Staff Profile | Faculty of Medical Sciences

Dr Paul Milne

Senior Research Associate

Telephone: +44 (0) 191 208 2795
Personal Website: https://research.ncl.ac.uk/hilab/
Address: Haematopoiesis and Immunogenomics Lab
Translational and Clinical Research Institute
Faculty of Medical Sciences
Newcastle University
M3.127, 3rd Floor Leech Building
Framlington Place
Newcastle upon Tyne
NE2 4HH

Publications

Batta K, Bossenbroek HM, Pemmaraju N, Wilks DP, Chasty R, Dennis M, Milne P, Collin M, Beird HC, Taylor J, Patnaik MM, Cargo CA, Somervaille TCP, Wiseman DH. Divergent clonal evolution of blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia from a shared TET2-mutated origin. Leukemia 2021, 35, 3299-3303.
Bhatt R, Semple T, Slater O, Nicholson AG, Casanueva L, Desai A, Hoschtitzky A, Milne P, Langley R. Extracorporeal membrane oxygenation: Bridging therapy in paediatric pulmonary Langerhans cell histiocytosis. Journal of Paediatrics and Child Health 2021, 58(5), 906-908.
Bellmann L, Zelle-Rieser C, Milne P, Resteu A, Tripp CH, Hermann-Kleiter N, Zaderer V, Wilflingseder D, Hortnagl P, Theochari M, Schulze J, Rentzsch M, Del Frari B, Collin M, Rademacher C, Romani N, Stoitzner P. Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function. Journal of Investigative Dermatology 2021, 141(1), 84-94.e6.
Cytlak U, Resteu A, Pagan S, Green K, Milne P, Maisuria S, McDonald D, Hulme G, Filby A, Carpenter B, Queen R, Hambleton S, Hague R, Lango Allen H, Thaventhiran JED, Doody G, Collin M, Bigley V. Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans. Immunity 2020, 53(2), 353-370.
Milne P, Wilhelm-Benartzi C, Grunwald MR, Bigley V, Dillon R, Freeman SD, Gallagher K, Publicover A, Pagan S, Marr H, Jones GL, Dickinson AM, Grech A, Burnett AK, Russell NH, Levis M, Knapper S, Collin M. Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia. Blood Advances 2019, 3(20), 3052-3061.
Donadieu J, Larabi IA, Tardieu M, Visser J, Hutter C, Sieni E, Kabbara N, Barkaoui M, Miron J, Chalard F, Milne P, Haroche J, Cohen F, Helias-Rodzewicz Z, Simon N, Jehanne M, Kolenova A, Pagnier A, Aladjidi N, Schneider P, Plat G, Lutun A, Sonntagbauer A, Lehrnbecher T, Ferster A, Efremova V, Ahlmann M, Blanc L, Nicholson J, Lambilliote A, Boudiaf H, Lissat A, Svojgr K, Bernard F, Elitzur S, Golan M, Evseev D, Maschan M, Idbaih A, Slater O, Minkov M, Taly V, Collin M, Alvarez J-C, Emile J-F, Heritier S. Vemurafenib for Refractory Multisystem Langerhans Cell Histiocytosis in Children: An International Observational Study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 2019, 37(31), 2857-2865.
Bigley V, Maisuria S, Cytlak U, Jardine L, Care MA, Green K, Gunawan M, Milne P, Dickinson R, Wiscombe S, Parry D, Doffinger R, Laurence A, Fonseca C, Stoevesandt O, Gennery A, Cant A, Tooze R, Simpson AJ, Hambleton S, Savic S, Doody G, Collin M. Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation. Journal of Allergy and Clinical Immunology 2018, 141(6), 2234-2248.
Fordham SE, Blair HJ, Elstob CJ, Plummer R, Drew Y, Curtin NJ, Heidenreich O, Pal D, Jamieson D, Park C, Pollard J, Fields S, Milne P, Jackson GH, Marr HJ, Menne T, Jones GJ, Allan JM. Inhibition of ATR acutely sensitises acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase. Blood Advances 2018, 2(10), 1157-1169.
Milne P, Bigley V, Bacon CM, Néel A, McGovern N, Bomken S, Haniffa M, Diamond EL, Durham BH, Visser J, Hunt D, Gunawardena H, Macheta M, McClain KL, Allen C, Abdel-Wahab O, Collin M. Hematopoietic origin of Langerhans cell histiocytosis and Erdheim Chester disease in adults. Blood 2017, 130(2), 167-175.
Hunt D, Milne P, Fernandes P, Bigley V, Collin M. Targeted treatment of brainstem neurohistiocytosis guided by urinary cell-free DNA. Neurology: Neuroimmunology & Neuroinflammation 2017, 4(1), e299.
Collin M, Milne P. Langerhans cell origin and regulation. Current Opinion in Hematology 2016, 23(1), 28-35.
Llibre A, Lopez-Macias C, Marafioti T, Mehta H, Partridge A, Kanzig C, Rivellese F, Galson JD, Walker LJ, Milne P, Phillips RE, Kelly DF, Freeman GJ, El Shikh ME, Klenerman P, Willberg CB. LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation. Journal of Immunology 2016, 196(5), 2085-2094.
Collin M, Milne P, Bigley V, Neel A, Haniffa M, Durham B, Diamond E, Abdel-Wahab O. The Hematopoietic Origin of Adult Histiocytosis. In: 32nd Annual Meeting of the Histiocyte Society. 2016, Dublin, Ireland: John Wiley & Sons, Inc.
Reynolds G, Milne P, Bigley V, Collin M, Isaacs J, Hilkens C, Haniffa M. Use of the dendritic cell marker, B and T lymphocyte attenuator, to identify functionally distinct subsets of human CD1c+ dendritic cells. In: Spring Meeting for Clinician Scientists in Training 2016. 2016, London, UK: Elsevier.
Milne P, Bigley V, Gunawan M, Haniffa M, Collin M. CD1c⁺ blood dendritic cells have Langerhans cell potential. Blood 2015, 125(3), 470-473.
Bigley V, McGovern N, Milne P, Dickinson R, Pagan S, Cookson S, Haniffa M, Collin M. Langerin-expressing dendritic cells in human tissues are related to CD1c⁺ dendritic cells and distinct from Langerhans cells and CD₁₄₁^high XCR1⁺ dendritic cells. Journal of Leukocyte Biology 2015, 97(4), 627-634.
Milne P, Collin M, Bigley V, Bacon CM, McGovern N, Windebank K, Allen C, McClain K, Haniffa M. Mapping the BRAFV600E Hematopoietic Clone of Adult Multi-System Langerhans Cell Histiocytosis. In: 30th Annual Meeting of the Histiocyte Society. 2015, Toronto, Ontario, Canada: Wiley-Blackwell.
Collin M, Milne P, McGovern N, Berres ML, Kaibo D, Bigley V, Haniffa M, Hicks JM, Shin A, Poidinger M, McClain K, Merad M, Allen CE, Ginhoux F. Studies on the Pathway of Differentiation of LCH Cells. In: 31st Annual Meeting of the Histiocyte Society. 2015, Athens, Greece: John Wiley & Sons, Inc.
Milne P, Bigley V, Gunawan M, Haniffa M, Collin M. CD1c+ blood dendritic cells have Langerhans cell potential. In: British Society for Immunology Annual Congress. 2014, Brighton, UK: Wiley-Blackwell Publishing Ltd.
McGovern N, Schlitzer A, Gunawan M, Jardine L, Shin A, Poyner E, Green K, Dickinson R, Wang XN, Low D, Best K, Covins S, Milne P, Pagan S, Aljefri K, Windebank M, Saavedra DM, Larbi A, Wasan PS, Duan K, Poidinger M, Bigley V, Ginhoux F, Collin M, Haniffa M. Human Dermal CD14⁺ Cells Are a Transient Population of Monocyte-Derived Macrophages. Immunity 2014, 41(3), 465-477.
Bigley V, Dickinson R, Jardine L, Milne PPS, Griffin H, Santibanez-Koref M, Haniffa M, Cant A, Hambleton S, Gennery A, Collin M. Human SHP-1 Mutation Causes an Autoinflammatory and Immunodeficiency Phenotype. In: European Society for Immunodeficiencies. 2014, Prague, Czech Republic: Springer.
McGovern N, Schlitzer A, Gunawan M, Jardine L, Shin A, Poyner E, Green K, Dickinson R, Wang XN, Low D, Best K, Covins S, Milne P, Pagan S, Aljefri K, Windebank M, Miranda-Saavedra D, Wasan P, Kaibo D, Poidinger M, Bigley V, Ginhoux F, Collin M, Haniffa M. Human tissue mononuclear phagocyte system revisited. In: British Society for Immunology Annual Congress. 2014, Brighton, UK: Wiley-Blackwell Publishing Ltd.
Llibre A, Walker LJ, Milne P, Collin M, Marafioti T, Freeman G, Klenerman P, Willberg CB. Lectin-like Transcript 1 in Germinal Centres. In: 18th Germinal Centre Conference. 2014, Uddevalla, Sweden: Wiley-Blackwell Publishing.
Dickinson RE, Milne P, Pagan S, Bigley V, Collin M. Reduced GATA-2 expression in individuals with DCML deficiency. In: British Society for Immunology Annual Congress. 2014, Brighton, UK: Wiley-Blackwell Publishing Ltd.
Culpin RE, Sieniawski M, Angus B, Menon GK, Proctor SJ, Milne P, McCabe K, Mainou-Fowler T. Prognostic significance of immunohistochemistry-based markers and algorithms in immunochemotherapy-treated diffuse large B-cell lymphoma patients. Histopathology 2013, 63(6), 788-801.
Bigley V, Dickinson R, Gennery A, Griffin H, Haniffa M, McGovern N, Milne P, Cant A, Santibanez-Koref M, Hambleton S, Collin M. Human dendritic cell deficiency. In: 15th Biennial Meeting European Society for Immunodeficiency (ESID). 2012, Florence, Italy: Springer.
Culpin R, Sieniawski M, Anderson J, Angus B, Proctor S, Menon G, McCabe K, Milne P, Crosier S, Mainou-Fowler T. Mature microRNAs of the miR-17-92 cluster predict for disease outcome in diffuse large B-cell lymphoma (DLBCL) patients treated with CHOP-R immunochemotherapy. In: International Journal of Molecular Medicine. 2011, Spandidos Publications.