Aims

Cancer is one of the major causes of mortality and a major research strength where Newcastle has impacted understanding, practice and policy worldwide. This module, delivered by research leaders, provides a background to the molecular basis of cancer and its therapy. The various causes, cellular and genetic processes central to the development of cancer will be discussed, alongside how this understanding is being exploited for disease detection, diagnosis and therapy.

Outline Of Syllabus

-The genetic and molecular basis of cancer.
-Mechanisms of action of oncogenes and tumour suppressor genes.
-Cell cycle disruption in cancer development.
-Metastasis and angiogenesis.
-Cell signaling pathways in cancer.
-Viruses in cancer.
-Genetic and chromosomal instability, DNA damage and repair in carcinogenesis.
-Cell states (apoptosis, senescence) in cancer.
-The tumour microenvironment and inflammation in cancer.
-Cancer metabolism.
-Mechanisms of action of standard chemotherapeutics and associated drug resistance mechanisms.
-Molecularly targeted therapies and drug development.
-Cell plasticity and stem cells in cancer development and treatment.
-Treatment-related late effects and molecular survivorship.
-The molecular pathology of cancer.
-Next-generation approaches to understanding cancer.
-Experimental models and imaging in cancer research.
-The therapy of cancer and related challenges.

Teaching Rationale And Relationship

Lecture materials will provide students with key information. Tutorials will encourage increased understanding of the material through discussion. Private study will allow students to extend their knowledge through reading of journal articles and other recommended references.

Assessment Rationale And Relationship

The assessment provides evidence of knowledge and understanding of the topics.

The open-book essay supports the students’ development of literature-based research, written communication and presentation skills, supplements the main areas of teaching delivered, and helps prepare them for the examination.

FMS Schools offering Semester One modules available as ‘Study Abroad’ will, where required, provide an alternative assessment time for examinations that take place after the Winter vacation. Coursework with submission dates after the Winter vacation will either be submitted at an earlier date or at the same time remotely. The assessment format will not normally vary from the original to ensure learning outcomes are met. Any changes to the original format must meet module learning outcomes and be approved by the school.