford Sarcoma Service, Nuffield Orthopaedic Centre Oxford, UK - March 2022

The Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, USA – June 2022

Funding has been generously provided by:

Orthopaedic Research UK

Bone Cancer Research Trust

Newcastle upon Tyne Hospitals NHS Charity

The National Sarcoma Awareness Project

Within our research group, I have taught 3 cohorts of MRes students lab based protocols and basic science skills, and I have supported 1 PhD student with CRISPR Cas9 gene editing (Principal Supervisor: Mr Kenneth Rankin).

• Articles

  • Brookes MJ, Chan CD, Crowley TP, Ragbir M, Ghosh KM, Beckingsale T, Rankin KS. Intraoperative near-infrared fluorescence guided surgery using indocyanine green (ICG) may aid the surgical removal of benign bone and soft tissue tumours. Surgical Oncology 2024, 55, 102091.
  • Brookes MJ, Chan CD, Crowley TP, Ragbir M, Beckingsale T, Ghosh KM, Rankin KS. What Is the Significance of Indeterminate Pulmonary Nodules in High-Grade Soft Tissue Sarcomas? A Retrospective Cohort Study. Cancers 2023, 15(13), 3531.
  • Pal R, Lwin TM, Krishnamoorthy M, Collins HR, Chan CD, Prilutskiy A, Nasrallah MLP, Dijkhuis TH, Shukla S, Kendall AL, Marshall MS, Carp SA, Hung YP, Shih AR, Martinez-Lage M, Zukerberg L, Sadow PM, Faquin WC, Nahed BV, Feng AL, Emerick KS, Mieog JSD, Vahrmeijer AL, Rajasekaran K, Lee JYK, Rankin KS, Lozano-Calderon S, Varvares MA, Tanabe KK, Kumar ATN. Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients. Nature Biomedical Engineering 2023, 7, 1649–1666.
  • Chan CD, Zhang L, Pandit RJ, Lewis CJ. A Very Unusual Burn Complication: Bilateral Endogenous Bacterial Endophthalmitis. ePlasty 2023, 23, e6.
  • Pringle TA, Chan CD, Luli S, Blair HJ, Rankin KS, Knight JC. Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas. Bioconjugate Chemistry 2022, 33(8), 1564-1573.
  • Li E, Hammond J, Moir J, Abbadessa F, Chan C, Dawe N, De Silva C, Ferrara M, Hillier R, Kadhim MR, Myszkowski S, Salisbury T, Sudworth P, Tingle S, Williams T. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia 2022, 77(1), 28-39.
  • Spence S, Doonan J, Farhan-Alanie OM, Chan CD, Tong D, Cho HS, Sahu MA, Traub F, Gupta S. Does the modified Glasgow Prognostic Score aid in the management of patients undergoing surgery for a soft-tissue sarcoma? An International Multicentre Study. Bone and Joint Journal 2022, 104-B(1), 168-170.
  • Rajasekaran RB, Ashford RU, Cosker TDA, Stevenson JD, Jeys L, Pollock R, Rankin KS, Cool P, Patton JT, Whitwell D, Gibbons CLMH, Carr A. What Proportion of Patients with Bone and Soft Tissue Tumors Contracted Coronavirus-19 and Died From Surgical Procedures During the Initial Period of the COVID-19 Pandemic? Results From the Multicenter British Orthopaedic Oncology Society Observational Study. Clinical Orthopaedics and Related Research 2021, 479(5), 1158-1166.
  • Nicoli F, Saleh DB, Ragbir M, Chan CD, Baljer B, Rankin KS. Response to the Comment on "Intraoperative Near-infrared Fluorescence (NIR) Imaging With Indocyanine Green (ICG) Can Identify Bone and Soft Tissue Sarcomas Which May Provide Guidance for Oncological Resection". Annals of Surgery 2021, 274(6), e782-e783.
  • Chan CD, Nyogi A, Jaffray B, Brodlie M, Gabra H. Lung biopsy in children: when is it useful?. Archives of Disease in Childhood 2021, 106(3), 291-293.
  • Brookes MJ, Chan CD, Nicoli F, Crowley TP, Ghosh KM, Beckingsale T, Saleh D, Dildey P, Gupta S, Ragbir M, Rankin KS. Intraoperative near‐infrared fluorescence guided surgery using indocyanine green (ICG) for the resection of sarcomas may reduce the positive margin rate: An extended case series. Cancers 2021, 13(24), 6284.
  • Nicoli F, Saleh DB, Baljer B, Chan CD, Beckingsale T, Ghosh KM, Ragbir M, Rankin KS. Intraoperative Near-infrared Fluorescence (NIR) Imaging With Indocyanine Green (ICG) Can Identify Bone and Soft Tissue Sarcomas which May Provide Guidance for Oncological Resection. Annals of Surgery 2021, 273(2), e63-e68.
  • Chan CD, Haagensen EJ, Tensaout HA, Rennie KJ, Gamie Z, Barry J, Birch MA, Gerrand CH, Nisar S, Robson CN, Lunec J, Rankin KS. Co‑localisation of intra‑nuclear membrane type‑1 matrix metalloproteinase and hypoxia inducible factor‑2α in osteosarcoma and prostate carcinoma cells. Oncology Letters 2021, 21(2), 158.

• Reviews

  • Brookes MJ, Chan CD, Baljer B, Wimalagunaratna S, Crowley TP, Ragbir M, Irwin A, Gamie Z, Beckingsale T, Ghosh KM, Rankin KS. Surgical Advances in Osteosarcoma. Cancers 2021, 13(3), 388.
  • Baljer BC, Kolhe S, Chan CD, Nicoli F, Ghanbasha A, Brookes MJ, Gamie Z, Ghosh KM, Beckinsale TB, Saleh DB, Ragbir M, Gerrand CH, Jeys L, Knight JC, Petrides G, Rankin KS. Advances in image enhancement for sarcoma surgery. Cancer Letters 2020, 483, 1-11.