Staff Profile

Qualifications

 D.Phil - University of Oxford.

Thesis title: cDNA libraries from the developing mouse pancreas as a resource to study normal and diabetic pancreata and from radiation hybrid transcript mapping. Supervised by Dr Roger Cox.

M.Biochem - University of Oxford.

Previous Positions

2012 –2013                   Postdoctoral Research Associate.

Institute of Genetic Medicine, Newcastle University.

Investigating the role of the protein RNF113A in a novel skeletal patterning disorder, X-linked absent radius spectrum (XLARS) in the team of Professor Judith Goodship.

2006 –2011                   Postdoctoral Research Associate.

Institute of Genetic Medicine, Newcastle University.

Studying the roles of proteins involved in childhood cystic kidney disease (nephrocystin proteins) using mouse, Zebrafish and cell based models in the team of Dr John Sayer.

2001 – 2006                  Postdoctoral Research Associate.

Institute of Genetic Medicine, Newcastle University.

Studying the Inversin protein and its role in cystic kidney disease and left right laterality using a mouse model and cell based systems in the team of Professor Judith Goodship and Professor Tom Strachan.

My main area of research is  to study how arterial valves form and what are the developmental origins of valve anomalies such as bicuspid aortic valve.

• Eley L, Alqahtani A, MacGrogan D, Richardson R, Murphy L, Salguero-Jimenez A, Rodriguez San Pedro M, Tiurma S, McCutcheon L, Gilmore A, de La Pompa JL, Chaudhry B, Henderson D. A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. eLife 2018, 7, e34110.
• Richardson R, Eley L, Donald-Wilson C, Davis J, Curley N, Alqahtani A, Murphy L, Anderson RH, Henderson DJ, Chaudhry B. Development and maturation of the fibrous components of the arterial roots in the mouse heart. Journal of Anatomy 2018, 232(4), 554-567.
• Al-Hamed MH, van Lennep C, Hynes AM, Chrystal P, Eley L, Al-Fadhly F, El Sayed R, Simms RJ, Meyer B, Sayer JA. Functional modelling of a novel mutation in BBS5. Cilia 2014, 3, 3.
• Hynes AM, Giles RH, Srivastava S, Eley L, Whitehead J, Danilenko M, Raman S, Slaats GG, Colville JG, Ajzenberg H, Kroes HY, Thelwall PE, Simmons NL, Miles CG, Sayer JA. Murine Joubert syndrome reveals Hedgehog signaling defects as a potential therapeutic target for nephronophthisis. Proceedings of the National Academy of Sciences of the United States of America 2014, 111(27), 9893-9898.
• Ramsbottom SA, Sharma V, Rhee HJ, Eley L, Phillips HM, Rigby HF, Dean C, Chaudhry B, Henderson DJ. Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development. PLoS Genetics 2014, 10(12), e1004871.
• Veland IR, Montjean R, Eley L, Pedersen LB, Schwab A, Goodship J, Kristiansen K, Pedersen SF, Saunier S, Christensen ST. Inversin/Nephrocystin-2 Is Required for Fibroblast Polarity and Directional Cell Migration. PLoS ONE 2013, 8(4), e60193.
• Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton BA, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJF, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Ysunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Joles JA, Janssen S, Allen SJ, Natarajan S, O'Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EYHP, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell 2012, 150(3), 533-548.
• Cheng YZ, Eley L, Hynes AM, Overman LM, Simms RJ, Barker A, Dawe HR, Lindsay S, Sayer JA. Investigating Embryonic Expression Patterns and Evolution of AHI1 and CEP290 Genes, Implicated in Joubert Syndrome. PloS One 2012, 7(9), e44975.
• Simms RJ, Hynes AM, Eley L, Inglis D, Chaudhry B, Dawe HR, Sayer JA. Modelling a ciliopathy: ahi1 knockdown in model systems reveals an essential role in brain, retinal and renal development. Cellular and Molecular Life Sciences 2011, 69(6), 993-1009.
• Simms RJ, Hynes AM, Eley L, Sayer JA. Nephronophthisis: a genetically diverse ciliopathy. International Journal of Nephrology 2011, 527137.
• Eley L, Simms RJ, Miles CG, Sayer JA. Development of a Novel Murine Model of Nephronophthisis. Pediatric Nephrology 2009, 24(9), 1802-1803.
• Simms RJ, Eley L, Sayer JA. Nephronophthisis. European Journal of Human Genetics 2009, 17(4), 406-416.
• Carr G, Moochhala SH, Eley L, Vandewalle A, Simmons NL, Sayer JA. The Pyrophosphate Transporter ANKH is Expressed in Kidney and Bone Cells and Colocalises to the Primary Cilium/Basal Body Complex. Cellular Physiology and Biochemistry 2009, 24(5-6), 595-604.
• Eley L, Gabrielides C, Adams M, Johnson CA, Hildebrandt F, Sayer JA. Jouberin localizes to collecting ducts and interacts with nephrocystin-1. Kidney International 2008, 74(9), 1139-1149.
• Eley L, Moochhala SH, Simms R, Hildebrandt F, Sayer JA. Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct. Biochemical and Biophysical Research Communications 2008, 371(4), 877-882.
• Krishnan R, Eley L, Sayer JA. Urinary concentration defects and mechanisms underlying nephronophthisis. Kidney and Blood Pressure Research 2008, 31(3), 152-162.
• Eley L, Sayer J. Expression studies of the novel nephrocystin protein jouberin. In: Nephrology, Dialysis, Transplantation: 44th ERA-EDTA Congress. 2007, Barcelona, Spain: Oxford University Press.
• Eley L, Yates LM, Goodship JA. Cilia and disease. Current Opinion in Genetics & Development 2005, 15(3), 308-314.
• Eley L, Turnpenny L, Yates LM, Craighead AS, Morgan D, Whistler C, Goodship JA, Strachan T. A perspective on inversin. Cell Biology International 2004, 28(2), 119-124.
• Hecksher-Sorensen J, Watson RP, Lettice LA, Serup P, Eley L, De Angelis C, Ahlgren U, Hill RE. The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development 2004, 131(19), 4665-4675.
• Morgan D, Eley L, Sayer J, Strachan T, Yates LM, Craighead AS, Goodship JA. Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. Human Molecular Genetics 2002, 11(26), 3345-3350.