Aims

To introduce the fundamental principles and reactions of organometallic chemistry; to introduce concepts of homogeneous catalysis; to demonstrate the diverse chemistry of the s- and p-elements; to introduce inorganic aspects of biological systems and metals in biomedicine; to introduce the fundamentals, diversity and applications of chemistry in the solid state

Outline Of Syllabus

The module will be presented in four courses – Organometallic Chemistry; Bio-inorganic Chemistry; Contemporary Main Group Chemistry; Solid-state Chemistry



Organometallic Chemistry

*Topics selected from the following

*Background and introduction

*The 18-Electron rule

*Important ligand types; carbonyl (bonding and binary carbonyls)

*Pi-ligands, hydrides, phosphines

*The synthesis of organometallic compounds

*Organometallic reaction mechanisms 1. Reaction at the metal: ligand substitution, oxidative addition and

reductive elimination

*Organometallic reaction mechanisms 2: Reactions involving the ligand: migratory insertion, reductive

elimination and nucleophilic additions and abstractions

*Transition metal carbene complexes: synthesis, structure and reactivity

*Homogeneous catalysis: an introduction



Bioinorganic Chemistry

*An introduction to bioinorganic chemistry; the essential metals, metal ion overload-deficiency and treatments.

*An introduction to metalloproteins. Protein structure, metal ion binding groups, protein function and role of metal ions.

*Further topics selected from the following

*Myoglobin– protein structure and function, haem group, oxidation and spin states of the metal centre before and after oxygen coordination

*Haemoglobin – protein structure and function, comparison with Mb,

*Metallo-enzymes – details of the structure and function of Zn and Fe-containing systems

*Metal ion binding in DNA. Discovery of metal-containing anti-tumour drugs. mode of action, side effects. Metal-based drugs



Comparative Main Group Chemistry

Topics selected from the following:

*General principles. Complexes of the s-elements: macrocycles and the macrocyclic effect, alkalides and electrides

*Organometallics of the electropositive metals: an introduction to electron-deficient compounds

*More electron-deficient compounds: boranes and carboranes, Zintl ions

*Low oxidation states of the p-block elements (groups 13 and 14)

*E=E bonds (groups 14 and 15); synthesis and reactions. Phosphorus (V) ylides and related compounds

*E=E’ bonds – stability, synthesis and reactions



Sold-state Chemistry

Topics selected from the following: 

 *Introduction to solid-state chemistry – background, applications, importance and diversity of materials and structures types of solid state, i.e., 0D to 3D, including crystals and molecular solids. 

*Structures of solids – crystal structure and chemistry, packing, unit cells and important structures. 

*Bonding and electronic structure in solids – types of bonding in solids, band theory, metals/semiconductors/insulators.   

*Electrical properties – metallic conductivity, superconductivity + semiconductors. 

*Ionic diffusion and conductivity – how ions move in solids, models and types of diffusion, role of ionic conductivity.   

*Defects, doping and non-stoichiometry in crystals – points defects and why they form, extended defects, role of doping and nonstoichiometry.

Teaching Rationale And Relationship

Lecture materials and revision sessions are delivered in-person and electronically and are used to impart knowledge/understanding.

Assessment Rationale And Relationship

A formative exam will assess the level of knowledge and understanding from topics studied in semester 1. This will allow the module team to review and feedback on any topic which may have been problematic.

The summative written examination will assess the level of knowledge and understanding of the content of the module. The examination will present students with questions from a selection of topics learnt throughout semester 1 and 2 module content.