Breakthrough in understanding mechanism of melanoma ulceration
A ground-breaking explanation of the mechanism by which early-stage melanomas become at risk of spreading has just been published in the British Journal of Dermatology.
19 January 2022
A ground-breaking explanation of the mechanism by which early-stage melanomas become at risk of spreading has just been published in the British Journal of Dermatology.
The team at Newcastle University, led by Professor Penny Lovat, in association with AMLo Biosciences have now described the process by which the secretion of TGFβ2 by a primary melanoma causes the reduction, or downregulation, of the proteins AMBRA1 and loricrin in the epidermis overlying the tumour. The growth factor TGFβ2 also causes the loss of claudin-1 leading to loss of the integrity of the skin thereby facilitating tumour ulceration.
This collaboration between Newcastle upon Tyne Hospitals (NuTH) and Newcastle University, harnesses the power of our biobanks, and high quality tissue-based diagnostics in NovoPath.