NES8808 : Synthetic Methodology for Drugs
- Offered for Year: 2024/25
- Available for Study Abroad and Exchange students, subject to proof of pre-requisite knowledge.
- Module Leader(s): Dr Michael Carroll
- Lecturer: Dr Cristina Navarro Reguero, Dr Julian Knight
- Owning School: Natural and Environmental Sciences
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 1 Credit Value: | 20 |
| ECTS Credits: | 10.0 |
| European Credit Transfer System | |
Aims
To familiarise students with the key synthetic methods used to prepare critical functionality in drug molecules.
Outline Of Syllabus
Chemical structure of organic compounds and the resulting physical properties
The synthesis and reactivity of diverse carbonyl group functionality
Aliphatic nucleophilic substitution reactions e.g. SN1 and SN2
Elimination reactions e.g. E1 and E2
Structure and reactivity (e.g. SEAr, SNAr) of aromatic and heteroaromatic compounds
Redox chemistry of selected functionality
Explanation of selectivity and reactivity based on mechanistic rationale
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Scheduled Learning And Teaching Activities | Lecture | 40 | 1:00 | 40:00 | 4 Lectures per week (10 weeks) PiP. |
| Guided Independent Study | Assessment preparation and completion | 2 | 10:00 | 20:00 | 2 x interim assessed exercises - Canvas MCQ |
| Structured Guided Learning | Academic skills activities | 15 | 1:00 | 15:00 | Workshops and revision sessions |
| Guided Independent Study | Independent study | 1 | 125:00 | 125:00 | Revision for end of module assessments |
| Total | 200:00 |
Teaching Rationale And Relationship
In lectures students learn concepts essential for the preparation of drug molecules, encompassing both synthetic and mechanistic principles. The online workshops allow practice of these methods.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
| Description | Length | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|---|
| Digital Examination | 120 | 1 | A | 50 | N/A |
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Prob solv exercises | 1 | M | 50 | 2 x Interim assessed exercises |
Assessment Rationale And Relationship
The assessment at the end of Semester 1 will test the students’ knowledge and understanding of the content of this module in the context of both synthetic and mechanistic chemistry. Two Interim Assessments will be set during Semester 1 to determine progress during the Module. Due to the diverse background of the students and that the material is taught as two blocks.
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- NES8808's Timetable