Staff Profile

I spent 6 years in the Wellcome Centre for Mitochondrial Research at Newcastle University where I carried out my PhD and postdoctoral research investigating the effects of ageing in colorectal cancer development. I subsequently worked for a global life science consultancy firm where I was involved in synthesising evidence and strategy planning, to help health technologies being developed by pharmaceutical companies gain market access. My current role in the NHIR Innovation Observatory involves objectively horizon scanning and synthesising evidence for various stakeholders including DHSC and NICE. 

About the NIHR Innovation Observatory

Home - NIHR Innovation Observatory

The NIHR Innovation Observatory is a world leading health and care innovation scanning centre providing data-driven insights to foster innovation and equitable access to high quality care. We aim to transform health systems and improve population health by providing advanced data-driven insights that foster innovation and equitable access to high quality care. At the core of our work is the development of data-driven methods to identify, capture and synthesise intelligence on new health innovations. We develop and share cutting edge methods in horizon scanning, building capacity in the systems across the public, voluntary and industry sectors.

We deliver essential intelligence and insights about medicines and MedTech innovation to the National Institute of Health and Care Excellence (NICE), NHS England, the Medicines and Healthcare Products Regulatory Agency (MHRA), the NIHR, the UK Health Security Agency, the Department for Health and Social Care and industry - allowing these organisations to prepare for policies, regulation and frontline delivery for new, emerging and disruptive technologies.

• Articles

  • Yu X, Arden C, Berlinguer-Palmini R, Chen C, Bradshaw C, Smith AL, Whitehall J, White M, Anderson S, Kattner N, Shaw J, Turnbull D, Greaves LC, Walker M. Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation. Molecular Metabolism 2022, 60, 101489.
  • Stamp C, Whitehall JC, Smith ALM, Houghton D, Bradshaw C, Stoll EA, Blain AP, Turnbull DM, Greaves LC. Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon. Aging Cell 2021, 20(3), e13321.
  • Smith ALM, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A, Houghton D, Hunt M, Sampson JN, Stamp C, Mallett G, Amarnath S, Leslie J, Oakley F, Wilson L, Baker A, Russell OM, Johnson R, Richardson CA, Gupta B, McCallum I, McDonald SAC, Kelly S, Mathers JC, Heer R, Taylor RW, Perkins ND, Turnbull DM, Sansom OJ, Greaves LC. Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis. Nature Cancer 2020, 1, 976-989.
  • Paish H, Reed L, Brown H, Bryan M, Govaere O, Leslie J, Barksby B, GarciaMacia M, Watson A, Xu X, Zaki M, Greaves L, Whitehall J, French J, White S, Manas D, Robinson S, Spoletini G, Griffiths C, Mann DA, Borthwick LA, Drinnan M, Mann J, Oakley F. A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices. Hepatology 2019, 70(4), 1377-1391.

• Book Chapter

  • Whitehall JC, Smith ALM, Greaves LC. Mitochondrial DNA Mutations and Ageing. In: Biochemistry and Cell Biology of Ageing: Part III Biomedical Science. Cham: Springer, 2023, pp.77-98.

• Reviews

  • Smith ALM, Whitehall JC, Greaves LC. Mitochondrial DNA mutations in ageing and cancer. Molecular Oncology 2022, 16(18), 3276-3294.
  • Whitehall JC, Greaves LC. Aberrant mitochondrial function in ageing and cancer. Biogerontology 2020, 21(4), 445-459.