Staff Profile

Qualifications

BSc (Hons) Biochemistry (Newcastle University)
PhD (Cancer Research Unit, Newcastle University)

Previous Positions

Postdoctoral research associate, MRC Protein Phosphorylation Unit, University of Dundee (Oct '02 - Feb '04)
MRC Career Development Fellow, MRC Protein Phosphorylation Unit, University of Dundee (Feb '04 - Feb'06)

Research Interests

Identification of novel cellular mechanisms that regulate genomic instability

Investigating potential adverse effects associated with medical radiation

Current Work

Novel mechanisms regulating the microcephalin-1 tumour suppressor

The impact of BRCA1/BRCA2 mutations on radiation sensitivity

Research Roles

Principal Investigator

Co-Investigator

Postgraduate Supervision

Co-supervision of PhD students (one current)

Supervision of BSc, MRes and MSci students

Funding

Department of Health, £309,586 (Principal Investigator), 'Quantifying the Potential Genotoxic Effects of Ionising Radiation on BRCA1/2 Mutant Cells' (November 2016 - April 2019).

NIHR, £3,387,712 (co-applicant), establishment of the Health Protection Research Unit in Chemical and Radiation Threats and Hazards' at Newcastle University (April 2014 - March 2020). 

Newcastle University PVC Discretionary Fund, £3,800 (Principal Investigator, July 2016 - January 2017).

Wellcome Trust Institutional Strategic Support Fund, £8,300 (Principal Investigator, April 2015 - March 2016).

Home Office, £1,100,000 (Co-applicant), 'Chronic Health Effects after Exposure to Chemical Agents' (March 2006 - March 2010).

Undergraduate Teaching

MMB8032 

Undergraduate research project supervision

• Ahmadimanesh M, Abbaszadegan MR, Morshedi Rad D, Moallem SA, Mohammadpour AH, Ghahremani MH, Farid Hosseini F, Behdani F, Akhondpour Manteghi A, Jowsey P, Shabani Behbahani F, Moallem SMH, Etemad L. Effects of selective serotonin reuptake inhibitors on DNA damage in patients with depression. Journal of Psychopharmacology 2019, 33(11), 1364-1376.
• Li J, Dang M, MartinezLopez N, Jowsey PA, Huang D, Lightowlers RN, Gao F, Huang JY. M2I‑1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti‑mitotic drugs via MCL‑1s. Cell Division 2019, 14(5).
• Meyer SK, Dunn M, Vidler DS, Porter A, Blain PG, Jowsey PA. Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1. The FASEB Journal 2019, 323(2), ePub ahead of Print.
• Khateri S, Balali-Mood M, Blain P, Williams F, Jowsey P, Soroush MR, Behravan E, Sadeghi M. DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure. Toxicology Letters 2018, 293, 67-72.
• Behravan E, Moallem SA, Kalalinia F, Ahmadimanesh M, Blain P, Jowsey P, Khateri S, Forghanifard MM, BalaliMood M. Telomere shortening associated with increased levels of oxidative stress in sulfur mustard-exposed Iranian veterans. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2018, 834, 1-5.
• Meyer SK, Probert PME, Lakey AK, Leitch A, Blake LI, Jowsey PA, Cooke MP, Blain PG, Wright MC. Environmental xenoestrogens super-activate a variant murine ER beta in cholangiocytes. Toxicological Sciences 2017, 156(1), 54-71.
• Meyer SK, Probert PME, Lakey AF, Axon AR, Leitch AC, Williams FM, Jowsey PA, Blain PG, Kass GEN, Wright MC. Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse. Toxicology Letters 2017, 273, 55-68.
• Langlands H, Blain PG, Jowsey PA. Fe65 is Phosphorylated on Ser²⁸⁹ after UV-Induced DNA Damage. PLoS One 2016, 11(5), e0155056.
• Probert PME, Meyer SK, Alsaeedi F, Axon AA, Fairhall EA, Wallace K, Charles M, Oakley F, Jowsey PA, Blain PG, Wright MC. An expandable donor-free supply of functional hepatocytes for toxicology. Toxicology Research 2015, 4(2), 203-222.
• Jowsey PA, Blain PG. Checkpoint kinase 1 is activated and promotes cell survival after exposure to sulphur mustard. Toxicology Letters 2015, 232(2), 413-421.
• Jowsey PA, Blain PG. Fe65 Ser²²⁸ is Phosphorylated by ATM/ATR and Inhibits Fe65-APP-Mediated Gene Transcription. Biochemical Journal 2014.
• Meyer S, Axon A, Jowsey P, Williams F, Blain P, Wright M. Tartrazine is not an activator of the mouse oestrogen ER alpha and ER beta receptors. In: 50th Congress of the European Societies of Toxicology (EUROTOX). 2014, Edinburgh: Elsevier Ireland.
• Jowsey PA, Blain PG. Whole Genome Expression Analysis in Primary Bronchial Epithelial Cells after Exposure to Sulphur Mustard. Toxicology Letters 2014, 230(3), 393-401.
• Behravan E, Moallem SA, Khateri S, Maraghi E, Jowsey P, Blain PG, Balali-Mood M. Deoxyribonucleic acid damage in Iranian veterans 25 years after wartime exposure to sulfur mustard. Journal of Research in Medical Sciences 2013, 18(3), 239-244.
• Jowsey PJ, Williams FM, Blain PG. DNA damage responses in cells exposed to sulphur mustard. Toxicology Letters 2012, 209(1), 1-10.
• Jowsey PA, Dunn M, Vidler D, Blain PG. Identification of Phosphorylation Sites in Microcephalin-1. In: American Society for Mass Spectromety. 2012, Vancouver.
• Jowsey PA, Williams FM, Blain PG. The role of homologous recombination in the cellular response to sulphur mustard. In: Toxicology: Annual Congress of The British Toxicology Society. 2011, Durham: Elsevier Ireland Ltd.
• Jowsey PA, Williams FM, Blain PG. The role of homologous recombination in the cellular response to sulphur mustard. Toxicology Letters 2010, 197(1), 12-18.
• Jowsey PA, Williams FM, Blain PG. DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide. Toxicology 2009, 257(3), 105-112.
• Remington SE, Jowsey PA, Williams FM, Blain PG. Investigations into the genotoxic potential of dichlorvos. In: Annual Congress of The British Toxicology Society. 2008, University of Surrey, Guildford, UK: Toxicology: Elsevier.
• Jowsey P, Morrice NA, Hastie CJ, McLauchlan H, Toth R, Rouse J. Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR. DNA Repair 2007, 6(10), 1536-44.
• Munoz IM, Jowsey PA, Toth R, Rouse J. Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. Nucleic Acids Research 2007, 35(16), 5312-5322.
• Jowsey PA, Doherty AJ, Rouse J. Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. Journal of Biological Chemistry 2004, 279(53), 55562-55569.
• Jowsey, P.A., Farnie, G., Durkacz, B.W., Lunec, J. The dependence of p63 induction and activity on poly (ADP-ribose) polymerase-1. British Journal of Cancer 2001, 85(Supplement 1), 80-80.