Staff Profile
Professor Rakesh Heer
Professor of Urology
- Email: rakesh.heer@ncl.ac.uk
- Telephone: +44 (0) 191 208 4300
- Fax: +44 (0) 191 208 4301
- Address: Paul O'Gorman Building
Medical School
Framlington Place
Newcastle upon Tyne
NE2 4HH
Background
- Cross cutting research spanning the spectrum of major clinical trials, translational studies and basic science.
- A focus on urological cancers and stem cell biology.
- Consultant Surgeon (2011-). Robotic surgery and leads regional urology for complex pelvic cancer.
- NIHR HTA Programme Deputy Chair (2022-).
- NICE Guidelines Chairman (2021-).
- National Clinical Excellence award (2021).
- NIHR Clinical Research Network (CRN) Executive for North East & North Cumbria (NENC) (2020-)
- Chairman of the NCRI localised prostate cancer subgroup (2017-2022)
Research
Clinical trials in kidney, bladder and prostate cancer:
- Chief Investigator, NIHR PARTIAL; £1.9M; 2022-2027. Randomised trial of the clinical and cost effectiveness of PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma
- Co-Investigator, CRUK Early Detection and Diagnosis Research PACIFIC; £1.7M; 2022-2026. Evaluating the role of fast MRI and image-fusion for detection of prostate cancer (Lead PI Ahmed)
- Chief Investigator, NIHR PHOTO; £2.4M; 2014-2021. A randomised trial comparing photodynamic guided resection with standard white light surgery
- Chief Investigator, NIHR VARIANT; £0.3M; 2018-2021. A trial of biomarker-driven treatment in prostate cancer
- Principle investigator, NIHR BRC; £0.2M; 2018-2021. Developing biomarkers using mitochondrial DNA mutation lineage tracing for early detection of bladder cancer
- Principle investigator, Innovate UK CICERO; £0.3M; 2017-2018. AI-embedded image-enhanced video cystoscopy for a bladder cancer detection
The characterisation of human prostate stem cells:
- Principle investigator, Prostate Cancer Foundation award; $1M; 2019-2021. Patient stem cell derived prostate organoids for preclinical testing and treatment stratification.
- Principle investigator, Prostate Cancer Research grant; £0.5M; 2022-2025. Mapping the epigenetic evolution of prostate carcinogenesis (Epi-Evo study).
- Co-investigator, Prostate Cancer Research grant; £0.5M; 2020-2024. Filling a critical knowledge gap in androgen receptor variant splicing to enable development of new prostate cancer therapies.
- CRUK Clinician Scientist Fellowship; £0.8M; 2011-2016.In situ characterisation of prostate stem cell fate.
- Royal College of Surgeon’s Hunterian Professorship and Medal 2010.
- MRC Clinician PhD Fellow; £0.1M; 2003-2006. The role of KGF in prostatic stem cell differentiation.
Teaching
- Newcastle University Director of MD studies and PG Associate Dean (2016-current)
- Cystectomy Program Director for the International Newcastle Robotic Surgery Course (2016-current)
- Urology lead ACF/ACL program (2015-current)
Publications
- Grayling MJ, McMenamin M, Chandler R, Heer R, Wason JMS. Improving power in PSA response analyses of metastatic castration-resistant prostate cancer trials. BMC Cancer 2022, 22, 111.
- Beyer K, Moris L, Lardas M, Omar MI, Healey J, Tripathee S, Gandaglia G, Venderbos LDF, Vradi E, van den Broeck T, Willemse P-P, Antunes-Lopes T, Pacheco-Figueiredo L, Monagas S, Esperto F, Flaherty S, Devecseri Z, Lam TBL, Williamson PR, Heer R, Smith EJ, Asiimwe A, Huber J, Roobol MJ, Zong J, Mason M, Cornford P, Mottet N, MacLennan SJ, N'Dow J, Briganti A, MacLennan S, Van Hemelrijck M. Updating and Integrating Core Outcome Sets for Localised, Locally Advanced, Metastatic, and Nonmetastatic Castration-resistant Prostate Cancer: An Update from the PIONEER Consortium. European Urology 2022, 81(5), 503-514.
- Grossmann S, Hooks Y, Wilson L, Moore L, O'Neill L, Martincorena I, Voet T, Stratton MR, Heer R, Campbell PJ. Development, maturation, and maintenance of human prostate inferred from somatic mutations. Cell Stem Cell 2021, 28(7), 1262-1274.e5.
- Tan WS, Arianayagam R, Khetrapal P, Rowe E, Kearley S, Mahrous A, Pal R, Fowler W, Heer R, Elajnaf M, Douglas-Moore J, Leyshon Griffiths TR, Voss J, Wilby D, Al Kadhi O, Noel J, Vasdev N, McKay A, Ahmad I, Abu-Nayla I, Lamb B, Hill GT, Narahari K, Kynaston H, Yousuf A, Kusuma VRM, Cresswell J, Cooke P, Chakravarti A, Barod R, Bex A, Kelly JD. Major Urological Cancer Surgery for Patients is Safe and Surgical Training Should Be Encouraged During the COVID-19 Pandemic: A Multicentre Analysis of 30-day Outcomes. European Urology Open Science 2021, 25, 39-43.
- Sims CHC, Autio MI, Buskin A, Cheung C, Heer R, Foo RSY, Wang X. Modified CRISPR/Cas9 mediated generation of two MKK7 knockout human embryonic stem cell lines. Stem Cell Research 2021, 52, 102238.
- Moore L, Cagan A, Coorens THH, Neville MDC, Sanghvi R, Sanders MA, Oliver TRW, Leongamornlert D, Ellis P, Noorani A, Mitchell TJ, Butler TM, Hooks Y, Warren AY, Jorgensen M, Dawson KJ, Menzies A, O'Neill L, Latimer C, Teng M, van Boxtel R, Iacobuzio-Donahue CA, Martincorena I, Heer R, Campbell PJ, Fitzgerald RC, Stratton MR, Rahbari R. The mutational landscape of human somatic and germline cells. Nature 2021, 597, 381-386.
- Veeratterapillay R, Gravestock P, Nambiar A, Gupta A, Aboumarzouk O, Rai B, Vale L, Heer R. Time to Turn on the Blue Lights: A Systematic Review and Meta-analysis of Photodynamic Diagnosis for Bladder Cancer. European Urology Open Science 2021, 31, 17-27.
- Smith ALM, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A, Houghton D, Hunt M, Sampson JN, Stamp C, Mallett G, Amarnath S, Leslie J, Oakley F, Wilson L, Baker A, Russell OM, Johnson R, Richardson CA, Gupta B, McCallum I, McDonald SAC, Kelly S, Mathers JC, Heer R, Taylor RW, Perkins ND, Turnbull DM, Sansom OJ, Greaves LC. Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis. Nature Cancer 2020, 1, 976-989.
- Hepburn AC, Sims CHC, Buskin A, Heer R. Engineering Prostate Cancer from Induced Pluripotent Stem Cells-New Opportunities to Develop Preclinical Tools in Prostate and Prostate Cancer Studies. International Journal of Molecular Sciences 2020, 21(3), 905.
- Hepburn AC, Curry EL, Moad M, Steele RE, Franco OE, Wilson L, Singh P, Buskin A, Crawford SE, Gaughan L, Mills IG, Hayward SW, Robson CN, Heer R. Propagation of human prostate tissue from induced pluripotent stem cells. Stem Cells Translational Medicine 2020, 9(7), 734-745.
- Hepburn AC, Steele RE, Veeratterapillay R, Wilson L, Kounatidou EE, Barnard A, Berry P, Cassidy JR, Moad M, El-Sherif A, Gaughan L, Mills IG, Robson CN, Heer R. Correction: The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance (Oncogene, (2019), 10.1038/s41388-019-0712-y). Oncogene 2019, 38, 4425.
- Clark E, Morton M, Sharma S, Fisher H, Howel D, Walker J, Wood R, Hancock H, Maier R, Marshall J, Bahl A, Crabb S, Jain S, Pedley I, Jones R, Staffurth J, Heer R. Prostate cancer androgen receptor splice variant 7 biomarker study - A multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced prostate cancer (the VARIANT trial) study protocol. BMJ Open 2019, 9(12), e034708.
- Hepburn AC, Steele RE, Veeratterapillay R, Wilson L, Kounatidou EE, Barnard A, Berry P, Cassidy JR, Moad M, El-Sherif A, Gaughan L, Mills IG, Robson CN, Heer R. The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance. Oncogene 2019, 38, 4412-4424.
- McClurg UL, Nabbi A, Ricordel C, Korolchuk S, McCracken S, Heer R, Wilson L, Butler LM, Irving-Hooper BK, Pedeux R, Robson CN, Riabowol KT, Binda O. Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. British Journal of Cancer 2018, 118, 713-726.
- Luk ACO, Pandian RMK, Heer R. Laparoscopic renal surgery is here to stay. Arab Journal of Urology 2018, 16(3), 314-320.
- Stamp C, Zupanic A, Sachdeva A, Stoll EA, Shanley DP, Mathers JC, Kirkwood TBL, Heer R, Simons BD, Turnbull DM, Greaves LC. Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts. EBioMedicine 2018, 31, 166-173.
- Hatina J, Parmar HS, Kripnerova M, Hepburn A, Heer R. Urothelial carcinoma stem cells: Current concepts, controversies, and methods. In: Schulz, WA; Hoffmann, MJ; Niegisch, G, ed. Urothelial Carcinoma: Methods and Protocols. New York: Humana Press Inc, 2018, pp.121-136.
- Hannezo E, Scheele CLGJ, Moad M, Drogo N, Heer R, Sampogna RV, van Rheenen J, Simons BD. A Unifying Theory of Branching Morphogenesis. Cell 2017, 171(1), 242-255.
- Moad M, Hannezo E, Buczacki SJ, Wilson L, ElSherif A, Sims D, Pickard R, Wright NA, Williamson SC, Turnbull DM, Taylor RW, Greaves L, Robson CN, Simons BD, Heer R. Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates. Cell Reports 2017, 20(7), 1609-1622.
- Moad M, Curry EL, Robson CN, Heer R. Role of Induced Pluripotent Stem Cells in Urological Disease Modeling and Repair. In: Deepak A. Lamba, ed. Patient-Specific Stem Cells. Taylor & Francis, 2017, pp.177-194.
- Sachdeva A, El-Sherif A, Turnbull D, Greaves L, Heer R. Development of prostate intra-epithelial neoplasia in an aging series of PolgA mutator mice suggests a role for mitochondrial DNA mutations in prostate carcinogenesis. In: EAU16 – 31st Annual Congress of the European Association of Urology. 2016, Munich, Germany: Elsevier.
- Pearson RA, Thelwall PE, Snell J, McKenna J, Pieniazek P, Fitzgerald EL, Heer R, McMenemin RM, Pedley ID, Azzabi AS, Newell H, Maxwell RJ, Plummer ER, Frew JA. Evaluation of early response to neoadjuvant chemotherapy in muscle-invasive bladder cancer using dynamic contrast-enhanced MRI and diffusion weighted MRI: MARBLE study. In: 2016 Genitourinary Cancers Symposium. 2016, San Francisco: American Society of Clinical Oncology.
- Pearson RA, Thelwall PE, Snell J, McKenna J, Pieniazek P, Fitzgerald E, Heer R, McMenemin RM, Pedley ID, Azzabi A, Maxwell RJ, Newell DR, Plummer ER, Frew JA. Evaluation of early responses to neoadjuvant chemotherapy in muscle-invasive bladder cancer using a dynamic contrast-enhanced MRI and diffusion-weighted MRI: MARBLE study. In: Genitourinary Cancers Symposium 2016. 2016, San Francisco, California: Journal of Clinical Oncology.
- Lazzarini N, Widera P, Williamson S, Heer R, Krasnogor N, Bacardit J. Functional networks inference from machine learning models. BioData Mining 2016, 9, 28.
- Veeratterapillay R, Heer R, Johnson MI, Persad R, Bach C. High-Risk Non-Muscle-Invasive Bladder Cancer—Therapy Options During Intravesical BCG Shortage. Current Urology Reports 2016, 17, 68.
- Veeratterapillay R, Ijabla R, Conaway D, Haslam P, Soomro N, Heer R. Contrast-enhanced CT in 100 clear cell renal cell cancers - an analysis of enhancement, tumour size, and survival. Clinical Radiology 2015, 70(12), 1357-1361.
- Iqbal MS, Pickles R, Pedley I, Frew J, Azzabi A, Heer R, Thorpe A, Johnson M, Robson L, McMenemin R. Delays in the diagnosis and treatment of muscle invasive bladder cancer: A pilot project mapping the pathway. Journal of Clinical Urology 2015, 8(4), 246-251.
- Veeratterapillay R, Gill S, Pedley I, Frew J, Heer R, Paez E, Johnson MI, Thorpe AC. Long-term oncological outcomes of patients undergoing neoadjuvant chemotherapy and cystectomy for muscle invasive bladder cancer. In: British Association of Urological Surgeons Annual Meeting. 2015, Manchester, UK: Wiley.
- Cano LQ, Lavery DN, Sin S, Spanjaard E, Brooke GN, Tilman JD, Abroaf A, Gaughan L, Robson CN, Heer R, Mauri F, de Rooij J, Driouch K, Bevan CL. The co-chaperone p23 promotes prostate cancer motility and metastasis. Molecular Oncology 2015, 9(1), 295-308.
- Curry EL, Moad M, Robson CN, Heer R. Using induced pluripotent stem cells as a tool for modelling carcinogenesis. World Journal of Stem Cells 2015, 7(2), 461-469.
- Ahmed HU, Berge V, Bottomley D, Cross W, Heer R, Kaplan R, Leslie T, Parker C, Relton C, Stephens R, Sydes MR, Turnbull L, van der Meulen J, Vickers A, Wilt T, Emberton M, Prostate Cancer RCT Consensus Group. Can we deliver randomized trials of focal therapy in prostate cancer?. Nature Reviews Clinical Oncology 2014, 11(8), 482-491.
- Williamson SC, Wilson L, Williamson GA, Greaves L, Tuppen H, Pickard R, Wright NA, Robson CN, Turnbull DM, Taylor RW, Heer R. Finding a niche. The location of human prostate stem cells. In: Annual Meeting of the Society-of-Academic-and-Research-Surgery. 2014, Univ Cambridge, Robinson Coll, Cambridge, ENGLAND: John Wiley & Sons Ltd.
- Shekarchi-Khanghahi E, Curtin NJ, Heer R. Investigating PARP-1 expression and activity in male and female, benign and malignant renal tissue. In: Annual Meeting of the Society-of-Academic-and-Research-Surgery. 2014, Univ Cambridge, Robinson Coll, Cambridge, ENGLAND: John Wiley & Sons, Inc.
- Rogers A, Adams F, Smith J, Johnson J, Thorpe A, Robson L, Pedley I, McMenemin R, Heer R. Metastases at presentation of transitional cell muscle invasive bladder carcinoma in a 10 year series of 427 patients: is staging computed tomography of the thorax always required?. In: British Association of Urological Surgeons Annual Meeting. 2014, Liverpool, UK: Wiley-Blackwell Publishing, Inc.
- Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco O, Cates J, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R. A novel model of urinary tract differentiation, tissue regeneration, and disease: Reprogramming human prostate and bladder cells into induced pluripotent stem cells. European Urology 2013, 64(5), 753-761.
- Williamson SC, Hartley AE, Heer R. A review of tasquinimod in the treatment of advanced prostate cancer. Drug Design, Development and Therapy 2013, 7, 167-174.
- Williamson SC, Mitter R, Hepburn AC, Wilson L, Mantilla A, Leung HY, Robson CN, Heer R. Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer. British Journal of Cancer 2013, 109(4), 950-956.
- Moad M, Hepburn A, Lako M, Pal D, Williamson S, Robson C, Heer R. Generation of induced pluripotent stem cells from human urinary tract cells. In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: John Wiley & Sons Ltd.
- Hepburn AC, Gaughan L, Williamson SC, Pal D, Moad M, Kanani MK, Robson CN, Heer R. Investigating the regulation and effects on androgen receptor expression using a novel stem cell environment model of castration resistant prostate cancer. In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: Wiley-Blackwell.
- Roushias S, Veeratterapillay R, McCracken S, Heer R. Penile strangulation by a substantial metal napkin ring: successful removal with medtronic midas rex® legend® stylus® drill system. Journal of Clinical Urology 2013, 6(3), 194-196.
- Townes CL, Ali A, Gross N, Pal D, Williamson SC, Heer R, Robson CN, Pickard R, Hall J. Prostate specific antigen enhances the innate defence of prostatic epithelium against Escherichia coli infection. The Prostate 2013, 73(14), 1529-1537.
- Heer R, Hepburn AC, Williamson SC, Kennedy A, El-Sherif A, Soomro NA, Brown CD, Robson CN. Renal differentiation from adult spermatogonial stem cells. Renal Failure 2013, 35(10), 1387-1391.
- Pal D, Moad M, Hepburn AC, Williamson SC, Robson CN, Heer R. Reply from Authors re: "Reprogramming Stromal Cell from the Urinary Tract and Prostate: A Trip to Pluripotency and Back?". European Urology 2013. In Press.
- Pal D, Moad M, Hepburn AC, Williamson SC, Robson CN, Heer R. Reply from Authors re: Felix Wezel, Jennifer Southgate. Reprogramming Stromal Cells from the Urinary Tract and Prostate: A Trip to Pluripotency and Back? Eur Urol 2013;64:762-4. European Urology 2013, 64(5), 764-765.
- Williamson C, Hepburn AC, Mantilla A, Wilson L, Leung HY, Robson CN, Heer R. Stockpiling testosterone; A unique mechanism of progression to castrate resistant disease. In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: Wiley-Blackwell.
- Coffey K, Rogerson L, Ryan-Munden C, Alkharaif D, Stockley J, Heer R, Sahadevan K, O'Neill D, Jones D, Darby S, Staller P, Mantilla A, Gaughan L, Robson CN. The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover. Nucleic Acids Research 2013, 41(8), 4433-4446.
- Pal D, Rigas AC, Williamson SC, Moad M, Carr-Wilkinson J, Lako L, Robson CN, Heer R. Induced pluripotent stem cell (iPSC) re-programming in the human prostate. In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
- Heer R, Glendinning RJ, Nesbitt CN, Pal D, Rix D, Menezes P, Johnson MI. Secondary haemorrhage following transurethral resection of bladder tumour — is it always related to infection?. British Journal of Medical and Surgical Urology 2012, 5(2), 61-66.
- Pal D, Rigas AC, Williamson SC, Moad M, Robson CN, Heer R. The role of epithelial to mesenchymal transition (EMT) in iPS induction of human prostate. In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
- Veeratterapillay R, Simren R, El-Sherif A, Johnson MI, Soomro N, Heer R. Accuracy of the revised 2010 TNM classification in predicting the prognosis of patients treated for renal cell cancer in the north east of England. Journal of Clinical Pathology 2012, 65(4), 367-371.
- Veeratterapillay R, Rakhra S, El-Sherif A, Johnson M, Soomro N, Heer R. Can the Kattan nomogram still accurately predict prognosis in renal cell carcinoma using the revised 2010 tumor-nodes-metastasis reclassification?. International Journal of Urology 2012, 19(8), 773-776.
- Williamson SC, Hepburn AC, Wilson L, Coffey K, Ryan-Munden CA, Pal D, Leung HY, Robson CN, Heer R. Human α2β1HI CD133+VE Epithelial Prostate Stem Cells Express Low Levels of Active Androgen Receptor. PLoS One 2012, 7(11), e48944.
- Williamson C, Blackwood JK, Greaves L, Wilson L, Pickard RS, Lako M, Robson CN, Turnbull DM, Taylor RW, Heer R. Lineage tracking in situ: Where are the prostate stem cells? What are they doing?. In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
- Rigas AC, Williamson SC, Kennedy A, El-Sherif A, Soomro NA, Brown CDA, Robson CN, Heer R. Renal differentiation from adult spermatogonial stem cells. In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
- Hepburn AC, Veeratterapillay R, Williamson SC, El-Sherif A, Sahay N, Thomas HD, Mantilla A, Pickard RS, Robson CN, Heer R. Side Population in Human Non-Muscle Invasive Bladder Cancer Enriches for Cancer Stem Cells That Are Maintained by MAPK Signalling. PLoS One 2012, 7(11), e50690.
- Blackwood JK, Williamson SC, Greaves LC, Wilson L, Rigas AC, Sandher R, Pickard RS, Robson CN, Turnbull DM, Taylor RW, Heer R. In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells. Journal of Pathology 2011, 225(2), 181-188.
- Williamson SC, Rigas AC, Robson CN, Heer R, Heer R. An update on the prostate cancer stem cell model-CD133+ve stem cell enriched human prostate cells express active androgen receptor. In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
- Jackson M, Heer R, El-Sherif A, Perros P, Thorpe A. Carcinoid tumour in an ileocystoplasty: A reminder to consider native bowel disease in the reconstructed urinary tract. British Journal of Medical and Surgical Urology 2011, 4(1), 39-41.
- Pal D, Williamson SC, Robson CN, Rigas AC, Heer R. Characterising potential for pluripotency induction in human prostate tissue. In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
- Williamson SC, Mitter R, Rigas AC, Robson CN, Heer R. Comparative meta-analysis of the human prostate stem cell transcriptome demonstrates that progenitor cells are the site of malignant transformation. In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
- Rigas AC, Jaiswal N, Williamson SC, Pickard R, Robson CN, Heer R. Side population in human bladder cancer enriches for cancer stem cells that can be targeted by MAPK inhibition. In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
- Pal D, Robson CN, Williamson SC, Nayernia K, Soleimanpour-Lichaei HR, Heer R. Stem-cell regulatory protein Piwil2 enriches for known stem-cell and cancer stem-cell markers in prostate cancer cells. In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
- Pridgeon SW, Heer R, Taylor GA, Newell DR, O'Toole K, Robinson M, Xu YZ, Karran P, Boddy AV. Thiothymidine combined with UVA as a potential novel therapy for bladder cancer. British Journal of Cancer 2011, 104(12), 1869-1876.
- Heer R, Clarke N, Rigas AC, Cheek TR, Pickard R, Leung HY. Phenotypic Modulation of Human Urinary Tract Stroma-derived Fibroblasts by Transforming Growth Factor β3. Urology 2010, 76(2), 509.e13-509.e20.
- McCracken SRC, Ramsay A, Heer R, Mathers ME, Jenkins BL, Edwards J, Robson CN, Marquez R, Cohen P, Leung HY. Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer. Oncogene 2008, 27(21), 2978-2988.
- Heer R, Robson CN. Editorial comment on: Delta-like 1 (Dlk-1), a novel marker of prostate basal and candidate epithelial stem cells, is downregulated by notch signalling in intermediate/transit amplifying cells of the human prostate. European Urology 2008, 54(6), 1353-1353.
- Clark EL, Coulson AC, Dalgliesh C, Rajan P, Nicol SM, Fleming S, Heer R, Gaughan L, Leung HY, Elliott DJ, Fuller-Pace FV, Robson CN. The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer. Cancer Research 2008, 68(19), 7938-7946.
- Heer R, Robson CN, Shenton BK, Leung HY. The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population (vol 2, pg 572, 2007). Journal of Cellular Physiology 2008, 215(1), 283-284.
- Clarke N, Heer R, Cheek T, Leung T, Pickard R. Changing the phenotype of urethral stroma by treatment with transforming growth factor beta-3. European Urology Supplements 2007, 6(2), 138-138.
- Heer, R., Robson, C. N., Shenton, B. K., Leung, H. Y. The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population. Journal of Cellular Physiology 2007, 212(3), 572-578.
- Heer, R., Collins, A., Robson, C.N., Shenton, B.K., Leung, H.K. KGF suppresses α2β1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium. Journal of Cell Science 2006, 119(7), 1416-1424.
- McKie AB, Olijslagers S, Atkins H, Heer R, Robson CN, Leung HY. Control of hSprouty2 Expression Critically Regulates Cell Growth, Migration and Invasion in Human Prostate Cancer. Manuscript in preparation 2005.
- McKie AB, Douglas DA, Olijslagers S, Graham J, Omar MM, Heer R, Gnanapragasam VJ, Robson CN, Leung HY. Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer. Oncogene 2005, 24(13), 2166-2174.
- McCracken SRC, Jenkins BL, Heer R, Mathers ME, Robson CN, Leung HY. Expression analysis of the MEK5/ERK5 signalling pathway in human prostate cancer. BJU International 2005, 95(s5), 82-83.
- Heer R, Dorkin TJ, Byrne RL, Griffiths TRL, Rangecroft L. A prospective audit of hypospadias correction in a regional paediatric surgery centre. European Journal of Pediatric Surgery 2004, 14(5), 328-332.
- Heer, R,, Douglas, D. A., Robson, C. N., Leung, H. Y. Fibroblast growth factor (FGF) 17 expression is up-regulated human prostate cancer and correlates to clinical prognosis. British Journal of Cancer 2004, 91(Supplement 1), S20-S20.
- Heer, R., Douglas, D. A., Mathers, M. E., Robson, C. N., Leung, H. Y. Fibroblast growth factor 17 is over-expressed in human prostate cancer. Journal of Pathology 2004, 204(5), 578-586.
- Heer R, Shrimankar J, Griffith CDM. Letter to the editor. Breast 2004, 13(3), 262.
- Heer, R., Collins, A. T., Robson, C. N., Leung, H. Y. Role of keratinocyte growth factor (KGF) and androgen in human prostatic epithelial stem cell differentiation. British Journal of Cancer 2004, 91(Supplement 1), S11-S11.
- Heer R, Shrimankar J, Griffith CDM. Untitled - Letter. The Breast 2004, 13(3), 262-262.
- Heer R, Shrimankar J, Griffith CDM. Granulomatous mastitis can mimic breast cancer on clinical, radiological or cytological examination: a cautionary tale. The Breast 2003, 12(4), 283-286.
- Heer R, Walker S, MacSweeney S. The effects of sublingual glyceryl trinitrate on walking distance in patients with intermittent claudication. A randomised, doubled-blind, placebo-controlled, cross-over study. Current Medical Research and Opinion 2001, 17(2), 113-115.
- Heer R, Dobson D, Plusa SM. How to alter surgical practice? The use of guidelines to encourage day-case haemorrhoidectomy. Journal of The Royal College of Surgeons of Edinburgh 2000, 45(6), 369-370.
- Walker SR, Heer R, MacSweeney ST. Vascular surgical society of great britain and ireland: prospective randomized double-blind placebo-controlled crossover study to assess the effect of sublingual glyceryl trinitrate in patients with intermittent claudication. British Journal of Surgery 1999, 86(5), 694.