Background

I am originally from Austria where I completed my undergraduate in Biomedicine and Biotechnology at the Veterinary University of Vienna. I subsequently moved to Newcastle where I completed a MSc in Drug Discovery. I completed my doctoral training in the Newcastle University spin off company Demuris, which focuses on antibiotic discovery from filamentous bacteria. Since 2016 I work in the research group of Prof. Errington.

Areas of expertise

• Drug discovery
• Purification of small molecules
• Genetics
• Cell morphogenesis of Streptomyces

Research

My main research focuses on growth, development and antibiotic product of actinomycetes. I am particularly interested in chemical genetics. I use specialized metabolites purified from actinomycetes to target pathways in the model organism B. subtilis.

I am further particularly interested in cell morphogenesis of Streptomyces.

Teaching

I am supervising Master students during their lab-based projects. I always look forward to work with dedicated students.

Publications

• Kepplinger B, Morton S, Seistrup K, Marrs E, Hopkins A, Perry J, Strahl H, Hall M, Errington J, Allenby N. Mode of Action and Heterologous Expression of the Natural Product Antibiotic Vancoresmycin. ACS Chemical Biology 2018, 13(1), 207-214.
• Mosaei H, Molodtsov V, Kepplinger B, Harbottle J, Moon C, Jeeves R, Ceccaroni L, Shin Y, Morton-Laing S, Marrs ECL, Wills C, Clegg W, Yuzenkova J, Perry JD, Bacon J, Errington J, Allenby NEE, Hall MJ, Murakami KS, Zenkin N. Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin Resistant Mycobacterium tuberculosis. Molecular Cell 2018, 72(2), 263-274.
• Baksh A, Kepplinger B, Isah H, Probert MR, Clegg W, Wills C, Goodfellow M, Errington J, Allenby N, Hall MJ. Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745. Natural Product Research 2017, 31(16), 1895-1900.
• Knaus T, Schober M, Kepplinger B, Faccinelli M, Pitzer J, Faber K, Macheroux P, Wagner U. Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates. FEBS Journal 2012, 279, 4374-4384.