Staff profiles | Newcastle Clinical Trials Unit

Dr Thomas Chadwick

Clinical Trials Statistician

Email: thomas.chadwick@ncl.ac.uk
Telephone: +44 (0) 191 208 6039
Address: Institute of Health and Society
Baddiley Clark Building
Richardson Road
Newcastle University
Newcastle upon Tyne
NE2 4AX
UK

Publications

Pickard RS, Chadwick T, Oluboyede Y, Brennand C, von Willamowitz-Moellendorff A, McClurg D, Wilkinson J, Ternent L, Ainsworth H, Walton K, McColl E, Vale L, Wood R, Abdel-Fattah M, Hilton P, Fader M, Harrison S, Larcombe J, Little P, Timoney A, N'Dow J, Armstrong H, Morris N, Walker K, Thiruchelvam N. Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT. Health Technology Assessment 2018, 22(24), i-102.
Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather T, Juss JK, Chilvers ER, Bowett SA, Parker J, McAuley DF, Conway Morris A, Simpson AJ. Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis. Thorax 2018, 73(10), 918-925.
Bell GM, Anderson AE, Diboll J, Reece R, Eltherington O, Harry RA, Fouweather T, MacDonald C, Chadwick T, McColl EM, Dunn J, Dickinson AM, Hilkens CMU, Isaacs JD. Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis. Annals of the Rheumatic Diseases 2017, 76(1), 227-234.
Payne B, Chadwick TJ, Blamire A, Anderson KN, Parikh J, Qian J, Hynes AM, Wilkinson J, Price DA. Does efavirenz replacement improve neurological function in treated HIV infection?. HIV Medicine 2017, 18(9), 690-695.
Wright SE, Thomas K, Watson G, Baker C, Bryant A, Chadwick TJ, Shen J, Wood R, Wilkinson J, Mansfield L, Stafford V, Wade C, Furneval J, Henderson A, Hugill K, Howard P, Roy A, Bonner S, Baudouin S. Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial. Thorax 2018, 73(3), 213-221.
Fisher A, Andreasson A, Chrysos A, Lally J, Mamasoula C, Exley C, Wilkinson J, Qian J, Watson G, Lewington O, Chadwick T, McColl E, Pearce M, Mann K, McMeekin N, Vale L, Tsui S, Yonan N, Simon A, Marczin N, Mascaro J, Dark J. An observational study of Donor Ex Vivo Lung Perfusion in UK Lung Transplantation : DEVELOP-UK. Health Technology Assessment 2016, 20(85).
Fisher A, Andreasson A, Chrysos A, Lally J, Mamasoula C, Exley C, Wilkinson J, Qian J, Watson G, Lewington O, Chadwick T, McColl E, Pearce M, Mann K, McMeekin N, Vale L, Tsui S, Yonan N, Simon A, Marczin N, Mascaro J, Dark J. An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK. Health Technology Assessment 2016, 20(85), 1-276.
Brennand C, von Wilamowitz-Moellendorff A, Dunn S, Wilkinson J, Chadwick T, Ternent L, Oluboyede Y, Wood R, Walton K, Fader M, N'Dow J, Abdel-Fattah M, McClurg D, Little P, Hilton P, Timoney A, Morris N, Thiruchelvam N, Lacombe J, Harrison S, Armstrong H, McColl E, Pickard R. Antibiotic treatment for intermittent bladder catheterisation with once daily prophylaxis (the AnTIC study): Study protocol for a randomised controlled trial. Trials 2016, 17, 276.
Payne B, Chadwick T, Blamire A, Qian J, Hynes AM, Wilkinson J, Price DA, Anderson K. Neurocognitive and neurometabolic effects of switch from efavirenz to ritonavir-boosted lopinavir. In: 22nd Annual Conference of the British HIV Association (BHIVA). 2016, Manchester: Wiley-Blackwell Publishing Ltd.
Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Allen T, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather A, Bowett S, Parker J, McAuley DF, Morris AC, Simpson AJ. Randomised Controlled Trial Of Granulocyte Macrophage Colony Stimulating Factor In Critically Ill Patients With Impaired Neutrophil Function. In: American Thoracic Society 2016 International Conference. 2016, San Francisco: American Thoracic Society.
Little SA, Leelarathna L, Walkinshaw E, Tan HK, Chapple O, Lubina-Solomon A, Chadwick TJ, Barendse S, Stocken DD, Brennand C, Marshall SM, Wood R, Speight J, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Recovery of hypoglycemia awareness in longstanding type 1 diabetes: A multicenter 2×2 factorial randomized controlled trial comparing insulin pump with multiple daily injections and continuous with conventional glucose selfmonitoring (HypoCOMPaSS). Diabetes Technology and Therapeutics 2016, 18(Suppl. 1), S27-S28.
Aspray TJ, Francis RM, McColl E, Chadwick T, Stamp E, Prentice A, Schoenmakers I. Vitamin D supplementation for 12 months in older people prevents bone loss and suppresses parathyroid hormone levels. In: 43rd Annual European Calcified Tissue Society Congress. 2016, Rome, Italy: ECTS.
Tan MP, Murray A, Hawkins T, Chadwick TJ, Kerr SRJ, Parry SW. Cardiac Iodine-123-Meta-Iodo-Benzylguanidine Uptake in Carotid Sinus Hypersensitivity. PLoS ONE 2015, 10(6), e0126241.
Thomas K, Wright SE, Watson G, Baker C, Stafford V, Wade C, Chadwick TJ, Mansfield L, Wilkinson J, Shen J, Deverill M, Bonner S, Hugill K, Howard P, Henderson A, Roy A, Furneval J, Baudouin SV. Extra Physiotherapy in Critical Care (EPICC) Trial Protocol: a randomised controlled trial of intensive versus standard physical rehabilitation therapy in the critically ill. BMJ Open 2015, 5(5), e008035.
Little SA, Leelarathna L, Walkinshaw E, Tan HK, Chapple O, Lubina-Solomon A, Chadwick TJ, Barendse S, Stocken DD, Brennand C, Marshall SM, Wood R, Speight J, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JA. Recovery of hypoglycemia awareness in long-standing type 1 diabetes: A multicenter 2X2 factorial randomized controlled trial comparing insulin pump with multiple daily injections and continuous with conventional glucose self-monitoring (HypoCOMPaSS). Diabetes Care 2015, 37(8), 2114-2122.
Little SA, Leelarathna L, Walkinshaw E, Kai Tan H, Chapple O, Lubina-Solomon A, Chadwick TJ, Barendse S, Stocken DD, Brennand C, Marshall SM, Wood R, Speight J, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Recovery of Hypoglycemia Awareness in Long-Standing Type 1 diabetes: A Multicenter 2x2 Factorial Randomized Controlled Trial Comparing Insulin Pump with Multiple Daily Injections and Continuous with Conventional Glucose Self-Monitoring (HypoCOMPaSS). Diabetes Care 2014, 37(8), 2114-2122.
Little SA, Leelarathna L, Walkinshaw E, Tan HK, Chapple O, Lubina-Solomon A, Chadwick TJ, Barendse S, Stocken DD, Brennand C, Marshall SM, Wood R, Speight J, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Response to Comment on Little et al. Recovery of Hypoglycemia Awareness in Long-standing Type 1 Diabetes: A Multicenter 2 x 2 Factorial Randomized Controlled Trial Comparing Insulin Pump With Multiple Daily Injections and Continuous With Conventional Glucose Self-monitoring (HypoCOMPaSS). Diabetes Care 2014;37:2114-2122. Diabetes Care 2014, 37(12), E272-E273.
Tan MP, Chadwick TJ, Kerr SRJ, Parry SW. Symptomatic Presentation of Carotid Sinus Hypersensitivity Is Associated With Impaired Cerebral Autoregulation. Journal of the American Heart Association 2014, 3(3), e000514.
Howel D, Stamp E, Chadwick TJ, Adamson AJ, White M. Are social inequalities widening in generalised and abdominal obesity and overweight among English adults?. PLoS One 2013, 8(11), e79027.
Leelarathna L, Little SA, Walkinshaw E, Tan HK, Lubina-Solomon A, Kumareswaran K, Lane AP, Chadwick T, Marshall SM, Speight J, Flanagan D, Heller SR, Shaw JA, Evans ML. Restoration of self-awareness of hypoglycemia in adults with long-standing Type 1 diabetes: hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial. Diabetes Care 2013, n/a, n/a.
Schoenmakers I, Francis RM, McColl E, Chadwick T, Goldberg GR, Harle C, Yarnall A, Wilkinson J, Parker J, Prentice A, Aspray T. Vitamin D supplementation in older people (VDOP): Study protocol for a randomised controlled intervention trial with monthly oral dosing with 12,000 IU, 24,000 IU or 48,000 IU of vitamin D₃. Trials 2013, 14, 299.
Little S, Chadwick T, Choudhary P, Brennand C, Stickland J, Barendse S, Olateju T, Leelarathna L, Walkinshaw E, Tan HK, Marshall SM, Thomas RM, Heller S, Evans M, Kerr D, Flanagan D, Speight J, Shaw JAM. Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial). BMC Endocrine Disorders 2012, 12(1), 33.
Tan MP, Kenny RAM, Chadwick TJ, Kerr SRJ, Parry SW. Carotid sinus hypersensitivity: disease state or clinical sign of ageing? Insights from a controlled study of autonomic function in symptomatic and asymptomatic subjects. Europace 2010, 12(11), 1630-1636.
Tan MP, Newton JL, Chadwick TJ, Gray JC, Nath S, Parry SW. Home orthostatic training in vasovagal syncope modifies autonomic tone: results of a randomized, placebo-controlled pilot study. Europace 2010, 12(2), 240-246.
Parry SW, Tan MP, Kenny RA, Chadwick TJ. A Prospective Case Control Study of Frequency Domain Heart Rate Variability in Individuals with Symptomatic and Asymptomatic Carotid Sinus Hypersensitivity. In: Journal of Cardiovascular Electrophysiology: 11th International Workshop on Cardiac Arrhythmias. 2009, Venice, Italy: Wiley-Blackwell Publishing, Inc.
Tan MP, Newton JL, Chadwick TJ, Nath S, Parry SW. A Randomized Placebo Controlled Pilot Study to Establish the Length of Training for Home Orthostatic Training in Vasosagal Syncope. In: Journal of Cardiovascular Electrophysiology: 11th International Workshop on Cardiac Arrhythmias. 2009, Venice, Italy: Wiley-Blackwell Publishing, Inc.
Aitkin M, Liu CC, Chadwick T. Bayesian model comparison and model averaging for small-area estimation. The Annals of Applied Statistics 2009, 3(1), 199-221.
Tan MP, Newton JL, Gray JC, Chadwick TJ, Nath S, Parry SW. Changes in Autonomic Responses Associated With Orthostatic Training in Vasovagal Syncope in a Randomized, Placebo-Controlled, Pilot Study. In: Journal of the American College of Cardiology: 58th Annual Scientific Session of the American College of Cardiology. 2009, Orlando, Florida: Elsevier Inc.
Papakonstantinou L, Leslie P, Gray JC, Chadwick TJ, Wilson JA. Laryngopharyngeal reflux: a prospective analysis of a 34 item symptom questionnaire. Clinical Otolaryngology 2009, 34(5), 455-459.
Schiessl B, Innes BA, Bulmer JN, Otun HA, Chadwick TJ, Robson SC, Lash GE. Localization of Angiogenic Growth Factors and Their Receptors in the Human Placental Bed Throughout Normal Human Pregnancy. Placenta 2009, 30(1), 79-87.
Rankin JM, Chadwick TJ, Natarajan M, Howel DM, Pearce MS, Pless-Mulloli T. Maternal exposure to ambient air pollutants and risk of congenital anomalies. Environmental Research 2009, 109(2), 181-187.
Tan MP, Newton JL, Reeve P, Murray A, Chadwick TJ, Parry SW. Results of carotid sinus massage in a tertiary referral unit - is carotid sinus syndrome still relevant?. Age and Ageing 2009, 38(6), 680-686.
Parry SW, Chadwick T, Gray JC, Bexton RS, Tynan M, Bourke JP, Nath S. The intravenous adenosine test: a new test for the identification of bradycardia pacing indications? A pilot study in subjects with bradycardia pacing indications, vasovagal syncope and controls. QJM 2009, 102(7), 461-468.
Parry SW, Tan MP, Newton JL, Chadwick TJ. The Relationship Between Baroreflex Sensitivity and the Hemodynamic Responses to Carotid Sinus Massage. In: Journal of Cardiovascular Electrophysiology: 11th International Workshop on Cardiac Arrhythmias. 2009, Venice, Italy: Wiley-Blackwell Publishing, Inc.
Parry SW, Tan MP, Kenny RA, Chadwick TJ. The Relationship Between Cerebral Autoregulation and Symptoms in Older Individuals with Carotid Sinus Hypersensitivity. In: Journal of Cardiovascular Electrophysiology: 11th International Workshop on Cardiac Arrhythmias. 2009, Venice, Italy: Wiley-Blackwell Publishing, Inc.
Stamp E, Howel D, Chadwick T, Adamson A, White M. Are inequalities in overweight, obesity and high waist-hip ratio among English adults widening?. In: 52nd Annual Scientific Meeting of the Society for Social Medicine. 2008, Southampton: BMJ Group.
Tan MP, Newton JL, Chadwick T, Parry SW. Changes in baroreflex sensitivity with home orthostatic training in vasovagal syncope - a randomized, placebo controlled pilot study. In: Hypertension: 13th Annual Meeting of the European Council for Cardiovascular Research. 2008, Nice, France: Lippincott Williams & Wilkins.
Tan MP, Newton JL, Chadwick TJ, Parry SW. The relationship between carotid sinus hypersensitivity, orthostatic hypotension, and vasovagal syncope: a case-control study. Europace 2008, 10(12), 1400-1405.
Adamson A, Chadwick T, Dezateaux C, Griffiths G, Howel D, Kelly S, Law C, Li L, Lo Conte R, Power C, Stamp E, White M. The changing social patterning of obesity: an analysis to inform practice and policy development. London, UK: Department of Health, 2007. Public Health Consortium.
Edwards R, Pless-Mulloli T, Howel D, Chadwick T, Bhopal R, Harrison R, Gribbin H. Does living near heavy industry cause lung cancer in women? A case-control study using life grid interviews. Thorax 2006, 61(12), 1076-1082.
Schiessl B, Innes BA, Otun HA, Lash GE, Chadwick TJ, Robson SC, Bulmer JN. Localization of angiopoietin-1, angiopoietin-2 and Tie 2 in the human placental bed throughout normal human pregnancy. Placenta 2006. In Press.
Mackintosh J, White M, Howel D, Chadwick T, Moffatt S, Deverill M, Sandell A. Randomised controlled trial of welfare rights advice accessed via primary health care: Pilot study [ISRCTN61522618]. BMC Public Health 2006, 6(162), 10.
White M, Moffatt S, Mackintosh J, Howel D, Sandell A, Chadwick T, Deverill M, Bell R, Whitton N. Randomised controlled trial to evaluate the health effects of welfare rights advice accessed via primary health care: a pilot study. Newcastle upon Tyne: University of Newcastle, 2006. Report to Department of Health.
Edwards R, Pless-Mulloli T, Howel D, Chadwick T. Association between residency near heavy industry and lung cancer in women. In: Epidemiology: 17th Annual Conference of the International Society for Environmental Epidemiology. 2005, Johannesburg, South Africa: Lippincott Williams & Wilkins.
Aitkin M, Boys RJ, Chadwick TJ. Bayesian point null hypothesis testing via the posterior likelihood ratio. Statistics and Computing 2005, 15(3), 217-230.
Snaith VJ, Howel D, Chadwick T, Deverill M, Hewison J, Sturgiss SN, Robson SC. [abstract] First trimester ultrasound screening - The psychological consequences of termination of pregnancy for foetal abnormality. Journal of Reproductive and Infant Psychology 2004, 22(3), 239.