Staff Profile

Current role

Dr Augustinas Silale joined Prof Bert van den Berg's laboratory as a postdoctoral researcher in November 2019. 

Research interests

• Structural biology (X-ray crystallography, cryo-EM)
• Membrane proteins
• Gram-negative bacteria
• Gut microbiota

Qualifications

2015-2019 - DPhil, University of Oxford

2011-2015 - BA (Hons) & MSci Natural Sciences, University of Cambridge

• Articles

  • White JBR, Silale A, Feasey M, Heunis T, Zhu Y, Zheng H, Gajbhiye A, Firbank S, Baslé A, Trost M, Bolam DN, van den Berg B, Ranson NA. Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes. Nature 2023, 618(7965), 583-589.
  • Silale A, Zhu Y, Witwinowski J, Smith RE, Newman KE, Bhamidimarri SP, Basle A, Khalid S, Beloin C, Gribaldo S, van den Berg B. Dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes. Nature Communications 2023, 14, 7152.
  • Abellon-Ruiz J, Jana K, Silale A, Frey AM, Baslé A, Trost M, Kleinekathöfer U, van den Berg B. BtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B₁₂ uptake in gut Bacteroides. Nature Communications 2023, 14, 4714.
  • van den Berg B, Silale A, Baslé A, Brandner AF, Mader SL, Khalid S. Structural basis for host recognition and superinfection exclusion by bacteriophage T5. Proc Natl Acad Sci U S A 2022, 119(42), e2211672119.

• Review

  • Silale A, van den Berg B. TonB-Dependent Transport Across the Bacterial Outer Membrane. Annual Review of Microbiology 2023, 77, 67-88.