Staff Profile
Dr Anna Smith
Research Associate
- Email: anna.smith@ncl.ac.uk
- Address: Mitochondrial Research Group,
Biosciences Institute,
Newcastle University,
Medical School,
Framlington Place,
NE2 4HH
Background
Qualifications
BSc (Hons) Biomedical Science, University of Manchester
MSc Biomedical Science, Manchester Metropolitan University
PhD entitled 'Investigating the effect of age-related mitochondrial dysfunction on intestinal tumour formation and progression', Newcastle University
Professional memberships
Institute of Biomedical Science
Teaching
BSc and MRes project supervisor
Publications
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Articles
- Yu X, Arden C, Berlinguer-Palmini R, Chen C, Bradshaw C, Smith AL, Whitehall J, White M, Anderson S, Kattner N, Shaw J, Turnbull D, Greaves LC, Walker M. Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation. Molecular Metabolism 2022, 60, 101489.
- Chen C, McDonald D, Blain A, Sachdeva A, Bone L, Smith ALM, Warren C, Pickett SJ, Hudson G, Filby A, Vincent AE, Turnbull DM, Reeve AK. Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease. npj Parkinson's Disease 2021, 7(1), 39.
- Stamp C, Whitehall JC, Smith ALM, Houghton D, Bradshaw C, Stoll EA, Blain AP, Turnbull DM, Greaves LC. Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon. Aging Cell 2021, 20(3), e13321.
- Smith ALM, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A, Houghton D, Hunt M, Sampson JN, Stamp C, Mallett G, Amarnath S, Leslie J, Oakley F, Wilson L, Baker A, Russell OM, Johnson R, Richardson CA, Gupta B, McCallum I, McDonald SAC, Kelly S, Mathers JC, Heer R, Taylor RW, Perkins ND, Turnbull DM, Sansom OJ, Greaves LC. Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis. Nature Cancer 2020, 1, 976-989.
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Book Chapter
- Whitehall JC, Smith ALM, Greaves LC. Mitochondrial DNA Mutations and Ageing. In: Biochemistry and Cell Biology of Ageing: Part III Biomedical Science. Cham: Springer, 2023, pp.77-98.
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Review
- Smith ALM, Whitehall JC, Greaves LC. Mitochondrial DNA mutations in ageing and cancer. Molecular Oncology 2022, 16(18), 3276-3294.