Oral Microbiology
Our research aims to understand the basic biology of microorganisms that are associated with human health and disease, including mechanisms of resistance to antimicrobial agents. We aim to develop more effective approaches to prevent or treat microbial-driven oral diseases such as dental caries (tooth decay) or periodontitis (gum disease).
.png)
Dr Chang's research aims, current projects and partners...
Our research aims to understand how do bacteria sense and respond to their surrounding environment and stresses by genetic and genomic approaches with advanced sequencing and microscopic techniques. We are also interested in harnessing bacteria to produce useful metabolites for therapeutical or biotechnological purposes.
Current projects
- Characterisation of nano-micelles for next generation antimicrobial agents
- Unravelling the complex metabolic interplay between Pseudomonas aeruginosa and host microenvironment in response to last-line antibiotics
- Characterising genetic regulations and heterogeneous phenotypes of antibiotic persistence in Pseudomonas aeruginosa
- Investigating the microbial influence on the metabolic imbalance in pulpitis
- Investigating the immunomodulatory mechanisms of oral bacteria causing inflammation on mucosal surfaces
Works with
Professor Jakubovics's research aims, current projects and partners...
Our group focuses on the impact of the microbiome on oral health, particularly aiming to understand the processes involved in the formation of dental biofilms. We aim to develop new approaches to control biofilm formation and biofilm-associated diseases in the mouth and elsewhere in the body.
Current projects
- Importance of bioaerosols for infection control in dentistry.
- Microbiome of dental calculus
- Ultrasmall bacteria in the oral microbiome
- Metabolic interactions in oral biofilms
- Characterising the oral biofilm matrix
Works with
Dr Da Silva Dantas's research aims, current projects and partners...
Replicative ageing, pathogenicity and drug resistance in Candida spp.
My lab is interested in determining how ageing heighten stress tolerance in pathogenic yeasts. We use a range of molecular, cellular and biochemical assays to determine the mechanistic basis on how Candida albicans exploits the ageing process to overcome extreme stresses posed in the mammalian niche.
Current projects
- Identification of molecular mechanisms driving antifungal drug resistance in aged Candida populations. Funded by The Royal Society.
- Dissecting the molecular mechanisms driving antifungal drug resistance and immune evasion in an aged Candida albicans population (MRC Dimen Studentship).
- How does age-associated stress tolerance in Candida albicans promote colonization and drive disease in a C. elegans model of infection
- Targeting redox sensitive antioxidants to combat antifungal resistance.
Works with
Follow Dr Da Silva Dantas on X