Staff Profile
Professor Alastair Hawkins
Emeritus Professor
- Email: alastair.hawkins@ncl.ac.uk
- Address: Biosciences Institute,
Cookson Building,
Newcastle University,
Medical School,
Framlington Place,
Newcastle upon Tyne,
NE2 4HH.
UK
Background
I am an honorary member of the Newcastle University Biosciences Institute.
Research
I am an Honorary member of the Newcastle University Biosciences Institute.
Publications
- Lence E, Maneiro M, Sanz-Gaitero M, van Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C. Self-Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product. Chemistry - A European Journal 2020, 26(36), 8035-8044.
- Maneiro M, Lence E, Sanz-Gaitero M, Otero JM, Van Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C. Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme. Organic Chemistry Frontiers 2019, 6(17), 3127-3135.
- Pernas M, Blanco B, Lence E, Thompson P, Hawkins AR, Gonzalez-Bello C. Synthesis of rigidified shikimic acid derivatives by ring-closing metathesis to imprint inhibitor efficacy against shikimate kinase enzyme. Organic Chemistry Frontiers 2019, 6(14), 2514-2528.
- Basle A, Hewitt L, Koh A, Lamb HK, Thompson P, Burgess JG, Hall MJ, Hawkins AR, Murray H, Lewis RJ. Crystal structure of NucB, a biofilm-degrading endonuclease. Nucleic Acids Research 2018, 46(1), 473-484.
- Rostami N, Shields RC, Yassin SA, Hawkins AR, Bowen L, Luo TL, Rickard AH, Holliday R, Preshaw PM, Jakubovics NS. A Critical Role for Extracellular DNA in Dental Plaque Formation. Journal of Dental Research 2017, 96(2), 208-216.
- Peon A, Robles A, Blanco B, Convertino M, Thompson P, Hawkins AR, Caflisch A, Gonzalez-Bello C. Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study. ChemMedChem 2017, 12(18), 1512-1524.
- Wilkinson DJ, Desilets A, Lin H, Charlton S, Del Carmen Arques M, Falconer A, Bullock C, Hsu Y-C, Birchall K, Hawkins A, Thompson P, Ferrell WR, Lockhart J, Plevin R, Zhang Y, Blain E, Lin S-W, Leduc R, Milner JM, Rowan AD. The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: Molecular mechanisms and implications for extracellular matrix turnover. Scientific Reports 2017, 7(1), 16693.
- Prado V, Lence E, Thompson P, Hawkins AR, Gonzalez-Bello C. Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme. Chemistry A European Journal 2016, 22(50), 17987-17999.
- Prado V, Lence E, Thompson P, Hawkins AR, Gonzalez-Bello C. Frontispiece: Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme. Chemistry - A European Journal 2016, 22(50).
- Prado V, Lence E, Maneiro M, Vazquez-Ucha JC, Beceiro A, Thompson P, Hawkins AR, Gonzalez-Bello C. Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme. Journal of Medicinal Chemistry 2016, 59(11), 5471-5487.
- Gonzalez-Bello C, Tizon L, Lence E, Otero JM, van Raaij MJ, Martinez-Guitian M, Beceiro A, Thompson P, Hawkins AP. Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct. Journal of the American Chemical Society 2015, 137(29), 9333-9343.