Staff Profile

Profile

Prof Angharad Gatehouse has the Chair of Invertebrate Molecular Biology at Newcastle University and is Director of Expertise for BioEconomy. Her research focuses on the molecular and biochemical bases of plant-pest interactions with a view to developing novel strategies for crop protection. Her group was one of the first to produce insect-resistant transgenic crops. More recently her group has been using functional genomics to better understand the molecular responses of crops to biotic stress (pathogens and insect pests) for the development of molecular markers. In collaboration with Durham University, her group are actively involved in developing novel biopesticides including those based on RNAi. In addition to their efficacy, the group is also involved in the biosafety of these strategies, notably in terms of their potential effects on beneficial insects such as pollinators and natural enemies.  She has published extensively in the field, including in discovery journals (Nature, PNAS). She was ranked 3rd in the world ratings for citations on work on GM crops and awarded an Honorary Doctorate for contributions to Biotechnology (Banat's University of Agricultural Science and Veterinary Medicine). In 2015 she was elected an Honorary Member of the National Italian Academy of Entomology and in 2016 she was awarded the ‘Certificate of Distinction in Recognition of Outstanding Achievements in Entomology’, by the Council of the International Congress of Entomology. She has been in receipt of substantial funding; her research is currently funded by BBSRC, EU and industry. She has extensive collaborations both within the UK and overseas in addition to having strong industrial links. She is a Visiting Professor at Shanxi Academy of Agricultural Sciences (2016-2022) and is Chair of the External Scientific Advisory Board of Agrotecnio (designated a Centre of Excellence for Agrifood Sciences, Spain).

Present post           

• Chair of Invertebrate Molecular Biology, Newcastle University (from 2004)
• Director of Expertise for BioEconomy, Newcastle University, (from 2017)
• N8 Lead for Newcastle University

Honours

• Certificate of Distinction for Outstanding Achievement, Council International Congress of Entomology (Conferred Sept 2016, Florida, USA)
• Elected to the Council of International Congress of Entomology (2016 - 2032)
• Honorary Member of the National Italian Academy of Entomology (Elected Nov 2015)
• Fellow of Royal Society of Biology (Elected Jan 2016)

Esteem

• Ranked 3^rd top in world ratings for citations on work on GM crops (http://www.esi-topics.com/gmc/authors/b1a.html)
• Visiting Professor Shanxi Academy Agricultural Sciences (from 2016)
• Honorary Doctorate; Banat's University of Agricultural Science and Veterinary Medicine (Conferred Oct 2005; for contributions to Biotechnology)
• Chair of External Scientific Advisory Board of Agrotecnio (designated a Centre of Excellence for Agrifood sciences, Spain) (2013 - present)
• Invited by US Department of State to visit Agri-Biotech sector and to meet with key US regulators and legislators (2004)
• US Department of State Alumni Member – invited
• Appointed to the ‘Centres for Agricultural Innovation’ Grant Panel for Innovate UK (formerly Technology Strategy Board; 2014)
• Editorial Board member for several international journals
• Keynote Speaker at major international conferences both in Plant and Insect Molecular Biology
• World Class University International Review Panel member (2008, 2010 USA)
• Conference organiser. Examples include:

1. Organising Committee International Congress Entomology, Helsinki 2020
2. Organising Committee of European Congress of Entomology, Naples 2018
3. Symposium Organizer: International Congress Entomology, Florida 2016 “Novel Biopesticides”
4. Second International Conference on Agrochemicals Protecting Crops, Health and Natural Environment - The Role of Chemistry for Sustainable Agriculture – February 2012.
5. International Conference on Invertebrate Reproduction and Development in the Age of Genetic Modifications-Prague – August 20 International Symposium on  ‘Insects and Diseases’, Aberdeen 2001.

Research Interests

Key Research Interests and Activities

Research Interests: Novel Approaches to Crop Protection

(i) Molecular and biochemical responses in plant/pest interactions to inform crop breeding programmes; (ii) Development of novel biopesticides; (iii) Genetic engineering of crops for resistance to pests and assessment of their impact in the environment and (iv) Safety of GM crops and novel foods to consumers (development of quantitative methodology based on genomics, transcriptomics, proteomics).  These research areas are underpinned by platform technologies in genomics and proteomics.

 

Specific Major Research Objectives:

• Identification of genes switched on in the plant/pest/predator interaction
• Molecular response in plants to biotic/abiotic stress
• Role of transgenic crops in agricultural systems
• Production of crops with enhanced resistance to pests, via recombinant DNA technology
• Environmental safety assessment of transgenic crops (in particular, effects on beneficial insects i.e.   pollinators, predators, parasitoids)
• Safety assessment of transgenic crops and novel foods for human consumption
• Insect digestive biochemistry and molecular biology
• Development of novel biopesticides, including RNA interference-based approaches

Scientific Achievements

The group is recognised as a world leader in the genetic modification of crops for enhanced levels of resistance to pests and the impact of such crops on beneficial insects. It was the first to produce insect resistant crops expressing plant-derived transgenes (Nature, 1987, 330: 160-163). It has maintained its lead in the field and is actively using both genomics and proteomics to better understand the molecular and biochemical responses of plants to both biotic and abiotic stress.

 I have published over 130 refereed papers in the field, and have written 30 invited reviews, 20 book chapters and edited 5 books; I also hold several patents relating to insecticidal molecules for crop protection.  I am committed to the Public Engagement of Science and regularly participate in national and international debates on the use of GM technologies.

 At present I am involved in several European Networks, in addition to having strong industrial links. I have extensive collaborations both within the UK and overseas.

 Active Collaborations

The linked research groups at Newcastle University and Durham University, headed by Prof Angharad Gatehouse and Prof John Gatehouse, have set out to bring a multidisciplinary approach to the study of plant-pest interactions, although the emphasis is on the molecular rather than the whole organism aspect of biology.

Major collaborators include:

John Gatehouse (Durham University)

Ari Sadanandom (Durham University)

Linda Walling (UC Riverside)

Gongyin Ye (Zhejiang University)

Qingyao Shu  (Zhejiang University)

Kanglai He (CAAS, Beijing)

Jianrong Bai (Shanxi Academy Agricultural Sciences)

Paul Christou (Lleida University)

Elaine Fitches (Defra/Durham University)

Franco Pennacchio (University Naples)

Heikki Hokkanen (Helsinki University)

Bruce Tabashnik (University of Arizona)

Neal Stewart (University of Tennessee)

Felix Ortego (CSIC Madrid)

Fatima Grossi de Sa (Embrapa, Brasilia)

Funding

The group attracts substantial funding, including from BBSRC, NERC, EU, Scottish Executive, Royal Society, Yorkshire Agriculture Society, Industry (e.g. KWS, Syngenta).

Recent Awards (since 2000)

2018 – 2023                Stacking of ecosystem services: mechanisms and interactions for optimal crop protection, pollination enhancement, and productivity.

Funding Body: EU Horizon2020

2016 – 2021                Modifying plants to produce interfering RNA (iPLANTA)

                                    Funding Body: EU –COST Action CA15223 (Member of Management Committee)

2016-2020                   Novel Approaches to the Sustainable Control of Crop Insect Pests

                                    Funding Body: BBSRC CASE with OXITEC (BBSRC grant BB/P504762/1)

2015-2019                   Nitrogen availability influences Septoria defence in wheat by modulating WRKY transcription factor gene expression

                                    Funding Body: BBSRC (Co-ordinator, A. Sadanandom; PI, AMRG; Link with KWS)

2013                            Capacity building to promote innovative solutions for control of current and emerging threats to UK trees and woodlands from pest invertebrates

                                    Funding Body: Defra (LWEC) (Co-ordinator; FERA, R.Weaver; AMRG, PI)

2012-2017                   Promoting the Power of Plant Genetic Innovation

Funding Body: EU FP7, ERDF (NIAB, Coordinator; AMRG, PI).

2012                            RNA interferance of chitin synthesis as a novel approach to control insect pests: Proof of concept

2011 – 2016                Endophytes in Biotechnology and Agriculture

                                    Funding Body: EU – FP7 COST Action FA1103

2011 – 2014                Fusion protein-based biopesticides for sustainable crop protection

                                    Funding Body: Technology Strategy Board (TSB)

2011                            Exploitation of Insecticidal Fusion Proteins for Crop Protection using Transgenic Approaches

Funding Body: Yorkshire Agric. Soc

2010 - 2011                 Doctoral Training Grant Awards – Systems Biology

Funding Body: BBSRC

2009- 2012                  Development of Benaki Phytopathological Institute as a Centre of Excellence in Plant Health and Crop

                                    Funding Body: EU – FP7 (AMRG PI)

2009 – 2014                Improving nutrient efficiency in major European food, feed and biofuel crops to reduce the negative environmental impact of crop production

Funding Body: EU FP7 222645

2008-2011                            Doctoral Training Grant Awards

                                  Funding Body: BBSRC (BB/F017243/1)

2008                          Enhancing Wheat Defence against Insect Pests

Funding Body: Yorkshire Agric. Soc

2007- 2010                  Enhancing resistance to existing and emerging insect pests of UK cereals

                                    Funding Body: BBSRC (BB/E0066761/1)

2006-2009                   Parasitoid wasps as a source of natural insecticidal molecules.

Funding Body: Yorkshire Agric. Soc

2006-2008                   Identification of Cry1Ab receptors in ACB midgut through proteomic analysis.

2005                           Engineering Biology (PI, AMRG)

                                   Funding Body: SRIFII (£3.7M)

2005                            Impact of Management Practices on Soil: Implications for Differential Gene Expression in Plants

                                    Funding Body: Yorkshire Agric. Soc

2004- 2007                  Quantitative risk assessment strategies for novel foods

                                    Funding Body: EU – FP6-506387

2003                                                 Development of Novel Methodologies for Control of Homopteran Pests of          Cereals.

2002 – 2004                Novel approaches for aphid control using entomopathogenic fungi

2002 – 2004                Novel approaches for aphid control using entomopathogenic fungi

                                    Funding Body: BBSRC 206/SAP11143

2001-2004                   New approaches to studying tritrophic interactions involving insect-resistant transgenic plants.

                                   Funding Body: BBSRC/NERC (13/GM114174)

2000-2003                   Impact of genetically modified crops on natural enemies of crop pests.

                                    Funding Body: Yorkshire Agric. Soc

2000-2002                   Gene expression induced by pest and pathogen attack in crops.

                                    Funding Body: Royal Society.

2000-2003                  European network safety assessment of genetically modified food      crops.

                                    Funding Body: EC – FP5

2000-2004:                 New methods for the safety testing of transgenic food

                                    Funding Body: EC – FP5 QLKI –1999-01182

1998-2001:                  Lower application of insecticides by the production of insect resistant crops using novel protease inhibitor genes.

                       

Undergraduate Teaching

BIO2015  Biotechnology 1 (Module Leader)

BIO3006 Plant-Animal Interactions 

Postgraduate Teaching

BIO8044  Gene Technology (Module Leader)

BIO8045  Genetically Engineered Organisms: Food, Pharmaceutical and Industrial Sectors (Module Leader)

• Lu Z, Dang C, Wang F, Liu Z, Chen J, Wang Y, Yao H, Fang Q, Peng Y, Gatehouse AMR, Hua H, Ye G. Does long-term Bt rice planting pose risks to spider communities and their capacity to control planthoppers?. Plant Biotechnology Journal 2020, 18(9), 1851-1853.
• Wang W, Zhou P, Mo X, Hu L, Jin N, Chen X, Meng J, Erb M, Shang Z, Gatehouse AMR, Wu J, Lou Y. Induction of defence in cereals by 4-FPA suppresses insect pest populations and increases crop yields in the field. Proceedings of the National Academy of Science 2020, 117(22), 12017-12028.
• Girón-Calva PS, Twyman RM, Albajes R, Gatehouse AMR, Christou P. The Impact of Environmental Stress on Bt Crop Performance. Trends in Plant Science 2020, 25(3), 264-278.
• AL-Harbi A, Lary S, Edwards MG, Qusti S, Cockburn A, Poulsen M, Gatehouse AMR. A proteomic-based approach to study underlying molecular responses of the small intestine of Wistar rats to genetically modified corn (MON810). Transgenic Research 2019, 28, 479-498.
• Conboy NJA, McDaniel T, Ormerod A, George D, Gatehouse AMR, Wharton E, Donohoe P, Curtis R, Tosh CR. Companion planting with French marigolds protects tomato plants from glasshouse whiteflies through the emission of airborne limonene. PloS ONE 2019, 14(3), e0213071.
• Wang Y, Quan Y, Yang J, Shu C, Wang Z, Zhang J, Gatehouse AMR, Tabashnik BE, He K. Evolution of asian corn borer resistance to Bt Toxins used singly or in Pairs. Toxins 2019, 11(8), 461.
• Alshukri B, Astarita F, Al-Esawy M, Abd El Halim HM, Pennacchio F, Gatehouse AMR, Edwards MG. Targeting Potassium Ion Channels Genes SK and SH, as a Novel Approach for Control of Insect Pests: Efficacy and Biosafety. Pest Management Science 2019, 75(9), 2505-2516.
• Shoala T, Edwards MG, Knight MR, Gatehouse AMR. OXI1 kinase plays a key role in resistance of Arabidopsis towards aphids (Myzus persicae). Transgenic Research 2018, 27(4), 355-366.
• Lu H-P, Luo T, Fu H-W, Wang L, Tan Y-Y, Huang J-Z, Wang Q, Ye G-Y, Gatehouse AMR, Lou Y-G, Shu Q-Y. Resistance of rice to insect pests mediated by suppression of serotonin biosynthesis. Nature Plants 2018, 4, 338-344.
• Laudani F, Strano CP, Edwards MG, Malacrino A, Campolo O, El Halim HMA, Gatehouse AMR, Palmeri V. RNAi-mediated gene silencing in Rhynchophorus ferrugineus (Oliver) (Coleoptera: Curculionidae). Open Life Sciences 2017, 12(1), 214-222.
• McDaniel T, Tosh CR, Gatehouse AMR, George D, Robson M, Brogan B. Novel resistance mechanisms of a wild tomato against the glasshouse whitefly. Agronomy for Sustainable Development 2016, 36(1), 14.
• Abd-El-Halim HM, Alshukri BMH, Ahmad MS, Nakasu EYT, Awwad MH, Salama EM, Gatehouse AMR, Edwards MG. RNAi-mediated knockdown of the voltage gated sodium ion channel TcNa_v causes mortality in Tribolium castaneum. Scientific Reports 2016, 6, 1-9.
• Nakasu EY, Karamaouna F, Partsinevelos GK, Abd-El-Halim HM, Fitches EC, Pyati P, Gatehouse JA, Gatehouse AMR, Edwards MG. Sublethal effects of the insecticidal fusion protein ω-ACTX-Hv1a/GNA on the parasitoid Eulophus pennicornis via its host Lacanobia oleracea. Pest Management Science 2016, 72(3), 585-590.
• Lu H, Edwards M, Wang Q, Zhao H, Fu H, Huang J, Gatehouse A, Shu Q. Expression of cytochrome P450 CYP81A6 in rice: tissue specificity, protein subcellular localization, and response to herbicide application. Journal of Zhejiang University-Science B 2015, 16(2), 113-122.
• Lee J, Orosa B, Millyard L, Edwards M, Kanyuka K, Gatehouse A, Rudd J, Hammond-Kosack K, Pain N, Sadanandom A. Functional analysis of a Wheat Homeodomain protein, TaR1, reveals that host chromatin remodelling influences the dynamics of the switch to necrotrophic growth in the phytopathogenic fungus Zymoseptoria tritici. New Phytologist 2015, 206(2), 598-605.
• Guan W, Ferry N, Edwards MG, Bell HA, Othman H, Gatehouse JA, Gatehouse AMR. Proteomic analysis shows that stress response proteins are significantly up-regulated in resistant diploid wheat (Triticum monococcum) in response to attack by the grain aphid (Sitobion avenae). Molecular Breeding 2015, 35, 57.
• Xu LN, Wang ZY, Zhang J, Ferry N, Edwards MG, Gatehouse AMR, He KL. Characterization of four midgut aminopeptidase N isozymes from Ostrinia furnacalis strains with different susceptibilities to Bacillus thuringiensis. Journal of Invertebrate Pathology 2014, 115, 95-98.
• Jin TT, Chang X, Gatehouse AMR, Wang ZY, Edwards MG, He KL. Downregulation and Mutation of a Cadherin Gene Associated with Cry1Ac Resistance in the Asian Corn Borer, Ostrinia furnacalis (Guenée). Toxins 2014, 6(9), 2676-2693.
• Zhang TT, He MX, Gatehouse AMR, Wang ZY, Edwards MG, Li Q, He KL. Inheritance Patterns, Dominance and Cross-Resistance of Cry1Ab-and Cry1Ac-Selected Ostrinia furnacalis (Guenée). Toxins 2014, 6(9), 2694-2707.
• Tétard-Jones C, Gatehouse AMR, Cooper J, Leifert C, Rushton S. Modelling pathways to Rubisco degradation: a structural equation network modelling approach. PLoS ONE 2014, 9(2), e87597.
• Nakasu EYT, Williamson SM, Edwards MG, Fitches EC, Gatehouse JA, Wright GA, Gatehouse AMR. Novel biopesticide based on a spider venom peptide shows no adverse effects on honeybees. Proceedings of the Royal Society B 2014, 281(1787), 20140619.
• Nakasu EYT, Edwards MG, Fitches E, Gatehouse JA, Gatehouse AMR. Transgenic plants expressing ω-ACTX-Hv1a and snowdrop lectin (GNA) fusion protein show enhanced resistance to aphids. Frontiers in Plant Science 2014, 5, 673.
• Xu LN, Ferry N, Wang ZY, Zhang J, Edwards MG, Gatehouse AMR, He KL. A proteomic approach to study the mechanism of tolerance to Bt toxins in Ostrinia furnacalis larvae selected for resistance to Cry1Ab. Transgenic Research 2013, 22(6), 1155-1166.
• Tétard-Jones C, Edwards MG, Rempelos L, Gatehouse AMR, Eyre M, Wilcockson SJ, Leifert C. Effects of previous crop management, fertilization regime and watersupply on potato tuber proteome and yield. Agronomy 2013, 3(1), 59-85.
• Gatehouse AMR, Boulter D, Hilder VA. Novel insect resistance using protease inhibitor genes. In: Dennis, E.S., Llewellyn, D.J, ed. Plant Gene Research: Molecular approaches to crop improvement. New York: Springer-Verlag, 2013. In Press.
• Raorane M, Popluechai S, Gatehouse AMR, Kohli A. Proteomic perspectives on understanding and improving Jatropha curcas L. In: Jatropha, Challenges for a New Energy Crop. New York, NY, USA: Springer New York, 2013, pp.375-391.
• Raorane M, Popluechai S, Gatehouse AMR, Kohli A. Proteomic perspectives on understanding and improving Jatropha curcas L. In: Jatropha, Challenges for a New Energy Crop: Volume 2: Genetic Improvement and Biotechnology. New York, NY, USA: Springer New York, 2013, pp.375-391.
• Rempelos L, Cooper J, Wilcockson S, Eyre M, Shotton P, Volakakis N, Orr CH, Leifert C, Gatehouse AMR, Tétard-Jones C. Quantitative proteomics to study the response of potato to contrasting fertilisation regimes. Molecular Breeding 2013, 31(2), 363-378.
• Tétard-Jones C, Shotton PN, Rempelos L, Cooper J, Eyre M, Orr CH, Leifert C, Gatehouse AMR. Quantitative proteomics to study the response of wheat to contrasting fertilisation regimes. Molecular Breeding 2013, 31(2), 379-393.
• Tétard-Jones C, Gatehouse AMR, Shotton PN, Rempelos L, Cooper J, Eyre M, Leifert C. Contrasting nutrient input and crop protection regimes lead to differences in the wheat leaf proteome. 2012. Submitted.
• George DM, Rind FC, Bendall MW, Taylor MA, Gatehouse AMR. Developmental studies of transgenic maize expressing Cry1Ab on the African stem borer, Busseola fusca, effects on midgut cellular structure. Pest Management Science 2012, 68(3), 330-339.
• Pyati P, Chellamuthu A, Gatehouse AMR, Fitches E, Gatehouse JA. Insecticidal activity of wheat Hessian fly responsive proteins HFR-1 and HFR-3 towards a non-target wheat pest, cereal aphid (Sitobion avenae F.). Journal of Insect Physiology 2012, 58(7), 991-999.
• Ferry N, Gatehouse AMR. Successes and failures in Plant-Insect Interactions: Is it possible to stay one step ahead of the insects?. In: Diaz, I., Smagghe, G, ed. Arthropod-Plant Interactions, Novel Insights and Aproaches for IPM. New York: Springer Publishing Company, 2012, pp.89-126.
• Gatehouse AMR, Edwards MG, Ferry N, Owen MDK. Transgenic Crops, Environmental Impact. In: Meyers, R.A, ed. Encyclopedia of Sustainability Science and Technology. Dordrecht: Springer Science, 2012, pp.10713-10732.
• Popluechai S, Froissard M, Jolivet P, Breviario D, Gatehouse AMR, O'Donnell AG, Chardot T, Kohli A. Jatropha curcas oil body proteome and oleosins: L-form JcOle3 as a potential phylogenetic marker. Plant Physiology and Biochemistry 2011, 49(3), 352-356.
• Popluechai S, Froissard M, Jolivet P, Breviario D, Gatehouse AMR, O'Donnell AG, Chardot T, Kohli A. Jatropha curcas oil body proteome and oleosins: L-form JcOle3 as a potential phylogenetic marker. Plant Physiology and Biochemistry 2011, 49(3), 352-356.
• George D, Babalola OO, Gatehouse AMR. Differential protein expression in maize (Zea mays) in response to insect attack. African Journal of Biotechnology 2011, 10(39), 7700-7709.
• Gatehouse AMR, Ferry N, Edwards MG, Bell HA. Insect-resistant biotech crops and their impacts on beneficial arthropods. Philosophical Transactions of the Royal Society B: Biological Sciences 2011, 366(1569), 1438-1452.
• Ferry N, Stavroulakis S, Guan WZ, Davison GM, Bell HA, Weaver RJ, Down RE, Gatehouse JA, Gatehouse AMR. Molecular interactions between wheat and cereal aphid (Sitobion avenae): Analysis of changes to the wheat proteome. Proteomics 2011, 11(10), 1985-2002.
• Raorane M, Popluechai S, Gatehouse AMR, Kohli A. Proteomics perspectives on understanding and improving Jatropha curcas. In: Bahadur, B., Mulpuri, S, ed. Compendium of Bioenergy Plants: Jatropha. New Hampshire,USA: Science Publishers, 2011, pp.101-108.
• Romeis J, Hellmich RL, Candolfi MP, Carstens K, De Schrjijver A, Gatehouse AMR, Herman RA, Huesing JE, McLean MA, Raybould A, Shelton AM, Waggoner A. Recommendations for the design of laboratory studies on non-target arthropods for risk assessment of genetically engineered plants. Transgenic Research 2011, 20(1), 1-22.
• Fang Q, Wang F, Gatehouse JA, Gatehouse AMR, Chen X-X, Hu C, Ye G-Y. Venom of Parasitoid, Pteromalus puparum, Suppresses Host, Pieris rapae, Immune Promotion by Decreasing Host C-Type Lectin Gene Expression. PLoS One 2011, 6(10), e26888.
• Emami K, Morris NJ, Cockell SJ, Golebiowska G, Shu QY, Gatehouse AMR. Changes in Protein Expression Profiles between a Low Phytic Acid Rice (Oryza sativa L. Ssp japonica) Line and Its Parental Line: A Proteomic and Bioinformatic Approach. Journal of Agricultural and Food Chemistry 2010, 58(11), 6912-6922.
• Mulligan EA, Ferry N, Jouanin L, Romeis J, Gatehouse AMR. Characterisation of adult green lacewing (Chrysoperla carnea) digestive physiology: impact of a cysteine protease inhibito and a synthetic pyrethroid. Pest Management Science 2010, 66(3), 325-336.
• Xu L, Wang Z, Zhang J, He K, Ferry N, Gatehouse AMR. Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins. Journal of Applied Entomology 2010, 134(5), 429-438.
• Naseri B, Fathipour Y, Moharramipour S, Hosseininaveh V, Gatehouse AMR. Digestive proteolytic and amylolytic activities of Helicoverpa armigera in response to feeding on different soybean cultivars. Pest Management Science 2010, 66(12), 1316-1323.
• Wakefield ME, Bell HA, Gatehouse AMR. Longevity and fecundity of Eulophus pennicornis, an ectoparasitoid of the tomato moth Lacanobia oleracea, is affected by nutritional state and diet quality. Agricultural and Forest Entomology 2010, 12(1), 19-27.
• Edwards MG, Gatehouse JA, Gatehouse AMR. Molecular and biochemical characterisation of a dual proteolytic system in vine weevil larvae (Otiorhynchus sulcatus Coleoptera: Curculionidae). Insect Biochemistry and Molecular Biology 2010, 40(11), 785-791.
• Price DRG, Tibbles K, Shigenobu S, Smertenko A, Russell CW, Douglas AE, Fitches E, Gatehouse AMR, Gatehouse JA. Sugar transporters of the major facilitator superfamily in aphids; from gene prediction to functional characterization. Insect Molecular Biology 2010, 19, 97-112.
• Wakefield ME, Fitches EC, Bell HA, Gatehouse AMR. The snowdrop lectin Galanthus nivalis agglutinin (GNA) and a fusion protein ButaIT/GNA have a differential affect on a pest noctuid Lacanobia oleracea and the ectoparasitoid Eulophus pennicornis. Physiological Entomology 2010, 35(4), 334-342.
• Ferry N, Gatehouse AMR. Transgenic Crop Plants for Resistance to Biotic Stress. In: Kole, C; Michler, C; Abbott AG; Hall, TC, ed. Transgenic Crop Plants: Volume 2: Utilization and Biosafety. Dordrecht: Springer-Verlag, 2010, pp.1-65.
• Ferry N, Gatehouse AMR. Agriculture, Innovation and Environment. In: Ferry, N; Gatehouse, AMR, ed. Environmental Impact of Genetically Modified Crops. Wallingford: CAB International, 2009, pp.383-409.
• Shelton AM, Naranjo SE, Romeis J, Hellmich RL, Wolt JD, Federici BA, Albajes R, Bigler F, Burgess EPJ, Dively GP, Gatehouse AMR, Malone LA, Roush R, Sears M, Sehnal F, Ferry N, Bell HA. Appropriate Analytical Methods Are Necessary to Assess Nontarget Effects of Insecticidal Proteins in GM Crops Through Meta-Analysis (Response to Andow et al. 2009). Environmental Entomology 2009, 38(6), 1533-1538.
• Pyati PS, Bell HA, Fitches E, Price DRG, Gatehouse AMR, Gatehouse JA. Cathepsin L-like cysteine proteinase (DcCathL) from Delia coarctata (wheat bulb fly): Basis of insecticidal activity. Insect Biochemistry and Molecular Biology 2009, 39(8), 535-546.
• Ferry N, Gatehouse AMR, ed. Environmental Impact of Genetically Modified Crops. Wallingford: CAB International, 2009.
• Konrad R, Connor M, Ferry N, Gatehouse AMR, Babendreier D. Impact of transgenic oilseed rape expressing oryzacystatin-1 (OC-1) and of insecticidal proteins on longevity and digestive enzymes of the solitary bee Osmia bicornis. Journal of Insect Physiology 2009, 55(4), 305-313.
• Popluechai IS, Breviario D, Mulpuri S, Makkar HPS, Raorane M, Reddy AR, Palchetti E, Gatehouse AMR, Syers JK, O'Donnell AG, Kohli A. Narrow genetic and apparent phenetic diversity in Jatropha curcas: initial success with generating low phorbol ester interspecific hybrids. Nature Publishing Group, 2009. Available at: http://dx.doi.org/10101/npre.2009.2782.1.
• Shelton AM, Naranjo SE, Romeis J, Hellmich RL, Wolt JD, Federici BA, Albajes R, Bigler F, Burgess EPJ, Dively GP, Gatehouse AMR, Malone LA, Roush R, Sears M, Sehnal F. Setting the record straight: a rebuttal to an erroneous analysis on transgenic insecticidal crops and natural enemies. Transgenic Research 2009, 18(3), 317-322.
• Malone LA, Gatehouse AMR, Barratt BIP. Beyond Bt: Alternative Strategies for Insect-Resistant Genetically Modified Crops. In: Romeis J; Shelton T; Kennedy G, ed. Integration of Insect-Resistant Genetically Modified Crops within IPM Programs. Netherlands: Springer, 2008, pp.357-417.
• Malone LA, Gatehouse AMR, Barratt BIP. Beyond Bt: Alternative strategies for insect-resistant crops. In: Romeis, J; Shelton, AM; Kennedy, GG, ed. Integration of Insect-Resistant Genetically Modified Crops within Integrated Pest Management Programs. Springer, 2008, pp.357-417.
• George D, Ferry N, Back EJ, Gatehouse AMR. Characterisation of midgut digestive proteases from the maize stem borer Busseola fusca. Pest Management Science 2008, 64(11), 1151-1158.
• Kroghsbo S, Madsen C, Poulsen M, Schroder M, Kvist PH, Taylor M, Gatehouse A, Shu Q, Knudsen I. Immunotoxicological studies of genetically modified rice expressing PHA-E lectin or Bt toxin in Wistar rats. Toxicology 2008, 245(1-2), 24-34.
• Konrad R, Ferry N, Gatehouse AMR, Babendreier D. Potential effects of oilseed rape expressing oryzacystatin-1 (OC-1) and of purified insecticidal proteins on larvae of the solitary bee Osmia bicornis. PLoS One 2008, 3(7), e2664.
• Álvarez-Alfageme F, Ferry N, Castañera P, Ortego F, Gatehouse A. Prey mediated effects of Bt maize on fitness and digestive physiology of the red spider mite predator Stethorus punctillum Weise (Coleoptera: Coccinellidae). Transgenic Research 2008, 17(5), 943-954.
• Poulsen M, Kroghsbo S, Schroder M, Wilcks A, Jacobsen H, Miller A, Frenzel T, Danier J, Rychlik M, Shu Q, Emami K, Sudhakar D, Gatehouse A, Engel K-H, Knudsen I. A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA). Food and Chemical Toxicology 2007, 45(3), 350-363.
• Schroder M, Poulsen M, Wilcks A, Kroghsbo S, Miller A, Frenzel T, Danier J, Rychlik M, Emami K, Gatehouse A, Shu Q, Engel K-H, Altosaar I, Knudsen I. A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats. Food and Chemical Toxicology 2007, 45(3), 339-349.
• Edwards MG, Gatehouse AMR. Biotechnology in crop protection: Towards sustainable insect control. In: Vurro, M, Gressel, J, ed. Novel Biotechnologies for Biocontrol Agent Enhancement and Management. Netherlands: Springer, 2007, pp.1-23.
• Ferry N, Mulligan EA, Majerus M, Gatehouse AMR. Bitrophic and tritrophic effects of Bt Cry3A transgenic potato on beneficial, non-target, beetles. Transgenic Research 2007, 16(6), 795-812.
• Poulsen M, Schroder M, Wilcks A, Kroghsbo S, Lindecrona RH, Miller A, Frenzel T, Danier J, Rychlik M, Shu Q, Emami K, Taylor M, Gatehouse A, Engel K-H, Knudsen I. Safety testing of GM-rice expressing PHA-E lectin using a new animal test design. Food and Chemical Toxicology 2007, 45(3), 364-377.
• Tsakirpaloglou N, Kohli A, Gatehouse A. Unusual expression patterns of SODs in rice. In: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. Abstracts of the Annual Main Meeting of the Society for Experimental Biology. 2007, Glasgow, UK: Elsevier Inc.
• Mulligan EA, Ferry N, Jouanin L, Walters KFA, Port GR, Gatehouse AMR. Comparing the impact of conventional pesticide and use of a transgenic pest-resistant crop on the beneficial carabid beetle Pterostichus melanarius. Pest Management Science 2006, 62(10), 999-1012.
• Hogervorst PAM, Ferry N, Gatehouse AMR, Wackers FL, Romeis J. Direct effects of snowdrop lectin (GNA) on larvae of three aphid predators and fate of GNA after ingestion. Journal of Insect Physiology 2006, 52(6), 614-624.
• Wakefield ME, Bell HA, Fitches EC, Edwards JP, Gatehouse AMR. Effects of Galanthus nivalis agglutinin (GNA) expressed in tomato leaves on larvae of the tomato moth Lacanobia oleracea (Lepidoptera: Noctuidae) and the effect of GNA on the development of the endoparasitoid Meteorus gyrator (Hymenoptera: Braconidae). Bulletin of Entomological Research 2006, 96(1), 43-52.
• Ferry N, Mulligan EA, Stewart CN, Tabashnik BE, Port GR, Gatehouse AMR. Prey-mediated effects of transgenic canola on a beneficial, non-target, carabid beetle. Transgenic Research 2006, 15(4), 501-514.
• Christou P, Capell T, Kohli A, Gatehouse JA, Gatehouse AMR. Recent developments and future prospects in insect pest control in transgenic crops. Trends in Plant Science 2006, 11(6), 302-308.
• Ferry N, Edwards MG, Gatehouse J, Capell T, Christou P, Gatehouse AMR. Transgenic plants for insect pest control: A forward looking scientific perspective. Transgenic Research 2006, 15(1), 13-19.
• Mehlo L, Gahakwa D, Nghia PT, Loc NT, Capell T, Gatehouse JA, Gatehouse AMR, Christou P. An alternative strategy for sustainable pest resistance in genetically enhanced crops. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(22), 7812-7816.
• Bell HA, Down RE, Edwards JP, Gatehouse JA, Gatehouse AMR. Digestive proteolytic activity in the gut and salivary glands of the predatory bug Podisus maculiventris (Heteroptera: Pentatomidae); effect of proteinase inhibitors. European Journal of Entomology 2005, 102(2), 139-145.
• Ferry N, Jouanin L, Ceci LR, Mulligan EA, Emami K, Gatehouse JA, Gatehouse AMR. Impact of oilseed rape expressing the insecticidal serine protease inhibitor, mustard trypsin inhibitor-2 on the beneficial predator Pterostichus madidus. Molecular Ecology 2005, 14(1), 337-349.
• Díaz-Mendoza M, Edwards M, Ortego F, Gatehouse AMR, Castañera P, Hernández-Crespo P. Producción de proteasas digestivas tipo tripsina del taladro del maíz Sesamia nonagrioides (Lefèbvre) mediante sistemas de expresión heteróloga. In: IV Congreso Nacional de Entomología Aplicada. 2005, Braganza, Portugal.
• Shah PA, Gatehouse AMR, Clark SJ, Pell JK. Wheat containing snowdrop lectin (GNA) does not affect infection of the cereal aphid Metopolophium dirhodum by the fungal natural enemy Pandora neoaphidis. Transgenic Research 2005, 14(4), 473-476.
• Sauvion N, Nardon C, Febvay G, Gatehouse AMR, Rahbe Y. Binding of the insecticidal lectin Concanavalin A in pea aphid, Acyrthosiphon pisum (Harris) and induced effects on the structure of midgut epithelial cells. Journal of Insect Physiology 2004, 50(12), 1137-1150.
• Ferry N, Edwards MG, Mulligan EA, Emami K, Petrova AS, Frantescu M, Davison GM, Gatehouse AMR. Engineering resistance to insect pests. In: Christou, P; Klee, H, ed. Handbook of Plant Biotechnology. Hoboken, New Jersey: John Wiley & Sons, 2004, pp.373-394.
• Fitches E, Edwards MG, Mee C, Grishin E, Gatehouse AMR, Edwards JP, Gatehouse JA. Fusion proteins containing insect-specific toxins as pest control agents: Snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestion. Journal of Insect Physiology 2004, 50(1), 61-71.
• Bell HA, Kirkbride-Smith AE, Marris GC, Edwards JP, Gatehouse AMR. Oral toxicity and impact on fecundity of three insecticidal proteins on the gregarious ectoparasitoid Eulophus pennicornis (Hymenoptera: Eulophidae). Agricultural and Forest Entomology 2004, 6(3), 215-222.
• Ferry N, Edwards MG, Gatehouse JA, Gatehouse AMR. Plant–insect interactions: molecular approaches to insect resistance. Current Opinion in Biotechnology 2004, 15(2), 155-161.
• Ferry N, Edwards MG, Gatehouse JA, Gatehouse AMR. Plant-insect interactions: Molecular approaches to insect resistance. Current Opinion in Biotechnology 2004, 15(2), 155-161.
• Edwards MG, Ferry N, Mulligan EA, Emami K, Petrova AS, Frantescu M, Davison GM, Gatehouse AMR. The Role of Biotechnology in Crop Protection:Current Status and Future Perspectives. In: Atti dell'Accademia Nazionale Italiana di Entomologia Rendiconti. Florence: Accademia Nazionale Italiana di Entomologia, 2004, pp.133-152.
• Cellini F, Chesson A, Colquhoun I, Constable A, Davies HV, Engel KH, Gatehouse AMR, Karenlampi S, Kok EJ, Leguay J-J, Lehesranta S, Noteborn HPJM, Pedersen J, Smith M. Unintended effects and their detection in genetically modified crops. Food and Chemical Toxicology 2004, 42(7), 1089-1125.
• Bell HA, Down RE, Fitches EC, Edwards JP, Gatehouse AMR. Impact of Genetically Modified Potato Expressing Plant-Derived Insect Resistance Genes on the Predatory Bug Podisus maculiventris (Heteroptera: Pentatomidae). Biocontrol Science and Technology 2003, 13(8), 729-741.
• Ferry N, Raemaekers RJM, Majerus MEN, Jouanin L, Port GR, Gatehouse JA, Gatehouse AMR. Impact of oilseed rape expressing the insecticidal cysteine protease inhibitor oryzacystatin on the beneficial predator Harmonia axyridis (multicoloured Asian ladybeetle). Molecular Ecology 2003, 12(2), 493-504.
• Mulligan EA, Ferry N, Port G, Gatehouse AMR, Walters K. Impacts of transgenic crop technology upon the field slug Deroceras reticulatum (Muller). In: Slugs and Snails: Agricultural, Veterinary and Environmental Perspectives. 2003, Canterbury, UK: British Crop Protection Council.
• Baumgartner P, Harper K, Raemaekers RJM, Durieux A, Gatehouse AMR, Davies HV, Taylor MA. Large-scale production and purification of recombinant Galanthus nivalis agglutinin (GNA) expressed in the methylotrophic yeast Pichia pastoris. Biotechnology Letters 2003, 25(15), 1281-1285.
• Down RE, Ford L, Woodhouse SD, Davison GM, Majerus MEN, Gatehouse JA, Gatehouse AMR. Tritrophic interactions between transgenic potato expressing snowdrop lectin (GNA), an aphid pest (peach-potato aphid; Myzus persicae (Sulz.) and a beneficial predator (2-spot ladybird; Adalia bipunctata L.). Transgenic Research 2003, 12(2), 229-241.
• Gatehouse AMR. Durable Resistance in Crops. In: Pimentel, ed. Encyclopedia of Pest Management. New York, USA: Marcel Dekker, 2002, pp.207-209.
• Baumgartner P, Raemaekers RJM, Durieux A, Gatehouse A, Davies H, Taylor M. Large-scale production, purification, and characterisation of recombinant Phaseolus vulgaris phytohemagglutinin E-form expressed in the methylotrophic yeast Pichia Pastoris. Protein Expression and Purification 2002, 26(3), 394-405.
• Thi Loc N, Tinjuangjun P, Gatehouse AMR, Christou P, Gatehouse JA. Linear transgene constructs lacking vector backbone sequences generate transgenic rice plants which accumulate higher levels of proteins conferring insect resistance. Molecular Breeding 2002, 9(4), 231-244.
• Foissac X, Edwards MG, Du JP, Gatehouse AMR, Gatehouse JA. Putative protein digestion in a sap-sucking homopteran plant pest (rice brown plant hopper; Nilaparvata lugens: Delphacidae) - identification of trypsin-like and cathepsin B-like proteases. Insect Biochemistry and Molecular Biology 2002, 32(9), 967-978.
• Gatehouse AM, Ferry N, Raemaekers RJM. The case of the monarch butterfly: a verdict is returned. Trends in Genetics 2002, 18(5), 249-251.
• Jouanin L, Gatehouse AMR. The role of insect-resistant transgenic crops in agriculture. In: Devillers, J; Pham-Delegue, M-H, ed. Honey Bees: Estimating the Environmental Impact of Chemicals. London: Taylor and Francis, 2002, pp.296-289.
• Bell HA, Fitches EC, Down RE, Ford L, Marris GC, Edwards JP, Gatehouse JA, Gatehouse AMR. Effect of dietary cowpea trypsin inhibitor (CpTI) on the growth and development of the tomato moth Lacanobia oleracea (Lepidoptera: Noctuidae) and on the success of the gregarious ectoparasitoid Eulophus pennicornis (Hymenoptera: Eulophidae). Pest Management Science 2001, 57(1), 57-65.
• Couty A, Down RE, Gatehouse AMR, Kaiser L, Pham-Delegue M-H, Poppy GM. Effects of artificial diet containing GNA and GNA-expressing potatoes on the development of the aphid parasitoid Aphidius ervi Haliday (Hymenoptera: Aphidiidae). Journal of Insect Physiology 2001, 47(12), 1357-1366.
• Maqbool SB, Riazuddin S, Loc NT, Gatehouse AMR, Gatehouse JA, Christou P. Expression of multiple insecticidal genes confers broad resistance against a range of different rice pests. Molecular Breeding 2001, 7(1), 85-93.
• Down RE, Ford L, Bedford SJ, Gatehouse LN, Newell C, Gatehouse JA, Gatehouse AMR. Influence of plant development and environment on transgene expression in potato and consequences for insect resistance. Transgenic Research 2001, 10(3), 223-236.
• Fitches E, Ilett C, Gatehouse AMR, Gatehouse LN, Greene R, Edwards JP, Gatehouse JA. The effects of Phaseolus vulgaris erythro- and leucoagglutinating isolectins (PHA-E and PHA-L) delivered via artificial diet and transgenic plants on the growth and development of tomato moth (Lacanobia oleracea) larvae; lectin binding to gut glycoproteins in vitro and in vivo. Journal of Insect Physiology 2001, 47(12), 1389-1398.
• Bell HA, Fitches EC, Marris GC, Bell J, Edwards JP, Gatehouse JA, Gatehouse AMR. Transgenic GNA expressing potato plants augment the beneficial biocontrol of Lacanobia oleracea (Lepidoptera; Noctuidae) by the parasitoid Eulophus pennicornis (Hymenoptera; Eulophidae). Transgenic Research 2001, 10(1), 35-42.
• Gatehouse JA, Gatehouse AMR, Bown DP. Control of phytophagous insect pests using serine proteinase inhibitors. In: Michaud, D, ed. Recombinant Protease Inhibitors in Plants. Texas, USA: Landes Bioscience Eurekah.comm Academic Press, 2000, pp.9-26.
• Tinjuangjun P, Loc NT, Gatehouse AMR, Gatehouse JA, Christou P. Enhanced insect resistance in Thai rice varieties generated by particle bombardment. Molecular Breeding 2000, 6(4), 391-399.
• Du JP, Foissac X, Carss A, Gatehouse AMR, Gatehouse JA. Ferritin acts as the most abundant binding protein for snowdrop lectin in the midgut of rice brown planthoppers (Nilaparvata lugens). Insect Biochemistry and Molecular Biology 2000, 30(4), 297-305.
• Gatehouse AMR, Down RE, Gatehouse JA, Christou P. Improved strategies for aphid resistant transgenic crops. In: British Crop Protection. 2000, Brighton: British Crop Protection Council.
• Foissac X, Loc NT, Christou P, Gatehouse AMR, Gatehouse JA. Resistance to green leafhopper (Nephotettix virescens) and brown planthopper (Nilaparvata lugens) in transgenic rice expressing snowdrop lectin (Galanthus nivalis agglutinin; GNA). Journal of Insect Physiology 2000, 46(4), 573-583.
• Down RE, Ford L, Woodhouse SD, Raemaekers RJM, Leitch B, Gatehouse JA, Gatehouse AMR. Snowdrop lectin (GNA) has no acute toxic effects on a beneficial insect predator, the 2-spot ladybird (Adalia bipunctata L.). Journal of Insect Physiology 2000, 46(4), 379-391.
• Gatehouse AMR, Davison GM, Stewart JN, Galehouse LN, Kumar A, Geoghegan IE, Birch ANE, Gatehouse JA. Concanavalin A inhibits development of tomato moth (Lacanobia oleracea) and peach-potato aphid (Myzus persicae) when expressed in transgenic potato plants. Molecular Breeding 1999, 5(2), 153-165.
• Gatehouse AMR, Norton E, Davison GM, Babbe SM, Newell CA, Gatehouse JA. Digestive proteolytic activity in larvae of tomato moth, Lacanobia oleracea; effects of plant protease inhibitors in vitro and in vivo. Journal of Insect Physiology 1999, 45(6), 545-558.
• Down RE, Ford L, Mosson HJ, Fitches E, Gatehouse JA, Gatehouse AMR. Protease activity in the larval stage of the parasitoid wasp, Eulophus pennicornis (Nees) (Hymenoptera : Eulophidae); effects of protease inhibitors. Parasitology 1999, 119(2), 157-166.
• H. A. Bell,E. C. Fitches,R. E. Down,G. C. Marris,J. P. Edwards,J. A. Gatehouse,A. M. R. Gatehouse. The effect of snowdrop lectin (GNA) delivered via artificial diet and transgenic plants on Eulophus pennicornis (Hymenoptera : Eulophidae), a parasitoid of the tomato moth Lacanobia oleracea (Lepidoptera : Noctuidae). Journal of Insect Physiology 1999, 45(11), 983-991.
• A. N. E. Birch,I. E. Geoghegan,M. E. N. Majerus,J. W. McNicol,C. A. Hackett,A. M. R. Gatehouse,J. A. Gatehouse. Tri-trophic interactions involving pest aphids, predatory 2-spot ladybirds and transgenic potatoes expressing snowdrop lectin for aphid resistance. Molecular Breeding 1999, 5(1), 75-83.
• Gatehouse AMR. Biotechnological applications of plant genes in the production of insect resistant crops. In: Clement, SL; Quisenberry, SS, ed. Global Plant Genetic Resources for Insect-Resistant Crops. Boca Raton: CRC Press, 1998, pp.263-281.
• A. J. Walker,L. Ford,M. E. N. Majerus,I. E. Geoghegan,N. Birch,J. A. Gatehouse,A. M. R. Gatehouse. Characterisation of the mid-gut digestive proteinase activity of the two-spot ladybird (Adalia bipunctata L.) and its sensitivity to proteinase inhibitors. Insect Biochemistry and Molecular Biology 1998, 28(3), 173-180.
• K. V. Rao,K. S. Rathore,T. K. Hodges,X. Fu,E. Stoger,D. Sudhakar,S. Williams,P. Christou,M. Bharathi,D. P. Bown,K. S. Powell,J. Spence,A. M. R. Gatehouse,J. A. Gatehouse. Expression of snowdrop lectin (GNA) in transgenic rice plants confers resistance to rice brown planthopper. Plant Journal 1998, 15(4), 469-477.
• Gatehouse JA, Gatehouse AMR. Genetic engineering of plants for insect resistance. In: Rechcigl, JE; Reichcigl, NA, ed. Biological and Biotechnological Control of Insect Pests. Boca Raton: CRC Press, 1998, pp.211-241.
• A. M. R. Gatehouse,J. A. Gatehouse. Identifying proteins with insecticidal activity: Use of encoding genes to produce insect-resistant transgenic crops. Pesticide Science 1998, 52(2), 165-175.
• K. S. Powell,J. Spence,M. Bharathi,J. A. Gatehouse,A. M. R. Gatehouse. Immunohistochemical and developmental studies to elucidate the mechanism of action of the snowdrop lectin on the rice brown planthopper, Nilaparvata lugens (Stal). Journal of Insect Physiology 1998, 44(7-8), 529-539.
• Gatehouse AMR, Bown DP, Wilkinson HS, Down RE, Ford L, Gatehouse JA, Bell HA, Edwards M. The use of transgenic plants for the control of insect pests. In: British crop Protection Conference - Biotechnology in Crop Protection: Facts and Fallacies. 1998, Brighton: British Crop Protection Council.
• Pusztai A, Grant G, Gatehouse AMR, Bardocz S. Transgenic plants - implications for human and animal health. In: Bardocz, S; White, A; Tiburcio, A, ed. COST 917:Biogenically Active Amines in Food. Luzembourg, Belgium: European Commission, 1998, pp.74-76.
• E. Fitches,A. M. R. Gatehouse,J. A. Gatehouse. Effects of snowdrop lectin (GNA) delivered via artificial diet and transgenic plants on the development of tomato moth (Lacanobia oleracea) larvae in laboratory and glasshouse trials. Journal of Insect Physiology 1997, 43(8), 727-739.
• A. M. R. Gatehouse,G. M. Davison,C. A. Newell,A. Merryweather,W. D. O. Hamilton,E. P. J. Burgess,R. J. C. Gilbert,J. A. Gatehouse. Transgenic potato plants with enhanced resistance to the tomato moth, Lacanobia oleracea: Growth room trials. Molecular Breeding 1997, 3(1), 49-63.
• N. Sauvion,Y. Rahbe,W. J. Peumans,E. J. M. VanDamme,J. A. Gatehouse,A. M. R. Gatehouse. Effects of GNA and other mannose binding lectins on development and fecundity of the peach-potato aphid Myzus persicae. Entomologia Experimentalis Et Applicata 1996, 79(3), 285-293.
• Gatehouse AMR, Gatehouse JA. Effects of lectins on insects. In: Bardocz, S., Gelencser, E., Pusztai, A, ed. Effects of antinutrients in the nutritional value of legume diets. Luzembourg: European Commission, 1996.
• Burgess EPJ, Gatehouse AMR. Insect pest resistance. In: McKersie, BD; Brown, DCW, ed. Biotechnology and the improvement of forage legumes. Wallingford: CAB International, 1996, pp.229-258.
• Powell KS, Gatehouse AMR. Mechanism of mannose-binding snowdrop lectin for use against brown planthopper in rice. In: Proceedings of the Third International Rice Genetics Symposium. 1996, Manila Philippines: International Rice Research Institute.
• R. E. Down,A. M. R. Gatehouse,W. D. O. Hamilton,J. A. Gatehouse. Snowdrop lectin inhibits development and decreases fecundity of the glasshouse potato aphid (Aulacorthum solani) when administered in vitro and via transgenic plants both in laboratory and glasshouse trials. Journal of Insect Physiology 1996, 42(11-12), 1035-1045.
• A. M. R. Gatehouse,R. E. Down,K. S. Powell,N. Sauvion,Y. Rahbe,C. A. Newell,A. Merryweather,W. D. O. Hamilton,J. A. Gatehouse. Transgenic potato plants with enhanced resistance to the peach-potato aphid Myzus persicae. Entomologia Experimentalis Et Applicata 1996, 79(3), 295-307.
• K. S. Powell,A. M. R. Gatehouse,V. A. Hilder,J. A. Gatehouse. Antifeedant Effects of Plant-Lectins and an Enzyme on the Adult Stage of the Rice Brown Planthopper, Nilaparvata-Lugens. Entomologia Experimentalis Et Applicata 1995, 75(1), 51-59.
• K. S. Powell,A. M. R. Gatehouse,V. A. Hilder,E. J. M. Vandamme,W. J. Peumans,J. Boonjawat,K. Horsham,J. A. Gatehouse. Different Antimetabolic Effects of Related Lectins Towards Nymphal Stages of Nilaparvata-Lugens. Entomologia Experimentalis Et Applicata 1995, 75(1), 61-65.
• V. A. Hilder,K. S. Powell,A. M. R. Gatehouse,J. A. Gatehouse,L. N. Gatehouse,Y. Shi,W. D. O. Hamilton,A. Merryweather,C. A. Newell,J. C. Timans,W. J. Peumans,E. Vandamme,D. Boulter. Expression of Snowdrop Lectin in Transgenic Tobacco Plants Results in Added Protection against Aphids. Transgenic Research 1995, 4(1), 18-25.
• Gatehouse AMR, Powell KS, Peumans WJ, Van Damme EJM, Gatehouse JA. Insecticidal properties of plant lectins: Their potential in plant protection. In: Pusztai, AJ; Bardocz, S, ed. Lectins: Biomedical perspectives. London: Taylor and Francis, 1995, pp.29-48.
• K. A. Johnston,M. J. Lee,G. Brough,V. A. Hilder,A. M. R. Gatehouse,J. A. Gatehouse. Protease Activities in the Larval Midgut of Heliothis-Virescens - Evidence for Trypsin and Chymotrypsin-Like Enzymes. Insect Biochemistry and Molecular Biology 1995, 25(3), 375-383.
• Y. Rahbe,N. Sauvion,G. Febvay,W. J. Peumans,A. M. R. Gatehouse. Toxicity of Lectins and Processing of Ingested Proteins in the Pea Aphid Acyrthosiphon-Pisum. Entomologia Experimentalis Et Applicata 1995, 76(2), 143-155.
• E. P. J. Burgess,C. A. Main,P. S. Stevens,J. T. Christeller,A. M. R. Gatehouse,W. A. Laing. Effects of Protease Inhibitor Concentration and Combinations on the Survival, Growth and Gut Enzyme-Activities of the Black Field Cricket, Teleogryllus-Commodus. Journal of Insect Physiology 1994, 40(9), 803-811.
• Gatehouse AMR, Hilder VA. Genetic manipulation of crops for insect resistance. In: Marshall, G; Walters, DR, ed. Molecular perspectives in crop protection. London: Chapman and Hall, 1994, pp.177-201.
• Gatehouse AMR, Hilder VA, Powell KS, Wang M, Davison GM, Gatehouse LN, Down RE, Edmonds HS, Boulter D, Newell CA, Merryweather A, Hamilton WDO, Gatehouse JA. Insect-Resistant Transgenic Plants - Choosing the Gene to Do the Job. Biochemical Society Transactions 1994, 22(4), 944-949.
• J. A. Gatehouse,A. M. R. Gatehouse,K. S. Powell,Y. Shi,M. B. Wang,C. Brough,V. A. Hilder,D. Boulter. Novel Genes for the Production of Insect-Resistant Transgenic Plants. Journal of Cellular Biochemistry 1994, 75-75.
• J. T. Christeller,A. M. R. Gatehouse,W. A. Laing. The Interactionof the Elastase Inhibitor, Eglin-C, with Insect Digestive Endopeptidases - Effect of Ph on the Dissociation-Constants. Insect Biochemistry and Molecular Biology 1994, 24(1), 103-109.
• Y. Shi,M. B. Wang,K. S. Powell,E. Vandamme,V. A. Hilder,A. M. R. Gatehouse,D. Boulter,J. A. Gatehouse. Use of the Rice Sucrose Synthase-1 Promoter to Direct Phloem-Specific Expression of Beta-Glucuronidase and Snowdrop Lectin Genes in Transgenic Tobacco Plants. Journal of Experimental Botany 1994, 45(274), 623-631.
• K. S. Powell,A. M. R. Gatehouse,V. A. Hilder,J. A. Gatehouse. Antimetabolic Effects of Plant-Lectins and Plant and Fungal Enzymes on the Nymphal Stages of 2 Important Rice Pests, Nilaparvata-Lugens and Nephotettix-Cinciteps. Entomologia Experimentalis Et Applicata 1993, 66(2), 119-126.
• Gatehouse AMR, Shi Y, Powell KS, Brough C, Hilder VA, Hamilton WDO, Newell CA, Boulter D, Gatehouse JA. Approaches to insect resistance using transgenic plants. Philosophical Transactions of the Royal Society of London B 1993, 342(1301), 279-286.
• A. M. R. Gatehouse,Y. Shi,K. S. Powell,C. Brough,V. A. Hilder,W. D. O. Hamilton,C. A. Newell,A. Merryweather,D. Boulter,J. A. Gatehouse. Approaches to Insect Resistance Using Transgenic Plants. Philosophical Transactions of the Royal Society of London Series B-Biological Sciences 1993, 342(1301), 279-286.
• M. V. Sousa,L. Morhy,M. Richardson,V. A. Hilder,A. M. R. Gatehouse. Effects of the Cytolytic Seed Protein Enterolobin on Coleopteran and Lepidopteran Insect Larvae. Entomologia Experimentalis Et Applicata 1993, 69(3), 231-238.
• Merryweather A, Lowe JM, Newell CA, Peries IDR, Gatehouse AMR, Hamilton WDO. Incorporation of insect resistance genes into potato. In: Witcombe, JR and Wright, D, ed. Compendium of Current Research in Plant Sciences. London: Overseas Development Administration, 1993, pp.58-60.
• A. Pusztai,G. Grant,J. C. Stewart,S. Bardocz,S. W. B. Ewen,A. M. R. Gatehouse. Nutritional-Evaluation of Raz-2, a New Phaseolus-Vulgaris Bean Cultivar Containing High-Levels of the Natural Insecticidal Protein Arcelin-1. Journal of Agricultural and Food Chemistry 1993, 41(3), 436-440.
• Burgess EPJ, Main CA, Stevens PS, Gatehouse AMR, Christeller JT, Laing WA. Protease inhibitors active against porina caterpillar (Wiseana cervinata). In: Proc. 6th Australian Conference on Grassland Invertebrate Ecology. 1993, University of Waikato, Hamilton, New Zealand: AgResearch.
• Hilder VA, Gatehouse AMR, Boulter D. Transgenic plants conferring insect tolerance: protease inhibitor approach. In: Kung, SD; Wu, R, ed. Transgenic Plants. London: Academic Press, 1993, pp.317-338.
• J. J. Dymock,W. A. Laing,B. D. Shaw,A. M. R. Gatehouse,J. T. Christeller. Behavioral and Physiological-Responses of Grass Grub Larvae (Costelytra-Zealandica) Feeding on Protease Inhibitors. New Zealand Journal of Zoology 1992, 19(3-4), 123-131.
• Gatehouse AMR, Hilder VA, Gatehouse JA. Control of insect pests by genetic engineering. Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences 1992, 99(3/4), 51-60.
• A. M. R. Gatehouse,V. A. Hilder,J. A. Gatehouse. Control of Insect Pests by Plant Genetic-Engineering. Proceedings of the Royal Society of Edinburgh Section B-Biological Sciences 1992, 99, 51-60.
• Hilder VA, Brough C, Gatehouse AMR, Gatehouse LN, Shi Y, Powell KS, Hamilton WDO. Genes for protecting transgenic crops from chewing and sap-sucking insect pests. In: Proceedings of the Brighton Crop Protection Conference-Pests and Deseases. 1992, Brighton: British Crop Protection Council.
• A. Pusztai,G. Grant,D. J. Brown,J. C. Stewart,S. Bardocz,S. W. B. Ewen,A. M. R. Gatehouse,V. Hilder. Nutritional-Evaluation of the Trypsin (Ec-3.4.21.4) Inhibitor from Cowpea (Vigna-Unguiculata Walp). British Journal of Nutrition 1992, 68(3), 783-791.
• Gatehouse AMR, Boulter D, Hilder VA. Potential of plant-derived genes in the genetic manipulation of crops for insect resistance. In: Gatehouse, AMR; Hilder, VA; Boulter, D, ed. Plant Genetic Manipulation for Crop Protection. Wallingford: CAB International, 1992, pp.155-181.
• Gatehouse AMR, Hilder VA, Powell K, Boulter D, Gatehouse JA. Potential of plant-derived genes in the genetic manipulation of crops for insect resistance. In: Proc. 8th International Symp. Insect-Plant Relationships. 1992, Wageningen, The Netherlands: Kluwer Academic Publishers.
• A. M. R. Gatehouse,D. S. Howe,J. E. Flemming,V. A. Hilder,J. A. Gatehouse. Biochemical Basis of Insect Resistance in Winged Bean (Psophocarpus-Tetragonolobus) Seeds. Journal of the Science of Food and Agriculture 1991, 55(1), 63-74.
• Gatehouse JA, Hilder VA, Gatehouse AMR. Genetic engineering of plants for insect resistance. In: Grierson, D, ed. Plant Genetic Engineering. Glasgow: Blackie and Son Ltd, 1991, pp.105-135.
• D. Boulter,G. A. Edwards,A. M. R. Gatehouse,J. A. Gatehouse,V. A. Hilder. Additive Protective Effects of Different Plant-Derived Insect Resistance Genes in Transgenic Tobacco Plants. Crop Protection 1990, 9(5), 351-354.
• Gatehouse AMR, Minney BHP, Dobie P, Hilder VA. Biochemical resistance to bruchid attack in legume seeds; investigation and exploitation. In: Proceedings of the Second International Symposium on Bruchids and Legumes. 1990, Okayama, Japan: Springer, Netherlands.
• B. H. P. Minney,A. M. R. Gatehouse,P. Dobie,J. Dendy,C. Cardona,J. A. Gatehouse. Biochemical-Bases of Seed Resistance to Zabrotes-Subfasciatus (Bean Weevil) in Phaseolus-Vulgaris (Common Bean) - a Mechanism for Arcelin Toxicity. Journal of Insect Physiology 1990, 36(10), 757-&.
• A. M. R. Gatehouse,L. Barbieri,F. Stirpe,R. R. D. Croy. Effects of Ribosome Inactivating Proteins on Insect Development Differences between Lepidoptera and Coleoptera. Entomologia Experimentalis Et Applicata 1990, 54(1), 43-51.
• Boulter D, Gatehouse AMR, Hilder VA. Engineering enhanced natural resistance to insect pests - a case study. In: Plant Gene Transfer : proceedings of a UCLA symposium on molecular and cellular biology. 1990, Park City, Utah: Wiley-Liss.
• Boulter D, Gatehouse JA, Gatehouse AMR, Hilder VA. Genetic engineering of plants for insect resistance. Endeavour 1990, 14, 185-190.
• P. Dobie,J. Dendy,C. Sherman,J. Padgham,A. Wood,A. M. R. Gatehouse. New Sources of Resistance to Acanthoscelides-Obtectus (Say) and Zabrotes-Subfasciatus Boheman (Coleoptera, Bruchidae) in Mature Seeds of 5 Species of Phaseolus. Journal of Stored Products Research 1990, 26(4), 177-186.
• Burgess EPJ, Dymock JJ, Stevens PS, Christeller JT, Laing WA, Shaw BD, Gatehouse AMR. Protease inhibitors as resistance factors against pasture pests. Symposia Biologica Hungarica 1990, 39, 449-450.
• Hilder VA, Gatehouse AMR. Transforming plants as a means of crop protection against insects. Outlook on Agriculture 1990, 19, 179-183.
• Boulter DA, Hilder VA, Gatehouse AMR. Engineering insect resistance into crop plants. Pesticide Science 1989, 26(1), 103-105.
• Hilder VA, Gatehouse AMR. Genetic engineering of crops for insect resistance using genes of plant origin. Genetic Engineering of Crop Plants 1989, 51-66.
• A. M. R. Gatehouse,S. J. Shackley,K. A. Fenton,J. Bryden,A. Pusztai. Mechanism of Seed Lectin Tolerance by a Major Insect Storage Pest of Phaseolus-Vulgaris, Acanthoscelides-Obtectus. Journal of the Science of Food and Agriculture 1989, 47(3), 269-280.
• V. A. Hilder,A. M. R. Gatehouse,D. Boulter. Potential for Exploiting Plant Genes to Genetically Engineer Insect Resistance, Exemplified by the Cowpea Trypsin-Inhibitor Gene. Pesticide Science 1989, 27(2), 165-171.
• V. A. Hilder,R. F. Barker,R. A. Samour,A. M. R. Gatehouse,J. A. Gatehouse,D. Boulter. Protein and Cdna Sequences of Bowman-Birk Protease Inhibitors from the Cowpea (Vigna-Unguiculata Walp). Plant Molecular Biology 1989, 13(6), 701-710.
• Boulter D, Gatehouse AMR, Hilder VA. Use of cowpea trypsin inhibitor (CpTI) to protect plants against insect predation. Biotechnology Advances 1989, 7, 489-497.
• Gatehouse AMR, Hilder VA. Introduction of genes involved in pest and disease resistance. In: Proceedings of the Brighton Crop Protection Conference. 1988, Brighton: British Crop Protection Council.
• V. A. Hilder,A. M. R. Gatehouse,S. E. Sheerman,R. F. Barker,D. Boulter. A Novel Mechanism of Insect Resistance Engineered into Tobacco. Nature 1987, 330(6144), 160-163.
• A. M. R. Gatehouse,P. Dobie,R. J. Hodges,J. Meik,A. Pusztai,D. Boulter. Role of Carbohydrates in Insect Resistance in Phaseolus-Vulgaris. Journal of Insect Physiology 1987, 33(11), 843-850.
• R. J. Nash,K. A. Fenton,A. M. R. Gatehouse,E. A. Bell. Effects of the Plant Alkaloid Castanospermine as an Antimetabolite of Storage Pests. Entomologia Experimentalis Et Applicata 1986, 42(1), 71-77.
• Boulter D, Croy RRD, Ellis RJ, Evans IM, Gatehouse AMR, Gatehouse JA, Shirsat A, Yarwood JN. Isolation of genes involved inpest and disease resistance. In: Magnien, E, ed. Biomolecular engineering in the European Community : achievements of the research programme (1982-1986) : final report. The Hague: Martinus Nijhoff, 1986, pp.715-725.
• A. M. R. Gatehouse,K. A. Fenton,I. Jepson,D. J. Pavey. The Effects of Alpha-Amylase Inhibitors on Insect Storage Pests - Inhibition of Alpha-Amylase Invitro and Effects on Development Invivo. Journal of the Science of Food and Agriculture 1986, 37(8), 727-734.
• A. M. R. Gatehouse,K. A. Fenton,J. H. Anstee. Carbohydrase and Esterase-Activity in the Gut of Larval Callosobruchus-Maculatus. Experientia 1985, 41(9), 1202-1205.
• S. V. Evans,A. M. R. Gatehouse,L. E. Fellows. Detrimental Effects of 2-Dihydroxymethyl-3 5-Dihydroxymethyl-3,4-Dihydroxypyrrolidine in Some Tropical Legume Seeds on Larvae of the Bruchid Callosobruchus-Maculatus. Entomologia Experimentalis Et Applicata 1985, 37(3), 257-261.
• Evans IM, Gatehouse AMR, Ellis RJ, Croy RRD, Boulter D. Isolation of genes involved in pest and disease resistance. In: Research and Training Programme in Biomolecular Engineering: Progress Report 1984. Brussels, Belgium: Research Office for Official Publications of the European Community, 1985, pp.441-446.
• A. M. R. Gatehouse,K. J. Butler,K. A. Fenton,J. A. Gatehouse. Presence and Partial Characterization of a Major Proteolytic-Enzyme in the Larval Gut of Callosobruchus-Maculatus. Entomologia Experimentalis Et Applicata 1985, 39(3), 279-286.
• Gatehouse AMR. Antinutritional proteins in plants. In: Hudson, BJF, ed. Development in Food Proteins. London: Elsevier Applied Science, 1984, pp.245-294.
• A. M. R. Gatehouse,F. M. Dewey,J. Dove,K. A. Fenton,A. Pusztai. Effect of Seed Lectins from Phaseolus-Vulgaris on the Development of Larvae of Callosobruchus-Maculatus - Mechanism of Toxicity. Journal of the Science of Food and Agriculture 1984, 35(4), 373-380.
• A. M. R. Gatehouse,D. Boulter. Assessment of the Antimetabolic Effects of Trypsin-Inhibitors from Cowpea (Vigna-Unguiculata) and Other Legumes on Development of the Bruchid Beetle Callosobruchus-Maculatus. Journal of the Science of Food and Agriculture 1983, 34(4), 345-350.
• R. J. Redden,P. Dobie,A. M. R. Gatehouse. The Inheritance of Seed Resistance to Callosobruchus-Maculatus F in Cowpea (Vigna-Unguiculata-L Walp) .1. Analyses of Parental, F1, F2, F3 and Backcross Seed Generations. Australian Journal of Agricultural Research 1983, 34(6), 681-695.
• A. M. R. Gatehouse,J. H. Anstee. The Presence and Partial Characterization of Carbohydrase Enzymes in the Gut of Callosobruchus-Maculatus. Experientia 1983, 39(9), 1013-1015.
• Gatehouse AMR. The role of trypsin inhibitors in conferring bruchid resistance in cowpea. In: 10th International Congress of Plant Protection. 1983, Brighton, England: The Lavenham Press Ltd.
• A. M. R. Gatehouse,J. A. Gatehouse,D. Boulter. Isolation and Characterization of Trypsin-Inhibitors from Cowpea (Vigna-Unguiculata). Phytochemistry 1980, 19(5), 751-756.
• J. A. Gatehouse,A. M. R. Gatehouse. 2 Simple Quantitative Assays for Trypsin-Inhibitors Using Immobilized Trypsin. Analytical Biochemistry 1979, 98(2), 438-444.
• A. M. R. Gatehouse,J. A. Gatehouse,P. Dobie,A. M. Kilminster,D. Boulter. Biochemical Basis of Insect Resistance in Vigna-Unguiculata. Journal of the Science of Food and Agriculture 1979, 30(10), 948-958.