Staff Profile

I am a Honorary Consultant Rheumatologist at Newcastle Hospitals and a NIHR SCPRA Senior Clinical Fellow at Newcastle University. I have interest in type 1 interferons and their role in autoimmune disease, particularly rheumatoid arthritis.

• Articles

  • Cooles FAH, Vidal Pedrola G, Naamane N, Pratt AG, Barron-Millar B, Anderson AE, Hilkens CMU, Casement J, Bondet V, Duffy D, Zhang F, Shukla R, Isaacs JD. Endogenous Retroelement Activation is Implicated in Interferon-α Production and Anti–Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis. Arthritis and Rheumatology 2025, epub ahead of print.
  • Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J, Smith GR, Allen B, Casement J, Diboll J, Harry R, Cooles FAH, Cope AP, Simpson G, Toward R, Noble H, Parke A, Wu W, Clarke F, Scott D, Scott IC, Galloway J, Lempp H, Ibrahim F, Schwank S, Molyneux G, Lazarov T, Geissmann F, Goodyear CS, McInnes IB, Donnelly I, Gilmour A, Virlan AT, Porter D, Ponchel F, Emery P, El-Jawhari J, Parmar R, McDermott MF, Fisher BA, Young SP, Jones P, Raza K, Filer A, Pitzalis C, Barnes MR, Watson DS, Henkin R, Thorborn G, Fossati-Jimack L, Kelly S, Humby F, Bombardieri M, Rana S, Jia Z, Goldmann K, Lewis M, Ng S, Barbosa-Silva A, Tzanis E, Gallagher-Syed A, John CR, Ehrenstein MR, Altobelli G, Martins S, Nguyen D, Ali H, Ciurtin C, Buch M, Symmons D, Worthington J, Bruce IN, Sergeant JC, Verstappen SMM, Stirling F, Hughes-Morley A, Tom B, Farewell V, Zhong Y, Taylor PC, Buckley CD, Keidel S, Cuff C, Levesque M, Long A, Liu Z, Lipsky S, Harvey B, Macoritto M, Hong F, Kaymakcalan S, Tsuji W, Sabin T, Ward N, Talbot S, Padhji D, Sleeman M, Finch D, Herath A, Lindholm C, Jenkins M, Ho M, Hollis S, Marshall C, Parker G, Page M, Edwards H, Cuza A, Gozzard N, Pandis I, Rowe A, Capdevila FB, Loza MJ, Curran M, Verbeeck D, Dan Baker, Mela CM, Vranic I, Mela CT, Wright S, Rowell L, Vernon E, Joseph N, Payne N, Rao R, Binks M, Belson A, Ludbrook V, Hicks K, Tipney H, Ellis J, Hasan S, Didierlaurent A, Burny W, Haynes A, Larminie C, Harris R, Dastros-Pitei D, Carini C, Kola B, Jelinsky S, Hodge M, Maciejewski M, Ziemek D, Schulz-Knappe P, Zucht H-D, Budde P, Coles M, Butler JA, Read S. RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients. Scientific Data 2022, 9(1), 196.
  • Lin CMA, Cooles FAH, Isaacs JD. Precision medicine: the precision gap in rheumatic disease. Nature Reviews Rheumatology 2022, 18, 725-733.
  • Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CMA, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG, Isaacs JD. Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming. Annals of the Rheumatic Diseases 2022, 81(9), 1214-1223.
  • Funston W, Ruchaud-Sparagano M-H, Scott J, Powell J, Cooles FAH, Shelmerdine L, McDowell C, O'Leary D, Booth KL, Clark SC, Ledingham SJ, Rostron AJ, Dark JH, Simpson AJ. A human model of bilateral pulmonary vein sampling to assess the effects of one-lung ventilation on neutrophil function. PLoS ONE 2022, 17(7), e0271958.
  • Cooles FAH, Anderson AE, Skelton A, Pratt AG, Kurowska-Stolarska MS, McInnes I, Hilkens CMU, Isaacs JD. Phenotypic and transcriptomic analysis of peripheral blood plasmacytoid and conventional dendritic cells in early drug naïve rheumatoid arthritis. Frontiers in Immunology 2018, 9, 755.
  • Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ. Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients. American Journal of Respiratory and Critical Care Medicine 2018, 198(3), 340-349.
  • Cooles FAH, Anderson AE, Drayton T, Harry RA, Diboll J, Munro L, Thalayasingham N, Ostor AJK, Isaacs JD. Immune reconstitution 20 years after treatment with alemtuzumab in a rheumatoid arthritis cohort: implications for lymphocyte depleting therapies. Arthritis Research & Therapy 2016, 18, 302.
  • Powell J, Cooles FAH, Carrie S, Paleri V. Is undergraduate medical education working for ENT surgery? A survey of UK medical school graduates. Journal of Laryngology and Otology 2011, 125(9), 896-905.
  • Cooles FAH, Isaacs JD. Treating to re-establish tolerance in inflammatory arthritis - lessons from other diseases. Best Practice & Research: Clinical Rheumatology 2010, 24(4), 497-511.

• Conference Proceedings (inc. Abstract)

  • Cooles FAH, Anderson AE, Hilkens C, Isaacs JD. The Interferon Gene Signature in Early Rheumatoid Arthritis Demonstrates No Significant Association with Disease Activity. In: 2015 ACR/ARHP Annual Meeting. 2015, San Francisco, CA, USA: Wiley.

• Letters

  • Cooles FAH, Anderson AE, Lendrem DW, Norris J, Pratt AG, Hilkens CMU, Isaacs JD. The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy. Journal of Allergy and Clinical Immunology 2017, 141(1), 445-448.e4.
  • Cooles FAH, Pratt AG, Lendrem DW, Ng WF, Aspray TJ, Isaacs JD. Retrospective analysis of the role of serum vitamin D in early rheumatic disease. Rheumatology 2015, 54(2), 374-375.
  • Cooles FAH, Pratt AG, Wilson G, Isaacs JD, Ng WF. Prevalence and diagnostic outcome relating to vitamin D deficiency in new patients presenting to an early arthritis clinic over 12 months. Clinical Rheumatology 2011, 30(8), 1137-1138.
  • Cooles FAH, Jackson GH, Menon G, Isaacs JD. Epstein-Barr virus-driven lymphoproliferative disorder post-CAMPATH-1H (alemtuzumab) in refractory polymyositis. Rheumatology 2011, 50(4), 810-812.

• Reviews

  • Lin CMA, Isaacs JD, Cooles FAH. Role of IFN-α in Rheumatoid Arthritis. Current Rheumatology Reports 2024, 26, 37–52.
  • Cooles FAH, Isaacs JD. The interferon gene signature as a clinically relevant biomarker in autoimmune rheumatic disease. The Lancet Rheumatology 2022, 4(1), e61-e72.
  • Reynolds G, Cooles FAH, Isaacs JD, Hilkens CMU. Emerging immunotherapies for rheumatoid arthritis. Human Vaccines & Immunotherapeutics 2014, 10(4), 822-837.
  • Cooles FA, Isaacs JD, Anderson AE. Treg Cells in Rheumatoid Arthritis: An Update. Current Rheumatology Reports 2013, 15(9), 1-9.
  • Cooles FAH, Isaacs JD. Pathophysiology of rheumatoid arthritis. Current Opinion in Rheumatology 2011, 23(3), 233-240.