Staff Profile
Professor Nicholas Jakubovics
Professor of Oral Microbiology
- Personal Website: https://blogs.ncl.ac.uk/nickjakubovics/
- Address: Oral Biology
School of Dental Sciences
Faculty of Medical Sciences
Newcastle University
Framlington Place
Newcastle upon Tyne
NE2 4BW
Introduction
After a BSc in Biochemistry from the University of Cambridge (1994) and a PhD in Microbiology at the University of Warwick (1998), I moved into the field of Oral Microbiology as a Post-Doctoral researcher in Prof. Howard Jenkinson's group at the Bristol Dental School. I spent 6 years at Bristol working on adhesion, colonisation and sensing mechanisms of oral streptococci before joining Dr Paul Kolenbrander's lab at the National Institute for Dental and Craniofacial Research in Bethesda, MD, USA on an NIH Post-Doctoral Fellowship. The focus of my research centred on cell-cell interactions in oral biofilms.
I joined Newcastle Dental School as Lecturer in Oral Microbiology in 2007, became Senior Lecturer in 2014 and Professor in 2022. My current research is still focussed on adhesion, colonisation and cell-cell interactions, primarily in oral biofilms. Our group employs techniques from molecular genetics to microbiome profiling to understand how oral biofilms form and to investigate the impact of different treatments. We also have a number of projects on health-related biofilms at sites outside the mouth, including prosthetic joint and middle ear infections. The overall goal of our research is to find new approaches to control biofilms and to translate these into products that can improve oral and general health.
Roles and Responsibilities
External
Editor-in-Chief of the Journal of Dental Research
Member of Board of Directors, International Association for Dental, Oral, and Craniofacial Research (IADR)
Member of Board of Directors, American Association for Dental, Oral, and Craniofacial Research (AADOCR)
Newcastle University
Deputy Director of Research (Dental Sciences)
Translational Oral Biosciences Strand Lead (Dental Sciences)
Biological and GM Safety Supervisor (Dental Sciences) and Member of University Biosafety Committee
Areas of expertise
Translational oral microbiology, Microbial biofilms, Streptococcal genetics
Qualifications
1994 BSc in Biochemistry (Cambridge)
1998 PhD in Microbiology (Warwick)
Previous Positions
1998-2004 Post-Doctoral researcher, Bristol Dental School
2004-2007 Post-Doctoral Fellow, NIDCR, Bethesda, MD, USA
Memberships
International Association for Dental Research (https://www.iadr.org)
Society for Applied Microbiology (http://www.sfam.org.uk/)
Microbiology Society UK (https://microbiologysociety.org)
Google scholar: Click here.
SCOPUS: Click here.
For more information about my research group, please visit my blog at: https://blogs.ncl.ac.uk/nickjakubovics
Research Interests
Molecular mechanisms of adhesion and colonisation by oral streptococci.
Bacterial biofilm formation, and the structure of biofilm matrices.
Interactions and communication between bacteria in mixed-species biofilms.
The formation of biofilms on dental materials.
I have edited a book on Oral Microbial Ecology, published in 2013 (http://www.horizonpress.com/oral-ecology)
Current Work
Dental caries and periodontitis (gum disease) are the leading causes of tooth loss in the Western World. Both of these diseases originate from dental plaque, a complex mixture of numerous different bacteria that accumulates on tooth surfaces between cleaning procedures. Detailed molecular studies of bacterial virulence factors require pure cultures of isolated strains, and therefore most of these studies have been conducted on bacteria in monoculture. However, it is becoming clear that bacteria adapt very rapidly to their surroundings and that they alter their make-up upon contact with other bacterial species or with a human host. My research group aims to identify changes that occur when one bacterial species interacts with another or with human tissues.
We are also interested in the structure of mixed-species biofilms, and in particular the nature of the extracellular matrix that surrounds bacterial cells and protects them from antimicrobial agents. We have shown that extracellular DNA is an important component of microbial biofilms such as dental plaque. We are developing enzymes to control biofilms by degrading the DNA. This work is focussed on a range of biofilms in the mouth and in the head and neck region as a whole, including biofilms that form on artificial speech valves, in the paranasal sinuses (causing chronic rhinosinusitis) and in the middle ear (causing glue ear).
Biofilm formation on artificial surfaces that are placed in the body is particularly problematic since, unlike our own tissues, the artificial surfaces do not contain protective mechanisms to limit microbial colonisation. Work in my lab is aimed towards understanding how micro-organisms interact with different surfaces such as acrylic materials used for prosthodontics, with a view to providing more effective measures for reducing microbial contamination.
Future Research
Future work will continue to be directed towards understanding the molecular mechanisms of bacterial cell-cell interactions and biofilm formation. The development of new agents for disrupting biofilm matrices is a high priority.
Postgraduate Supervision
Lead supervisor for 1 PhD student; Co-supervisor for 10 PhD students.
Funding
Our research has received funding from a range of sources including UK Research Councils, Professional Societies (Society for Applied Microbiology, Microbiology Society UK, International Association for Dental Research), industry and charities (e.g. the Dunhill Medical Trust, Orthopaedic Research UK).
Undergraduate Teaching
Stage 1 BDS Cell Biology
Stage 2 BDS Microbiology for Dentistry
Stage 5 BDS Current Opinion
I supervise undergraduate student laboratory projects from Biomedical Sciences and I regularly supervise summer student projects in the lab.
Postgraduate Teaching
I teach on the MSc Human Health Microbiome module, parts of the MRes programme and on the MClinDent course in the School of Dental Sciences.
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Articles
- Tian X, Teo WFA, Yang Y, Dong L, Wong A, Chen L, Ahmed H, Choo SW, Jakubovics NS, Tan GYA. Genome characterisation and comparative analysis of Schaalia dentiphila sp. nov. and its subspecies, S. dentiphila subsp. denticola subsp. nov., from the human oral cavity. BMC Microbiology 2024, 24(1), 185.
- Sangha JS, Barrett P, Curtis TP, Métris A, Jakubovics NS, Ofiteru ID. Effects of glucose and lactate on Streptococcus mutans abundance in a novel multispecies oral biofilm model. Microbiology Spectrum 2024, 12(4), e03713-23.
- Stewart LJ, Hong Y, Holmes IR, Firth SJ, Ahmed Y, Quinn J, Santos Y, Cobb SL, Jakubovics NS, Djoko KY. Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci. ACS Infectious Diseases 2023, 9(3), 631–642.
- Udduttula A, Jakubovics N, Khan I, Pontiroli L, Rankin KS, Gentile P, Ferreira AM. Layer-by-Layer Coatings of Collagen-Hyaluronic acid Loaded with an Antibacterial Manuka Honey Bioactive Compound to Fight Metallic Implant Infections. ACS Applied Materials and Interfaces 2023, 15(50), 58119-58135.
- Tian X, Teo WFA, Wee WY, Yang Y, Ahmed H, Jakubovics NS, Choo SW, Tan GYA. Genome characterization and taxonomy of Actinomyces acetigenes sp. nov., and Actinomyces stomatis sp. nov., previously isolated from the human oral cavity. BMC Genomics 2023, 24(1), 734.
- Allison JR, Dowson C, Jakubovics NS, Nile C, Durham J, Holliday R. Waterline Disinfectants Reduce Dental Bioaerosols: A Multitracer Validation. Journal of Dental Research 2022, 101(10), 1198-1204.
- Zhu Y, McHale G, Dawson J, Armstrong S, Wells G, Han R, Liu H, Vollmer W, Stoodley P, Jakubovics NS, Chen J. Slippery Liquid-Like Solid Surfaces with Promising Antibiofilm Performance in both Static and Flow Conditions. ACS Applied Materials & Interfaces 2022, 14(5), 6307-6317.
- Serrage HJ, FitzGibbon L, Alibhai D, Cross S, Rostami N, Jack AA, Lawler CRE, Jakubovics NS, Jepson MA, Nobbs AH. Quantification of Extracellular DNA Network Abundance and Architecture within Streptococcus gordonii Biofilms Reveals Modulatory Factors. Applied and Environmental Microbiology 2022, 88(13), e00698-22.
- Zemouri C, Beltrán EO, Holliday R, Jakubovics NS, Allison JR. Monkeypox: what do dental professionals need to know?. British Dental Journal 2022, 233, 569-574.
- Allison JR, Dowson C, Pickering K, Cervinskyte G, Durham J, Jakubovics N, Holliday R. Local Exhaust Ventilation to Control Dental Aerosols and Droplets. Journal of Dental Research 2022, 101(4), 384-391.
- Rostami N, Shield RC, Serrage H, Lawler C, Brittan JL, Yassin S, Ahmed H, Treumann A, Thompson P, Waldron K, Nobbs A, Jakubovics N. Interspecies competition in oral biofilms mediated by Streptococcus gordonii extracellular deoxyribonuclease SsnA. npj Biofilms and Microbiomes 2022, 8(1), 96.
- Choo SW, Mohammed WK, Mutha NVR, Rostami N, Ahmed H, Krasnogor N, Tan GYA, Jakubovics NS. Transcriptomic Responses to Coaggregation between Streptococcus gordonii and Streptococcus oralis. Applied and Environmental Microbiology 2021, 87(22), e01558-21.
- Allison JR, Edwards DC, Bowes C, Pickering K, Dowson C, Stone SJ, Lumb J, Durham J, Jakubovics N, Holliday R. The effect of high-speed dental handpiece coolant delivery and design on aerosol and droplet production. Journal of Dentistry 2021, 112, 103746.
- Jakubovics NS, Goodman SD, Mashburn-Warren L, Stafford GP, Cieplik F. The dental plaque biofilm matrix. Periodontology 2000 2021, 86(1), 32-56.
- Chinnaraj SB, Jayathilake PG, Dawson J, Ammar Y, Portoles J, Jakubovics NJ, Chen J. Modelling the combined effect of surface roughness and topography on bacterial attachment. Journal of Materials Science & Technology 2021, 81, 151-161.
- Holliday R, Allison JR, Currie CC, Edwards DC, Bowes C, Pickering K, Reay S, Durham J, Lumb J, Rostami N, Coulter J, Nile CJ, Jakubovics N. Evaluating contaminated dental aerosol and splatter in an open plan clinic environment: Implications for the COVID-19 pandemic. Journal of Dentistry 2021, 105, 103565.
- Allison JR, Currie CC, Edwards DC, Bowes C, Coulter J, Pickering K, Kozhevnikova E, Durham J, Nile CJ, Jakubovics N, Rostami N, Holliday R. Evaluating aerosol and splatter following dental procedures: Addressing new challenges for oral health care and rehabilitation. Journal of Oral Rehabilitation 2021, 48(1), 61-72.
- Llandro H, Allison JR, Currie CC, Edwards DC, Bowes C, Durham J, Jakubovics N, Rostami N, Holliday R. Evaluating aerosol and splatter during orthodontic debonding: implications for the COVID-19 pandemic. British Dental Journal 2021, (ePub ahead of Print).
- Holliday R, Chaffee BW, Jakubovics NS, Kist R, Preshaw PM. Electronic Cigarettes and Oral Health. Journal of Dental Research 2021, 100(9), 906-913.
- Ruiz-Sanchez AJ, Guerin AJ, El-Zubir O, Dura G, Ventura C, Dixon LI, Houlton A, Horrocks BR, Jakubovics NS, Guarda P-A, Simeone G, Clare AS, Fulton DA. Preparation and evaluation of fouling-release properties of amphiphilic perfluoropolyether-zwitterion cross-linked polymer films. Progress in Organic Coatings 2020, 140, 105524.
- Zemouri C, Ofiteru ID, Jakubovics NS. Future directions for studying resilience of the oral ecosystem. British Dental Journal 2020, 229(12), 769-773.
- Cao Y, Jana S, Bowen L, Liu H, Jakubovics NS, Chen J. Bacterial nanotubes mediate bacterial growth on periodic nano-pillars. Soft Matter 2020, 16(32), 7613-7623.
- Moynihan PJ, Jakubovics N. Around the World in 100 Years: The Global Expansion of the IADR and Regional Contributions to Oral Health Research. Journal of Dental Research 2020, 99(4), 355-359.
- Cao Y, Jana S, Tan X, Bowen L, Zhu Y, Dawson J, Han R, Exton J, Liu H, McHale G, Jakubovics NS, Chen J. Antiwetting and Antifouling Performances of Different Lubricant-Infused Slippery Surfaces. Langmuir 2020, 36(45), 13396–13407.
- Mutha NVR, Mohammed WK, Krasnogor NK, Tan GYA, Wee WY, Li Y, Choo SW, Jakubovics NS. Transcriptional profiling of coaggregation interactions between Streptococcus gordonii and Veillonella parvula by Dual RNA-Seq. Scientific Reports 2019, 9, 7664.
- Zemouri C, Jakubovics NS, Crielaard W, Zaura E, Dodds M, Schelkle B, Loos BG. Resistance and resilience to experimental gingivitis: a systematic scoping review. BMC Oral Health 2019, 19, 212.
- Cao Y, Jana S, Bowen L, Tan X, Liu H, Rostami N, Brown J, Jakubovics NJ, Chen J. Hierarchical rose-petal surfaces delay the early-stage bacterial biofilm growth. Langmuir 2019, 35(45), 14670-14680.
- Coulter J, Jakubovics NS, Preshaw PM, German MJ. An in vitro model to assess effects of a desensitising agent on bacterial biofilm formation. Acta Biomaterialia Odontologica Scandinavica 2019, 5(1), 1-8.
- Ahmed P, Alam MK, Jakubovics NS, Schwendicke F, Asif JA. 100 years of the Journal of Dental Research:A bibliometric analysis. Journal of Dental Research 2019, 98(13), 1425-1436.
- Mutha NVR, Mohammed WK, Krasnogor N, Tan GYA, Choo SW, Jakubovics NS. Transcriptional Responses of Streptococcus gordonii and Fusobacterium nucleatum to Coaggregation. Molecular Oral Microbiology 2018, 33(6), 450-464.
- Cao Y, Su B, Chinnaraj S, Jana S, Bowen L, Charlton S, Duan P, Jakubovics NS, Chen J. Nanostructured titanium surfaces exhibit recalcitrance towards Staphylococcus epidermidis biofilm formation. Scientific Reports 2018, 8, 1071.
- Kandemir N, Vollmer W, Jakubovics NS, Chen J. Mechanical interactions between bacteria and hydrogels. Scientific Reports 2018, 8, 10893.
- Robinson JC, Rostami N, Casement J, Vollmer W, Rickard AH, Jakubovics NS. ArcR modulates biofilm formation in the dental plaque colonizer Streptococcus gordonii. Molecular Oral Microbiology 2018, 33(2), 143-154.
- Mohammed WK, Krasnogor N, Jakubovics NS. Streptococcus gordonii Challisin protease is required for sensing cell-cell contact with Actinomyces oris. FEMS Microbiology Ecology 2018, 94(5), fiy043.
- Jakubovics NS. The sixth sensor: A Candida albicans biofilm master regulator that responds to inter-kingdom interactions. Virulence 2017, 8(8), 1465-1467.
- Naylor J, Fellermann H, Ding Y, Mohammed W, Jakubovics N, Mukherjee J, Biggs C, Wright P, Krasnogor N. Simbiotics: A Multiscale Integrative Platform for 3D Modeling of Bacterial Populations. ACS Synthetic Biology 2017, 6(7), 1194-1210.
- Zheng W, Tan MF, Old LA, Paterson IC, Jakubovics NS, Choo SW. Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis. Scientific Reports 2017, 7(1), 2949.
- Rostami N, Shields RC, Yassin SA, Hawkins AR, Bowen L, Luo TL, Rickard AH, Holliday R, Preshaw PM, Jakubovics NS. A Critical Role for Extracellular DNA in Dental Plaque Formation. Journal of Dental Research 2017, 96(2), 208-216.
- Wee WY, Tan TK, Jakubovics NS, Choo SW. Whole-Genome Sequencing and Comparative Analysis of Mycobacterium brisbanense Reveals a Possible Soil Origin and Capability in Fertiliser Synthesis. PLoS ONE 2016, 11(3), e0152682.
- Zheng WN, Tan TK, Paterson IC, Mutha NVR, Siow CC, Tan SY, Old LA, Jakubovics NS, Choo SW. StreptoBase: An Oral Streptococcus mitis Group Genomic Resource and Analysis Platform. PLoS One 2016, 11(5), e0151908.
- Zheng WN, Mutha NVR, Heydari H, Dutta A, Siow CC, Jakubovics NS, Wee WY, Tan SY, Ang MY, Wong GJ, Choo SW. NeisseriaBase: a specialised Neisseria genomic resource and analysis platform. PeerJ 2016, 4, e1698.
- Yassin SA, German MJ, Rolland SL, Rickard AH, Jakubovics NS. Inhibition of multispecies biofilms by a fluoride-releasing dental prosthesis copolymer. Journal of Dentistry 2016, 48, 62-70.
- Tan SY, Dutta A, Jakubovics NS, Ang MY, Siow CC, Mutha NV, Heydari H, Wee WY, Wong GJ, Choo SW. YersiniaBase: a genomic resource and analysis platform for comparative analysis of Yersinia. BMC Bioinformatics 2015, 16, 9.
- Holliday R, Preshaw P, Bowen L, Jakubovics N. The ultrastructure of subgingival dental plaque, revealed by high-resolution field emission scanning electron microscopy. BDJ Open 2015, 1, 15003.
- Kolderman E, Bettampadi D, Samarian D, Dowd SE, Foxman B, Jakubovics NS, Rickard AH. L-Arginine Destabilizes Oral Multi-Species Biofilm Communities Developed in Human Saliva. PLOS ONE 2015, 10(5), e0121835.
- Jakubovics NS, Burgess JG. Extracellular DNA in oral microbial biofilms. Microbes and Infection 2015, 17(7), 531-537.
- Jakubovics NS, Robinson JC, Samarian DS, Kolderman E, Yassin SA, Bettampadi D, Bashton M, Rickard AH. Critical Roles of Arginine in Growth and Biofilm Development by Streptococcus gordonii. Molecular Microbiology 2015, 97(2), 281-300.
- Stevens MR, Luo TL, Vornhagen J, Jakubovics NS, Gilsdorf JR, Marrs CF, Møretrø T, Rickard AH. Coaggregation occurs between microorganisms isolated from different environments. FEMS Microbiology Ecology 2015, 91(11), fiv123.
- Samarian DS, Jakubovics NS, Luo TL, Rickard AH. Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms. Jove - Journal of Visualized Experiments 2014, (94).
- Katharios-Lanwermeyer S, Xi C, Jakubovics NS, Rickard AH. Mini-review: Microbial coaggregation: ubiquity and implications for biofilm development. Biofouling 2014, 30(10), 1235-1251.
- Greenwood M, Meechan JG, Stroud C. General medicine and surgery for dental practitioners: part 5. Immunological disease and dental practice. British Dental Journal 2014, 217(3), 129-132.
- Jakubovics N, Greenwood M, Meechan JG. General medicine and surgery for dental practitioners: part 4. Infections and infection control. British Dental Journal 2014, 217(2), 73-77.
- Ang MY, Heydari H, Jakubovics NS, Mahmud MI, Dutta A, Wee WY, Wong GJ, Mutha NVR, Tan SY, Choo SW. FusoBase: an online Fusobacterium comparative genomic analysis platform. Database 2014, 2014, fusobase.
- Heydari H, Siow CC, Tan MF, Jakubovics NS, Wee WY, Mutha NVR, Wong GJ, Ang MY, Yazdi AH, Choo SW. CoryneBase: Corynebacterium Genomic Resources and Analysis Tools at Your Fingertips. PLoS One 2014, 9(1), e86318.
- Shields RC, Mokhtar N, Ford M, Hall MJ, Burgess JG, ElBadawey MR, Jakubovics NS. Efficacy of a Marine Bacterial Nuclease against Biofilm Forming Microorganisms Isolated from Chronic Rhinosinusitis. PLoS One 2013, 8(2), e55339.
- Shakir A, ElBadawey MR, Shields RC, Jakubovics NS, Burgess JG. Removal of Biofilms from Tracheoesophageal Speech Valves Using a Novel Marine Microbial Deoxyribonuclease. Otolaryngology: Head and Neck Surgery 2012, 147(3), 509-514.
- Field CA, Gidley MD, Preshaw PM, Jakubovics N. Investigation and quantification of key periodontal pathogens in patients with type 2 diabetes. Journal of Periodontal Research 2012, 47(4), 470-478.
- Jakubovics NS, Brittan JL, Dutton LC, Jenkinson HF. Multiple adhesin proteins on the cell surface of Streptococcus gordonii are involved in adhesion to human fibronectin. Microbiology 2009, 155(11), 3572-3580.
- Stoll KE, Draper WE, Kliegman JI, Golynskiy MV, Brew-Appiah RA, Phillips RK, Brown HK, Breyer WA, Jakubovics NS, Jenkinson HF, Brennan RG, Cohen SM, Glasfeld A. Characterization and structure of the manganese-responsive transcriptional regulator ScaR. Biochemistry 2009, 48, 10308-10320.
- Thompson J, Jakubovics N, Abraham B, Hess S, Pikis A. The sim operon facilitates the transport and metabolism of sucrose isomers in Lactobacillus casei ATCC 334. Journal of Bacteriology 2008, 190(9), 3362-3373.
- Jakubovics NS, Gill SR, Vickerman MM, Kolenbrander PE. Role of hydrogen peroxide in competition and cooperation between Streptococcus gordonii and Actinomyces naeslundii. FEMS Microbiology Ecology 2008, 66(3), 637-644.
- Jakubovics NS, Gill SR, Iobst SE, Vickerman MM, Kolenbrander PE. Regulation of gene expression in a mixed-genus community: stabilized arginine biosynthesis in Streptococcus gordonii by coaggregation with Actinomyces naeslundii. Journal of Bacteriology 2008, 190(10), 3646-3657.
- Kerrigan SW, Jakubovics NS, Keane C, Maguire P, Wynne K, Jenkinson HF, Cox D. The role of Streptococcus gordonii surface proteins SspA/B and Hsa in platelet function. Infection and Immunity 2007, 75(12), 5740-5747.
- Jakubovics NS, Kerrigan SW, Nobbs AH, Stromberg N, van Dolleweerd CJ, Cox DM, Kelly CG, Jenkinson HF. Functions of cell surface-anchored antigen I/II family and Hsa polypeptides in interactions of Streptococcus gordonii with host receptors. Infection and Immunity 2005, 73(10), 6629-6638.
- Loimaranta V, Jakubovics NS, Hytonen J, Finne J, Jenkinson HF, Stromberg N. Fluid- or Surface-Phase Human Salivary Scavenger Protein gp340 Exposes Different Bacterial Recognition Properties. Infection and Immunity 2005, 73(4), 2245-2252.
- Jakubovics NS, Kelly CG, Stromberg N, van Dolleweerd CJ, Jenkinson HF. Differential binding specificities of oral streptococcal antigen I/II family adhesins for human or bacterial ligands. Molecular Microbiology 2005, 55(5), 1591-1605.
- Low YL, Jakubovics NS, Flatman JC, Jenkinson HF, Smith AW. Manganese-dependent regulation of the endocarditis-associated virulence factor EfaA of Enterococcus faecalis. Journal of Medical Microbiology 2003, 52(2), 113-119.
- Heddle C, Nobbs AH, Jakubovics NS, Gal M, Mansell JP, Dymock D, Jenkinson HF. Host collagen signal induces antigen I/II adhesin and invasin gene expression in oral Streptococcus gordonii. Molecular Microbiology 2003, 50(2), 597-607.
- Jakubovics NS, Smith AW, Jenkinson HF. Oxidative stress tolerance is manganese (Mn2+) regulated in Streptococcus gordonii. Microbiology 2002, 148(10), 3255-3263.
- Jakubovics NS, Smith AW, Jenkinson HF. Expression of the virulence-related Sca (Mn2+) permease in Streptococcus gordonii is regulated by a diphtheria toxin metallorepressor-like protein ScaR. Molecular Microbiology 2000, 38(1), 140-153.
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Editorials
- Schwendicke F, Marazita ML, Jakubovics NS, Krois J. Big Data and Complex Data Analytics: Breaking Peer Review?. Journal of Dental Research 2022, 101(4), 369-370.
- Jakubovics NS, Shi W. A New Era for the Oral Microbiome. Journal of Dental Research 2020, 99(6), 595-596.
- Jakubovics NS, Valentine RA. A new direction for manganese homeostasis in bacteria: identification of a novel efflux system in Streptococcus pneumoniae. Molecular Microbiology 2009, 72(1), 1-4.
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Letter
- Choo SW, Chong JL, Gaubert P, Hughes AC, O'Brien S, Chaber A-L, Antunes A, Platto S, Sun NC-M, Yu L, Koepfli K-P, Suwal TL, Thakur M, Ntie S, Panjang E, Kumaran JV, Mahmood T, Heighton SP, Dorji D, Gonedele BS, Nelson BR, Djagoun CAMS, Loh IH, Kaspal P, Pauklin S, Michelena T, Zhu H, Lipovich L, Tian X, Deng S, Mason CE, Hu J, White R, Jakubovics NS, Wee WY, Tan TK, Wong KT, Paterson S, Chen M, Zhang Y, Othman RY, Brown LC, Shen B, Shui G, Ang MY, Zhao Y, Li Y, Zhang B, Chong CT, Meng Y, Wong A, Su J, Omar H, Shen H, Tan CH, Xu H, Paterson IC, Wang M, Chan C-K, Zhang S, Dutta A, Tee TS, Juvigny-Khenafou NPD, Mutha NVR, Aziz MA. A collective statement in support of saving pangolins. Science of the Total Environment 2022, 824, 153666.
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Notes
- Cieplik F, Jakubovics NS. Preprocedural Mouthwashes for Reduction of SARS-CoV-2 Viral Load and Infectivity. Journal of Dental Research 2022, 101(12), 1421-1423.
- Jakubovics NS, Giannobile WV. JDR Historical Highlights Centennial Series: Stepping Back in Time. Journal of Dental Research 2019, 98(1), 7-8.
- Wakeling L, Jakubovics N, McHanwell S, Stewart J. Challenging the basic sciences 'learn and forget' culture. Medical Education 2016, 50(5), 578-579.
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Reviews
- Alhulaefi SS, Watson AW, Ramsay SE, Jakubovics NS, Matu J, Griffiths A, Kimble R, Siervo M, Brandt K, Shannon OM. Effects of dietary nitrate supplementation on oral health and associated markers of systemic health: a systematic review. Critical Reviews in Food Science and Nutrition 2024, epub ahead of print.
- Zhang OL, Niu JY, Yu OY, Mei ML, Jakubovics NS, Chu CH. Peptide Designs for Use in Caries Management: A Systematic Review. International Journal of Molecular Sciences 2023, 24(4), 4247.
- Schmalz G, Jakubovics N, Schwendicke F. Normative approaches for oral health: Standards, specifications and guidelines. Journal of Dental Research 2022, 101(5), 489-494.
- Serrage HJ, Jepson MA, Rostami N, Jakubovics NS, Nobbs A. Understanding the matrix: The role of extracellular DNA in oral biofilms. Frontiers in Oral Health 2021, 2, 640129.
- Mao X, Jakubovics NS, Bachle M, Buchalla W, Hiller K-A, Maisch T, Hellwig E, Kirschneck C, Gessner A, Al-Ahmad A, Cieplik F. Colonization of Helicobacter pylori in the oral cavity–an endless controversy?. Critical Reviews in Microbiology 2021, 47(5), 612-629.
- Cieplik F, Jakubovics NS, Buchalla W, Maisch T, Hellwig E, Al-Ahmad A. Resistance toward chlorhexidine in oral bacteria - is there cause for concern?. Frontiers in Microbiology 2019, 10, 587.
- Jakubovics NS. An ion for an iron: Streptococcal metal homeostasis under oxidative stress. Biochemical Journal 2019, 476(4), 699-703.
- Jakubovics NS. Saliva as the sole nutritional source in the development of multispecies communities in dental plaque. Microbiology Spectrum 2015, 3(3).
- Jakubovics NS. Intermicrobial interactions as a driver for community composition and stratification in oral biofilms. Journal of Molecular Biology 2015, 427(23), 3662-3675.
- Jakubovics NS, Yassin SA, Rickard AH. Community Interactions of Oral Streptococci. Advances in Applied Microbiology 2014, 87, 43-110.
- Jakubovics NS, Shields RC, Rajarajan N, Burgess JG. Life after death: the critical role of extracellular DNA in microbial biofilms. Letters in Applied Microbiology 2013, 57(6), 467-475.
- Nobbs AH, Jenkinson HF, Jakubovics NS. Stick to Your Gums: Mechanisms of Oral Microbial Adherence. Journal of Dental Research 2011, 90(11), 1271-1278.
- Preshaw PM, Walls AWG, Jakubovics NS, Moynihan PJ, Jepson NJA, Loewy Z. Association of removable partial denture use with oral and systemic health. Journal of Dentistry 2011, 39(11), 711-719.
- Jakubovics NS, Kolenbrander PE. The road to ruin: the formation of disease-associated oral biofilms. Oral Diseases 2010, 16(8), 729-739.
- Jakubovics NS. Talk of the Town: Interspecies Communication in Oral Biofilms. Molecular Oral Microbiology 2010, 25(1), 4-14.
- Kolenbrander PE, Palmer RJ, Periasamy S, Jakubovics NS. Oral multispecies biofilm development and the key role of cell-cell distance. Nature Reviews Microbiology 2010, 8(7), 471-480.
- Kolenbrander PE, Palmer RJ, Rickard AH, Jakubovics NS, Chalmers NI, Diaz PI. Bacterial interactions and successions during plaque development. Periodontology 2000 2006, 42(1), 47-79.
- Jakubovics NS, Jenkinson HF. Out of the iron age: new insights into the critical role of manganese homeostasis in bacteria. Microbiology 2001, 147(7), 1709-1718.