Staff Profile

I am currently an Academic Clinical Lecturer (NIHR) and Paediatric Registrar in Immunology and Infectious Diseases. I completed a post-doctoral Academic Clinical Fellowship in Newcastle following an integrated MB PhD and foundation training in London. My thesis examined an inducible model of ZAP70 deficiency focussing on the role of T cell receptor signalling in T cell homeostasis. Work during my Academic Clinical Fellowship involved the characterisation of a novel inborn error of the immune system caused by NUDCD3 deficiency, a chaperone protein with no previously known role in the immune system. I have recently been awarded a Starter Grant for Clinical Lecturers to study how immuno and thymoproteasome dysfunction through naturally occuring variants in PSMB10 causes impaired T cell function and development.

My research focuses on developing a detailed molecular and cellular understanding of known and novel pathways that regulate T cell homeostasis specifically by investigating children who have impaired T cell development or function.

• Articles

  • van der Made C, Kersten S, Chorin O, Engelhardt KR, Ramakrishnan G, Griffin H, van der Loeff IS, Venselaar H, Rothschild AR, Segev M, Schuurs-Hoeijmakers JHM, Mantere T, Essers R, Esteki MZ, Avital AL, Loo PS, Simons A, Pfundt R, Warris A, Seyger MM, van de Veerdonk F, Netea MG, Slatter MA, Flood T, Gennery AR, Simon AM, Lev A, Frizinsky S, Barel O, van der Burg M, Somech R, Hambleton S, Henriet SRVS, Hoischen A. Expanding the PRAAS spectrum: De novo mutations of immunoproteasome subunit b- type 10 in six infants with SCID-Omenn syndrome. American Journal of Human Genetics 2024, (ePub ahead of Print).
  • Chen R, Lukianova E, van der Loeff IS, Spegarova JS, Willet JDP, James KD, Ryder EJ, Griffin H, IJspeert H, Gajbhiye A, Lamoliatte F, Marin-Rubio JL, Woodbine L, Lemos H, Swan DJ, Pintar V, Sayes K, Ruiz-Morales ER, Eastham S, Dixon D, Prete M, Prigmore E, Jeggo P, Boyes J, Mellor A, Huang L, van der Burg M, Engelhardt KR, Stray-Pedersen A, Erichsen HC, Gennery AR, Trost M, Adams DJ, Anderson G, Lorenc A, Trynka G, Hambleton S. NUDCD3 deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome. Science Immunology 2024, 9(95), eade5705.
  • Vlachogiannis N, Baker K, Georgiopoulos G, Lazaridis C, Schim van der Loeff I, Hanrath A, Sopova K, Tual-Chalot S, Gatsiou A, Spyridopoulos I, Stamatelopoulos K, Duncan C, Stellos K. Clinical frailty, and not features of acute infection, is associated with late mortality in COVID-19: a retrospective cohort study. Journal of Cachexia, Sarcopenia and Muscle 2022, 13(3), 1502-1513.
  • Tsilifis C, Schim van der Loeff I, Williams E, Owens S, Powell S, Gennery AR, Slatter M. BCG lymphadenitis: a potential complication of immune reconstitution following haematopoietic stem cell transplant. Archives of Diseases in Childhood: Education and Practice Edition 2022, 107(4), 274-275.
  • Stephenson E, Reynolds G, Botting RA, Calero-Nieto FJ, Morgan MD, Tuong ZK, Bach K, Sungnak W, Worlock KB, Yoshida M, Kumasaka N, Kania K, Engelbert J, Olabi B, Spegarova JS, Wilson NK, Mende N, Jardine L, Gardner LCS, Goh I, Horsfall D, McGrath J, Webb S, Mather MW, Lindeboom RGH, Dann E, Huang N, Polanski K, Prigmore E, Gothe F, Scott J, Payne RP, Baker KF, Hanrath AT, Schim van der Loeff ICD, Barr AS, Sanchez-Gonzalez A, Bergamaschi L, Mescia F, Barnes JL, Kilich E, de Wilton A, Saigal A, Saleh A, Janes SM, Smith CM, Gopee N, Wilson C, Coupland P, Coxhead JM, Kiselev VY, van Dongen S, Bacardit J, King HW, Rostron AJ, Simpson AJ, Hambleton S, Laurenti E, Lyons PA, Meyer KB, Nikolic MZ, Duncan CJA, Smith KGC, Teichmann SA, Clatworthy MR, Marioni JC, Göttgens B, Haniffa M. Single-cell multi-omics analysis of the immune response in COVID-19. Nature Medicine 2021, 27, 904-916.
  • Hanrath AT, Schim van der Loeff I, Lendrem DW, Baker KF, Price DA, McDowall P, McDowall K, Cook S, Towns P, Schwab U, Evans A, Dixon J, Collins J, Burton-Fanning S, Saunders D, Harwood J, Samuel J, Schmid ML, Pareja-Cebrian L, Hunter E, Murphy E, Taha Y, Payne BAI, Duncan CJA. SARS-CoV-2 Testing of 11,884 Healthcare Workers at an Acute NHS Hospital Trust in England: A Retrospective Analysis. Frontiers in Medicine 2021, 8, 636160.
  • Baker KF, Hanrath AT, Schim van der Loeff I, Kay LJ, Back J, Duncan CJA. National Early Warning Score 2 (NEWS2) to identify inpatient COVID-19 deterioration: a retrospective analysis. Clinical Medicine 2021, 21(2), 84-89.
  • Calderon M, Li A, Bazo-Alvarez JC, Dennis J, Baker KF, Schim van der Loeff I, Hanrath AT, Capstick R, Payne BAI, Weiand D, Hunter E, Schwab U. Evaluation of procalcitonin-guided antimicrobial stewardship in patients admitted to hospital with COVID-19 pneumonia. JAC-Antimicrobial Resistance 2021, 3(3).
  • Stamatelopoulos K, Georgiopoulos G, Baker KF, Tiseo G, Delialis D, Lazaridis C, Barbieri G, Masi S, Vlachogiannis NI, Sopova K, Mengozzi A, Ghiadoni L, Ajdini B, Ghiadoni L, van der Loeff IS, Vlachopoulos C, Dimopoulos MA, Falcone M, Stellos K, Duncan CJA, Tiseo G, Barbieri G, Masi S, Mengozzi A, Falcone M, Monzani F, Menichetti F, Virdis A, Forfori F, Rubia B, Pietro B, Francesco C, Alessandra DR, Giulia B, Fabio G, Paolo M, Marco M, Chiara P, Naria P, Alessandro C, Carrozzi L, Francesco C, Santini M, Alessandro C, Martina B, Matteo B, Elia N, Stefano S, Francesca R, Giovanna F, Maria S, De Marco S, Rachele A, Valeria C, Simone P, Luciano C, Chiara S, Valentina G, Uliana M, Baker KF, van der Loeff IS, Hanrath AT, Hanrath AT, Duncan CJA, Tee SA, Capstick R, Marchitelli G, Li A, Barr A, Eid A, Ahmed S, Bajwa D, Mohammed O. Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19. Scientific Reports 2021, 11(1), 20239.
  • Schim van der Loeff I, Sprenkeler EGG, Tool ATJ, Abinun M, Grainger A, Engelhardt KR, van Houdt M, Janssen H, Kuijpers TW, Hambleton S. Defective neutrophil development and specific granule deficiency caused by a homozygous splice-site mutation in SMARCD2. Journal of Allergy and Clinical Immunology 2021, 147(6), 2381-2385.e2.
  • Baker KF, Hanrath AT, Schim van der Loeff I, Tee SA, Capstick R, Marchitelli G, Li A, Barr A, Eid A, Ahmed S, Bajwa D, Mohammed O, Alderson N, Lendrem C, Lendrem DW, COVID Control Group THE, COVID Clinical Group THE, Pareja-Cebrian L, Welch A, Field J, Payne BAI, Taha Y, Price DA, Gibbins C, Schmid ML, Hunter E, Duncan CJA. COVID-19 Management in a UK NHS Foundation Trust with a High Consequence Infectious Diseases Centre: A Retrospective Analysis. Medical Sciences 2021, 9(1), 6.
  • Manson JJ, Crooks C, Naja M, Ledlie A, Goulden B, Liddle T, Khan E, Mehta P, Martin-Gutierrez L, Waddington KE, Robinson GA, Ribeiro Santos L, McLoughlin E, Snell A, Adeney C, Schim van der Loeff I, Baker KF, Duncan CJA, Hanrath AT, Lendrem BC, De Soyza A, Peng J, J'Bari H, Greenwood M, Hawkins E, Peckham H, Marks M, Rampling T, Luintel A, Williams B, Brown M, Singer M, West J, Jury EC, Collin M, Tattersall RS. COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study. The Lancet Rheumatology 2020, 2(10), e594-e602.
  • Sinclair C, Manoj S, Schim van der Loeff I, Sakaguchi S, Seddon B. The Long-Term Survival Potential of Mature T Lymphocytes Is Programmed During Development in the Thymus. Science Signalling 2011, 4(199), ra77.

• Letter

  • Hunter E, Price DA, Murphy E, Schim van der Loeff I, Baker KF, Lendrem D, Lendrem C, Schmid ML, Pareja-Cebrian L, Welch A, Payne BAI, Duncan CJA. First experience of COVID-19 screening of health-care workers in England. The Lancet 2020, 395(10234), e77-e78.

• Review

  • Schim van der Loeff I, Owens S. Non-tuberculous mycobacterial infection in children. Paediatrics and Child Health (United Kingdom) 2021, 31(3), 102-109.