Staff Profile
Dr Cecilia Piergentili
Research Associate
- Email: cecilia.piergentili@ncl.ac.uk
- Address: School of Biology
Devonshire Building
Newcastle University
Newcastle upon Tyne
NE1 7RU
I received my Bachelor's Degree in Chemistry in 2006 from the Universita’ degli Studi di Parma (Italy) with a thesis on the synthesis and characterization of inorganic self-assembled supramolecules known as metallacrowns. I investigated metallacrowns stability in presence of competing ligands and managed study of core metal substitution performed by UV-visible titrations.
I then attended a two-year Master Degree in Chemistry (specialising in Inorganic Chemistry) at the same institution studying the anticancer activity of a series of compounds based on thiosemicarbazone complexes of copper and nickel.
In 2011 I moved to Durham (UK) to study for a PhD in Nigel Robinson group. My PhD work focussed on dissecting how levels of transition metals are selectively balanced and managed by regulatory proteins within a bacterial system. I investigated factors determining selective responses of DNA-binding metal-sensors, including analysis of the formaldehyde sensor FrmR.
I am currently working at Newcastle University with Jon Marles-Wright as postdoctoral research associate. This BBSRC project will investigate how the structure of encapsulated ferritin enzymes relates to their function within the encapsulin iron-megastores.
- Osman D, Piergentili C, Chen J, Sayer LN, Usón I, Huggins TG, Robinson NJ, Pohl E. The Effectors and Sensory Sites of Formaldehyde-responsive Regulator FrmR and Metal-sensing Variant. Journal of Biological Chemistry 2016, 291(37), 19502-19516.
- Osman D, Piergentili C, Chen J, Chakrabarti B, Foster AW, Lurie-Luke E, Huggins TG, Robinson NJ. Generating a Metal-responsive Transcriptional Regulator to Test What Confers Metal Sensing in Cells. The Journal of Biological Chemistry 2015, (290), 19806-22.