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Pain

Pain is defined as a sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage(1). As we increasingly understand more about pain and the multiple factors that influence it we also understand the many different ways in which we might aim to change the experience of pain.

Our cross-disciplinary research seeks to understand and address pain at every stage – from basic mechanisms to application in clinical practice and wider cultural influences.

1. Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. PAIN. 2020 Sep;161(9):1976.

Current Areas of Interest

Basic Science

Investigating the role of the Kynurenine pathway in irreversible pulpitis.

Principal Investigator Jamie Coulter 

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Modulation of pain perception

Principal Investigator Quoc Vuong

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Human iPSC-derived Sensory Neurons to Interrogate the Molecular Interplay between MTORC1 and Histamine Receptors in the Progression of Neuropathic Pain and Parkinson’s disease

Principal Investigator Mouhamed Alsaqati

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Exploring irreversible pulpitis and its treatment’s effects on peripheral and central mechanisms: ExtirPate study

Principal Investigator David Edwards

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ELUCIDATE: Exploring pain and autonomic dysfunction in ME/CFS and TMD.

Principal Investigator James Allison 

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Mechanisms of spinal cord stimulation in the management of chronic neuropathic pain

Principal Investigator Ilona Obara

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Investigating the role of the histamine system in chronic pain

Principal Investigator Ilona Obara

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Clinically Applied Research

A pragmatic randomised controlled trial of Botulinum toxin type A, lidocaine, and amitriptyline/gabapentin, with internal pilot and cost-effectiveness analysis

Principal Investigator Justin Durham

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Experiences of patients seeking treatment for persistent, painful temporomandibular disorders

Principal Investigator Chris Penlington

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Mediators and moderators of change for patients following attendance of a Pain Management Programme

Principal Investigator Chris Penlington

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Oldpain2go

Principal Investigator Kate Swainston

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SARCOPANC study

Principal Investigator Kate Swainston

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Regional anaesthesia vs haematoma block in the management of distal radius fractures? Introduction of a regional anaesthesia list

Principal Investigator Kate Swainston

Patient reported outcomes and experiences of forefoot problems in hallux valgus and / or hallux rigidus: A triangulated longitudinal cohort study

Principal Investigator Kate Swainston

The impact of dysmenorrhea on students’ wellbeing, attendance, engagement and attainment in Higher Education

Principal Investigator Kate Swainston

Formulation of a pain management programme to support adults receiving substance disorder treatment (PAPERS study)

Principal Investigator Kate Swainston

Social Science

Visual images in pain communication, diagnosis and treatment

Principal Investigator Jen Tarr

Additional Information and Resources

English clinical Guidelines for the management of temporomandibular disorders
What to do about jaw pain

Access the Newcastle Hospitals NHS Foundation Trust's Facial Pain webpage here

Student Projects

We regularly supervise projects at undergraduate and postgraduate level across our full portfolio of work.

Lead Investigators