Staff Profile
Professor John Bythell
Professor of Coral Reef Biology, School of Natural and Environmental Sciences
- Email: john.bythell@ncl.ac.uk
- Address: School of Natural and Environmental Sciences
4.64 Ridley Building
Newcastle University
Newcastle Upon Tyne
NE1 7RU
Background
Coral reef ecology is at the forefront of national and international media attention because of the serious threats to these ecosystems from global climate change, disease and over-exploitation. As long ago as 1998, a global sea surface temperature event is estimated to have killed 17% of the corals of the world. Regional mass bleaching events are now common occurrences, often followed by disease outbreaks. My research has addressed two main foci in the study of coral health and disease: 1) the development of a culture-independent molecular microbial ecology approach to the study of emergent diseases in reef corals, and 2) The cellular and molecular responses of reef corals to infection and environmental stress, most recently in relation to the selection of stress-tolerant phenotypes as part of the Coralassist project (Coralassist) and latterly the CoralAdapt project. As genomic information becomes available for corals and related lower invertebrates, post-genomic and proteomic approaches to stress and disease tolerance have also become possible.
I am currently in the process of flexi-retirement and working one day a week (20% FTE).
Google Scholar page: http://scholar.google.co.uk/citations?user=6pqp1LEAAAAJ&hl=en
Research Interests
Large-scale coral bleaching episodes were unknown prior to 1979 but have become more frequent with repeated mass coral bleaching events on the Great Barrier Reef in 2016 and 2017. These events are linked to environmental stress, particularly temperature increases, and in addition to the local and regional loss of biodiversity, may represent the first case of the functional collapse of an ecosystem due to global climate change. Concurrent with these mass bleaching events, there has been widespread concern over the emergence of coral diseases over the past three decades. Reef core data from Belize indicates that the mass mortality of two of the dominant coral species in the Caribbean is unprecedented in at least the last 3-4000 years, which suggests a link to anthropogenic activities. Unfortunately, identification and characterisation of the causal agents of most coral diseases remains unresolved or poorly characterised, with traditional microbiological approaches to determining disease causation being misleading in these typically polymicrobial diseases. My research group addresses these areas by applying molecular approaches to understanding microbial ecology of corals and coral reefs. Other research interests focus on the host responses to environmental stress and host-microbe interactions.
Module Leader:
- SPG8013 Environmental Impact Assessment (Flexible Learning)
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Articles
- Humanes A, Lachs L, Beauchamp E, Bukurou L, Buzzoni D, Bythell J, Craggs JRK, de la Torre Cerro R, Edwards AJ, Golbuu Y, Martinez HM, Palmowski P, van der Steeg E, Sweet M, Ward A, Wilson AJ, Guest JR. Selective breeding enhances coral heat tolerance to marine heatwaves. Nature Communications 2024, 15(1), 8703.
- Lachs L, Humanes A, Pygas DR, Bythell JC, Mumby PJ, Ferrari R, Figueira WF, Beauchamp E, East HK, Edwards AJ, Golbuu Y, Martinez HM, Sommer B, van der Steeg E, Guest JR. No apparent trade-offs associated with heat tolerance in a reef-building coral. Communications Biology 2023, 6(1), 400.
- Lachs L, Donner SD, Mumby PJ, Bythell JC, Humanes A, East HK, Guest JR. Emergent increase in coral thermal tolerance reduces mass bleaching under climate change. Nature Communications 2023, 14(1), 4939.
- Humanes A, Lachs L, Beauchamp EA, Bythell JC, Edwards AJ, Golbuu Y, Martinez HM, Palmowski P, Treuman A, van der Steeg E, van Hooidonk R, Guest JR. Within-population variability in coral heat tolerance indicates climate adaptation potential. Proceedings of the Royal Society B 2022, 289(1981), 20220872.
- Bouderlique T, Petersen J, Faure L, Abed-Navandi D, Bouchnita A, Mueller B, Nazarov M, Englmaier L, Tesarova M, Frade PR, Zikmund T, Koehne T, Kaiser J, Fried K, Wild C, Pantos O, Hellander A, Bythell J, Adameyko I. Surface flow for colonial integration in reef-building corals. Current Biology 2022, 32(12), 2596-2609.
- Ferrari R, Lachs L, Pygas DR, Humanes A, Sommer B, Figueira WF, Edwards AJ, Bythell JC, Guest JR. Photogrammetry as a tool to improve ecosystem restoration. Trends in Ecology and Evolution 2021, 36(12), 1093-1101.
- Lachs L, Bythell JC, East HK, Edwards AJ, Mumby PJ, Skirving WJ, Spady BL, Guest JR. Fine-tuning heat stress algorithms to optimise global predictions of mass coral bleaching. Remote Sensing 2021, 13(14), 2677.
- Humanes A, Beauchamp EA, Bythell JC, Carl MK, Craggs JR, Edwards AJ, Golbuu Y, Lachs L, Martinez HM, Palmowski P, Paysinger F, Randle JL, van der Steeg E, Sweet M, Treumann A, Guest JR. An Experimental Framework for Selectively Breeding Corals for Assisted Evolution. Frontiers in Marine Science 2021, 8, 669995.
- O'Hara EP, Caldwell GS, Bythell J. The composition of anthozoan nematocyst intracapsular fluid varies with and between nematocyst types. 2019.
- Guppy R, Brown B, Bythell JC. Preserving the viscous coral surface mucus layer using low-acid glycol methacrylate (GMA) resin. Coral Reefs 2019, 38(3), 521-526.
- Bakshani CR, Morales-Garcia AL, Althaus M, Wilcox MD, Pearson JP, Bythell JC, Burgess G. Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection. npj Biofilms and Microbiomes 2018, 4(14), 1-12.
- O'Hara EP, Caldwell GS, Bythell J. Equistatin and equinatoxin gene expression is influenced by environmental temperature in the sea anemone Actinia equina. Toxicon 2018, 153, 12-16.
- Bythell JC, Brown BE, Kirkwood TBL. Do reef corals age?. Biological Reviews 2018, 93(2), 1192-1202.
- Sweet MJ, Bythell JC. The role of viruses in coral health and disease. Journal of Invertebrate Pathology 2017, 147, 136-144.
- Sweet MJ, Bythell JC. White Syndrome in Acropora muricata: nonspecific bacterial infection and ciliate histophagy. Molecular Ecology 2015, 24(5), 1150-1159.
- Smith D, Leary P, Craggs J, Bythell J, Sweet M. Microbial Communities Associated with Healthy and White Syndrome-Affected Echinopora lamellosa in Aquaria and Experimental Treatment with the Antibiotic Ampicillin. PLoS ONE 2015, 10(3), e0121780.
- Miller J, Sweet MJ, Wood E, Bythell JC. Baseline coral disease surveys within three marine parks in Sabah, Borneo. PeerJ 2015, 3, e1391.
- Sweet MJ, Croquer A, Bythell JC. Experimental antibiotic treatment identifies potential pathogens of white band disease in the endangered Caribbean coral Acropora cervicornis. Proceedings of the Royal Society B 2014, 281(1788), 20140094.
- Sweet MJ, Smith D, Bythell JC, Craggs J. Changes in microbial diversity associated with two coral speciesrecovering from a stressed state in a public aquarium system. Journal of Zoo and Aquarium Research 2013, 1(2), 52-60.
- Sweet M, Craggs J, Robson J, Bythell JC. Assessment of the microbial communities associated with white syndrome and brown jelly syndrome in aquarium corals. Journal of Zoo and Aquarium Research 2013, 1(1), 20-27.
- Sweet MJ, Bythell JC, Nugues MM. Algae as Reservoirs for Coral Pathogens. PLoS ONE 2013, 8(7), e69717.
- Sweet MJ, Kirkham N, Bendall M, Currey L, Bythell JC, Heupel M. Evidence of Melanoma in Wild Marine Fish Populations. PLoS ONE 2012, 7(8), e41989.
- Palmer CV, Bythell JC, Willis BL. Enzyme activity demonstrates multiple pathways of innate immunity in Indo-Pacific anthozoans. Proceedings of the Royal Society B: Biological Sciences 2012, 279(1743), 3879-3887.
- Sweet MJ, Bythell JC. Ciliate and bacterial communities associated with White Syndrome and Brown Band Disease in reef-building corals. Environmental Microbiology 2012, 14(8), 2184-2199.
- Sweet MJ, Croquer A, Bythell JC. Dynamics of bacterial community development in the reef coral Acropora muricata following experimental antibiotic treatment. Coral Reefs 2011, 30(4), 1121-1133.
- Sweet MJ, Croquer A, Bythell JC. Development of bacterial biofilms on artificial corals in comparison to surface-associated microbes of hard corals. PLoS One 2011, 6(6), e21195.
- Palmer CV, Traylor-Knowles NG, Willis BL, Bythell JC. Corals use similar immune cells and wound-healing processes as those of higher organisms. PLoS One 2011, 6(8), e23992.
- Sweet MJ, Croquer A, Bythell JC. Bacterial assemblages differ between compartments within the coral holobiont. Coral Reefs 2011, 30(1), 39-52.
- Palmer CV, Bythell JC, Willis BL. A comparative study of phenoloxidase activity in diseased and bleached colonies of the coral Acropora millepora. Developmental & Comparative Immunology 2011, 35(10), 1098-1101.
- Heidelberg KB, O'Neil KL, Bythell JC, Sebens KP. Vertical distribution and diel patterns of zooplankton abundance and biomass at Conch Reef, Florida Keys (USA). Journal of Plankton Research 2010, 32(1), 75-91.
- Sweet M, Croquer A, Bythell J. Temporal and Spatial Patterns in Waterborne Bacterial Communities of an Island Reef System. Aquatic Microbial Ecology 2010, 61(1), 1-11.
- Palmer CV, Bythell JC, Willis BL. Levels of immunity parameters underpin bleaching and disease susceptibility of reef corals. FASEB Journal 2010, 24(6), 1935-1946.
- Jatkar AA, Brown BE, Bythell JC, Guppy R, Morris NJ, Pearson JP. Coral Mucus: The Properties of Its Constituent Mucins. Biomacromolecules 2010, 11(4), 883-888.
- Pantos O, Bythell JC. A novel reef coral symbiosis. Coral Reefs 2010, 29(3), 761-770.
- Jatkar AA, Brown BE, Bythell JC, Guppy R, Morris NJ, Pearson JP. Measuring mucus thickness in reef corals using a technique devised for vertebrate applications. Marine Biology 2010, 157(2), 261-267.
- Fitt WK, Gates RD, Hoegh-Guldberg O, Bythell JC, Jatkar A, Grottoli AG, Gomez M, Fisher P, Lajuenesse TC, Pantos O, Iglesias-Prieto R, Franklin DJ, Rodrigues LJ, Torregiani JM, van Woesik R, Lesser MP. Response of two species of Indo-Pacific corals, Porites cylindrica and Stylophora pistillata, to short-term thermal stress: The host does matter in determining the tolerance of corals to bleaching. Journal of Experimental Marine Biology and Ecology 2009, 373(2), 102-110.
- Naser H, Bythell J, Thomason J. Ecological assessment: An initial evaluation of the ecological input in environmental impact assessment reports in Bahrain. Impact Assessment and Project Appraisal 2008, 26(3), 201-208.
- Ledlie MH, Graham NAJ, Bythell JC, Wilson SK, Jennings S, Polunin NVC, Hardcastle J. Phase shifts and the role of herbivory in the resilience of coral reefs. Coral Reefs 2007, 26(3), 641-653.
- Field SN, Glassom D, Bythell J. Effects of artificial settlement plate materials and methods of deployment on the sessile epibenthic community development in a tropical environment. Coral Reefs 2007, 26(2), 279-289.
- Lesser MP, Bythell JC, Gates RD, Johnstone RW, Hoegh-Guldberg O. Are infectious diseases really killing corals? Alternative interpretations of the experimental and ecological data. Journal of Experimental Marine Biology and Ecology 2007, 346(1-2), 36-44.
- Guppy R, Bythell JC. Environmental effects on bacterial diversity in the surface mucus layer of the reef coral Montastraea faveolata. Marine Ecology Progress Series 2006, 328, 133-142.
- Pantos O, Bythell JC. Bacterial community structure associated with white band disease in the elkhorn coral Acropora palmata determined using culture-independent 16S rRNA techniques. Diseases of Aquatic Organisms 2006, 69(1), 79-88.
- Dunn SR, Thomason JC, Le Tissier MDA, Bythell JC. Heat stress induces different forms of cell death in sea anemones and their endosymbiotic algae depending on temperature and duration. Cell Death and Differentiation 2004, 11(11), 1213-1222.
- Pantos O, Cooney RP, Le Tissier MDA, Barer MR, O'Donnell AG, Bythell JC. The bacterial ecology of a plague-like disease affecting the Caribbean coral Montastrea annularis. Environmental Microbiology 2003, 5(5), 370-382.
- Dunn SR, Bythell JC, Le Tissier MDA, Burnett WJ, Thomason JC. Programmed cell death and cell necrosis activity during hyperthermic stress-induced bleaching of the symbiotic sea anemone Aiptasia sp. Journal of Experimental Marine Biology and Ecology 2002, 272(1), 29-53.
- Bythell JC, Barer MR, Cooney RP, Guest JR, O'Donnell AG, Pantos O, Le Tissier MDA. Histopathological methods for the investigation of microbial communities associated with disease lesions in reef corals. Letters in Applied Microbiology 2002, 34(5), 359-364.
- Cooney RP, Pantos O, Le Tissier MDA, Barer MR, O'Donnell AG, Bythell JC. Characterization of the bacterial consortium associated with black band disease in coral using molecular microbiological techniques. Environmental Microbiology 2002, 4(7), 401-413.
- Bythell J, Pan P, Lee J. Three-dimensional morphometric measurements of reef corals using underwater photogrammetry techniques. Coral Reefs 2001, 20(3), 193-199.
- Walker ST, Mantle D, Bythell JC, Thomason JC. Oxidative-stress: Comparison of species specific and tissue specific effects in the marine bivalves Mytilus edulis (L.) and Dosinia lupinus (L.). Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology 2000, 127(3), 347-355.
- Bythell JC, Hillis-Starr ZM, Rogers CS. Local variability but landscape stability in coral reef communities following repeated hurricane impacts. Marine Ecology Progress Series 2000, 204, 93-100.
- Hillis ZM, Bythell JC. "Keep up or give up": hurricanes promote coral survival by interrupting burial from sediment accumulation. CORAL REEFS 1998, 17(3), 262-262.
- BYTHELL JC, GLADFELTER EH, BYTHELL M. CHRONIC AND CATASTROPHIC NATURAL MORTALITY OF 3 COMMON CARIBBEAN REEF CORALS. CORAL REEFS 1993, 12(3-4), 143-152.
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Book Chapter
- Bythell JC, Pantos O, Richardson LL. White plague, white band, and other "white" diseases. In: Rosenberg, E., Loya, Y, ed. Coral Health and Disease. New York: Springer, 2004, pp.351-365.
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Conference Proceedings (inc. Abstracts)
- Lindop AAM, Hind EJ, Bythell JC. The unknowns in coral disease identification: An experiment to assess consensus of opinion amongst experts. In: Proc 11th Int Coral Reef Symp. 2009, Ft. Lauderdale, Florida.
- Bythell J, Johnstone R, Pantos O. The influence of microbial communities in mediating enviromental stress events on coral reefs. In: Comparative Biochemistry and Physiology A: Molecular & Integrative Physiology, Annual Main Meeting of the Society for Experimental Biology. 2006, Canterbury, UK: Elsevier Inc.
- Dunn SR, Thomason JC, Le Tissier MDA, Bythell JC. Detection of cell death activity during experimentally induced bleaching of the symbiotic sea anemone Aiptasia sp. In: 9th International Coral Reef Symposium. 2002, Bali: ICRS.
- Rogers C, Gladfelter W, Hubbard D, Gladfelter E, Bythell J, Dunsmore R, Loomis C, Devine B, Hillis-Starr Z, Phillips B. Acropora in the U.S. Virgin Islands: A Wake or an Awakening? A Status Report Prepared for the National Oceanographic and Atmospheric Administration. In: Proceedings of the Caribbean Acropora Workshop. 2002, Miami, Florida: US Dept of Commerce.
- BYTHELL JC, BYTHELL M, GLADFELTER EH. INITIAL RESULTS OF A LONG-TERM CORAL-REEF MONITORING PROGRAM - IMPACT OF HURRICANE HUGO AT BUCK ISLAND REEF NATIONAL MONUMENT, ST-CROIX, UNITED-STATES VIRGIN-ISLANDS. In: JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY. 1993.
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Note
- Leggat W, Ainsworth T, Bythell J, Dove S, Gates R, Hoegh-Guldberg O, Iglesias-Prieto R, Yellowlees D. The hologenome theory disregards the coral holobiont. Nature Reviews Microbiology 2007, 5(10).
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Report
- HoeghGuldberg O, Loya Y, Bythell J, Fitt W, Gates R, IglesiasPrieto R, Lesser M, McClanahan T, vanWoesik R, Wild C. Bleaching and related ecological factors. Australia: University of Queensland, 2009. CRTR Working Group Findings 2004-2009 004/2009.
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Reviews
- Sweet MJ, Jones R, Bythell JC. Coral diseases in aquaria and in nature. Journal of the Marine Biological Association of the UK 2012, 92(4), 791-801.
- Wild C, Hoegh-Guldberg O, Naumann M, Colombo-Pallotta MF, Fitt W, Ateweberhan M, Iglesias-Prieto R, Palmer C, Bythell JC, Ortiz JC, Loya Y, van Woesik R. Climate change impedes scleractinian corals as primary reef ecosystem engineers. Marine and Freshwater Research 2011, 62(2), 205-215.
- Bythell JC, Wild C. Biology and ecology of coral mucus release. Journal of Experimental Marine Biology and Ecology 2011, 408(1-2), 88-93.
- Brown BE, Bythell JC. Perspectives on mucus secretion in reef corals. Marine Ecology Progress Series 2005, 296, 291-309.