Aims

i)       To inform students about the genetic and molecular basis of cancer.
ii)       To examine the mechanisms of action of oncogenes and tumour suppressor genes.
iii)       To understand the role of cell cycle disruption in cancer development.
iv)       To understand the processes of metastasis and angiogenesis.
v)       To understand the roles of cell signaling pathways in cancer.
vi)       To understand the roles that chromosomal instability, DNA damage and repair play in carcinogenesis.
vii)       To understand the basic mechanisms of apoptosis and their relevance to cancer.
viii)       To introduce current technologies used in cancer detection, diagnostics and molecular pathology.
ix)       To discuss how experimental models and imaging techniques are being applied to advance our understanding of cancer.
x)       To understand the basis of and problems associated with cancer treatments.
xi)       To provide students with an understanding of cancer stem cells.

In Summary:
Cancer is one of the major causes of mortality. This module provides a background to the molecular basis of cancer and its therapy. The various causes, cellular and genetic processes central to the development of cancer will be discussed, alongside how this understanding is being exploited for disease detection, diagnosis and therapy.

Outline Of Syllabus

- An introduction to the molecular basis of cancer
- Oncogenes
- Tumour suppressor genes (TSGs) I: Identification
- Tumour suppressor genes II: Mechanisms of action
- Metastases and Angiogenesis
- Cell signaling in cancer
- Viruses and Cancer
- Cell states:  Apoptosis, senescence
- DNA repair and cancer predisposition syndromes / Genetic instability and cancer
- Cancer treatments and drug resistance
- Targeted therapies & drug development strategies
- Treatment-related late effects
- The Pathology of Cancer
- Molecular studies linking genomic arrays, diagnostics and pathology in cancer detection
- Systems biology, bioinformatic and next-generation approaches to understanding cancer biology
- Cancer stem cells
- Application of experimental models and imaging in cancer
- Leukaemia and its therapy
- Therapy for Prostate Cancer

Teaching Rationale And Relationship

Lecture materials will provide students with key information. Tutorials will encourage increased understanding of the material through discussion. Private study will allow students to extend their knowledge through reading of journal articles and other recommended references.

Assessment Rationale And Relationship

The assessment provides evidence of knowledge and understanding of the topics.

The open-book essay supports the students’ development of literature-based research, written communication and presentation skills, supplements the main areas of teaching delivered, and helps prepare them for the examination.

FMS Schools offering Semester One modules available as ‘Study Abroad’ will, where required, provide an alternative assessment time for examinations that take place after the Winter vacation. Coursework with submission dates after the Winter vacation will either be submitted at an earlier date or at the same time remotely. The assessment format will not normally vary from the original to ensure learning outcomes are met. Any changes to the original format must meet module learning outcomes and be approved by the school.