Staff Profile

The HDBR Atlas (https://hdbratlas.org/) is a unique resource which aims to facilitate the understanding of human embryonic and fetal development. 3D models provide a framework in which anatomical structures are defined and gene expression data is mapped. The Atlas also hosts annotated high resolution histology sections throughout the embryonic and early fetal period.

• Articles

  • Anderson RH, Lamers WH, Hikspoors JPJM, Mohun TJ, Bamforth SD, Chaudhry B, Eley L, Kerwin J, Crosier M, Henderson DJ. Development of the arterial roots and ventricular outflow tracts. Journal of Anatomy 2024, 244(3), 497-513.
  • Queen R, Crosier M, Eley L, Kerwin J, Turner JE, Yu J, Alqahtani A, Dhanaseelan T, Overman L, Soetjoadi H, Baldock R, Coxhead J, Boczonadi V, Laude A, Cockell SJ, Kane MA, Lisgo S, Henderson DJ. Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genetics 2023, 19(11).
  • Yamanaka Y, Hamidi S, Yoshioka-Kobayashi K, Munira S, Sunadome K, Zhang Y, Kurokawa Y, Ericsson R, Mieda A, Thompson JL, Kerwin J, Lisgo S, Yamamoto T, Moris N, Martinez-Arias A, Tsujimura T, Alev C. Reconstituting human somitogenesis in vitro. Nature 2023, 614(7948), 509-520.
  • Alzu'bi A, Sankar N, Crosier M, Kerwin J, Clowry GJ. Tyramide signal amplification coupled with multiple immunolabeling and RNAScope in situ hybridization in formaldehyde-fixed paraffin-embedded human fetal brain. Journal of Anatomy 2022, 241(1), 33-41.
  • Alzubi A, Lindsay S, Kerwin J, Looi SJ, Khalil F, Clowry GJ. Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human telencephalon. Brain Structure and Function 2017, 222(5), 2309–2328.
  • Captur G, Ho CY, Schlossarek S, Kerwin J, Mirabel M, Wilson R, Rosmini S, Obianyo C, Reant P, Bassett P, Cook AC, Lindsay S, McKenna WJ, Mills K, Elliott PM, Mohun TJ, Carrier L, Moon JC. The embryological basis of subclinical hypertrophic cardiomyopathy. Scientific Reports 2016, 6, 27714.
  • Sarma S, Thompson J, Kerwin J, Lindsay S. Identification and characterisation of the rostral signaling center Anterior Neural Ridge during Early Human cortical Development [abstract]. Journal of Anatomy 2011, 218(3), 355-355.
  • Kerwin J, Yang YY, Merchan P, Sarma S, Thompson J, Wang XX, Sandoval J, Puelles L, Baldock R, Lindsay S. The HUDSEN Atlas: a three-dimensional (3D) spatial framework for studying gene expression in the developing human brain. Journal of Anatomy 2010, 217(4), 289-299.
  • Feng G, Burton N, Hill B, Davidson D, Kerwin JM, Scott M, Lindsay S, Baldock R. JAtlas View: A Java atlas-viewer for browsing biomedical 3D images and atlases. BMC Bioinformatics 2005, 6(47), 7.
  • Kerwin JM, Scott MK, Sharpe J, Puelles L, Robson SC, Martínez de la Torre M, Ferran JL, Feng G, Baldock R, Strachan T, Davidson D, Lindsay SJ. 3 dimensional modelling of early human brain development using optical projection tomography. BMC Neuroscience 2004, 5, 27.
  • Court JA, Perry EK, Spurden D, Griffiths M, Kerwin JM, Morris CM, Johnson M, Oakley AE, Birdsall NJM, Clementi F, Perry RH. The role of the cholinergic system in the development of the human cerebellum. Developmental Brain Research 1995, 90(1-2), 159-167.
  • MORRIS CM, CANDY JM, KERWIN JM, EDWARDSON JA. TRANSFERRIN RECEPTORS IN THE NORMAL HUMAN HIPPOCAMPUS AND IN ALZHEIMERS-DISEASE. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 1994, 20(5), 473-477.
  • MORRIS CM, KERWIN JM, EDWARDSON JA. NONHEME IRON HISTOCHEMISTRY OF THE NORMAL AND ALZHEIMERS-DISEASE HIPPOCAMPUS. NEURODEGENERATION 1994, 3(4), 267-275.
  • Court JA, Perry EK, Johnson M, Piggott MA, Kerwin JA, Perry RH, Ince PG. Regional patterns of cholinergic and glutamate activity in the developing and aging human brain. Developmental Brain Research 1993, 74(1), 73-82.
  • Kerwin JM, Morris CM, Johnson M, Perry RH, Perry EK. Hippocampal p75 Nerve Growth Factor Receptor Immunoreactivity in Development, Normal Aging and Senescence. Acta Anatomica 1993, 147(4), 216-222.
  • Perry EK, Irving D, Kerwin JM, McKeith IG, Thompson P, Collerton D, Fairbairn AF, Ince PG, Morris CM, Cheng AV, Perry RH. Cholinergic Transmitter and Neurotrophic Activities in Lewy Body Dementia: Similarity to Parkinson's and Distinction from Alzheimer Disease. Alzheimer Disease & Associated Disorders 1993, 7(2), 69-79.
  • Perry EK, Court JA, Johnson M, Smith CJ, James V, Cheng AV, Kerwin JM, Morris CM, Piggott MA, Edwardson JA, Birdsall NJM, Turner JT, Perry RH. Autoradiographic comparison of cholinergic and other transmitter receptors in the normal human hippocampus. Hippocampus 1993, 3(3), 307-315.
  • Kerwin JM, Morris CM, Perry RH, Perry EK. Nerve Growth Factor Receptor-Like Immunoreactivity in the Human Spinal Cord. Acta Anatomica 1992, 144(4), 348-353.
  • Kerwin JM, Morris CM, Perry RH, Perry EK. Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease. Neuroscience Letters 1992, 143(1-2), 101-104.
  • Perry EK, Johnson M, Kerwin JM, Piggott MA, Court JA, Shaw PJ, Ince PG, Brown A, Perry RH. Convergent cholinergic activities in aging and Alzheimer's disease. Neurobiology of Aging 1992, 13(3), 393-400.
  • Perry EK, McKeith I, Thompson P, Marshall E, Kerwin J, Jabeen S, Edwardson JA, Ince P, Blessed G, Irving D, Perry RH. Topography, extent, and clinical relevance of neurochemical deficits in dementia of Lewy body type, Parkinson's disease, and Alzheimer's disease. Annals of the New York Academy of Sciences 1991, 640, 197-202.
  • Kerwin J, Morris C, Oakley A, Perry R, Perry E. Distribution of Nerve Growth Factor Receptor Immunoreactivity in the human hippocampus. Neuroscience Letters 1991, 121, 178-182.
  • Perry EK, Perry RH, Kerwin JM, Blessed G. Visual hallucinations and the cholinergic system in dementia. Journal of Neuurology, Neurosurgery and Psychiatry 1990, 53, 1-11.
  • Kerwin JM, Perry EK, Morris CM, Perry RH. Nerve Growth Factor Receptor‑Positive Fibre Pathways in the Human Neocortex. Biochemical society Transactions 1990, 18, 661-663.
  • SAHGAL A, KEITH AB, LLOYD S, KERWIN JM, PERRY EK, EDWARDSON JA. MEMORY FOLLOWING CHOLINERGIC (NBM) AND NORADRENERGIC (DNAB) LESIONS MADE SINGLY OR IN COMBINATION - POTENTIATION OF DISRUPTION BY SCOPOLAMINE. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 1990, 37(4), 597-605.
  • Perry EK, Kerwin JM, Perry RH, Irving D, Blessed G, Fairbairn AF. Cerebral Cholinergic Activity is Related to the Incidence of Visual Hallucinations in Senile Dementia of Lewy body Type. Dementia 1990, 1, 2-4.

• Conference Proceedings (inc. Abstracts)

  • Keenan ID, Solim ZN, Quigg S, Kerwin J, Lindsay S. Enhancing student learning of human embryology with aprototype e-learning resource. In: Anatomical Society Winter Meeting 2016. 2017, King's College London, UK: Wiley-Blackwell Publishing Ltd.
  • Kerwin J, Hill B, Yang YY, Merchan P, Sandoval J, Sarma S, Baldock R, Puelles L, Lindsay S. The HUDSEN Atlas: A new resource for studying morphogenesis and gene expression during human embryonic development. In: 16th Annual Conference of the International Society of Development Biologists. 2009, Edinburgh, Scotland: Mechanisms of Development: Elsevier.
  • Sarma S, Kerwin J, Puelles L, Scott M, Strachan T, Feng G, Sharpe J, Davidson D, Baldock R, Lindsay S. 3D modelling, gene expression mapping and post-mapping image analysis in the developing human brain. In: Evolution and Development of Nervous Systems - Proceedings of the 4th European Conference on Comparative Neurobiology. 2005, Oxford: Brain Research Bulletin, Elsevier.
  • Lindsay S, Scott M, Sarma S, Woods H, Crosier M, Lisgo S, Kerwin J, Strachan T, Robson SC. Human developmental gene expression: an important link between disorder and understanding. In: Journal of Medical Genetics: British Human Genetics Conference. 2004, York, UK: BMJ Group.
  • Robson SC, Woods HM, Issac A, Sharpe JA, Kerwin JM, Scott MK, Baldock RA, Davidson D, Strachan T, Lindsay S. 3-dimensional modelling of human development using optical projection tomography. In: 51st Annual Meeting of the Society for Gynecologic Investigation. 2004, Houston, Texas: Journal of the Society for Gynecologic Investigation: Elsevier.
  • SAHGAL A, KEITH AB, LLOYD S, KERWIN JM, PERRY EK. EFFECTS OF COMBINED CHOLINERGIC AND NORADRENERGIC LESIONS ON RAT MEMORY. In: PSYCHOPHARMACOLOGY. 1990.

• Letters

  • Perry EK, Kerwin JM, Perry RH. On neuronal ill health. Trends in Neurosciences 1994, 17(2), 51-51.
  • Perry EK, Kerwin J, Perry RH, Blessed G, Fairbairn AF. Visual hallucinations and the cholinergic system in dementia. Journal of Neurology, Neurosurgery and Psychiatry 1990, 53(1), 88-88.

• Notes

  • COURT JA, KEITH AB, KERWIN JM, PERRY EK. FIMBRIA-FORNIX LESIONS IN AGED RATS CAUSE INCREASED CARBACHOL-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN THE HIPPOCAMPUS, BUT NO CHANGE IN MUSCARINIC RECEPTOR-BINDING. BRAIN RESEARCH 1990, 532(1-2), 333-335.
  • Perry EK, Marshall E, Kerwin J, Smith CJ, Jabeen S, Cheng AV, Perry RH. Evidence of a Monoaminergic-Cholinergic Imbalance Related to Visual Hallucinations in Lewy Body Dementia. Journal of Neurochemistry 1990, 55(4), 1454-1456.

• Reviews

  • Anderson RH, Kerwin J, Lamers WH, Hikspoors JPJM, Mohun TJ, Chaudhry B, Lisgo S, Henderson DJ. Cardiac development demystified by use of the HDBR atlas. Journal of Anatomy 2024, 245(4), 517-534.
  • Clowry GJ, Alzu'bi A, Harkin LF, Sarma S, Kerwin J, Lindsay S. Charting the protomap of the human telencephalon. Seminars in Cell and Developmental Biology 2018, 76, 3-14.
  • Lindsay S, Sarma S, Martinez-De-La-Torre M, Kerwin J, Scott M, Luis Ferran J, Baldock R, Puelles L. Anatomical and gene expression mapping of the ventral pallium in a three-dimensional model of developing human brain. Neuroscience 2005, 136(3), 625-632.