Staff Profile
Dr Hannah Stewart
Senior Post Doctoral Research Associate, CRUK Drug Discovery Unit
- Telephone: +441912086913
- Address: CRUK Drug Discovery unit,
Newcastle University
Bedson Building,
Newcastle University,
Newcastle Upon Tyne, NE1 7RU
I am a Senior Research Associate in medicinal chemistry at the CRUK Drug Discovery Unit, Newcastle University Centre for Cancer. Working on the development of novel approaches to high value cancer targets with a focus on irreversible inhibition. I have delivered potent covalent inhibitors across three projects. My ambition is to establish an independent research group addressing challenging cancer and infection targets by developing novel covalent inhibitors. I have a record of outstanding research: 10 papers, 1 book chapter, 2 filed patent applications.
I joined the Newcastle Drug Discovery Group in 2019 as a medicinal chemist after completing my PhD at the University of Cambridge exploring the diversity-oriented synthesis of partially saturated bicyclic heteroaromatic scaffolds for drug discovery. .
I teach first year undergraduate tutorials in Fundamentals of Organic Chemistry CHY1110.
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Articles
- Pirie R, Stanway-Gordon HA, Stewart HL, Wilson KL, Paton S, Tyerman J, Cole DJ, Fowler K, Waring MJ. An analysis of the physicochemical properties of oral drugs from 2000 to 2022. RSC Medicinal Chemistry 2024, epub ahead of print.
- Morese PA, Anthony N, Bodnarchuk M, Jennings C, Martin MP, Noble RA, Phillips N, Thomas HD, Wang LZ, Lister A, Noble MEM, Ward RA, Wedge SR, Stewart HL, Waring MJ. Targeting cytotoxic agents through EGFR-mediated covalent binding and release. Journal of Medicinal Chemistry 2023, 66(17), 12324-12341.
- Stewart HL, Bon M, Wills C, Martin MP, Wang L, Mackenzie ES, Wadell PG, Waring MJ. Conformational study into alkyl-aryl ureas to inform drug discovery . Bioorganic and Medicinal Chemistry 2023, 91, 117387.
- Uguen M, Davison G, Sprenger LJ, Hunter JH, Martin MP, Turberville S, Watt JE, Golding BT, Noble MEM, Stewart HL, Waring MJ. Build–Couple–Transform: A paradigm for lead-like library synthesis with scaffold diversity. Journal of Medicinal Chemistry 2022, 65(16), 11322-11339.
- Al-Khawaldeh I, Aldred GG, Alyassiri M, Basmadjian C, Bordoni C, Harnor SJ, Heptinstall AB, Hobson SJ, Jennings CE, Khalifa S, Lebraud H, Miller DC, Shrives HJ, de Souza JV, Stewart HL, Temple M, Totobenazara J, Tucker JA, Tudhope SJ, Wang LZ, Bronowska AK, Cano C, Endicott JA, Golding BT, Hardcastle IR, Hickson I, Wedge SR, Willmore E, Noble MEM, Waring MJ. An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK). Journal of Medicinal Chemistry 2021, 64(14), 10001-10018.