Background

In my current role as Core Physicist at the Newcastle Magnetic Resonance Centre, I work internal and external collaborators to develop diverse range of MR imaging methodology with strong emphasis on clinical applications. Please see research and publication tabs for additional details 

Area of expertise and technical skills:  MRI Physics and data analysis, Deep learning, programming (Python, Tensorflow, C (plus, plus), Matlab)

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Teaching

I support supervision of research projects for PhD, M-Res and BSc student and training of Clinical Fellows

Research

My current research interests include

Neuroscience 

• Development of novel multi-parametric protocols and advance modelling techniques for translational research

• Development of techniques non-invasive measurement of inhibitory (GABA) and excitatory (Glutamate) neuro-trasmitters, including computational modelling.

• Application: Parkinson Disorders, Dementia, Tinnitus, Understanding audio-visual interaction and pain,traumatic Brain injury, Cognitive decline in auto-immune disorders e.g.  AIDS, PBC

Body MRI

• Development and optimisation of the full spectrum of the cardiac/body imaging methodologies include cine imaging, cardiac tagging, 4D flow imaging and Cardiac MR spectroscopy. Clinical application include

• Healthy ageing and hypertension, crypotgenic stroke, diabetes, clinical trials (Thyrami and Bezafibrate), renal diseases 

Deep Learning/Machine Learning 

Development of advance deep learning method towards automated imaging and analysis workflows topics include

• Advance Computer vision algorithms  
• Generative models and self-supervised learning
• Knowledge Graphs

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Publications

• Steele H, Gomez-Duran A, Pyle A, Hopton S, Newman J, Stefanetti RJ, Charman SJ, Parikh JD, He L, Viscomi C, Jakovljevic DG, Hollingsworth KG, Robinson AJ, Taylor RW, Bottolo L, Horvath R, Chinnery PF. Metabolic effects of bezafibrate in mitochondrial disease. EMBO Molecular Medicine 2020, 12(3), e11589.
• Firbank MJ, Parikh J, Murphy N, Killen A, Allan CL, Collerton D, Blamire AM, Taylor JP. Reduced occipital GABA in Parkinson disease with visual hallucinations. Neurology 2018, 91(7), e675-e685.
• MacGowan GA, Parikh JD, Hollingsworth KG. Diffusion Tensor Magnetic Resonance Imaging of the Heart: Looking Into the Layers of the Myocardium. Journal of the American College of Cardiology 2017, 69, 677-678.
• Parikh JD, Hollingsworth KG, Wallace D, Blamire AM, MacGowan GA. Left ventricular functional, structural and energetic effects of normal aging: Comparison with hypertension. Plos One 2017, 12(5), e0177404.
• Parikh JD, Kakarla J, Keavney B, O'Sullivan JJ, Ford GA, Blamire AM, Hollingsworth KG, Coats L. 4D flow MRI assessment of right atrial flow patterns in the normal heart - influence of caval vein arrangement and implications for the patent foramen ovale. PLoS One 2017, 12(3), e0173046.
• Payne B, Chadwick TJ, Blamire A, Anderson KN, Parikh J, Qian J, Hynes AM, Wilkinson J, Price DA. Does efavirenz replacement improve neurological function in treated HIV infection?. HIV Medicine 2017, 18(9), 690-695.
• Jabbar A, Ingoe L, Junejo S, Carey P, Addison C, Thomas H, Parikh JD, Austin D, Hollingsworth KG, Stocken DD, Pearce SHS, Greenwood JP, Zaman A, Razvi S. Effect of levothyroxine on left ventricular ejection fraction in patients with subclinical hypothyroidism and acute myocardial infarction: a randomized clinical trial. JAMA: The Journal of the American Medical Association 2020, 324(3), 249-258.
• Parikh J, Hollingsworth KG, Wallace D, Blamire AM, MacGowan GA. Normal age-related changes in left ventricular function: Role of afterload and subendocardial dysfunction. International Journal of Cardiology 2016, 223, 306-312.
• Parikh JD, Hollingsworth KG, Kunadian V, Blamire AM, MacGowan GA. Measurement of pulse wave velocity in normal ageing: comparison of Vicorder and magnetic resonance phase contrast imaging. BMC Cardiovascular Disorders 2016, 16, 50.
• Cassidy S, Thoma C, Hallsworth K, Parikh J, Hollingsworth KG, Taylor R, Jakovljevic DG, Trenell MI. High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial. Diabetologia 2016, 59(1), 56-66.
• Sedley W, Parikh J, Edden R, Tait V, Blamire A, Griffiths T. Human auditory cortex neurochemistry reflects the presence and severity of tinnitus. Journal of Neuroscience 2015, 35(44), 14822-14828.
• Parikh J, Thrippleton M, Murray C, Harris B, Wardlaw J, Deary I, Andrews P, Starr J, Marshall I. Proton spectroscopic imaging of brain metabolities in basal ganglia of healthy older adults. Magnetic Resonance Materials in Physics, Biology and Medicine 2015, 28(3), 251-257.
• Thrippleton M, Parikh J, Harris B, Semple S, Andrews P, Wardlaw J, Marshall I. Reliability of MRSI Brain Temperature mapping at 1.5 and 3 T. NMR in Biomedicine 2014, 27(2), 183-190.
• Vuong QC, Parikh JD, Laing M, Blamire AM, Rees A. Visual modulation of auditory discrimination correlates with GABA in parietal multisensory area. In: Organisation of Human Brain Mapping OHBM 2016 Annual General Meeting. 2016, Geneva: Organization for Human Brain Mapping.
• Parikh J, Hollingsworth KG, Wallace D, Blamire AM, MacGowan GA. Aortic stiffness, cardiac energetic, systolic and diastolic function in healthy ageing. In: Proceedings of International Society of Magnetic Resonance in Medicine. 2015, Toronto, Canada: International Society of Magnetic Resonance in Medicine.
• Parikh J, Kakarla J, Hollingsworth KG, Keavney B, O'Sullivan JJ, Ford GA, Blamire AM, Coats L. Variations in right atrial flow patterns in the normal heart a potential contributor to cryptogenic stroke in the setting of patent foramen ovale. In: 18th Annual Society of Cardiovascular Magnetic Resonance Sessions. 2015, Nice, France: BioMed Central Ltd.
• Kakarla J, Parikh JD, Hollingsworth KG, Keavney B, Ford GA, O'Sullivan JJ, Blamire AM, Coats L. Right atrial flow patterns in the normal heart - a new clue in the patent foramen ovale and cryptogenic stroke story. In: European Society of Cardiology Congress. 2015, London, UK: Oxford University Press.
• Cassidy SA, Thoma C, Hallsworth K, Jakovljevic DG, Parikh J, Hollingsworth KG, Taylor R, Trenell MI. High intensity intermittent exercise reverses abnormal cardiac function in people with type 2 diabetes: an MRI/S study. In: 50th General Assembly of the European Association for the Study of Diabetes. 2014, Vienna, Austria: Springer.
• Kakarla J, Coats L, Parikh JD, Hollingsworth KG, O'Sullivan J. Platydeoxia Orthopnoea – Revisiting a Rare Clinical Phenomenon with a Novel Imaging Modality. In: British Cardiovascular Society Annual Conference. 2014, Manchester: BMJ Group.
• Parikh J, Thrippleton M, Marshall I. Reduction of systematic error in MRSI based brain temperature mapping. In: Proceedings of International Society of Magnetic Resonance in Medicine. 2012, (Melbourne, 2012).
• Parikh J, Marshall I, Murray C, Allerhand M, Harris B, Thrippleton M, Wardlaw J, Deary I, Andrews J, Starr J. Regional metabolites and brain temperature measured using ¹H MRSI: A pilot study on healthy elderly volunteers from Lothian Birth Cohort 1936 (LBC1936). In: European Society of Magnetic Resonance in Medicine. 2011, Leipzig, Germany.
• Sithamparanathan S, Rocha MC, Parikh JD, Rygiel KA, Falkous G, Grady JP, Hollingsworth KG, Trenell MI, Taylor RW, Turnbull DM, Gorman GS, Corris PA. Skeletal muscle mitochondrial oxidative phosphorylation function in idiopathic pulmonary arterial hypertension: in vivo and in vitro study. Pulmonary Circulation 2018, 8(2), 1-5.