PED2001 : Drug Disposition and Pharmacokinetics
- Offered for Year: 2024/25
- Available to incoming Study Abroad and Exchange students
- Module Leader(s): Dr Simon Wilkinson
- Other Staff: Professor Matthew Wright, Dr Lindi Chen, Dr Shelby Barnett, Prof. Ann Daly
- Owning School: Biomedical, Nutritional and Sports Scien
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
Semester 2 Credit Value: | 20 |
ECTS Credits: | 10.0 |
European Credit Transfer System | |
Aims
The aims of the course are to:
(i) Provide an understanding how drugs are handled by the body, the factors that may influence this process and how drug metabolism is studied experimentally.
(ii) Provide students with a detailed knowledge and understanding of the role of drug absorption, distribution, metabolism, excretion, pharmacokinetics and the enzymes of drug metabolism.
(iii)Introduce students to modern experimental methods commonly used in drug metabolism studies and to develop practical, critical and written communication skills. This will equip students with an appreciation of the role of studies on drug disposition in the drug development process.
Outline Of Syllabus
The syllabus will be divided into four themes which cover drug disposition following administration, the role of individual enzymes systems in drug metabolism, factors affecting drug metabolism, and transport of drug metabolites out of tissues and excretion from the body. The syllabus will cover the principles of administration and distribution of drugs (including the influence of delivery systems and routes), the different enzyme systems involved in metabolism of drugs and how this process is modulated, the influence of genetic polymorphisms on drug efficacy and toxicity, experimental methods for reaction phenotyping employed in drug development, and how metabolites are effluxed from cells and tissues and excreted from the body. The syllabus also covers exemplar techniques for measuring key metabolic activities, the induction of enzyme activities and the detection of genetic polymorphisms in enzymes and the functional consequences of polymorphisms for drug metabolism.
Teaching Methods
Teaching Activities
Category | Activity | Number | Length | Student Hours | Comment |
---|---|---|---|---|---|
Guided Independent Study | Assessment preparation and completion | 1 | 6:00 | 6:00 | Timed essay |
Scheduled Learning And Teaching Activities | Lecture | 21 | 1:00 | 21:00 | In person - Lectures |
Scheduled Learning And Teaching Activities | Lecture | 1 | 1:00 | 1:00 | In person - Intro talk |
Scheduled Learning And Teaching Activities | Practical | 6 | 3:00 | 18:00 | In person - laboratory practicals |
Scheduled Learning And Teaching Activities | Small group teaching | 4 | 1:00 | 4:00 | In person 4 seminars |
Scheduled Learning And Teaching Activities | Drop-in/surgery | 1 | 1:00 | 1:00 | In person - End of module summary, feedback, Q&A session |
Guided Independent Study | Independent study | 1 | 149:00 | 149:00 | Writing up lecture notes, revision and general reading |
Total | 200:00 |
Teaching Rationale And Relationship
Lectures will impart new information regarding fundamental principles and will act as an indication of the scope of material required for guided independent study.
Seminar sessions will reinforce taught material and will provide an opportunity for students to clarify concepts or challenge their learning through peer and staff discussions, as well as developing scientific writing skills and laboratory record keeping.
The drop-in surgery will provide critical feedback on assessed material and encourage an increased understanding of the material through discussion.
The practical class will provide experience in performing fundamental techniques, recording and analysing data to support the core module knowledge as well as the opportunity to carry out scientific calculations.
Guided independent study will be used for self-directed learning, including further reading and preparation for assessments.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
Description | Length | Semester | When Set | Percentage | Comment |
---|---|---|---|---|---|
Written Examination | 60 | 2 | A | 42 | PIP invigilated handwritten exam, 2 written essay questions from choice of 4 & Inspera invigilated digital exam Quiz format, 50 questions max. Part 1 Inspera Part 2 Written, exams scheduled together. Inspera to be open for duration of the exam-120mins |
Digital Examination | 60 | 2 | A | 28 | PIP Inspera invigilated digital exam Quiz format, 50 questions max & invigilated handwritten exam, 2 written essay questions from choice of 4. Part 1 Inspera Part 2 Written, exams scheduled together Inspera to be open for the duration of the exam-120mins |
Other Assessment
Description | Semester | When Set | Percentage | Comment |
---|---|---|---|---|
Essay | 2 | M | 10 | Invigilated Timed essay 45 mins (hand written) |
Practical/lab report | 2 | M | 20 | Structured report (1250 words) |
Formative Assessments
Formative Assessment is an assessment which develops your skills in being assessed, allows for you to receive feedback, and prepares you for being assessed. However, it does not count to your final mark.
Description | Semester | When Set | Comment |
---|---|---|---|
Practical/lab report | 2 | M | Practical lab book practice |
Assessment Rationale And Relationship
The examination questions will be used to assess knowledge, independent learning and understanding of the material relevant to this module, the ability to integrate this material, the ability to communicate clearly in writing and ability for critical thought and problem solving.
The timed essay is used to assess knowledge and understanding of material and ability to integrate across sources.
The practical report ensures an understanding of practical work undertaken and provides practice in numerical calculations. The first two practicals provide formative practice in completing an effective laboratory record book.
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- PED2001's Timetable