Staff Profile

Roles and Responsibilities

Professor of Cardiology and Cardiovascular Gerontology

      Fellow of the European Society of Cardiology (FESC)

      Fellow of the Royal Society of Physicians (FRCP)

Hon. Consultant Interventional Cardiology, Freeman Hospital

Co-Lead NIHR Clinical Research Network Cardiovascular (CRN) 

        North East and North Cumbria

Translational and Clinical Research Institute

Programme director Masters course "Cardiovascular Science in Health & Disease"

Deputy Lead and Educational Lead Vascular Biology and Medicine Theme 

ORCID number 0000-0002-2750-2444

https://scholar.google.com/citations?user=7oAyMWsAAAAJ&hl=en

Our group is interested on the role of the immune system during cardiovascular ageing, such as how the immune system regulates inflammation (“Inflammaging”). Our approach is translational, identifying relevant questions in patients with coronary artery disease and modelling them in the lab. We will translate our results back to the patient through development of pathway-specific drugs.

What is the Role of T-lymphocytes in Myocardial ischemia/reperfusion Injury and Infarct Healing ?

Coronary artery disease is the single largest cause of mortality worldwide, with myocardial infarction being the most serious manifestation. Timely and effective myocardial reperfusion using primary PCI in acute ST elevation myocardial infarction (STEMI) has substantially improved clinical outcomes of patients. Following reopening of the blocked artery, reperfusion itself can cause myocardial injury and cell death (myocardial ischaemia/reperfusion injury). Studies in animal MI models and human therapeutic interventions indicate that ischemia/reperfusion injury is responsible for up to 50% of final infarct size. While CD4 T-lymphocytes (T-cells) have been shown to promote myocardial ischemia/reperfusion injury in the mouse model, their role during STEMI in humans is by large unknown. A low number of lymphocytes following myocardial infarction is a negative predictor of survival, and we have previously shown (PLoS One 2012) that CD4 and CD8 T-cells drop by up to 50% in the peripheral blood during the first 30 min following reperfusion. At the moment we are conducting three BHF and NIHR funded studies to investigate the role of T-cells in myocardial ischemia-reperfusion and peri-infarct inflammation. We have also previously shown (Circulation 2009) that prior infection with cytomegalovirus (CMV) is associated with shorter telomeres of CD8 T-cells in patients with previous myocardial infarction, correlating with left ventricular function. Another aim of our studies is therefore to find out if CMV seropositivity has an impact on peri-infarct inflammation and healing.

What is the Role of Telomerase in Atherosclerosis ?

Atherosclerosis is an age-related systemic disease characterized by systemic oxidative stress and low grade chronic inflammation, mediated by various leukocyte populations. Telomere dysfunction has been implicated in ageing and senescence of different cell types. Shorter leukocyte telomeres, possibly the result of decreased telomerase activity, are also associated with increased cardiovascular risk and mortality. However, so far no mechanistic link on a cellular level has been found between ageing and atherosclerosis. Telomerase as a DNA polymerase principally functions to protect and elongate telomeres; however, we and others have shown additional “non-canonical” effects of telomerase that are potentially of relevance to atherosclerosis. In our current project we aim to investigate whether telomerase could prove to be a decelerator of atherosclerosis by maintaining generation and suppressive function of CD4 regulatory T-cells, potent suppressors of inflammation and atherogenesis.

Postdoctoral Fellows

Karim Bennaceur, PhD

Sharon Cookson, PhD

PhD Students

Yasemine Ekinci

MD Students

Dr Bilal Bawamia

Dr Shu Loh

Dr Ayman Al-Atta

Original Publications since 2020  

1.      Spray L, Park C, Cormack S, Mohammed A, Panahi P, Boag S, Bennaceur K, Sopova K, Richardson G, Stangl VM, Rech L, Rainer PP, Ramos GC, Hofmann U, Stellos K, Spyridopoulos I. The Fractalkine Receptor CX₃CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling. Front Immunol. 2021;12:605857.

2.      Delgobo M, Heinrichs M, Hapke N, Ashour D, Appel M, Srivastava M, Heckel T, Spyridopoulos I, Hofmann U, Frantz S, Ramos GC. Terminally Differentiated CD4  T Cells Promote Myocardial Inflammaging. Front Immunol. 2021;12:584538.

3.      Owens WA, Walaszczyk A, Spyridopoulos I, Dookun E, Richardson GD. Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls. Mech Ageing Dev. 2021;198:111540.

4.      Marsh SA, Park C, Redgrave RE, Singh E, Draganova L, Boag SE, Spray L, Ali S, Spyridopoulos I, Arthur HM. Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury. FASEB J. 2021;35:e21604.

5.      Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil SER, Gaskin D, Bakogiannis C, Sopova K, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall AJ, Stellos K, Stamatelopoulos K, Spyridopoulos I. Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction. Heart. 2021heartjnl-2021.

6.      McClements J, Seumo Tchekwagep PM, Vilela Strapazon AL, Canfarotta F, Thomson A, Czulak J, Johnson RE, Novakovic K, Losada-Pérez P, Zaman A, Spyridopoulos I, Crapnell RD, Banks CE, Peeters M. Immobilization of Molecularly Imprinted Polymer Nanoparticles onto Surfaces Using Different Strategies: Evaluating the Influence of the Functionalized Interface on the Performance of a Thermal Assay for the Detection of the Cardiac Biomarker Troponin I. ACS Appl Mater Interfaces. 2021

7.      Maier R, Bawamia B, Bennaceur K, Dunn S, Marsay L, Amoah R, Kasim A, Filby A, Austin D, Hancock H, Spyridopoulos I. Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial. JMIR Res Protoc. 2020;9:e19456.

8.      Coelho-Lima J, Mohammed A, Cormack S, Jones S, Ali A, Panahi P, Barter M, Bagnall A, Ali S, Young D, Spyridopoulos I. Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion. Clin Chem. 2020;66:247-256.

9.      Granic A, Martin-Ruiz C, Dodds RM, Robinson L, Spyridopoulos I, Kirkwood TB, von Zglinicki T, Sayer AA. Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85 Study. Mech Ageing Dev. 2020111321.

10.    Egred M, Bagnall A, Spyridopoulos I, Purcell IF, Das R, Palmer N, Grech ED, Jain A, Stone GW, Nijveldt R, McAndrew T, Zaman A. Effect of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size in anterior STEMI: PiCSO in ACS study. Int J Cardiol Heart Vasc. 2020;28:100526.

11.    Cormack S, Mohammed A, Panahi P, Das R, Steel AJ, Chadwick T, Bryant A, Egred M, Stellos K, Spyridopoulos I, CAPRI I. Effect of ciclosporin on safety, lymphocyte kinetics and left ventricular remodelling in acute myocardial infarction. Br J Clin Pharmacol. 2020;86:1387-1397.

12.    Martin-Ruiz C, Hoffmann J, Shmeleva E, Zglinicki TV, Richardson G, Draganova L, Redgrave R, Collerton J, Arthur H, Keavney B, Spyridopoulos I. CMV-independent increase in CD27-CD28 CD8 EMRA T cells is inversely related to mortality in octogenarians. NPJ Aging Mech Dis. 2020;6:3.

13.    Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual-Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep OE, Santin Y, Mialet-Perez J, Andrew Owens W, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery. Aging Cell. 2020e13249.

Invited Reviews and Editorials since 2017

1.      Hoffmann J, Richardson G, Haendeler J, Altschmied J, Andrés V, Spyridopoulos I. Telomerase as a Therapeutic Target in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2021;41:1047-1061.

2.      Lazaridis, C, Vlachogiannis, NI, Bakogiannis, C, Spyridopoulos, I, Stamatelopoulos, K, Kanakakis, I, Vassilikos, V, Stellos, K. Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery. Hellenic J Cardiol. 2020

3.      Nobian, A, Mohamed, A, Spyridopoulos, I. The role of arginine vasopressin in myocardial infarction and reperfusion. Kardiol Pol. 2019;77(10):908–917.

4.      Stellos, K, Spyridopoulos, I. Exercise, telomerase activity, and cardiovascular disease prevention. Eur Heart J. 2019;40(1):47–49.

5.      Coelho-Lima, J, Spyridopoulos, I. Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases. Exp Gerontol. 2018;109:38–46.

6.      Spyridopoulos, I. Molecular mechanisms and therapy of cardiovascular ageing. Exp Gerontol. 2018;109:1–4.

7.      Heiss, C, Spyridopoulos, I, Haendeler, J. Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules. Exp Gerontol. 2018;109:108–118.

8.      Marsh, SA, Arthur, HM, Spyridopoulos, I. The secret life of nonclassical monocytes. Cytometry A. 2017;91(11):1055–1058.

9.      Spyridopoulos, I, Arthur, HM. Microvessels of the heart: Formation, regeneration, and dysfunction. Microcirculation. 2017;24(1)

10.    Boag, SE, Andreano, E, Spyridopoulos, I. Lymphocyte Communication in Myocardial Ischemia/Reperfusion Injury. Antioxid Redox Signal. 2017;26(12):660–675.

I am programme lead for our Universities Masters of Research program "Cardiovascular Science in Health and Disease"

• McClements J, Seumo P, Vilalela Strapazon A, Canfarotta F, Thomson A, Czulak J, Johnson R, Novakovic K, Losada-Perez P, Zaman A, Spyridopoulos I, Crapnell R, Banks C, Peeters M. Immobilization of Molecularly Imprinted Polymer Nanoparticles onto Surfaces using Different Strategies: Evaluating the Influence of the Functionalised Interface on the Performance of a Thermal Assay for the Detection of Cardiac Biomarker Troponin I. ACS Applied Materials and Interfaces 2021, 13(24), 27868-27879.
• Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil Syeda, Gaskin D, Bakogiannis C, Sopova k, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall A, Stellos K, Stamatelopoulos K, Spyridopoulos I. Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction. Heart BMJ 2021, 107(23), 1881-1888.
• Marsh SA, Park C, Redgrave RE, Singh E, Draganova L, Boag SE, Spray L, Ali S, Spyridopoulos I, Arthur HM. Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury. FASEB Journal 2021, 35(5), e21604.
• Owens WA, Walaszczyk A, Spyridopoulos I, Dookun E, Richardson GD. Senescence and Senolytics in Cardiovascular disease: Promise and Potential Pitfalls. Mechanisms of Ageing and Development 2021, 198, 111540.
• Hoffmann J, Richardson GD, Haendeler J, Altschmied J, Andrés V, Spyridopoulos I. Telomerase As a Therapeutic Target in Cardiovascular Disease. Arteriosclerosis, Thrombosis, and Vascular Biology 2021, 41(3), 855-865.
• Delgobo M, Heinrichs M, Hapke N, Ashour D, Appel M, Srivastava M, Heckel T, Spyridopoulos I, Hofmann U, Frantz S, Ramos GC. Terminally Differentiated CD4⁺ T Cells Promote Myocardial Inflammaging. Frontiers in Immunology 2021, 12, 584538.
• Spray L, Park C, Cormack S, Mohammed A, Panahi P, Boag S, Bennaceur K, Sopova K, Richardson G, Stangl V, Rech L, Rainer P, Ramos G, Hofmann U, Stellos K, Spyridopoulos I. The Fractalkine Receptor CX3CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling. Frontiers in Immunology 2021, 12, 605857.
• Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery. Aging Cell 2020, 19(10), e13249.
• Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery. Aging Cell 2020, 19(10), e13249.
• Martin-Ruiz C, Hoffmann J, Shmeleva E, von Zglinicki T, Richardson G, Draganova L, Redgrave R, Collerton J, Arthur H, Keavney B, Spyridopoulos I. CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians. npj Aging and Mechanisms of Disease 2020, 6, 3.
• Cormack S, Mohammed A, Panahi P, Das R, Steel AJ, Chadwick T, Bryant A, Egred M, Stellos K, Spyridopoulos I. Effect of ciclosporin on safety, lymphocyte kinetics and left ventricular remodelling in acute myocardial infarction. British Journal of Clinical Pharmacology 2020, 86(7), 1387-1397.
• Egred M, Bagnall A, Spyridopoulos I, Purcell IF, Das R, Palmer N, Grech ED, Jain A, Stone GW, Nijveldt R, McAndrew T, Zaman A. Effect of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size in anterior STEMI: PiCSO in ACS study. IJC Heart and Vasculature 2020, 28, 100526.
• Granic A, Martin-Ruiz C, Dodds RM, Robinson L, Spyridopoulos I, Kirkwood TBL, von Zglinicki T, Sayer AA. Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study. Mechanisms of Ageing and Development 2020, 190, 111321.
• Liu D, Richardson G, Benli FM, Park C, de Souza JV, Bronowska AK, Spyridopoulos I. Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies. Clinical Science 2020, 134(17), 2243-2262.
• Lazaridis C, Vlachogiannis NI, Bakogiannis C, Spyridopoulos I, Stamatelopoulos K, Kanakakis I, Vassilikos V, Stellos K. Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery. Hellenic Journal of Cardiology 2020, 61(6), 381-395.
• Coelho-Lima J, Mohammed A, Cormack S, Jones S, Ali A, Panahi P, Barter M, Bagnall A, Ali S, Young D, Spyridopoulos I. Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion. Clinical Chemistry 2020, 66(1), 247-256.
• Spray L, Park C, Cormack S, Mohammad A, Panahi P, Boag S, Bennaceur K, Richardson G, Arthur H, Stellos K, Spyridopoulos I. Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction. European Heart Journal 2020, 41(Suppl. 2), ehaa946.1289.
• Maier R, Bawamia B, Bennaceur K, Dunn S, Marsay L, Amoah R, Kasim A, Filby A, Austin D, Hancock H, Spyridopoulos I. Telomerase activation to reverse immunosenescence in elderly patients with acute coronary syndrome: Protocol for a randomized pilot trial. JMIR Research Protocols 2020, 9(9), e19456.
• Stellos K, Spyridopoulos I. Exercise, telomerase activity, and cardiovascular disease prevention. European Heart Journal 2019, 40(1), 47-49.
• Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Navitoclax eliminates senescence attenuating remodelling and improving outcome to cardiac ischemia-reperfusion injury. In: Senescence Symposium. 2019, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.
• Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot A, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD. Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging Cell 2019, 18(3), e12945.
• Yausep Oliver, Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. The Effects of Senolytics on Murine Cardiac Function and Morphology Post-Ischemia Reperfusion Injury. In: 24th ASEAN Federation Cardiology Congress (24th AFCC) 28th Annual Scientific Meeting of the Idonesian Heart Association (28th ASMIHA). 2019, Faculty of Medicine, University of Indonesia, Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia.
• Luke P, Eggett C, Spyridopoulos I, Irvine T. A comparative analysis of British and American Society of Echocardiography recommendations for the assessment of left ventricular diastolic function. Echo Research and Practice 2018, 5(4), 139-147.
• Dookun ER, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson GD. Accumulation of cardiomyocyte senescence following ischaemia-reperfusion injury (IRI); a potential therapeutic target?. In: BAS/BSCR Spring Meeting 2018. 2018, Manchester, UK: Heart.
• Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Cardiomyocyte Senescence accumulates following Myocardial Infarction and Ischaemia-Reperfusion Injury. In: 26th Northern Cardiovascular Research Group Meeting. 2018, Newcastle upon Tyne.
• Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, Aufenvenne K, von Ameln F, Zurek M, Spannbrucker T, Eckermann O, Jakob S, Gorressen S, Abrams M, Grandoch M, Fischer JW, Kohrer K, Deenen R, Unfried K, Altschmied J, Haendeler J. CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine. PLoS Biology 2018, 16(6), e2004408.
• Heiss C, Spyridopoulos I, Haendeler J. Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules. Experimental Gerontology 2018, 109, 108-118.
• Spyridopoulos I. Molecular mechanisms and therapy of cardiovascular ageing. Experimental Gerontology 2018, 109, 1-4.
• Coelho-Lima J, Spyridopoulos I. Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases. Experimental Gerontology 2018, 109, 38-46.
• Coelho-Lima J, Mohammed A, Cormack S, Jones S, Das R, Egred M, Panahi P, Ali S, Spyridopoulos I. Overcoming Heparin-Associated RT-qPCR Inhibition and Normalization Issues for microRNA Quantification in Patients with Acute Myocardial Infarction. Thrombosis and Haemostasis 2018, 118(7), 1257-1269.
• Walaszczyk A, Dookun ER, Redgrave R, Tual-Chalot S, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson GD. Senescence as a therapeutic target for myocardial ageing. In: BAS/BSCR Spring Meeting 2018. 2018, Manchester, UK: Heart.
• Walaszczyk A, Dookun E, Redgrave R, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Senescence contributes age related cardiac dysfunction. In: 26th Northern Cardiovascular Research Group Meeting. 2018, Newcastle, UK.
• Walaszczyk A, Dookun E, Redgrave R, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Senescence contributes to reduced survival and impaired cardiac function following myocardial infraction in aged mice. In: 9th Annual Alliance for Healthy Aging Conference. 2018, Mayo Clinic Rochester, MN, USA.
• Richardson G, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault D, Mallat Z, Spyridopoulos I. Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2018, 38(6), 1283-1296.
• Boag SE, Andreano E, Spyridopoulos I. Lymphocyte Communication in Myocardial Ischemia/Reperfusion Injury. Antioxidants and Redox Signaling 2017, 26(12), 660-675.
• Spyridopoulos I, Arthur HM. Microvessels of the heart: Formation, regeneration and dysfunction. Microcirculation 2017, 24(1), e12338.
• Giannoudi M, Spyridopoulos I. Telomere length in cardiovascular disease. In: Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities. Boca Raton, FL, USA: CRC Press, 2017, pp.68-82.
• Andres V, Dorado B, Spyridopoulos I. Telomeres and cardiovascular diseases: Facts, controversies and limitations. In: Mechanisms Linking Aging, Diseases and Biological Age Estimation. Boca Raton, FL, USA: CRC Press, 2017, pp.150-160.
• Marsh SA, Arthur HM, Spyridopoulos I. The secret life of nonclassical monocytes. Cytometry Part A 2017, 91(11), 1055-1058.
• Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, Kirkwood T, von Zglinicki T. CMV-seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians - results from the Newcastle 85+ study. Aging Cell 2016, 15(2), 389-392.
• Shmeleva EV, Boag SE, Murali S, Bennaceur K, Das R, Egred M, Purcell I, Edwards R, Todryk S, Spyridopoulos I. Differences in immune responses between CMV-seronegative and -seropositive patients with myocardial ischemia and reperfusion. Immunity, Inflammation and Disease 2015, 3(2), 56-70.
• Hoffmann J, Shmeleva EV, Boag SE, Fiser K, Bagnall A, Murali S, Dimmick I, Pircher H, Martin-Ruiz C, Egred M, Keavney B, von Zglinicki T, Das R, Todryk S, Spyridopoulos I. Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients. Circulation Research 2015, 116(1), 87-98.
• Hoffmann J, Spyridopoulos I. Senescent cytotoxic T cells in acute myocardial infarction: innocent bystanders or the horsemen of apocalypse?. Cellular & Molecular Immunology 2015, 12(4), 510-512.
• Spyridopoulos I, Noman A, Ahmed JM, Das R, Edwards R, Purcell I, Bagnall A, Zaman A, Egred M. Shock-index as a novel predictor of long-term outcome following primary percutaneous coronary intervention. European Heart Journal: Acute Cardiovascular Care 2015, 4(3), 270-277.
• Boag SE, Das R, Shmeleva EV, Bagnall A, Egred M, Howard N, Bennaceur K, Zaman A, Keavney B, Spyridopoulos I. T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in patients. Journal of Clinical Investigation 2015, 125(8), 3063-3076.
• Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis 2014, 236(2), 312-320.
• Al-Ajmi N, Saretzki G, Miles C, Spyridopoulos I. Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbate the ageing phenotype. Experimental Gerontology 2014, 58, 113-119.
• Boag S, Schmeleva E, Das R, Egred M, Zaman A, Bagnall A, Owens WA, Keavney B, Ahmed J, Spyridopoulos I. Dynamic Changes in T-Lymphocyte Counts Following Primary Percutaneous Coronary Intervention Predict Infarct Size and Microvascular Obstruction. In: British Cardiovascular Society Annual Conference 2014. 2014, Manchester, UK: BMJ Publishing Group.
• Shmeleva E, Boag S, Murali S, Bennaceur K, Todryk S, Spyridopoulos I. Effect of CMV-seropositivity on acute outcome of acute myocardial infarction. In: The British Society for Immunology Annual Congress 2014. 2014, Brighton, UK: Wiley-Blackwell.
• Spyridopoulos I, Noman A, Ahmed J, Egred M. Shock-Index as a Novel Predictor of Longterm Outcome Following Primary Percutaneous Coronary Intervention. In: British Cardiovascular Society Annual Conference 2014. 2014, Manchester, UK: BMJ Publishing Group.
• Spyridopoulos I, von Zglinicki T. Telomere length predicts cardiovascular disease. British Medical Journal 2014, 349, g4373.
• Bagnall A, Spyridopoulos I. The evidence base for revascularisation of chronic total occlusions. Current Cardiology Reviews 2014, 10(2), 88-98.
• Honold J, DeRosa S, Spyridopoulos I, Fischer-Rasokat U, Seeger FH, Leistner D, Lotz S, Levy WC, Zeiher AM, Assmus B. Comparison of the Seattle Heart Failure Model and Cardiopulmonary Exercise Capacity for Prediction of Death in Patients With Chronic Ischemic Heart Failure and Intracoronary Progenitor Cell Application. Clinical Cardiology 2013, 36(3), 153-159.
• Schwietz T, Ehrlich JR, DeRosa S, Fichtlscherer S, Schächinger V, Baier G, Laskowski R, Zeiher AM, Spyridopoulos I, Lehmann R. Prognostic impact of using drug-eluting-stents on outcome and strategy in multivessel PCI: data from the Frankfurt MV-PCI registry. Journal of Cardiology 2013, 61(1), 38-43.
• Badar A, Scaife J, Yan AT, Robinson SD, Zaman AG, Purcell IF, Ahmed JM, Egred M, Edwards RJ, Spyridopoulos I, Keavney BD, Bagnall AJ. Provision of Gastroprotective Medication and Bleeding Risk Following Acute Coronary Syndrome. Journal of Invasive Cardiology 2013, 25(8), 397-401.
• Badar A, Scaife J, Yan AT, Robinson SD, Zaman AG, Purcell IF, Ahmed JM, Egred M, Edwards RJ, Spyridopoulos I, Keavney BD, Bagnall AJ. Provision of Gastroprotective Medication and Bleeding Risk Following Acute Coronary Syndrome. Journal of Invasive Cardiology 2013, 25(8), 397-401.
• Wald DS, Morris JK, Wald NJ, Chase AJ, Edwards RJ, Hughes LO, Berry C, Oldroyd KG, PRAMI Investigators. Randomized trial of preventive angioplasty in myocardial infarction. New England Journal of Medicine 2013, 369(12), 1115-1123.
• Schwietz T, Spyridopoulos I, Pfeiffer S, Laskowski R, Palm S, De Rosa S, Jens K, Zeiher AM, Schachinger V, Fichtlscherer S, Lehmann R. Risk Stratification Following Complex PCI: Clinical Versus Anatomical Risk Stratification Including "Post PCI Residual SYNTAX-Score" as Quantification of Incomplete Revascularization. Journal of Interventional Cardiology 2013, 26(1), 29-37.
• Hoffmann J, Fiser K, Weaver J, Dimmick I, Loeher M, Pircher H, Martin-Ruiz C, Veerasamy M, Keavney B, von Zglinicki T, Spyridopoulos I. High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction. PLoS one 2012, 7(10), e47155.
• Lehmann R, Ehrlich JR, DeRosa S, Spyridopoulos I, Laskowski R, Kremer J, Herrmann E, Zeiher AM, Schächinger V, Fichtlscherer S. Impact of interventional strategy for unprotected left main coronary artery percutaneous coronary intervention on long-term survival. Canadian Journal of Cardiology 2012, 28(5), 553-560.
• Noman A, Egred M, Bagnall A, Spyridopoulos I, Jamieson S, Ahmed J. Impact of thrombus aspiration during primary percutaneous coronary intervention on mortality in ST-segment elevation myocardial infarction. European Heart Journal 2012, 33(24), 3054-3061.
• Fischer-Rasokat U, Spyridopoulos I, Walter J, Honold J, Zeiher AM, Fichtlscherer S. Microvascular dysfunction and pulse wave reflection characterize different vascular pathologies in patients at cardiovascular risk. Vasa 2012, 41(3), 192-199.
• Noman A, Ahmed JM, Spyridopoulos I, Bagnall A, Egred M. Mortality outcome of out-of-hours primary percutaneous coronary intervention in the current era. European Heart Journal 2012, 33(24), 3046-3053.
• Spyridopoulos I. Is telomerase a potential target for vascular rejuvenation?. Atherosclerosis 2011, 216(1), 19-20.
• Lehmann R, Fichtlscherer S, Schachinger V, Held L, Hobler C, Baier G, Zeiher AM, Spyridopoulos I. Complete Revascularization in Patients Undergoing Multivessel PCI is an Independent Predictor of Improved Long-term Survival. Journal of Interventional Cardiology 2010, 23(3), 256-263.
• Lehmann R, Luxembourg B, Miesbach W, Suess C, Leus M, Lindhoff-Last E, Zeiher AM, Spyridopoulos I. Idiopathic (unexplained) pulmonary embolism is associated with an impaired prognosis compared to other entities of pulmonary embolism. Blood Coagulation & Fibrinolysis 2010, 21(1), 70-76.
• Spyridopoulos I, Hoffmann J, Aicher A, Brummendorf TH, Doerr HW, Zeiher AM, Dimmeler S. Accelerated Telomere Shortening in Leukocyte Subpopulations of Patients With Coronary Heart Disease: Role of Cytomegalovirus Seropositivity. Circulation 2009, 120(14), 1364-1372.
• Seeger FH, Chen L, Spyridopoulos I, Altschmied J, Aicher A, Haendeler J. Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells. PLoS ONE 2009, 4(2), e4529.
• Lehmann R, Fichtlscherer S, Schachinger V, Held L, Hobler C, Baier G, Zeiher AM, Spyridopoulos I. Favorable Long-Term Survival in Patients Undergoing Multivessel-PCI Compared to Predicted Prognosis of CABG Estimated by EuroSCORE: Procedural and Clinical Determinants of Long-Term Outcome. Journal of Interventional Cardiology 2009, 22(6), 511-519.
• Lehmann R, Suess C, Leus M, Luxembourg B, Miesbach W, Lindhoff Last E, Zeiher AM, Spyridopoulos I. Incidence, clinical characteristics, and long-term prognosis of travel-associated pulmonary embolism. European Heart Journal 2009, 30(2), 233-241.
• Haendeler J, Drose S, Buchner N, Jakob S, Altschmied J, Goy C, Spyridopoulos I, Zeiher AM, Brandt U, Dimmeler S. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arteriosclerosis, Thrombosis, and Vascular Biology 2009, 29(6), 929-935.
• Fischer-Rasokat U, Brenck F, Zeiher AM, Spyridopoulos I. Radial augmentation index unmasks premature coronary artery disease in younger males. Blood Pressure Monitoring 2009, 14(2), 59-67.
• Linzbach S, Samigullin A, Yilmaz S, Tsioga M, Zeiher AM, Spyridopoulos I. Role of N-Terminal Pro-Brain Natriuretic Peptide and Cystatin C to Estimate Renal Function in Patients With and Without Heart Failure. American Journal of Cardiology 2009, 103(8), 1128-1133.
• Hoffmann J, Erben Y, Zeiher AM, Dimmeler S, Spyridopoulos I. Telomere length-heterogeneity among myeloid cells is a predictor for chronological ageing. Experimental Gerontology 2009, 44(5), 363-366.
• Spyridopoulos I, Fichtlscherer S, Popp R, Toennes SW, Fisslthaler B, Trepels T, Zernecke A, Liehn EA, Weber C, Zeiher AM, Dimmeler S, Haendeler J. Caffeine enhances endothelial repair by an AMPK-dependent mechanism. Arteriosclerosis, Thrombosis, and Vascular Biology 2008, 28(11), 1967-1974.
• Jakob S, Schroeder P, Lukosz M, Buchner N, Spyridopoulos I, Altschmied J, Haendeler J. Nuclear Protein Tyrosine Phosphatase Shp-2 Is One Important Negative Regulator of Nuclear Export of Telomerase Reverse Transcriptase. Journal of Biological Chemistry 2008, 283(48), 33155-33161.
• Spyridopoulos I, Erben Y, Brummendorf TH, Haendeler J, Dietz K, Seeger F, Kissel CK, Martin H, Hoffmann J, Assmus B, Zeiher AM, Dimmeler S. Telomere gap between granulocytes and lymphocytes is a determinant for hematopoetic progenitor cell impairment in patients with previous myocardial infarction. Arteriosclerosis, Thrombosis, and Vascular Biology 2008, 28(5), 968-974.
• Honold J, Geiger L, Assmus B, Fischer Rasokat U, Schachinger V, Zeiher AM, Spyridopoulos I. The initial slope of the VCO2/VO2-curve (s1) in cardiopulmonary exercise testing is a strong and independent predictor of outcome in patients with previous myocardial infarction. Clinical Research in Cardiology 2008, 97(12), 882-890.