Molecular Biophysics
Molecular Biophysics
We are highly experienced in the following techniques:
- Direct information about of macromolecule mass, stoichiometry and interactions in solution
- Quality control of biopharmaceuticals (protein aggregates’ profile)
- Experimental analysis of biomolecule shape/conformation in solution
- Analysis of biomolecule thermostability and thermodynamics of biomolecular interactions
Equipment
Beckman ProteomeLab XLA-XLI analytical ultracentrifuge (equipped with absorbance and interference detection)
- Microcal VC-ITC
- Microcal VC-DSC
Sciex 6600 QToF Mass Spectrometer (intact protein)
We also have access to instruments which complement our expertise in the following techniques:
- Surface plasmon resonance (Biacore S-200)
- Small-angle X-ray scattering instruments (Diamond synchrotron)
- Small angle neutron scattering (RAL)
- Fourrier-transform infra-red spectroscopy (Perkin Elmer)
- Circular dichroism spectroscopy
