Aims

This module aims to;

Demonstrate the relationship between structure and function of biomolecules

Introduce the molecular basis of cellular processes and the principles that underlie these events

Consider the implications in relation to health and disease

Provide an introduction to experimental methods which can be applied to generate information about biomolecules

Provide a range of both practical laboratory skills and generic study skills essential to students studying biomolecular and biomedical sciences.

Provide opportunities for students to apply and strengthen theoretical knowledge gained in complementary and co-requisite modules in the performance of key analytical techniques and interpretation of data generated.

Develop safe laboratory practice

Outline Of Syllabus

Lectures and seminars will cover the following topics:

Amino acids and proteins: proteins and their building blocks; proteins in health and disease; enzymes; methods used in protein purification.

Carbohydrates: the structure of sugars and their role in biology.

Nucleic acids: the importance of phosphorus in biology; the relationship between DNA, RNA and proteins; the structure of DNA and how this relates to its function replication; DNA sequencing and the human genome.

The control of gene expression: transcription (RNA synthesis) and translation (protein synthesis).

Energy and cellular metabolism: glycolysis; citric acid cycle; oxidative phosphorylation; gluconeogenesis; glycogen metabolism; fat metabolism; basic amino acid metabolism; alcohol metabolism.

Laboratory-based practicals cover topics:
spectrophotometry, ion exchange chromatography and enzyme kinetics; as well as online practical material covering the control of gene transcription.

Online material will supplement practical skills in advance of and following each session as formative pre-and post-practical quizzes.

The module is offered ONLY to Study abroad and exchange students. Students on other programmes in the School
of Biomedical, Nutritional and Sport Sciences may take the same practical classes as part of CMB1011.

Teaching Rationale And Relationship

Lectures will define the scope of the course and communicate basic knowledge as a basis for further study. Seminars will encourage students to develop their understanding of the subject and interpersonal communication skills. They provide an opportunity for students to ask questions and exchange ideas in a small group setting. Skills practiced include critical thinking, numeracy, communication & team working.
Private study is used for self-directed learning and includes: reading lecture notes and texts; preparation for seminars; using learning resources on the Web. Skills practiced include critical thinking, active learning, numeracy, planning and organisation and independence.
Practicals will provide experience of laboratory work; information presented in practicals will include knowledge and understanding of the underlying principles of essential practical techniques and laboratory health and safety.
Students will gain hands-on experience of a range of practical techniques and safe laboratory practice. Practical classes will allow students to develop skills in recording and analysing biological data, carrying out scientific calculations and using computers. Practicals also provide an opportunity for students to ask questions and exchange ideas with peers, demonstrators and academic staff in a relatively informal setting. Skills practised include critical thinking, data synthesis, numeracy & use of computer applications.
Independent study is used for self-directed learning and includes: reading lecture notes and texts relevant to the practicals; preparation for practicals and completing assessments.

Assessment Rationale And Relationship

The end of semester examination assess knowledge and understanding of the course material. The formative quiz format questions will help students assess their knowledge and understanding of course material as well as familiarise students with the format of a quiz format exam via Inspera.

Formative pre and post practical quizzes will support student's understanding of the theory and practical skills associated with each of the 3 labs. The lab report will help students knowledge and understanding of practical techniques, alongside their ability to record and analyse biological data.

FMS Schools offering Semester One modules available as ‘Study Abroad’ will, where required, provide an alternative assessment time for examinations that take place after the Christmas vacation. Coursework with submissions dates after the Christmas vacation will either be submitted at an earlier date or at the same time remotely.