Staff Profile
Dr Othman Almusaimi
Lecturer in Medicinal Chemistry
- Email: othman.almusaimi@ncl.ac.uk
- Telephone: 0191 208 2344
- Address: King George VI Building
Faculty of Medical Sciences - School of Pharmacy
Newcastle University
Newcastle upon Tyne
NE1 7RU
Background
Dr Othman Al Musaimi assumed the role of Lecturer in Medicinal Chemistry at the School of Pharmacy in September 2023. Before joining this position, he worked as a Research Associate at Imperial College London. Dr Al Musaimi holds a PhD in Pharmaceutical Chemistry from the University of Kwazulu-Natal in South Africa. His research interests primarily revolve around the development of synthetic, greening, separation, and purification methodologies for peptides.
Professional Affiliations
- Fellow of Higher Education Academy (FHEA).
- Honorary Associate Fellow.
- Translational and Clinical Research Institute Fellow.
- Community Associate, ACS.
- UKRI Talent Peer Review College Member.
- European Peptide Society (EPS).
- Royal Society of Chemistry Affiliate.
- American Peptide Society (APS).
Academic roles
- Academic Lead for Peer Mentoring.
- Duputy Admissions Tutor.
Research
Othman's research interests center on developing innovative methodologies for the synthesis, separation, and purification of peptides, as well as engineering peptides for therapeutic and aesthetic applications.
Funds
- 2024
- RSC Researcher Development and Travel Grant
- Co-PI: Adventurous Manufacturing Grant - Round 3: EPSRC
- PI: Research Excellence Development Award: Newcastle University
- 2023
- PI: Seed Fund: Imperial College London
- PI: Deep Technology Prime: Imperial College London
- 2021
- Co-I: Julia Higgins Engineering Postdoc Collaborative Research Fund: Imperial College London
- 2022
- PI: Dame Julia Higgins Engineering Postdoc Collaborative Research Fund: Imperial College London
- 2015
- PI: Research & Development Grant: King Abdulaziz City for Science and Technology (KACST)
Awards
- Winner: Emerging Technologies Competetion 2024 - Enabling Technologies Category - Royal Society of Chemistry (RSC)
- Winner: Unsung Heroes - Advancement of Knowledge - C-DICE, the Centre for Postdoctoral Development in Infrastructure Cities and Energy
- Travel Grant Winner: 28th American Peptide Symposium. Peptide at the Frontier. Scottsdale, AZ – June 24 – 29, 2023.
- Winner: Creating a Positive Research Environment - Imperial College London
- Winner: Departmental Team Gold Award - Department of Chemical Engineering - Imperial College London
- Travel Grant Winner: 27th American Peptide Symposium. Peptide Science at the Summit. Whistler, BC – June 11 – 16, 2022
MPharm Students
- Hannah Stephenson: Non-invasive Therapy for Soft Tissue Reconstruction - Aesthetic Applications
- Carys Hockley: Peptide-Based Hydrogels as Novel Systems for Prostate-Specific Membrane Antigen (PSMA)
- Olivia Killen: Delivering Cell Penetrating Peptides Non-Invasively into the Brain to Target Glial-Related Brain Diseases and as Antimicrobial Agents
MRes Students
- Amabella Lim: Non-invasive Therapy for Soft Tissue Reconstruction - Therapeutic Applications
Connect
Google Scholar Research Gate LinkedIn Al Musaimi's Research Group
Teaching
Stage 1
- Acid-base 1-2
- Acid-base 3-4
- Thermodynamics 1
- Thermodynamics 2
- Thermodynamics 3
- Volumetric Titrations
- Synthesis of Paracetamol
- Hydrolysis of Aspirin
Stage 2
- Antibiotic Chemistry
- Antibiotic Chemistry Seminar
- Drug Likeness and Druggability
- Case study - GI drugs
- Physicochemical Properties 1
- Physicochemical Properties 2
- Case study - Salbutamol / Salmeterol
- Mini Project Tutorial 2
- Synthesis of Sulfonamides
Stage 3
- Chemistry of Sildenafil: case study
Stage 4
- Mechanistic basis of antibacterial therapy
- Antibacterial chemistry seminar
- Mechanistic basis of chemotherapy 1
- Mechanistic basis of chemotherapy 2
- Mechanistic basis of chemotherapy 3
- PARP inhibitors
- Chemotherapy chemistry seminar
- Development of TKIs
Publications
-
Articles
- Al Musaimi O. Unlocking the Potential of Retro-Inverso (RI) Peptides as Future Drug Candidates. International Journal of Peptide Research and Therapeutics 2024, 30, 56.
- Al Musaimi, O. Towards Green, Scalable Peptide Synthesis: Leveraging DEG-Crosslinked Polystyrene Resins to Overcome Hydrophobicity Challenges. RSC Advances 2024. In Press.
- Zulfiqar N, Nadeem R, Al Musaimi O. Photocatalytic Degradation of Antibiotics via Exploitation of a Magnetic Nanocomposite: A Green Nanotechnology Approach toward Drug-Contaminated Wastewater Reclamation. ACS Omega 2024, 9(7), 7986-8004.
- Al Musaimi O. Peptide Therapeutics: Unveiling the Potential against Cancer—A Journey through 1989. Cancers 2024, 16(5), 1032.
- Al Musaimi O. Oligonucleotides: evolution and innovation. Medicinal Chemistry Research 2024, 33, 2204–2220.
- Al Musaimi O. Lasso Peptides Realm: Insights and Applications. Peptides 2024, 182, 171317.
- Al Musaimi O. FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond. Journal of Peptide Science 2024, 30(11), e3627.
- Al Musaimi, O. Exploring FDA-Approved Frontiers: Insights into Natural and Engineered Peptide Analogues in the GLP-1, GIP, GHRH, CCK, ACTH, and α-MSH Realms. Biomolecules 2024, 14(3), 264.
- Dickerson H, Diab A, Al Musaimi O. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer: Current Use and Future Prospects. International Journal of Molecular Sciences 2024, 25(18), 10008.
- Al Musaimi O, Ng KW, Gavva V, Valenzo OMM, Haroon HB, Williams DR. Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System. Gels 2024, 10(8), 531.
- Al Musaimi O, Jaradat Da’san M M. Advances in Therapeutic Peptides Separation and Purification. Separations 2024, 11(8), 233.
- Al Musaimi O, Al Shaer D, Albericio F, de la Torre BG. 2023 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals 2024, 17(2), 243.
- Al Musaimi O, Morse SV, Lombardi L, Serban S, Basso A, Williams DR. Successful synthesis of a glial-specific blood–brain barrier shuttle peptide following a fragment condensation approach on a solid-phase resin. Peptide Science 2023, 29(2), e3448.
- Gavva V, Al Musaimi O, Bent C, Williams DR. Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups. Separations 2023, 10(8), 456.
- Al Musaimi O, Gavva V, Williams DR. Greener Cleavage of Protected Peptide Fragments from Sieber Amide Resin. ChemistryOpen 2022, 11(12), e202200236.
- Jaradat DMM, Al Musaimi O, Albericio F. Advances in solid-phase peptide synthesis in aqueous media (ASPPS). Green Chemistry 2022, 24(17), 6360-6372.
- Al Musaimi O, Wisdom R, Talbiersky P, de la Torre BG, Albericio F. Propylphosphonic Anhydride (T3P®) as Coupling Reagent for Solid-Phase Peptide Synthesis. ChemistrySelect 2021, 6(11), 2649-2657.
- Al Musaimi O, Al Shaer D, Albericio F, de la Toree BG. 2020 FDA TIDES (Peptides and Oligonucleotides) Harvest. Pharmaceuticals 2021, 14(2), 145.
- Al Musaimi, O. Greening Fmoc/tBu solid-phase peptide synthesis. Green Chemistry 2020, 22, 996-1018.
- Al Shaer D, Al Musaimi O, Albericio F, de la Toree B G. 2019 FDA TIDES (peptides and oligonucleotides) harvest. Pharmaceuticals 2019, 13(3), 40.
-
Patents
- Othman, Al. Solution Phase Peptide Synthesis. GB2409647.1, 2024. Submitted.
- Al Musaimi, O. Methods of Chemical Synthesis of Peptides. CT/EP2024/067557, 2024. Submitted.
- Al Musaimi O, Williams DR. Methods of Chemical Synthesis of Oligonucleotides. 2415649.9, 2024. Submitted.
- Al Musaimi, O. Methods of Chemical Synthesis of Peptides. UK, GB2312735.0, 2023. Submitted.