Ear, Nose and Throat
NAIROS - Closed
NAIROS - Nasal Airway Obstruction Study
- Study Stage: Closed
- Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Funder: NIHR HTA
- Therapeutic area: Ear, Nose and Throat
- Type of study: CTIMP
Aim: To establish, and inform guidance for, the best management strategy for patients with nasal obstruction associated with a deviated septum via a randomised controlled trial of surgery (within 8 weeks) versus defined medical management.
Primary outcome: SNOT-22 questionnaire at 6 months follow up
- Population: Adult
- Clinical Phase: III
- Design: RCT, Qualitative and Health Economics
- Setting: Secondary Care
Website: http://nairos.co.uk/
NATTINA - Closed
NAIROS - Nasal Airway Obstruction Study
- Study Stage: Closed
- Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Funder: NIHR HTA
- Therapeutic area: Ear, Nose and Throat
- Type of study: CTIMP
Aim: To establish, and inform guidance for, the best management strategy for patients with nasal obstruction associated with a deviated septum via a randomised controlled trial of surgery (within 8 weeks) versus defined medical management.
Primary outcome: SNOT-22 questionnaire at 6 months follow up
- Population: Adult
- Clinical Phase: III
- Design: RCT, Qualitative and Health Economics
- Setting: Secondary Care
Website: http://nairos.co.uk/
TALGiTS - Recruiting
A pragmatic, multicentre, placebo controlled, double blind, parallel, randomised controlled trial of liquid alginate (Gaviscon Advance) for the treatment of persistent throat symptoms
- Study Stage: Recruiting
- Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Funder: IIT (Reckitt)
- Therapeutic area: Ear, Nose and Throat
- Type of study: CTIMP
Aim: To compare the symptomatic response in patients with persistent throat symptoms to a liquid alginate (Gaviscon Advance) compared to matched placebo.
Primary Outcome: Total Reflux Symptom Index (RSI) score at 8 weeks
- Population: Adult
- Design: RCT (double-blind)
- Setting: Secondary Care
- Phase: III
- Planned Sample Size: 250
TOPPITS - Closed
Trial of Proton Pump Inhibitors in Throat Symptoms
- Study Stage: Closed
- Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Funder: NIHR HTA
- Therapeutic area: Ear, Nose and Throat
- Type of study: CTIMP
Aim: To compare the symptomatic response in patients with persistent throat symptoms at the end of four months (16 weeks) therapy of treatment with lansoprazole versus placebo
Primary Outcome: The change in Reflux Symptom Index (RSI) at four months in the treatment and placebo groups in an intention to treat analysis.
- Clinical Phase: III
- Population: Adult
- Design: RCT
- Setting: Secondary Care
- Planned Sample Size: 332