Staff Profile

Click here to access the JCK research group website

Click here to access the JCK research group website

Degree Programme Director for MSc Drug Chemistry

• Articles

  • Pringle TA, Ramon-Gil E, Leslie J, Oakley F, Wright MC, Knight JC, Luli S. Synthesis and Preclinical Evaluation of a ⁸⁹Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury. Scientific Reports 2024, 14, 633.
  • Melemenidis S, Knight JC, Kersemans V, Perez-Balderas F, Zarghami N, Soto MS, Cornelissen B, Muschel RJ, Sibson NR. In Vivo PET Detection of Lung Micrometastasis in Mice by Targeting Endothelial VCAM-1 Using a Dual-Contrast PET/MRI Probe. International Journal of Molecular Sciences 2024, 25(13), 7160.
  • Cooke L, Gristwood K, Adamson K, Sims M, Deary M, Bruce D, Antoniou A, Walden H, Knight JC, Antoine-Brunet T, Joly M, Goyard D, Lanoë PH, Berthet N, Kozhevnikov V. Annealing 1,2,4-Triazine to Iridium(III) Complexes Induces Luminogenic Behaviour in Bioorthogonal Reactions with Stain Alkynes. Dalton Transactions 2024, Epub ahead of print.
  • Gristwood K, Luli S, Rankin KS, Knight JC. Synthesis and In Vitro Evaluation of a HER2-Specific ImmunoSCIFI Probe. ACS Omega 2023, 8(50), 47905-47912.
  • Pringle TA, Coleman O, Kawamura A, Knight JC. The influence of degree of labelling upon cellular internalisation of antibody-cell penetrating peptide conjugates. RSC Advances 2022, 12(43), 27716-27722.
  • Pringle TA, Chan CD, Luli S, Blair HJ, Rankin KS, Knight JC. Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas. Bioconjugate Chemistry 2022, 33(8), 1564-1573.
  • Gristwood K, Luli S, Rankin KS, Knight JC. In situ excitation of BODIPY fluorophores by ⁸⁹Zr-generated Cerenkov luminescence. Chemical Communications 2022, 83(58), 11689-11692.
  • Knight JC, Torres JB, Goldin R, Mosley M, Dias GM, Bravo LC, Kersemans V, Allen PD, Mukherjee S, Smart S, Cornelissen B. Early Detection in a Mouse Model of Pancreatic Cancer by Imaging DNA Damage Response Signalling. Journal of Nuclear Medicine 2020, 61(7), 1006-1013.
  • Poty S, Mandeylwala K, O'Neill E, Knight JC, Cornelissen B, Lewis JS. ⁸⁹Zr-PET imaging of DNA double-strand breaks for the early monitoring of response following alpha- and beta-particle radioimmunotherapy in a mouse model of pancreatic ductal adenocarcinoma. Theranostics 2020, 10(13), 5802-5814.
  • Baljer BC, Kolhe S, Chan CD, Nicoli F, Ghanbasha A, Brookes MJ, Gamie Z, Ghosh KM, Beckinsale TB, Saleh DB, Ragbir M, Gerrand CH, Jeys L, Knight JC, Petrides G, Rankin KS. . 2020, 483, 1-11.
  • Marculescu C, Lakshminarayanan A, Gault J, Knight JC, Folkes LK, Spink T, Robinson CV, Valis K, Davis BG, Cornelissen B. Probing the Limits of Q-Tag Bioconjugation of Antibodies. Chemical Communications 2019, 55(76), 11342-11345.
  • Wilson T, Xavier MA, Knight JC, Verhoog S, Baguna Torres J, Mosley M, Hopkins SL, Wallington S, Allen D, Kersemans V, Hueting R, Smart S, Gouverneur V, Cornelissen B. PET Imaging of PARP Expression using [¹⁸F]olaparib. Journal of Nuclear Medicine 2019, 60(4), 504-510.
  • Knight JC, Mosley MJ, Kersemans V, Dias GM, Allen PD, Smart S, Cornelissen B. Dual-isotope imaging allows in vivo immunohistochemistry using radiolabelled antibodies in tumours. Nuclear Medicine and Biology 2019, 70, 14-22.
  • Torres JB, Knight JC, Mosley MJ, Kersemans V, Koustoulidou S, Allen D, Kinchesh P, Smart S, Cornelissen B. Imaging of Claudin-4 in Pancreatic Ductal Adenocarcinoma Using a Radiolabelled Anti-Claudin-4 Monoclonal Antibody. Molecular Imaging and Biology 2018, 20(2), 292-299.
  • Knight JC, Mosley M, Uyeda HT, Cong M, Fan F, Faulkner S, Cornelissen B. In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme. Molecular Pharmaceutics 2017, 14(7), 2307-2313.
  • Knight JC, Mosley MJ, Bravo LC, Kersemans V, Allen PD, Mukherjee S, O'Neill E, Cornelissen B. ⁸⁹Zr-anti-gH2AX-TAT but not ¹⁸F-FDG allows early monitoring of response to chemotherapy in a mouse model of pancreatic ductal adenocarcinoma. Clinical Cancer Research 2017, 23(21), 6498-6504.
  • Knight JC, Amoroso AJ, Edwards PG, Singh N, Ward BD. Shaping and enforcing coordination spheres: Probing the ability of tripodal ligands to favour trigonal prismatic geometry. Dalton Transactions 2016, 45(26), 10630-10642.
  • Knight JC, Paisey SJ, Dabkowski AM, Marculescu C, Williams AS, Marshall C, Cornelissen B. Scaling-down antibody radiolabeling reactions with zirconium-89. Dalton Transactions 2016, 45(15), 6343-6347.
  • Sharma SK, Sevak KK, Monette S, Carlin SD, Knight JC, Wuest FR, Sala E, Zeglis BM, Lewis JS. Preclinical ⁸⁹Zr Immuno-PET of high-grade serous ovarian cancer and lymph node metastasis. Journal of Nuclear Medicine 2016, 57(5), 771-776.
  • Saad FA, Knight JC, Kariuki BM, Amoroso AJ. Co-ordination behaviour of a novel tristhiourea tripodal ligand; Structural variations in a series of transition metal complexes. Dalton Transactions 2016, 45(25), 10280-10288.
  • Perreault A, Knight JC, Wang M, Way J, Wuest F. ¹⁸F-Labeled wild-type annexin V: Comparison of random and site-selective radiolabeling methods. Amino Acids 2016, 48(1), 65-74.
  • Knight JC, Topping C, Mosley M, Kersemans V, Falzone N, Fernandez-Varea JM, Cornelissen B. PET imaging of DNA damage using ⁸⁹Zr-labelled anti-γH2AX-TAT immunoconjugates. European Journal of Nuclear Medicine and Molecular Imaging 2015, 42(11), 1707-1717.
  • Hillyar CRT, Knight JC, Vallis KA, Cornelissen B. PET and SPECT imaging for the acceleration of anti-cancer drug development. Current Drug Targets 2015, 16(6), 582-591.
  • Knight JC, Mosley M, Stratford MRL, Uyeda HT, Benink HA, Cong M, Fan F, Faulkner S, Cornelissen B. Development of an enzymatic pretargeting strategy for dual-modality imaging. Chemical Communications 2015, 51(19), 4055-4058.
  • Mosley M, Knight J, Neesse A, Michl P, Iezzi M, Kersemans V, Cornelissen B. Claudin-4 SPECT imaging allows detection of aplastic lesions in a mouse model of breast cancer. Journal of Nuclear Medicine 2015, 56(5), 745-751.
  • Foerster C, Knight JC, Wuest M, Rowan B, Lapi SE, Amoroso AJ, Edwards PG, Wuest F. Synthesis, complex stability and small animal PET imaging of a novel ⁶⁴Cu-labelled cryptand molecule. MedChemComm 2014, 5(7), 958-962.
  • Cornelissen B, Able S, Kartsonaki C, Kersemans V, Allen PD, Cavallo F, Cazier J-B, Iezzi M, Knight J, Muschel R, Smart S, Vallis KA. Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer. Journal of Nuclear Medicine 2014, 55(12), 2026-2031.
  • Sathiyajith CW, Knight JC, Kariuki BM, Edwards PG, Amoroso AJ. Crystal Structure of the Moonoprotonated Tripodal Ligand 2,2’-bipyrid-6-yl) Methanol. Open Chemistry Journal 2014, 1, 15-20.
  • Knight JC, Cornelissen B. Bioorthogonal chemistry: implications for pretargeted nuclear (PET/SPECT) maging and therapy. American Journal of Nuclear Medicine and Molecular Imaging 2014, 4(2), 96-113.
  • Knight JC, Wuest M, Saad FA, Wang M, Chapman DW, Jans H-S, Lapi SE, Kariuki BM, Amoroso AJ, Wuest F. Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions. Dalton Transactions 2013, 42, 12005-12014.
  • Knight JC, Richter S, Wuest M, Way JD, Wuest F. Synthesis and evaluation of an ¹⁸F-labelled norbornene derivative for copper-free click chemistry reactions. Organic and Biomolecular Chemistry 2013, 11(23), 3817-3825.
  • Saad FA, Knight JC, Kariuki BM, Amoroso AJ. Co-ordinative properties of a tripodal trisamide ligand with a capped octahedral preference. Dalton Transactions 2013, 42, 14826-14835.
  • Knight JC, Prabaharan R, Amoroso AJ, Edwards PG, Ooi L-L. Synthesis and co-ordination chemistry of tris(picolyl-2-carboxyamido-6- pyridyl) methanol: A ligand with a strong preference for trigonal prismatic geometries. Polyhedron 2012, 31, 457-462.
  • Knight JC, Wuest FR. Nuclear (PET/SPECT) and optical imaging probes targeting the CXCR4 chemokine receptor. MedChemComm 2012, 3, 1039-1053.
  • Saad FA, Buurma NJ, Amoroso AJ, Knight JC, Kariuki BM. Co-ordination behaviour of a novel bisthiourea tripodal ligand: Structural, spectroscopic and electrochemical properties of a series of transition metal complexes. Dalton Transactions 2012, 41, 4608-4617.
  • Knight JC, Edwards PG, Paisey SJ. Fluorinated contrast agents for magnetic resonance imaging; A review of recent developments. RSC Advances 2011, 1, 1415-1425.
  • Knight JC, Hallett AJ, Brancale A, Paisey SJ, Clarkson RWE, Edwards PG. Evaluation of a fluorescent derivative of AMD3100 and its interaction with the CXCR4 chemokine receptor. ChemBioChem 2011, 12, 2692-2698.
  • Knight JC, Prabaharan R, Edwards PG, Amoroso AJ. Co-ordination of a new bis-terpyridine ligand with cupric perchlorate yielding a dinuclear M2L species. Journal of Molecular Structure 2011, 989, 86-90.
  • Carcedo C, Knight JC, Pope SJA, Fallis IA, Dervisi A. Chiral silver and gold rings: Synthesis and structural, spectroscopic, and photophysical properties of Ag and Au metallamacrocycles of bridging NHC ligands. Organometallics 2011, 30, 2553-2562.
  • Knight JC, Amoroso AJ, Edwards PG, Prabaharan R, Singh N. The co-ordination chemistry of bis(2,2′-bipyrid-6′-yl)ketone with first row transition metals: The reversible interconversion of a mononuclear complex and a dinuclear hemiketal containing species. Dalton Transactions 2010, 39, 8925-8936.
  • Edwards PG, Knight JC, Newman PD. Synthesis of (1R,4S,6R)-5,5,6-trimethyl-2-phosphabicyclo[2.2.2]octane and derivatives. Dalton Transactions 2010, 39, 3851-3860.
  • Knight JC, Alvarez S, Amoroso AJ, Edwards PG, Singh N. A novel bipyridine-based hexadentate tripodal framework with a strong preference for trigonal prismatic co-ordination geometries. Dalton Transactions 2010, 39, 3870-3883.
  • Knight JC, Prabaharan R, Ward BD, Amoroso AJ, Edwards PG, Kariuki BM. A facile one-pot synthesis of a new cryptand via a Pd(II)-catalysed carbonylation reaction. Dalton Transactions 2010, 39(42), 10031-10033.
  • Knight JC, Fallis IA. 1,1′-(Ethane-1,2-diyl)bis(1,4,7-triazonane). Acta Crystallographica Section E 2010, 66.
  • Amoroso AJ, Edwards PG, Howard ST, Kariuki BM, Knight JC, Ooi L, Malik KMA, Stratford L, Al-Sudani A-RH. The synthesis and coordination chemistry of a tris-8-aminoquinoline tripodal ligand. Dalton Transactions 2009, (39), 8356-8362.
  • Knight JC, Saad FA, Amoroso AJ, Kariuki BM, Coles SJ. Rac-N-{6-[Bromo-(hydr-oxy)meth-yl]-2-pyrid-yl}pivalamide. Acta Crystallographica Section E 2009, 65.
  • Iglesias M, Beetstra DJ, Knight JC, Ooi L-L, Stasch A, Coles S, Male L, Hursthouse MB, Cavell KJ, Dervisi A, Fallis IA. Novel expanded ring N-heterocyclic carbenes: Free carbenes, silver complexes, and structures. Organometallics 2008, 27, 3279-3289.
  • Knight JC, Amoroso AJ, Prabaharan R, Edwards PG. Bis{N-[bis-(6-bromo-pyridin-2-yl)methyl-ene-N]ethane-1,2-diamine- 2 N,N′}nickel(II) bis-(perchlorate). Acta Crystallographica Section E 2007, 63, m1046-m1047.
  • Knight JC, Tatchell T, Fallis IA. 2-(Cyclo-hexyl-amino)-1,4-naphthoquinone. Acta Crystallographica Section E 2007, 63, o1226-o1227.
  • Knight JC, Amoroso AJ, Edwards PG, Ooi L-L. Catena-Poly[[[diaquacadmium(II)]-μ-2,2′- Bipyridine-6,6′- dicarboxylato] dihydrate]. Acta Crystallographica Section E 2006, 62, m3306-m3308.

• Book Chapters

  • Knight JC, Cornelissen B. Click Chemistry in Radiopharmaceutical Chemistry. In: Lewis JS; Windhorst AD; Zeglis BM, ed. Radiopharmaceutical Chemistry. Cham: Springer, 2019, pp.467-479.
  • Knight JC, Cornelissen B. Preservation of Ligand Functionality by Click Chemistry. In: Dong Soo Lee, ed. Radionanomedicine. Cham: Springer, 2018, pp.251-262.

• Reviews

  • Luu T, Gristwood K, Knight JC, Jörg M. Click Chemistry: Reaction rates and their suitability for biomedical applications. Bioconjugate Chemistry 2024, 35(6), 715–731.
  • Baljer BC, Kolhe S, Chan CD, Nicoli F, Ghanbasha A, Brookes MJ, Gamie Z, Ghosh KM, Beckinsale TB, Saleh DB, Ragbir M, Gerrand CH, Jeys L, Knight JC, Petrides G, Rankin KS. Advances in image enhancement for sarcoma surgery. Cancer Letters 2020, 483, 1-11.
  • Wuest M, Perreault A, Richter S, Knight JC, Wuest F. Targeting phosphatidylserine for radionuclide-based molecular imaging of apoptosis. Apoptosis 2019, 24, 221–244.
  • Cornelissen B, Knight JC, Mukherjee S, Evangelista L, Xavier C, Caobelli F, Vecchio S, Rbah-Vidal L, Barbet J, de Jong M, van Leeuwen FWB. Translational molecular imaging in exocrine pancreatic cancer. European Journal of Nuclear Medicine and Molecular Imaging 2018, 45(13), 2442-2455.
  • Knight JC, Koustoulidou S, Cornelissen B. Imaging the DNA damage response with PET and SPECT. European Journal of Nuclear Medicine and Molecular Imaging 2017, 44(6), 1065-1078.