Staff Profile

Introduction

I joined Newcastle University in October 2012. Supported by the NIHR Newcastle Biomedical Research Centre (BRC), and as a member of the AGE Research Group and the NIHR Newcastle BRC Ageing, Sarcopenia and Multimorbidity (ASM) Theme, I am investigating the risk factors and mechanisms of skeletal muscle ageing, sarcopenia, and multiple long-term conditions (MLTC) in older adults.

Areas of expertise

• Epidemiology of ageing
• Nutrition in older adults
• Interdisciplinary approach to mechanisms of skeletal muscle ageing, sarcopenia, and MLTC

Qualifications

• PhD (Aging Studies/Gerontology), University of South Florida, Tampa, USA; December 2011
• MA (Gerontology), University of South Florida, Tampa, USA; August 2008

Roles and Responsibilities

• Principal Research Associate in Interdisciplinary Ageing Studies, AGE Research Group (PI: Prof Avan A Sayer) 
• AGE Research Group lead in interdisciplinary collaborations in mechanistic studies of ageing, sarcopenia, and MLTC
• Co-Investigator, NIHR Newcastle BRC Ageing, Sarcopenia and Multimorbidity (ASM) Theme (leads: Profs Avan A Sayer, Miles D. Witham); EDI Lead for the ASM Theme (Founder: NIHR Newcastle BRC; 12/2022-11/2027)
• PI, MIlk Intervetion Muscle AgeiNg (MIlkMAN): pilot study (CI: Dr Terry Aspray; Founder: NIHR Newcastle BRC; 05/2018-03/2020).
• Co-Investigator, Muscle Ageing Sarcopenia Study_Lifecourse (MASS_Lifecourse): Establishing a life course cohort for advances in the prevention, diagnosis and treatment of sarcopenia. (CI: Prof Avan A Sayer; Founder: NIHR Newcastle BRC; 06/2018-present). 
• Researcher, Prevention Of  Malnutrition In Senior Subjects (PROMISS) in the EU (Horizon 2020, Project Leader: Prof Marjolein Visser, VA University Amsterdam; 04/2016-12/2020); WP1: 'Dietary characteristics, daily food intake patterns and clinical outcomes' (WP1 lead: Prof Carol Jagger; 04/2015-04-2016). 
• Co-investigator, Muscle Ageing Sarcopenia Study Parkinson's Disease (MASS_PD): Muscle ageing in Parkinson's disease (CI: Profs Avan A Sayer; PI: Prof Alison Yarnall; Founder: NIHR Newcastle BRC; 2017-2018)
• Co-Investigator, Muscle Ageing Sarcopenia Study_Pilot (MASS_Pilot): Evaluation of novel biomarkers of mitochondrial function and dystrophin expression in sarcopenia through integration of expertise in muscle disease, imaging and population-based studies of the very old (CI: Prof Avan Sayer; Founder: Newcastle University (MRC Confidence in Concept) and the Newcastle upon Tyne Hospitals NHS Foundation Trust; 01/2016-07/2016)  

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My research interest is in the fields of functional ageing and multiple long-term conditions (MLTC) approached from an interdisciplinary perspective. It includes the development of a broad understanding of bio-modulators and risk factors of physical impairment, and the key biological pathways that lead to decline in skeletal muscle function, and the development of MLTC. Utilising data from observational studies of ageing studies, I am investigating the role of blood-based biomarkers, diet (dietary patterns), and malnutrition in physical and cognitive decline, MLTC and survival in older adults. Of special interest are dietary interventions with whole foods ('myoprotective foods') and diets in combination with exercise for muscle health in older adults, and mechanistic studies of skeletal muscle ageing through interdisciplinary collaborations. 

Research interests

• Determinants of muscle strength and physical performance decline (sarcopenia) and MLTC in old adults
• Interdisciplinarity in mechanistic studies of ageing, sarcopenia and MLTC
• The role of diet, dietary patterns and malnutrition in physical and cognitive functioning and decline in older adults
• Dietary interventions for sarcopenia ('myoprotective foods and diets' for skeletal muscle health and function)  
• Blood-based biomarkers and the risk of physical and cognitive decline in older adults
• Novel biomarkers of sarcopenia and MLTC
• Genomic instability and chromosome mis-segregation in neurodegenerative and age-related diseases

Projects

• AGE Research Group lead in interdisciplinary collaborations in mechanistic studies of ageing, sarcopenia, and MLTC (Regeneron, Wellcome Sanger Institute).
• AGE Research Group (PI: ProfAvan A Sayer): Predictors of muscle strength and physical performance decline in older adults: The role of diet, malnutrition and blood-based biomarkers (04/2015-Present).
• AGEing of the Immune System Collaborative (AGEing IS): Determining the regulation of immune checkpoints co-receptors in an ageing immune system (11/2021- Present). PI: Dr Shoba Amarnath; Co-Investigators: Profs Derek Mann, Andrew Filby, Avan Sayer. Founder: NIHR Newcastle BRC. 
• MIlk Intervention Muscle AgeiNg (MIlkMAN): pilot study (05/2018-03/2020). CI: Dr Terry Aspray; PI: Dr Antoneta Granic; Co-Investigators: Dr Karen Davies, Prof Emma Stevenson; Academic lead: Prof Avan A Sayer. Founder: NIHR Newcastle BRC. 
• Muscle Ageing Sarcopenia Study_Lifecourse (MASS_Lifecourse): Establishing a life course cohort for advances in the prevention, diagnosis and treatment of sarcopenia. (06/2018-12/2024). CI: Prof Avan A Sayer; Deputy CI; Prof Rachel Cooper; PI: Prof Miles D Witham; Founder: NIHR Newcastle BRC. 
• Horizon 2020: Prevention Of Malnutrition In Senior Subjects (PROMISS) in the EU. Project Leader(s): Principal: Prof Marjolein Visser, Collaborator (Epidemiology Team): Prof Carol Jagger (04/2015-04/2016).
• Muscle Ageing Sarcopenia Study_Parkinson's Disease (MASS_PD): Muscle ageing in Parkinson's disease (CI: Prof Avan A Sayer; PI: Prof Alison Yarnall; Founder: NIHR Newcastle BRC; 2017-2018).
• Confidence in Concept Project (MRC CiC): Muscle and Ageing Science Study (MASS), Evaluation of novel biomarkers of mitochondrial function and dystrophin expression in sarcopenia through integration of expertise in muscle disease, imaging and population-based studies of the very old. Project Leader(s): CI: Prof Avan A Sayer, PI: Dr Karen Davies; Co-Investigators: Dr Antoneta Granic, Prof Grainne Gorman, Dr Kieran Hollingsworth, Prof Volker Straub, Prof Kate Bushby, Dr Rita Barresi, and Prof Sir Doug Turnbull (01/2016-07/2016).
• Diet as a Driver of Longevity and Healthy Cognitive Ageing: Lessons from the Newcastle 85 Study. Project Leader(s): Principal: Prof Carol Jagger, Co-PI: Prof John C. Mathers (10/2012-03/2015).

Lectures & Modules 

• Biology of Ageing 2014 (BMS2014): Epidemiology of Ageing & Healthy Ageing, School of Biomedical Sciences, Faculty of Medicine, Newcastle University; Biomedical Sciences BSc; 2015; 2017-Present.
• MMB8004 Ageing and Health: Epidemiology of Ageing, Newcastle University; 2019-Present.  
• MBBS Frailty and Ageing: Nutrition and Ageing, School of Medical Education, Newcastle University; 2019, 2022-Present.
• Accelerated MBBS: Nutrition and Ageing, School of Medical Education, Newcastle University; 2019, 2022-Present.
• MBBS Life Cycle 3 (PDS4.7): Epidemiology of Ageing, School of Medical Education, Newcastle University; 2017; 2018. 

Other academic involvement 

• Ageing, Sarcopenia, and Multimorbidity Newcastle BRC Theme EDI Lead, 2023.
• AGE Research Group & Long-term Conditions and Multimorbidity Theme EDI Lead, 2021-Present. 
• Newcastle BRC PhD studentship (2024-2027). Lead supervisor; PhD project: 'In-depth morphological characterisation of human skeletal muscle across the lifecourse: understanding selective vulnerability of type II muscle fibres with ageing'; Newcastle University and Northumbria University.
• CIMA PhD studentship; The MRC – Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (2018-2021): Co-supervisor; PhD thesis: ‘Whole food approaches to enhance exercise recovery, muscle strength and functional performance in older adults’; Faculty of Medical Sciences, Newcastle University (Lead: Prof Emma Stevenson).
• The Academic Foundation Program student co-supervision, 2020-2023.
• Newcastle University MBBS selector, 2020-2022.  
• MSc in Clinical Sciences E-learning masters dissertation module (MCR8013), Newcastle University Biosciences Institute, 2021.
• MRes in Ageing and Health (MMBS), Faculty of Medicine, Newcastle University, 2022.
• LIFE3135: Nutrition and Exercise in Epidemiology and Public Health. Nutritional Epidemiology and Muscle Health: focus on sarcopenia and frailty. University of Nottingham, Guest lecturer, 2022.
• NIHR Newcastle BRC training network; Supporting role for BRC PhD students (2017-2020): training opportunities and development within the Newcastle BRC.
• Newcastle BRC PhD studentship (2017-2021). Co-supervisor; PhD thesis: ‘Cellular senescence in muscle ageing’; Ageing Biology Centre, Newcastle University and Mayo Clinic, Rochester, USA (Lead: Prof Joao Passos).
• Introduction to quantitative research methods (HSC8053): Cohort studies in epidemiology. Graduate course. Faculty of Medical Sciences, FMS Graduate School, Newcastle University; Lead: Prof Blossom Stephan; 2016.
• MSc in Health Policy Programme (Module 3): Ageing and Health, Imperial College, London. Masters in Science. Guest speaker; 2015.
• NIHR/ESRC Doctoral Training Programme: Analysis of Large Datasets and Advanced Statistics in Health Research, Institute of Health and Society, Newcastle University; Lead: Prof Blossom Stephan; 2015.
• Instructing molecular and cell biology techniques in the Alzheimer's disease research laboratory, University of South Florida; 2006-2012. 

• Articles

  • Granic A, Cooper R, Robinson SM, Sayer AA. Myoprotective whole foods, muscle health and sarcopenia in older adults. Current Opinion in Clinical Nutrition and Metabolic Care 2024, 27(3), 244-251.
  • Rimmer L, Mann D, Sayer AA, Amarnath S, Granic A. A Silver Bullet for Ageing Medicine?: Clinical Relevance of T-Cell Checkpoint Receptors in normal Human Ageing. Frontiers in Immunology 2024, 15, 1360141.
  • Dismore L, Hurst C, Granic A, Tullo E, Witham MD, Dodds RM, Sayer AA, Robinson SM. Why are older adults living with the complexity of multiple long-term conditions, frailty and a recent deterioration in health under-served by research? A narrative synthesis review of the literature. Journal of Frailty, Sarcopenia and Falls 2023, 8(4), 230-239.
  • Robinson S, Granic A, Cruz-Jentoft AJ, Sayer AA. The role of nutrition in the prevention of sarcopenia. The American Journal of Clinical Nutrition 2023, 118(5), 852-864.
  • Dodds RM, Bunn JG, Hillman SJ, Granic A, Murray J, Witham MD, Robinson SM, Cooper R, Sayer AA. Simple approaches to characterising multiple long-term conditions (multimorbidity) and rates of emergency hospital admission: Findings from 495,465 UK Biobank participants. Journal of Internal Medicine 2023, 293(1), 100-109.
  • Witham MD, Granic A, Pearson E, Robinson SM, Sayer AA. Repurposing drugs for diabetes mellitus as potential pharmacological treatments for sarcopenia – a narrative review. Drugs Aging 2023, 40, 703–719.
  • Hayes EJ, Stevenson E, Sayer AA, Granic A, Hurst C. Recovery from resistance exercise in older adults: a systematic scoping review. Sports Medicine - Open 2023, 9, 51.
  • Witham MD, Granic A, Miwa S, Passos JF, Richardson GD, Sayer AA. New Horizons in cellular senescence for clinicians. Age and Ageing 2023, 52(7), afad127.
  • Granic A, Cooper R, Dodds RM, Hillman SJ, Sayer AA, Robinson SM. Milk intake across adulthood and muscle strength decline from mid- to late life: the MRC National Survey of Health and Development. British Journal of Nutrition 2023, 129(5), 820-831.
  • Granic A, Suetterlin K, Shavlakadze T, Grounds M, Sayer AA. Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men. Clinical Science 2023, 137(22), 1721-1751.
  • Hurst C, Dismore L, Granic A, Tullo E, Noble JM, Hillman SJ, Witham MD, Sayer AA, Dodds RM, Robinson SM. Feasibility of engaging older adults living with multiple long-term conditions, frailty, and a recent deterioration in health in a study of lifestyle: protocol for the LiLL-OPM study. Journal of Frailty, Sarcopenia and Falls 2023, 8(2), 127-135.
  • Hurst C, Dismore L, Granic A, Tullo E, Noble JM, Hillman SJ, Witham MD, Sayer AA, Dodds R, Robinson SM. Attitudes and barriers to resistance exercise training for older adults living with multiple long-term conditions, frailty, and a recent deterioration in health: Qualitative findings from the Lifestyle in Later Life – Older People’s Medicine (LiLL-OPM) study. BMC Geriatrics 2023, 23, 771.
  • Adamson A, Davies K, Wham C, Kepa M, Foster E, Jones A, Mathers J, Granic A, Teh R, Moyes S, Hayman K, Siervo M, Maxted E, Redwood K, Collerton J, Jagger C, Kirkwood T, Dyall L, Kerse N. Assessment of Dietary Intake in Three Cohorts of Advanced Age in Two Countries: Methodology Challenges. Journal of Nutrition, Health and Aging 2023, 27, 59-66.
  • Granic A, Hurst C, Dismore L, Dodds RM, Witham MD, Robinson SM, Sayer AA. Advanced glycation end products in skeletal muscle health and sarcopenia: A systematic review of observational studies. Mechanisms of Ageing and Development 2023, 209, 111744.
  • Habiballa L, Hruby A, Granic A, Dodds RM, Hillman SJ, Jurk D, Passos JF, Sayer AA. Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study. GeroScience 2023, 46, 1141–1158.
  • Hurst C, Robinson SM, Witham MD, Dodds RM, Granic A, Buckland C, DeBiase S, Finnegan S, Rochester L, Skelton DA, Sayer AA. Resistance exercise as a treatment for sarcopenia: prescription and delivery. Age and Ageing 2022, 51(2), afac003.
  • Hayes EJ, Stevenson E, Sayer AA, Granic A, Hurst C. Recovery from resistance exercise in older adults: a protocol for a scoping review. BMJ Open Sport & Exercise Medicine 2022, 8, e001229.
  • Granic A, Martin-Ruiz C, Rimmer L, Dodds RM, Robinson LA, Spyridopoulos I, Kirkwood TBL, von Zglinicki T, Sayer AA. Immunosenescence profiles of lymphocyte compartments and multiple long-term conditions (multimorbidity) in very old adults: The Newcastle 85+ Study. Mechanisms of Ageing and Development 2022, 208, 111739.
  • Zhang X, Habiballa L, Aversa Z, Ng YE, Sakamoto AE, Englund DA, Pearsall VM, White TA, Robinson MM, Rivas DA, Dasari S, Hruby AJ, Lagnado AB, Jachim SK, Granic A, Sayer AA, Jurk D, Lanza IR, Khosla S, Fielding RA, Nair KS, Schafer MJ, Passos JF, LeBrasseur NK. Characterization of cellular senescence in aging skeletal muscle. Nature Aging 2022, 2(7), 601-615.
  • Dodds RM, Hurst C, Hillman SJ, Davies K, Roberts L, Aspray TJ, Granic A, Sayer AA. Advancing our understanding of skeletal muscle across the lifecourse: Protocol for the MASS_Lifecourse study and characteristics of the first 80 participants. Experimental Gerontology 2022, 166, 111884.
  • Dodds RM, Murray JC, Granic A, Hurst C, Uwimpuhwe G, Richardson S, Brayne C, Matthews FE, Sayer AA, CFAS MRC. Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II (CFAS II) and proposed Newcastle protocol for use in the assessment of sarcopenia. Journal of Cachexia, Sarcopenia and Muscle 2021, 12(2), 308-318.
  • Hayes EJ, Granic A, Hurst C, Dismore L, Sayer AA, Stevenson E. Older adults' knowledge and perceptions of whole foods as an exercise recovery strategy. Frontiers in Nutrition 2021, 8, 748882.
  • Ni Lochlainn M, Cox NJ, Wilson T, Hayhoe RP, Ramsay SE, Granic A, Isanejad M, Roberts HC, Wilson D, Welch C, Hurst C, Atkins JL, Mendonça N, Horner K, Tuttiett ER, Morgan Y, Heslop P, Williams EA, Steves CJ, Greig C, Draper J, Corish CA, Welch A, Witham MD, Sayer AA, Robinson S. Nutrition and Frailty: Opportunities for Prevention and Treatment. Nutrients 2021, 13(7), 2349.
  • Robinson S, Granic A, Sayer AA. Micronutrients and sarcopenia: current perspectives. Proceedings of the Nutrition Society 2021, 80(3), 311-318.
  • Hurst C, Murray JC, Granic A, Hillman SJ, Cooper R, Sayer AA, Robinson SM, Dodds RM. Long-term conditions, multimorbidity, lifestyle factors and change in grip strength over 9 years of follow-up: findings from 44,315 UK Biobank participants. Age and Ageing 2021, 50(6), 2222-2229.
  • Yarnall AJ, Granic A, Waite S, Hollingsworth KG, Warren C, Vincent AE, Turnbull DM, Taylor RW, Dodds RM, Sayer AA. The feasibility of muscle mitochondrial respiratory chain phenotyping across the cognitive spectrum in Parkinson’s disease. Experimental Gerontology 2020, 138, 110997.
  • Dismore L, Hurst C, Sayer AA, Stevenson E, Aspray T, Granic A. Study of the older adults’ motivators and barriers engaging in a nutrition and resistance exercise intervention for sarcopenia: An embedded qualitative project in the MIlkMAN pilot study . Gerontology & Geriatric Medicine 2020, 6.
  • Dodds RM, Granic A, Robinson SM, Sayer AA. Sarcopenia, long-term conditions and multimorbidity: findings from UK Biobank participants. Journal of Cachexia Sarcopenia and Muscle 2020, 11(1), 62-68.
  • Mendonça N, Kingston A, Granic A, Jagger C. Protein intake and transitions between frailty states and to death in very old adults: the Newcastle 85+ study. Age and Ageing 2020, 49(1), 32–38.
  • Granic A, Dismore L, Hurst C, Robinson SM, Sayer AA. Myoprotective whole foods, muscle health and sarcopenia: a systematic review of observational and intervention studies in older adults. Nutrients 2020, 12(8), 2257.
  • Granic A, Hurst C, Dismore L, Aspray T, Stevenson E, Witham MD, Sayer AA, Robinson S. Milk for skeletal muscle health and sarcopenia in older adults: a narrative review. Clinical Interventions in Aging 2020, 2020(15), 695-714.
  • Granic A, Martin-Ruiz C, Dodds RM, Robinson L, Spyridopoulos I, Kirkwood TBL, von Zglinicki T, Sayer AA. Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study. Mechanisms of Ageing and Development 2020, 190, 111321.
  • Granic A, Hurst C, Dismore L, Stevenson E, Sayer AA, Aspray T. Feasibility and acceptability of a milk and resistance exercise intervention to improve muscle function in community-dwelling older adults (MIlkMAN): Pilot study . PLoS ONE 2020, 15(7), e0235952.
  • Granic A, Mendonça N, Sayer AA, Hill TR, Davies K, Siervo M, Mathers JC, Jagger C. Effects of dietary patterns and low protein intake on sarcopenia risk in the very old: the Newcastle 85+ Study. Clinical Nutrition 2020, 39(1), 166-173.
  • Mendonça N, Kingston A, Granic A, Hill TR, Mathers JC, Jagger C. Contribution of protein intake and its interaction with physical activity to transitions between disability states and to death in very old adults: the Newcastle 85+ Study. European Journal of Nutrition 2020, 59, 1909-1918.
  • Dodds RM, Pakpahan E, Granic A, Davies K, Sayer AA. The recent secular trend in grip strength among older adults: findings from the English Longitudinal Study of Ageing. European Geriatric Medicine 2019, 10(3), 395-401.
  • Mendonca N, Jagger C, Granic A, Martin-Ruiz C, Mathers JC, Seal CJ, Hill TR. Plasma Vitamin B12, Supplementation and Mortality. The Journals of Gerontology: Series A 2019, 74(1), 138-138.
  • Robinson S, Granic A, Sayer AA. Nutrition and Muscle Strength, As the Key Component of Sarcopenia: An Overview of Current Evidence. Nutrients 2019, 11(12), 2942.
  • Granic A, Hurst C, Dismore L, Davies K, Stevenson E, Sayer AA, Aspray T. Milk and resistance exercise intervention to improve muscle function in community-dwelling older adults at risk of sarcopenia (MIlkMAN): protocol for a pilot study. BMJ Open 2019, 9(10), e031048.
  • Shannon O, Stephan BCM, Granic A, Lentjes M, Hayat S, Mulligan A, Brayne C, Khaw KT, Bundy R, Aldred S, Hornberger M, Paddick S-M, Muniz-Tererra G, Minihane A-M, Mathers JCM, Siervo M. Mediterranean diet adherence and cognitive function in older UK adults: the European Prospective Investigation into Cancer and Nutrition–Norfolk (EPIC-Norfolk) Study. The American Journal of Clinical Nutrition 2019, 110(4), 938-948.
  • Granic A, Davies K, Dodds RM, Duncan R, Uwimpuhwe G, Pakpahan E, Robinson S, Sayer AA. Factors associated with change in self-reported physical activity in the very old: The Newcastle 85+ Study. PLoS ONE 2019, 14(7), e0218881.
  • Potter H, Chial HJ, Caneus J, Elos M, Elder N, Borysov S, Granic A. Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative and Neurodevelopmental Disorders. Frontiers in Genetics 2019, 10, 1092.
  • Mendonça N, Granic A, Hill TR, Siervo M, Mathers JC, Kingston A, Jagger C. Protein intake and disability trajectories in the very old: The Newcastle 85+ Study. Journal of the American Geriatrics Society 2018, 67(1), 50-56.
  • Granic A, Mendonça N, Hill TR, Jagger C, Stevenson EJ, Mathers JC, Sayer AA. Nutrition in the Very Old. Nutrients 2018, 10(3), 269.
  • Caneus J, Granic A, Rademakers R, Dickson DW, Coughlan CM, Chial HJ, Potter H. Mitotic Defects Lead to Neuronal Aneuploidy and Apoptosis in Frontotemporal Lobar Degeneration Caused by MAPT Mutations. Molecular Biology of the Cell 2018, 29(5), 575-586.
  • Dodds RM, Davies K, Granic A, Hollingsworth KG, Warren C, Gorman G, Turnbull DM, Sayer AA. Mitochondrial respiratory chain function and content are preserved in the skeletal muscle of active very old men and women. Experimental Gerontology 2018, 113, 80-85.
  • Stephan BCM, Muniz-Terrera G, Granic A, Collerton J, Davies K, Saxby BK, Wesnes KA, Kirkwood TBL, Jagger C. Longitudinal changes in global and domain specific cognitive function in the very-old: findings from the Newcastle 85+ Study. International Journal of Geriatric Psychiatry 2018, 33(2), 298-306.
  • Granic A, Mossop H, Engstrom G, Davies K, Dodds R, Galvin JE, Ouslander JG, Tappen R, Sayer AA. Factors associated with physical performance measures in a multiethnic cohort of older adults. Gerontology and Geriatric Medicine 2018, 4, 1-14.
  • Mendonça N, Jagger C, Granic A, Martin-Ruiz C, Mathers JC, Seal CJ, Hill TR. Elevated total homocysteine in all participants and plasma vitamin B12 concentrations in women are associated with all-cause and cardiovascular mortality in the very old: The Newcastle 85+ Study. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences 2018, 73(9), 1258-1264.
  • Granic A, Hill TR, Davies K, Jagger C, Adamson A, Siervo M, Kirkwood TBL, Mathers JC, Sayer AA. Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study. Nutrients 2017, 9(4), 379.
  • Dodds RM, Granic A, Davies K, Kirkwood TBL, Jagger C, Sayer AA. Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study. Journal of Cachexia, Sarcopenia and Muscle 2017, 8(2), 229-237.
  • Mendonca N, Granic A, Mathers JC, Hill TR, Siervo M, Adamson AJ, Jagger C. Prevalence and determinants of low protein intake in very old adults: insights from the Newcastle 85+ Study. European Journal of Nutrition 2017, 57(8), 2713-2722.
  • Harrison SL, de Craen AJM, Kerse N, Teh R, Granic A, Davies K, Wesnes KA, den Elzen WPJ, Gussekloo J, Kirkwood TBL, Robinson L, Jagger C, Siervo M, Stephan CMB. Predicting Risk of Cognitive Decline in Very Old Adults Using Three Models: The Framingham Stroke Risk Profile; the Cardiovascular Risk Factors, Aging, and Dementia Model; and Oxi-Inflammatory Biomarkers. Journal of the American Geriatrics Society 2017, 65(2), 381-389.
  • Mendonca N, Granic A, Mathers JC, Martin-Ruiz C, Wesnes KA, Seal CJ, Jagger C, Hill TR. One-Carbon Metabolism Biomarkers and Cognitive Decline in the Very Old: The Newcastle 85+ Study. Journal of the American Medical Directors Association 2017, 18(9), 806.e19-806.e27.
  • Rygiel KA, Dodds RM, Patel HP, Syddall HE, Westbury LD, Granic A, Cooper C, Cliff J, Rocha MC, Turnbull DM, Sayer AA. Mitochondrial respiratory chain deficiency in older men and its relationship with muscle mass and performance. Journal of Cachexia, Sarcopenia and Muscle - Clinical Reports 2017, 2(2), e00035.
  • Granic A, Mendonca N, Sayer AA, Hill TR, Davies K, Adamson A, Siervo M, Mathers JC, Jagger C. Low protein intake, muscle strength and physical performance in the very old: the Newcastle 85+ Study. Clinical Nutrition 2017, 37(6), 2260-2270.
  • Granic A, Davies K, Jagger C, Dodds R, Kirkwood TBL, Sayer AA. Initial level and rate of change in grip strength predict all-cause mortality in very old adults. Age and Ageing 2017, 46(6), 970-976.
  • Mendonca N, Granic A, Mathers JC, Martin-Ruiz C, Wesnes KA, Seal CJ, Jagger C, Hill TR. Homocysteine, Tryptophan, and Cognition in the Very Old. Journal of the American Medical Directors Association 2017, 18(10), 895-896.
  • Granic A, Davies K, Martin-Ruiz C, Jagger C, Kirkwood TBL, von Zglinicki T, Sayer AA. Grip strength and inflammatory biomarker profiles in very old adults. Age and Ageing 2017, 46(6), 976-982.
  • Hill TR, Mendonca N, Granic A, Siervo M, Jagger C, Seal CJ, Kerse N, Wham C, Adamson AJ, Mathers JC. What do we know about the nutritional status of the very old? Insights from three cohorts of advanced age from the UK and New Zealand. Proceedings of the Nutrition Society 2016, 75(3), 420-430.
  • Hill TR, Granic A, Davies K, Collerton J, Martin-Ruiz C, Siervo M, Mathers JC, Adamson AJ, Francis RM, Pearce SH, Razvi S, Kirkwood TBL, Jagger C. Serum 25-hydroxyvitamin D concentration and its determinants in the very old: The Newcastle 85+ study. Osteoporosis International 2016, 27(3), 1199-1208.
  • Mendonça N, Hill TR, Granic A, Davies K, Collerton J, Mathers JD, Siervo M, Wrieden WL, Seal CJ, Kirkwood TBL, Jagger C, Adamson AJ. Micronutrient intake and food sources in the very old: Analysis of the Newcastle 85+ Study. British Journal of Nutrition 2016, 116(4), 751-761.
  • Mendonça N, Hill TR, Granic A, Davies K, Collerton J, Mathers JC, Siervo M, Wrieden WL, Seal C, Jagger C, Adamson AJ. Macronutrient intake and food sources in the very old: analysis of the Newcastle 85+ Study. British Journal of Nutrition 2016, 115(12), 2170-2180.
  • Granic A, Davies K, Jagger C, Kirkwood T, Syddall HE, Sayer AA. Grip strength decline and its determinants in the very old: longitudinal findings from the Newcastle 85+ Study. PLoS ONE 2016, 11(9), e0163183.
  • Granic A, Jagger C, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Sayer AA. Effect of dietary patterns of muscle strength and physical performance in the very old: findings from the Newcastle 85+ Study. PLOS One 2016, 11(3), e0149699.
  • Granic A, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Jagger C. Dietary Patterns High in Red Meat, Potato, Gravy, and Butter Are Associated with Poor Cognitive Functioning but Not with Rate of Cognitive Decline in Very Old Adults. Journal of Nutrition 2016, 146(2), 265-274.
  • Granic A, Hill TR, Kirkwood TBL, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Saxby BK, Wesnes KA, Collerton D, Mathers JC, Jagger C. Serum 25-hydroxyvitamin D and cognitive decline in the very old: The Newcastle 85+ study. European Journal of Neurology 2015, 22(1), 106-e7.
  • Harrison SL, Stephan BCM, Siervo M, Granic A, Davies K, Wesnes KA, Kirkwood TBL, Robinson L, Jagger C. Is There an Association Between Metabolic Syndrome and Cognitive Function in Very Old Adults? The Newcastle 85+Study. Journal of the American Geriatrics Society 2015, 63(4), 667-675.
  • Granic A, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Jagger C. Dietary Patterns and Socioeconomic Status in the Very Old: The Newcastle 85+ Study. PLoS ONE 2015, 10(10), e0139713.
  • Peters R, Collerton J, Granic A, Davies K, Kirkwood T, Jagger C. Antihypertensive drug use and risk of cognitive decline in the very old: an observational study, The Newcastle 85+ Study. The Journal of Hypertension 2015, 33(10), 2156-2164.
  • Granic A, Aspray T, Hill T, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Kirkwood TB, Mathers JC, Jagger C. 25-hydroxyvitamin D and increased all-cause mortality in very old women: the Newcastle 85+ study. Journal of Internal Medicine 2015, 277(4), 456-467.
  • Granic A, Potter H. Mitotic Spindle Defects and Chromosome Mis-Segregation Induced by LDL/Cholesterol--Implications for Niemann Pick C1, Alzheimer’s, and Atherosclerosis. PLoS ONE 2013, 8(4), 1-16.
  • Granic A, Andel R, Dhal A, Gatz M, Pedersen NL. Midlife dietary patterns and mortality in the population-based study of Swedish twins. Journal of Epidemiology and Community Health 2013, 67(7), 578-586.
  • Borysov SI, Granic A, Padmanabhan J, Norden M, Walcsak C, Potter H. Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors. Cell Cycle 2011, 10(9), 1397-1410.
  • Young TL, Granic A, Chen T, Haley C, Edwards JD. Everyday reasoning abilities in persons with Parkinson’s disease. Movement Disorders 2010, 25(16), 2756-2761.
  • Granic A, Padmanabhan J, Norden M, Potter H. Alzheimer Aβ Peptide Induces Chromosome Mis-Segregation and Aneuploidy, Including Trisomy 21: Requirement for Tau and APP. Molecular Biology of the Cell 2010, 21(4), 511-520.
  • Boeras DI, Granic A, Padmanabhan J, Crespo NC, Rojiani AM, Potter H. Alzheimer’s presenilin 1 cause chromosome missegregation and aneuploidy. Neurobiology of Aging 2008, 29(3), 319-328.

• Book Chapters

  • Hill TR, Granic A, Aspray TJ. Vitamin D and Ageing. In: J. Robin Harris and Viktor I. Korolchuk, ed. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science. Singapore: Springer, 2018, pp.191-220.
  • Caneus J, Granic A, Chial HJ, Potter H. Using Fluorescence In Situ Hybridization (FISH) Analysis to Measure Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative Diseases. In: Frade, JM; Gage, FH, ed. Genomic Mosaicism in Neurons and Other Cell Types. Humana Press, 2017, pp.329-359.
  • Granic A, Potter H. Down Syndrome Model of Alzheimer's Disease: Beyond Trisomy 21 Nondisjunction. In: Subrata Dey, ed. Genetics and Etiology of Down Syndrome. Rijeka, Croatia: InTech, 2011, pp.159-176.

• Conference Proceedings (inc. Abstracts)

  • Birkbeck MG, Hillman S, Hurst C, Granic A, Aspray T, Sayer AA, Dodds RM. Assessing changes in physical activity in community dwelling older adults before and after COVID-19 restrictions in the United Kingdom. In: International Sarcopenia Translational Research Conference 2021. 2021, Virtual: Hylonome Publications.
  • Granic A, Davies K, Jagger C, Kirkwood T, Syddal HE, Sayer AA. Grip strength decline and its determinants in the very old: longitudinal findings from the Newcastle 85+ Study. In: 60th Annual Scientific Meeting Society for Social Medicine. 2016, York: BMJ Group.
  • Harrison S, Siervo M, Granic A, Davies K, Kirkwood T, Robinson L, Jagger C, Stephan BC. The Framingham Stroke Risk Score and elevated biomarkers predict cognitive impairment in the very old. In: Gerontological Society of America 68th Annual Scientific Meeting. 2015, Washington, DC: Oxford University Press.
  • Mendonaca N, Hill TR, Granic A, Mathers JC, Wrieden W, Siervo M, Seal C, Jagger C, Adamson AJ. Micronutrient intake and food sources in the very old. In: Irish Section Meeting, Nutrition at key life stages: new findings, new approaches. 2015, Cork, Ireland: Cambridge University Press.
  • Mendonca N, Hill TR, Granic A, Mathers JC, Wrieden W, Siervo M, Seal C, Jagger C, Adamson AJ. Dietary intake and food sources in the very old. In: Nutrition Society Irish Section Meeting. 2015, Cork, Ireland: Cambridge University Press.
  • Mendonca N, Granic A, Mathers JC, Wrieden W, Siervo M, Seal C, Jagger C, Adamson AJ, Hill TR. Contribution of animal products to dietary intakes in the very old. In: Nutrition Society Summer Meeting 2015. 2015, Nottingham University, UK: Cambridge University Press.
  • Harrison S, Stephan BC, Siervo M, Granic A, Davies K, Robinson L, Kirkwood T, Jagger C. Metabolic syndrome and cognitive decline in the very old; the Newcastle 85+ study. In: Gerontological Society of America 67th Annual Scientific Meeting. 2014, Washington DC: Oxford University Press.
  • Granic A, Davies K, Adamson A, Mathers JC, Kirkwood T, Siervo M, Jagger C. Food for Thought: Dietary Patterns and Their Effects on Cognitive Decline in the Newcastle 85+ Study. In: Gerontological Society of America 67th Annual Scientific Meeting. 2014, Washington, DC: Oxford University Press.
  • Granic A, Hill T, Kirkwood T, Davies K, Collerton J, Mathers JC, Jagger C. Association between serum 25(OH)D and the risk of cognitive decline in the very old: The Newcastle 85+study. In: Nutrition Society Annual Summer Meeting. 2013, Newcastle upon Tyne, UK: Cambridge University Press.
  • Granic A, Kirkwood T, Davies K, Collerton J, Hill T, Martin-Ruiz C, vonZglinicki T, Aspray T, Mathers JC, Jagger C. 25-hydroxyvitamin D and increased risk of all-cause mortality in very old women: The Newcastle 85+ study. In: UK Molecular Epidemiology Group (MEG) Winter Meeting on The Future of Epidemiology: Biomarkers meet Populations. 2013, Newcastle University: Oxford University Press.

• Reviews

  • Granic A, Sayer AA, Robinson SM. Dietary patterns, skeletal muscle health and sarcopenia in older adults. Nutrients 2019, 11(4), 745.
  • Potter H, Granic A, Caneus J. Role of trisomy 21 mosaicism in sporadic and familial Alzheimer's disease. Current Alzheimer Research 2016, 13(1), 7-17.