Staff Profile

I am currently working as a Data Manager at the NIHR Newcastle Clinical Research Facility. I have previously worked as a Research Technician in both academia and industry. Having a keen interest in Clinical Trials I transitioned to my current post, in which I am managing early phase clinical trials delivered by the CRF in partnership with the Newcastle Hospitals and the Faculty of Medical Sciences.

https://newcastle.crf.nihr.ac.uk/

Qualifications

BSc (Hons) Biochemistry & Biotechnology

MRes Stem Cells and Regenerative Medicine

Memberships

RSciTech Member of the Institute of Biomedical Science

• Articles

  • Rice SJ, Roberts JB, Tselepi M, Brumwell A, Falk J, Steven C, Loughlin J. Genetic and Epigenetic Fine-Tuning of TGFB1 Expression Within the Human Osteoarthritic Joint. Arthritis and Rheumatology 2021, 73(10), 1866-1877.
  • Sorial AK, Hofer IM, Tselepi M, Cheung K, Parker E, Deehan DJ, Rice SJ, Loughlin J. Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC. Osteoarthritis and Cartilage 2020, 28(11), 1448-1458.
  • Rice SJ, Tselepi M, Sorial AK, Aubourg G, Shepherd C, Almarza D, Skelton AJ, Pangou I, Deehan DJ, Reynard L, Loughlin J. Prioritization of PLEC and GRINA as osteoarthritis risk genes through the identification and characterization of novel methylation quantitative trait loci. Arthritis and Rheumatology 2019, 71(8), 1285-1296.
  • Rice SJ, Aubourg G, Sorial AK, Almarza D, Tselepi M, Deehan DJ, Reynard LN, Loughlin J. Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk. Human Molecular Genetics 2018, 27(19), 3464-3474.
  • Hatzikotoulas K, Roposch A, Shah KM, Clark MJ, Bratherton S, Limbani V, Steinberg J, Zengini E, Warsame K, Ratnayake M, Tselepi M, Schwartzentruber J, Loughlin J, Eastwood DM, Zeggini E, Wilkinson JM. Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5. Communications Biology 2018, 1, 56.
  • Ratnayake M, Tselepi M, Bloxham R, Plöger F, Reynard LN, Loughlin J. A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5. PLoS ONE 2017, 12(5), e0176523.
  • Barter MJ, Tselepi M, Gomez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA. Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p. Stem Cells 2015, 33(11), 3266-3280.

• Conference Proceedings (inc. Abstracts)

  • Rice SJ, Sorial AK, Aubourg G, Shepherd C, Tselepi M, Almarza D, Skelton AJ, Deehan D, Reynard LN, Loughlin J. Identification of novel methylation quantitative trait loci (mqtls) and functional characterization using CRISPR/CAS9 and gene expression analysis prioritizes PLEC as an OA risk gene. In: 2018 OARSI World Congress on Osteoarthritis Promoting Clinical and Basic Research in Osteoarthritis. 2018, Liverpool: Elsevier.
  • Tselepi M, Ratnayake M, Bloxham R, Reynard LN, Loughlin J. Differences in the response of mesenchymal stem cells from healthy donors and OA patients to exogenous GDF5 during chondrogenic differentiation. In: 2016 OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis. 2016, Amsterdam, Netherlands: Elsevier.