Staff Profile

I am an Academic Neurologist with a special interest in neurogenetic disorders. Clinically I see patients with inherited mutations that cause neurological disease and have a particular research interest in the role of somatic mutations (mutations that arise within cells with age) and how they may also promote the development of neurological disorders.

I have completed a:

Bachelor of Medical Sciences (BMedSci) (1st Class),

Bachelor of Medicine (BMBS) (with Honours),

Master of Resarch in Neurology (MRes),

Master of Clinical Research (MClinRes) (with Distinction)

PhD from the University of Cambridge (Prize winning PhD thesis)

Research Fellowship in Gene Therapy in the USA (Centre for Gene Therapy, Ohio)

Clinically I currently see patients at the RVI and Freeman Hospital on a Wednesday and Thursday each week.

Our current research programme aims to take innovative and interdisciplinary approaches to understand how somatic mutations in cells (particularly within the immune system) can interact with the ageing brain to promote the development of disease. In parallel we are also developing gene therapy approaches for patients with inherited forms of degenerative muscle disease with a view to slow or arrest their disease.

We utilise a variety of laboratory and imaging approaches in both the laboratory and in patients and volunteers to understand these mechanisms and are highly collaborative working with groups around the world.

I am highly active in undergraduate teaching and am the Undergraduate Lead for Neurology together with teaching on the BMedSci and Master's programmes within the University

• Articles

  • Kurzawa-Akanbi M, Keogh M, Tsefou E, Ramsay L, Johnson M, Keers S, Ochieng LW, McNair A, Singh P, Khan A, Pyle A, Hudson G, Ince PG, Attems J, Burn J, Chinnery PF, Morris CM. Neuropathological and Biochemical Investigation of Hereditary Ferritinopathycases with Ferritin Light Chain Mutation: Prominent Protein Aggregation in the Absence of Major Mitochondrial or Oxidative Stress. Neuropathology and Applied Neurobiology 2021, 47(1), 26-42.
  • van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernandez I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleo A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illan-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodriguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodriguez Rodriguez E, Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tarraga L, Maier W, Dols-Icardo O, Kawalia A, Dalmasso MC, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain AL, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff-Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sorensen TIA, Heutink P, Sanchez-Juan P, Posthuma D, Coppola G, Karydas AM, Varpetian A, Foroud TM, Levey AI, Kukull WA, Mendez MF, Ringman J, Chui H, Cotman C, DeCarli C, Miller BL, Geschwind DH, Clarimon J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM, Holstege H. A nonsynonymous mutation in PLCG₂ reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathologica 2019, 138(2), 237-250.
  • Keogh MJ, Wei W, Aryaman J, Wilson I, Talbot K, Turner MR, McKenzie C-A, Troakes C, Attems J, Smith C, AlSarraj S, Morris CM, Ansorge O, Pickering-Brown S, Jones N, Ironside JW, Chinnery PF. Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains. Journal of Neurology, Neurosurgery and Psychiatry 2018, 89(8), 813-816.
  • Keogh MJ, Jaiser SR, Steele HE, Horvath R, Chinnery PF, Baker MR. PLP1 mutations and central demyelination: evidence from electrophysiologic phenotyping in female manifesting carriers. Neurology: Clinical Practice 2017, 7(5).
  • Wei W, Keogh MJ, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF. Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains. Acta Neuropathologica Communications 2017, 5, 17.
  • Keogh MJ, Wei W, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibariez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF. Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource. Genome Reseach 2017, 27(1), 165-173.
  • Lindsay SJ, Xu YB, Lisgo SN, Harkin LF, Copp AJ, Gerrelli D, Clowry GJ, Talbot A, Keogh MJ, Coxhead J, Santibanez-Koref M, Chinnery PF. HDBR Expression: A Unique Resource for Global and Individual Gene Expression Studies during Early Human Brain Development. Frontiers in Neuroanatomy 2016, 10, 86.
  • Keogh MJ, Kurzawa-Akanbi M, Griffin H, Douroudis K, Ayers KL, Hussein RI, Hudson G, Pyle A, Cordell HJ, Attems J, McKeith IG, O'Brien JT, Burn DJ, Morris CM, Thomas AJ, Chinnery PF. Exome sequencing in dementia with Lewy bodies. Translational Psychiatry 2016, 6, e728.
  • Keogh MJ, Aribisala BS, He J, Tulip E, Butteriss D, Morris C, Gorman G, Horvath R, Chinnery PF, Blamire AM. Voxel-based analysis in neuroferritinopathy expands the phenotype and determines radiological correlates of disease severity. Journal of Neurology 2015, 262(10), 2232-2240.
  • Bargiela D, Yu-Wai-Man P, Keogh M, Horvath R, Chinnery PF. Prevalence of neurogenetic disorders in the North of England. Neurology 2015, 85(14), 1195-1201.
  • Keogh MJ, Steele H, Douroudis K, Pyle A, Duff J, Hussain R, Smertenko T, Griffin H, Santibanez-Koref M, Horvath R, Chinnery PF. Frequency of rare recessive mutations in unexplained late onset cerebellar ataxia. Journal of Neurology 2015, 262(8), 1822-1827.
  • Keogh MJ, Pyle A, Daud D, Griffin H, Douroudis K, Eglon G, Miller J, Horvath R, Chinnery PF. Clinical heterogeneity of primary familial brain calcification due to a novel mutation in PDGFB. Neurology 2015, 84(17), 1818-1820.
  • Keogh MJ, Daud D, Pyle A, Duff J, Griffin H, He L, Alston CL, Steele H, Taggart S, Basu AP, Taylor RW, Horvath R, Ramesh V, Chinnery PF. A novel de novo STXBP1 mutation is associated with mitochondrial complex I deficiency and late-onset juvenile-onset parkinsonism. Neurogenetics 2015, 16(1), 65-67.
  • Horvath R, Lewis-Smith D, Douroudis K, Duff J, Keogh M, Pyle A, Fletcher N, Chinnery PF. SCP2 mutations and neurodegeneration with brain iron accumulation. Neurology 2015, 85(21), 1909-1911.
  • Heckman MG, Schottlaender L, Soto-Ortolaza AI, Diehl NN, Rayaprolu S, Ogaki K, Fujioka S, Murray ME, Cheshire WP, Uitti RJ, Wszolek ZK, Farrer MJ, Sailer A, Singleton AB, Chinnery PF, Keogh MJ, Gentleman SM, Holton JL, Aoife K, Mann DMA, Al-Sarraj S, Troakes C, Dickson DW, Houlden H, Ross OA. LRRK2 exonic variants and risk of multiple system atrophy. Neurology 2014, 83(24), 2256-2261.
  • Keogh MJ, Chinnery PF. Next generation sequencing for neurological diseases: New hope or new hype?. Clinical Neurology and Neurosurgery 2013, 115(7), 948-953.
  • Keogh MJ, Chinnery PF. How to spot mitochondrial disease in adults. Clinical Medicine 2013, 13(1), 87-92.
  • Keogh MJ, Jonas P, Coulthard A, Chinnery PF, Burn J. Neuroferritinopathy: a new inborn error of iron metabolism. Neurogenetics 2012, 13(1), 93-96.
  • Sedehizadeh S, Keogh M, Wills AJ. Reversible Hypomagnesaemia-Induced Subacute Cerebellar Syndrome. Biological Trace Element Research 2011, 142(2), 127-129.

• Conference Proceedings (inc. Abstract)

  • Keogh M, Drury P, Booth LC, Maathi S, Davidson J, Bennet L, Gunn AJ. The association between seizure activity and neural injury following endotoxin exposure and hypoxic-ischaemic insults in a preterm ovine model. In: Journal of Neurology, Neurosurgery and Psychiatry: Association of British Neurologists Annual Meeting. 2012, Gateshead, UK: BMJ Group.

• Editorial

  • Keogh M, Chinnery PF. Hereditary mtDNA Heteroplasmy: A Baseline for Aging?. Cell Metabolism 2013, 18(4), 463-464.

• Letters

  • Pyle A, Griffin H, Keogh MJ, Horvath R, Chinnery PF. Reply: Evaluation of exome sequencing variation in undiagnosed ataxias. Brain 2015, 138, 1-2.
  • Talim B, Pyle A, Griffin H, Topaloglu H, Tokatli A, Keogh MJ, Santibanez-Koref M, Chinnery PF, Horvath R. Multisystem fatal infantile disease caused by a novel homozygous EARS₂ mutation. Brain 2013, 136(2), e228.

• Reviews

  • Keogh MJ, Chinnery PF. Mitochondrial DNA mutations in neurodegeneration. Biochimica et Biophysica Acta (BBA) - Bioenergetics 2015, 1847(11), 1401-1411.
  • Sedehizadeh S, Keogh M, Maddison P. The Use of Aminopyridines in Neurological Disorders. Clinical Neuropharmacology 2012, 35(4), 191-200.
  • Keogh MJ, Chinnery PF. Current Concepts and Controversies in Neurodegeneration with Brain Iron Accumulation. Seminars in Pediatric Neurology 2012, 19(2), 51-56.
  • Keogh M, Sedehizadeh S, Maddison P. Treatment for Lambert-Eaton myasthenic syndrome. Cochrane Database of Systematic Reviews 2011, (2), CD003279.