Staff Profile

Introduction

I am a Consultant Paediatrician in Allergy and Immunology at The Great North Children's Hospital (GNCH), Newcastle upon Tyne Hospitals NHS Foundation Trust. I am also a Senior Lecturer within the Population Health Sciences Institute, Faculty of Medicine, Newcastle University where I am a Principle Investigator within the themes of Reproduction, Development and Child Health Research. Our research has an alliance within the Translational and Clinical Research Institute within the theme of Immunity and Inflammation.

I read for my PhD under the tutelage of Professors Graham Roberts, John Holloway, Tony Williams, Hasan Arshad (Southampton University) and Catherine Thornton (Swansea University) (2018) on 'Immune tolerance in early childhood'. I continue to develop and understanding of childhood allergic diseases with an interest in immune tolerance, dysbiosis and Th2 related allergic inflammatory disorders.

We develop and deliver phase I/II/III portfolio clinical trials within the GNCH-Research Community (GNCH-RC), translating the development of new diagnostic immune mechanisms, immunotherapy and novel targeted therapies into clinical practice. Together within the 'Model of Seamless Allergy Care' North East, we improve delivery of Education and Research of Allergic Disease in Children (REACH).

Qualifications

BSc(Hons), MBChB, MRCPCH, MSc, PhD

Roles and responsibilities

• Paediatric Secretary British Society of Allergy Clinical Immunology Registry for Immunotherapies (BRIT), 2020 onwards
• Member British Society Allergy Clinical Immunology, Scientific Committee, 2020 onwards
• Paediatric stage 4 lead undergraduate immunology allergy curriculum, 2020 onwards
• Member British Society Allergy Clinical Immunology, Allergy Education Network (BAEN) Committee, 2019 onwards
• Member Royal College of Paediatrics and Child Health, SPIn Curriculum, 2019 onwards
• Member European Academy of Allergy and Clinical Immunology, Taskforce for Food Allergy and Anaphylaxis, 2019 onwards
• Faculty Allergy eModule, Newcastle University (Lead Immunology/ skin), 2014 onward
• Faculty MSc Allergy, Southampton University, 2008 onward
• Member Northern Paediatric Allergy Network, Chair, 2013 - 2018

Areas of expertise

• Allergic inflammation
• Anaphylaxis
• Drug allergy
• Immunotherapy
• Targeted therapies
• Transplant associated allergies

Awards

• Barry Kay Award, Clinical Paediatrics, British Society of Allergy and Clinical Immunology, 2020
• Finalist, Research Supervisor of the Year, Newcastle University, 2020
• Education Category Award, RCPCH Drugs and Bugs sepsis podcast, Bright Ideas in Health Awards, 2019
• Service Improvement Category Award, Honeycomb Model of Seamless Allergy Care, Bright Ideas in Health Awards, 2017
• NIHR NENC Commercial Study Team of the Year, 2017
• NIHR Leading Principle Investigator Award, 2016

ORCiD ID: 0000 0001 8229 154X

Google Scholar: https://scholar.google.co.uk/citations?user=tyazG1IAAAAJ&hl=en

Twitter: @NPAGNetwork

Outline

The Research and Education of Allergic Disease of Children Programme (REACH) focuses on increasing the understanding of childhood allergic disease and translating cutting edge clinical discoveries to support the development of new diagnostic immune mechanistic platforms and targeted therapies.

Within the three Institutes of the Faculty of Medicine Sciences, Newcastle University teams work together to improve the health, care and well-being of children with allergic disease. In collaboration with the Clinical Research Facility of the Great North Children's Hospital Research Community (GNCH-RC) we bring our research to the clinical interface.

All projects can be further reviewed on my website above.

The Population Health Sciences allergy (PHSI) team

As winners of the Service Improvement Category Bright Ideas in Health Awards (2017) our team brings 'The Model of Seamless Allergy Care' to the North East. Research and Academic Health Partners within PHSI unite within the Academic Health Science Network for the North East and North Cumbria (AHSN NENC), to bring clinicians and allied health professionals of the Department of Paediatric Allergy, Immunology and Infectious Diseases at The Great North Children's Hospital and Benfield Park Medical Group together. Within the Theme of Reproduction, Development and Child Health Research we aim to improve the delivery of care for children with allergy. 

Current projects

• ADAGIO Complex
• Drug Allergy and Peri-Operative Anaphylaxis
• Model of Seamless Allergy Care
• Transplant Associated Allergies (TAA)
• The Trilogy of Allergy in Cystic Fibrosis

The Clinical and Translational Research Institute allergy (CTRI) team

Within the Theme of Immunity and Inflammation, scientists, academics and clinical researchers collaborate with a goal to increase awareness and understanding of allergic inflammatory diseases. Alongside the Flow Cytometry Core Facility, and collaborations with the Universities of Liverpool, Kings College London, Southampton and Swansea we aim to translate laboratory findings into new diagnostic platforms. Current MRES Newcastle University projects are diverse with our basic science team collaborating with the GNCH- Research Community and GNCH Clinical Research Facility to develop and support epidemiological and interventional studies.

Current projects

• Biomarkers in Eosinophilic Allergic Disease (BREAD STUDY)
• ORigins of CHildhood Eosinophilic and SysTemic Allergic Inflammatory Disease (ORCHESTRA)
• Atopic dermatitis with Gastrointestinal inflammatory Origins (ADAGIO)

The Biosciences Institute Allergy (BI) team

Members of the CTRI allergy team collaborate with immunologists, allergists, geneticists and nutritionists to further understand the immune mechanisms and signalling pathways of Th2 allergic inflammation and the role of the microbiome, fungome and virome in dysbiosis.

Current Projects

• Microbiome and dysbiosis in Allergic Eosinophilic Gastrointestinal Related Origins (ALLEGRO)
• Genetic associations of the ADAGIO Complex 

The Great North Children's Hospital Clinical Research Facility (GNCH-CRF)

The Paediatric Allergy Team supports active participation in a variety of regional, national and international NIHR Phase I/II/III portfolio Clinical Trials. 

Current Clinical Trials

2020

13. A prospective, double blind, placebo controlled trial to evaluate the immunological benefits and clinical effects of an elimination diet using amino acid based formula with a symbiotic blend on gut microbiota and stool characteristics in infants with IgE-mediated cow's milk allergy (PRESTO).

Previous Published Clinical Trials (Newcastle)

2017

12. Advanced clinical blood analysis: Imaging flow cytometry for detection and differentiation of eosinophilia in multiple diseases of childhood (BREAD).

11. A randomised, double blind, placebo controlled study to assess the effect of an amino acid based formula with a symbiotic blend on gut microbiota and stool characteristics in infants with suspected gastrointestinal non-IgE mediated cow's milk allergy (ASSIGN). 

2016

10. Prospective, double blind, multi-centre clinical trial on Grasax: asthma prevention study (GAP). 

2015

9.Randomised control trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood (MAPS). 

2014

8. Safety of live attenuated nasal influenzae immunisation in young people with egg allergic children - a follow -on a multi-centre prospective cohort study (SNIFFLE II). 

2013

7. Safety of live attenuated nasal influenzae immunisation in young people with egg allergic children - a multi-centre prospective cohort study (SNIFFLE I, IV). 

Previous Published Clinical (Southampton)

6. Study in healthy children of GSK Biologicals' DTPa-IPV/Hib-MenC-TT vaccine, GSK2197870A, co-administered with Prevenar as a three-dose primary vaccination course in infancy followed by a booster dose of Mentorix at 12 months of age. 

5. A multi-centre, open-label, randomised, parallel group, mulit-centre study to evaluate the safety, tolerability and immunogenicity of Baxter H1N1 vaccine and GSK H1N1 vaccine in children 6 to 12 months of age. 

4. A multi-centre open-label, clinical, phase IV trial, following on from a head-to-head comparison study of two H1N1 influenzae vaccines in children, to compare firstly the persistence of antibody against the A/California/7/2009 (H1N1) virus and secondly the immunogenecity and reactogenecity of one dose of non-adjuvanted trivalent seasonal influenzae vaccine, in children who had received either 2 dose immunisation regime of Celvapan or Pandemrix, those who have receivd a single dose of Pandemrix, to those who have not received H1N1 influenzae vaccine. 

3. A Follow on, multi-centre, open label, clinical, phase IV trial to investigate the persistence of serotype-specific antibodies at 40 months of age in children who have received either the 7-valent or the 13-valent pneumococcal conjugate vaccine at 2,4, and 12 months of age (PCV 13). 

2.An open label, randomised controlled study to evaluate the induction of immune memory following infant vaccination with a glyco-conjugate Neisseria Meningitidis serogroup C vaccine and to assess the immune response to the concurrent infant routine immunisations administered in consistent versus alternating limbs (BOOSTERIX).

1. Phase II study of a three-dose primary vaccination course of DTPa-IPV/Hib-MenC-TT followed by a 12 month Hib-MenC-TT booster in healthy infants (MALTA).

I believe teaching and networking are vital to bring the very best clinical practice and research to our region and beyond.

Locally, I continue to actively support the Northern Paediatric Allergy Group (NPAG), and The Medical School, Newcastle University undergraduate stage 4, SSC and MRes Programmes. In addition I support as part of faculty the successful digital and virtual Newcastle University Allergy eModule.

Regionally, the Research and Education of Allergic Disease of Children Programme (REACH) focuses on increasing the understanding of childhood allergic disease and translating cutting edge clinical discoveries to support the development of new diagnostic immune mechanistic platforms and targeted therapies.

Nationally, as Faculty and Committee Member, I continue to participate in and lecture for the MSc Allergy (Southampton University); British Society of Allergy and Clinical Immunology (BSACI) Registry in Immunotherapy; BSACI Allergy Education Network; and the Royal College of Paediatrics and Child Health (Allergy SPIn Curriculum).

Internationally, I remain involved in academia as a full time clinician. As previous Chair of NPAG I champion and steer the @NPAGNetwork twitter feed whilst continuing to write articles, reviews and chapters to educate professionals, students and patients in all things 'allergy'. As a mentor, I support students from Europe and worldwide in their training in Immunology and Allergy. I remain a Committee Member of the European Academy of Allergy and Clinical Immunology (Food allergy and anaphylaxis Taskforce).

• Wopereis H, Van Ampting MTJ, Cetinyurek-Yavuz A, Slump R, Candy DCA, Butt AM, Peroni DG, Vandenplas Y, Fox AT, Shah N, Roeselers G, Harthoorn LF, Michaelis LJ, Knol J, West CE. A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow's milk allergic infants: A randomized controlled trial. Clinical and Translational Allergy 2019, 9(1), 27.
• Lippeveld M, Knill C, Ladlow E, Fuller A, Michaelis LJ, Saeys Y, Filby A, Peralta D. Classification of Human White Blood Cells Using Machine Learning for Stain-Free Imaging Flow Cytometry. Cytometry Part A 2019, 97(3), 308-319.
• Netts P, Michaelis LJ. An interpretation of the new international MAP guideline for the management of Milk Allergy in Primary Care. Clinical and Translational Allergy 2017, 7, 34.
• Michaelis LJ, Wopereis H, Van Ampting MT, Nijhuis MMO, Candy DC, Butt AM, Peroni DG, Fox AT, Shah N, Harthoorn LF, Knol J. An amino acid-based formula with synbiotics affects faecal microbiota in Non-IgE mediated cow's milk allergic infants. In: European Academy of Allergy and Clinical Immunology Congress. 2016, Vienna, Austria: Wiley-Blackwell Publishing Ltd.
• Dean HJ, McKean M, Gardner J, Pentland J, Vance G, Gennery A, Michaelis LJ. Respiratory Acute Life-Threatening Event (R-ALTE) admissions to Paediatric Intensive Care Unit (PICU) and the association with Food Allergy (FA) at Great North Children's Hospital (GNCH), Newcastle, UK - Part 1. In: European Academy of Allergy and Clinical Immunology Congress. 2016, Vienna, Austria: Wiley-Blackwell Publishing Ltd.
• Dean HJ, McKean M, Gardner J, Pentland J, Vance G, Gennery A, Michaelis LJ. Respiratory acute life-threatening event (R-ALTE) reviews from Paediatric Intensive Care Unit (PICU) and the association with food allergy (FA) at Great North Children's Hospital (GNCH), Newcastle, UK - part 2. In: European Academy of Allergy and Clinical Immunology Congress. 2016, Vienna, Austria: Wiley-Blackwell Publishing Ltd.
• Cheetham T, Plumb E, Callaghan J, Jackson M, Michaelis L. Dietary restriction causing iodine-deficient goitre. Archives of Disease in Childhood 2015, 100(8), 784-786.
• Davidson NA, Vines J, Bartindale T, Comber R, Balaam M, Mcnaney D, Sutton S, Green D, Michaelis L, Salter L, Olivier P, Vance G. Educating adolescents at risk of anaphylaxis (the ERA study). In: European Academy of Allergy and Clinical Immunology Congress. 2015, Barcelona, Spain: Wiley-Blackwell.
• Zolkipli Z, Roberts G, Cornelius V, Clayton B, Pearson S, Michaelis L, Djukanovic R, Kurukulaaratchy R, Arshad H. Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood. Journal of Allergy and Clinical Immunology 2015, 136(6), 1541-1547.
• Smith PK, Soutter V, Michaelis LJ, Strobel S. Chromosome 18q21.2-21.3 deletions associated with anaphylaxis, severe eczema and allergic airways disease. J Allergy Clin Immunology 2013, 6(1), 13.
• Noakes PS, Michaelis LJ. Innate and adaptive immunity. In: Diet, Immunity and Inflammation. Cambridge: Woodhead Publishing Limited, 2013, pp.3-33.
• Meyer R, Fleming C, Ortega-Dominguez G, Lindley K, Michaelis L, Thapar N, Elawad M, Chakravarti V, Fox AT, Shah N. Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastrointestinal unit. World Allergy Organ Journal 2013, 6(1), 13.
• Khatami A, Snape MD, Ohene-Kena B, Young K, Oeser C, Michaelis LJ, Macleod E, Smee H, VanDerMeeren O, Leyssen M, Caubet M, Yu LM, Heath PT, Faust SN, Finn A, Pollard AJ. Phase II study of a three-dose primary vaccination course of DTPa-IPV/Hib-MenC-TT followed by a 12 month Hib-MenC-TT booster in healthy infants. Pediatr Infect Dis J 2013, 32(6), 675-81.
• Walker WT, deWhalley P, Andrews N, Oeser C, Casey M, Michaelis L, Hoschler K, Harrill C, Moulsdale P, Thompson B, Jones C, Chalk J, Kerridge S, John TM, Okike I, Ladhani S, Tomlinson R, Heath PT, Miller E, Faust SN, Snape MD, Finn A, Pollard AJ. H1N1 antibody persistence 1 year after immunisation with an adjuvanted or whole virion pandemic vaccine and immunogenicity and reactogenecity of subsequent seasonal influenza vaccine: a multi-center follow-on study. Clin Infect Dis 2012, 54(5), 661-9.
• Andrews NJ, Walker WT, Finn A, Heath PT, Collinson AC, Pollard AJ, Snape MD, Faust SN, Waight PA, Hoschler K, Sheasby L, Waddington C, Kerridge S, Chalk J, Reiner A, John T, Fletcher M, Allen R, Fineman N, Wilkins S, Casey M, Michaelis L, Oeser C, Okike I, Ladhani S, Miller E. Predictors of immune response and reacto-genecity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines. vaccine 2011, 29(45), 7913-9.
• Kufeji O, Withana K, Michaelis L. Chronic recurrent multifocal osteomyelitis is a differential of childhood limp. Arch Dis Child 2006, 91(1), 30.
• McIntosh N, Michaelis L, Barclay C, Muir M, Stephen R, Sedowofia K. Dissociation of osmoregulation from plasma arginine vasopressin levels following thermal injury in childhood. Burns 2000, 26(6), 543-7.