NES8803 : Theory and Practice of Chemotherapy
- Offered for Year: 2024/25
- Module Leader(s): Dr Celine Cano
- Lecturer: Dr Ian Hardcastle
- Owning School: Natural and Environmental Sciences
- Teaching Location: Newcastle City Campus
Semesters
Your programme is made up of credits, the total differs on programme to programme.
| Semester 2 Credit Value: | 20 |
| ECTS Credits: | 10.0 |
| European Credit Transfer System | |
Aims
To introduce the basic concepts of the aetiology of cancer and pathogenic disease; to impart an understanding of the host-pathogen relationship, and the concepts of selective toxicity and resistance; to equip students with an understanding of the basic principles of chemotherapy of cancer and infectious disease; to provide an understanding of the molecular mechanisms underpinning the action of anticancer and anti-infective drugs.
Outline Of Syllabus
Cancer Chemotherapy
Dr C Cano
1 Introduction to cancer
2 DNA reactive drugs
3 Antimetabolites
4 DNA Topoisomerase inhibitors
5 Mitotic poisons
6 DNA Repair Enzymes
7 Antiendocrine drugs
8 Current approaches to cancer chemotherapy
9 New thearapies: Targetting receptor tyrosine kinase signalling
10 Kinase inhibitors case studies
Chemotherapy of Infectious Diseases
Professor Bernard Golding
1 Introduction and historical overview
2 Principles of antimicrobial chemotherapy
3 Antibacterial agents – Penicillin and related β-lactam
4 Antibacterial agents – Glycopeptides, quinolones, and oxazolidinones
5 Antifungal agents – Polyenes and azoles
6 Antifungal agents – Azoles and other antifungals
7 Metronidazole
8 Malaria and its treatment
9 Antiviral chemotherapy
10 Acyclovir and maraviroc
Teaching Methods
Teaching Activities
| Category | Activity | Number | Length | Student Hours | Comment |
|---|---|---|---|---|---|
| Guided Independent Study | Assessment preparation and completion | 10 | 0:30 | 5:00 | Revision for end of semester examination |
| Guided Independent Study | Assessment preparation and completion | 1 | 15:00 | 15:00 | Preparation for examination |
| Guided Independent Study | Assessment preparation and completion | 2 | 18:00 | 36:00 | preparation for presentation and questions |
| Structured Guided Learning | Structured non-synchronous discussion | 8 | 0:30 | 4:00 | Online email support |
| Guided Independent Study | Independent study | 1 | 120:00 | 120:00 | Background reading and practice past paper examination questions |
| Scheduled Learning And Teaching Activities | Module talk | 20 | 1:00 | 20:00 | PiP seminars scheduled LTA, |
| Total | 200:00 |
Teaching Rationale And Relationship
Students acquire an understanding of the subject through online lectures. An understanding of the topics is reinforced by problem solving, and critical background reading of the scientific literature. The literature assignment will develop skills in reading, understanding and assimilating new information, and subsuming the acquired knowledge into a concise written review.
Assessment Methods
The format of resits will be determined by the Board of Examiners
Exams
| Description | Length | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|---|
| Digital Examination | 120 | 2 | A | 50 | N/A |
Other Assessment
| Description | Semester | When Set | Percentage | Comment |
|---|---|---|---|---|
| Oral Presentation | 2 | M | 50 | Presentation and questions |
Formative Assessments
Formative Assessment is an assessment which develops your skills in being assessed, allows for you to receive feedback, and prepares you for being assessed. However, it does not count to your final mark.
| Description | Semester | When Set | Comment |
|---|---|---|---|
| Digital Examination | 2 | M | 1hour digital mock exam |
Assessment Rationale And Relationship
The presentation will test the student's acquisition and understanding of the lecture/seminar material; presentations will assess students’ conceptual understanding and ability to collate and synthese knowledge in the key subject areas
Reading Lists
Timetable
- Timetable Website: www.ncl.ac.uk/timetable/
- NES8803's Timetable