Staff Profile
Dr Sinead Mullally
Lecturer in Neuropsychology
- Email: sinead.mullally@ncl.ac.uk
- Telephone: +44 (0) 191 208 3869
- Address: Translational and Clinical Research Institute
Henry Wellcome Building
Faculty of Medical Sciences
Newcastle University
Framlington Place
Newcastle upon Tyne
NE2 4HH
Background
In 2005, I completed my PhD in Cognitive Neuroscience at Trinity College Dublin, where I used a novel disruption technique to explore the mnemonic functions of the human hippocampus in healthy adults. From 2006 to 2008, I continued my research on this topic at a postdoctoral level, whilst simultaneously helping to establish and support a plan of clinical research investigating a range of topics (including an exploration of the neuro-cognitive sequelae of hypothyroidism) using facilities at the then newly-founded Trinity College Institute of Neuroscience. I then undertook a Wellcome Trust funded postdoctoral position in Professor Eleanor Maguire’s Memory and Space group at University College London where I spent five years investigating the role of the hippocampus in constructing scenes and how this relates to episodic memory, imagination of the future and spatial navigation. To interrogate these issues I used a range of metacognitive, cognitive, neuropsychological and neuroimaging techniques in both healthy adults and in patients with severe memory loss. In 2013, I joined Newcastle University as a lecturer of Neuropsychology.
Research
My current research interests are focused on understanding the many cognitive functions associated with the human hippocampus. These include better understanding its’ well-documented role in episodic memory, its’ more recently appreciated role in imagination and prediction, and the link between these seemingly disparate cognitive processes and the ability to visualise coherent spatial environments. I am also interested in the early ontogeny of the human hippocampus. More specifically, I am interested in understanding how infants and young children learn to remember their personal pasts and to imagine their personal futures. I aim to use a combination of behavioural testing (in healthy and neurological populations) and brain imaging (high-resolution structural and functional MRI) to address these questions.
Teaching
PSY3027 Developmental Disorders
PSY2004 Individual Differences
Publications
- Mullally SL, Maguire EA. Exploring the role of space-defining objects in constructing and maintaining imagined scenes. Brain and Cognition 2013, 82(1), 100-107.
- Mullally SL, Maguire EA. Memory, Imagination, and Predicting the Future: A Common Brain Mechanism?. Neuroscientist 2014, 20(3), 220-234.
- Mullally SL, O'Mara SM. Suppressing the encoding of new information in memory: a behavioral study derived from principles of hippocampal function. PLoS One 2013, 8(1), e50814.
- Chadwick MJ, Mullally SL, Maguire EA. The hippocampus extrapolates beyond the view in scenes: An fMRI study of boundary extension. Cortex 2013, 49(8), 2067-2079.
- Maguire EA, Mullally SL. The Hippocampus: A Manifesto for Change. Journal of Experimental Psychology: General 2013, 142(4), 1180-1189.
- Mullally SL, Intraub H, Maguire EA. Attenuated boundary extension produces a paradoxical memory advantage in amnesic patients. Current Biology 2012, 22(4), 261-268.
- Zeidman P, Mullally SL, Schwarzkopf DS, Maguire EA. Exploring the parahippocampal cortex response to high and low spatial frequency spaces. NeuroReport 2012, 23(8), 503-507.
- Auger SD, Mullally SL, Maguire EA. Retrosplenial cortex codes for permanent landmarks. PLoS ONE 2012, 7(8), e43620.
- Mullally SL, Hassabis D, Maguire EA. Scene construction in amnesia: an FMRI study. Journal of Neuroscience 2012, 32(16), 5646-5653.
- Mullally SL, Maguire EA. A new role for the parahippocampal cortex in representing space. Journal of Neuroscience 2011, 31(20), 7441-7449.
- Griffin ÉW, Mullally S, Foley C, Warmington SA, O'Mara SM, Kelly AM. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiology & Behavior 2011, 104(5), 934-941.
- Correia N, Mullally S, Cooke G, Tun TK, Phelan N, Feeney J, Fitzgibbon M, Boran G, O'Mara S, Gibney J. Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism 2009, 94(10), 3798-3797.
- Roche RA, Mullally SL, McNulty JP, Hayden J, Brennan P, Doherty CP, Fitzsimons M, McMackin D, Prendergast J, Sukumaran S, Mangaoang MA, Robertson IH, O'Mara SM. Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain. BMC Neuroscience 2009, 10(1), 136.
- Lad M, Mullally SL, Houston AL, Kelly T, Griffiths TD. Characterising memory loss in patients with autoimmune limbic encephalitis hippocampal lesions. Hippocampus 2019, 29(11), 1114-1120.
- Jajdelska E, Anderson M, Butler C, Fabb N, Finnigan E, Garwood I, Kelly S, Kirk W, Kukkonen K, Mullally S, Schwan S. Picture this: a review of research relating to narrative processing by moving image versus language. Frontiers in Psychology 2019, 10, 1161.
- De Luca F, McCormick C, Mullally SL, Intraub H, Maguire EA, Ciaramelli E. Boundary extension is attenuated in patients with ventromedial prefrontal cortex damage. Cortex 2018, 108, 1-12.
- Maguire EA, Intraub H, Mullally SL. Scenes, Spaces, and Memory Traces: What Does the Hippocampus Do?. Neuroscientist 2016, 22(5), 432-439.
- Mullally SL. Commentary: Elucidating the neural correlates of early childhood memory. International Journal of Behavioral Development 2015, 39(4), 306-307.
- Mullally SL, Maguire EA. Counterfactual Thinking in Patients with Amnesia. Hippocampus 2014, 24(11), 1261-1266.
- Cooke G, Mullally S, Correia N, O'Mara S, Gibney J. Hippocampal volume is decreased in adults with hypothyroidism. Thyroid 2014, 24(3), 433-440.
- Mullally SL, Maguire EA. Learning to remember: The early ontogeny of episodic memory. Developmental Cognitive Neuroscience 2014, 9, 12-29.
- Mullally SL, Vargha-Khadem F, Maguire EA. Scene construction in developmental amnesia: An fMRI study. Neuropsychologia 2014, 52, 1-10.
- Smith KJ, Mullally S, McLoughlin D, O'Mara SM. Validation of the Face-Name Pairs Task in Major Depression: Impaired recall but not recognition. Frontiers in Psychology 2014, 5, 92.