Staff Profile
Dr David Bulmer
Experimental Scientific Officer
- Telephone: +44 (0) 191 208 6813
- Address: Bio-Imaging Unit
Newcastle University
The Medical School
Framlington Place
Newcastle upon Tyne
NE2 4HH
Publications
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Articles
- Hipps D, Dobson PF, Warren C, McDonald D, Fuller A, Filby A, Bulmer D, Laude A, Russell O, Deehan DJ, Turnbull DM, Lawless C. Detecting respiratory chain defects in osteoblasts from osteoarthritic patients using imaging mass cytometry. Bone 2022, 158, 116371.
- Somboon K, Doble A, Bulmer D, Baslé A, Khalid S, van den Berg B. Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion. Nature Communications 2020, 11, 6331.
- Meekrathok P, Stubbs KA, Aunkham A, Kaewmaneewat A, Kardkuntod A, Bulmer DM, van den Berg B, Suginta W. NAG-thiazoline is a potent inhibitor of the Vibrio campbellii GH20 β-N-Acetylglucosaminidase. The FEBS Journal 2020, 287(22), 4982-4995.
- Ndeh D, Munoz JM, Cartmell A, Bulmer D, Wills C, Henrissat B, Gray J. The human gut microbe Bacteroides thetaiotaomicron encodes the founding member of a novel glycosaminoglycan-degrading polysaccharide lyase family PL29. Journal of Biological Chemistry 2018, 293(46), 17906-17916.
- Suginta W, Sritho N, Ranok A, Bulmer DM, Kitaoku Y, van den Berg B, Fukamizo T. Structure and function of a novel periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria. Journal of Biological Chemistry 2018, 293(14), 5150-5159.
- Dean P, Quitard S, Bulmer D, Roe AJ, Kenny B. Cultured enterocytes internalise bacteria across their basolateral surface for, pathogen-inhibitable, trafficking to the apical compartment. Scientific Reports 2015, 5, 17359.
- El-Sayed Ali M, Bulmer DM, Dettmar PW, Pearson JP. Mucin Gene Expression in Reflux Laryngeal Mucosa:Histological and In Situ Hybridization Observations. International Journal of Otolaryngology 2014, 2014, 264075.
- Bulmer DM, Kharraz L, Grant AJ, Dean P, Morgan FJ, Karavolos MH, Doble AC, McGhie EJ, Koronakis V, Daniel RA, Mastroeni P, Khan CMA. The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella. PLoS Pathogens 2012, 8(1), e1002500.
- Staniewicz L, Donald AM, Stokes DJ, Thomson N, Sivaniah E, Grant A, Bulmer D, Khan A. The Application of STEM and In situ Controlled Dehydration to Bacterial Systems Using ESEM. Scanning 2012, 34(4), 237-246.
- Karavolos MH, Bulmer D, Spencer H, Rampioni G, Schmalen I, Baker S, Pickard D, Gray J, Fookes M, Winzer K, Ivens A, Dougan G, Williams P, Khan CMA. Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E. EMBO Reports 2011, 12(3), 252-258.
- Boonyom R, Karavolos MH, Bulmer DM, Khan CM. Salmonella pathogenicity island 1 (SPI-1) type III secretion of SopD involves N- and C-terminal signals and direct binding to the InvC ATPase. Microbiology 2010, 156(6), 1805-1814.
- Bulmer DM, Ali MS, Brownlee IA, Dettmar PW, Pearson JP. Laryngeal Mucosa: Its Susceptibility to Damage by Acid and Pepsin. Laryngoscope 2010, 120(4), 777-782.
- Spencer H, Karavolos MH, Bulmer DM, Aldridge P, Chhabra SR, Winzer K, Williams P, Khan CMA. Genome-Wide Transposon Mutagenesis Identifies a Role for Host Neuroendocrine Stress Hormones in Regulating the Expression of Virulence Genes in Salmonella. Journal of Bacteriology 2010, 192(3), 714-724.
- Perrett CA, Karavolos MH, Humphrey S, Mastroeni P, Martinez-Argudo I, Spencer H, Bulmer D, Winzer K, McGhie E, Koronakis V, Williams P, Khan CMA, Jepson MA. LuxS-Based Quorum Sensing Does Not Affect the Ability of Salmonella enterica Serovar Typhimurium To Express the SPI-1 Type 3 Secretion System, Induce Membrane Ruffles, or Invade Epithelial Cells. Journal of Bacteriology 2009, 191(23), 7253-7259.
- Karavolos MH, Bulmer DM, Winzer K, Wilson M, Mastroeni P, Williams P, Khan CMA. LuxS affects flagellar phase variation independently of quorum sensing in Salmonella enterica serovar typhimurium. Journal of Bacteriology 2008, 190(2), 769-771.
- McKelvie ND, Khan SA, Karavolos MH, Bulmer DM, Lee JJ, DeMarco R, Maskell DJ, Zavala F, Hormaeche CE, Anjam Khan CM. Genetic detoxification of an aroA Salmonella enterica serovar Typhimurium vaccine strain does not compromise protection against virulent Salmonella and enhances the immune responses towards a protective malarial antigen. FEMS Immunology and Medical Microbiology 2008, 52(2), 237-246.
- Karavolos MH, Spencer H, Bulmer DM, Thompson A, Winzer K, Williams P, Hinton JCD, Anjam Khan CM. Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses. BMC Genomics 2008, 9(1), 458.
- Liu W-T, Karavolos MH, Bulmer DM, Allaoui A, Hormaeche RDCE, Lee JJ, Anjam Khan CM. Role of the universal stress protein UspA of Salmonella in growth arrest, stress and virulence. Microbial Pathogenesis 2007, 42(1), 2-10.
- Paleri V, Pearson JP, Bulmer D, Jeannon JP, Wight RG, Wilson JA. Expression of much gene products in laryngeal squamous cancer. Otolaryngology - Head and Neck Surgery 2004, 131(1), 84-88.
- Bulmer D, Ross PE, Axford SE, Johnston N, Gill GA, Pearson JP, Dettmar PW, Panetti M, Pignatelli M, Koufman JA. Cell biology of laryngeal epithelial defenses in health and disease: Further studies. Annals of Otology, Rhinology and Laryngology 2003, 112(6), 481-491.
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Conference Proceedings (inc. Abstract)
- Macfarlane JG, Ruchaud-Sparagano MH, Scott JA, Bulmer DA, Khan CMA, Simpson AJ. Src Kinase Inhibition Attenuates Neutrophil Degranulation Without Impairing Bacterial Killing: A Possible Therapeutic Strategy for Acute Lung Injury?. In: British Thoracic Society Winter Meeting. 2013, London, UK: BMJ Publishing Group.
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Editorial
- Doble AC, Bulmer DM, Kharraz L, Karavolos MH, Khan CMA. The function of the bacterial cytoskeleton in Salmonella pathogenesis. Virulence 2012, 3(5), 446-449.