Staff Profile
Dr Ramzi Lakhdar
Research Associate
- Address: Translational and Clinical Research Institute
Faculty of Medical Sciences
Newcastle University
M2.049 2nd Floor Leech Building
Framlington Place
Newcastle upon Tyne
NE2 4HH
Publications
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Articles
- Kumar P, Zavala-Reyes JC, Kalaiarasan G, Abubakar-Waziri H, Young G, Mudway I, Dilliway C, Lakhdar R, Mumby S, Klosowski MM, Pain CC, Adcock IM, Watson JS, Sephton MA, Chung KF, Porter AE. Characteristics of fine and ultrafine aerosols in the London underground. Science of the Total Environment 2023, 858(Part 1), 159315.
- Garcia Giner V, Mumby S, Lakhdar R, Mudway I, Chung F, Adcock I, Porter A. (Cryo-) Electron Microscopy Workflows of Interactions between Airborne Pollution Particles and Nasal Epithelial Cells. Microscopy and Microanalysis 2023, 28(S1), 1312-1314. In Preparation.
- Lakhdar R, McGuinness D, Drost EM, Shiels PG, Bastos R, Macnee W, Rabinovich RA. Role of accelerated aging in limb muscle wasting of patients with COPD. International Journal of COPD 2018, 13, 1987-1998.
- Lakhdar R, Drost EM, MacNee W, Bastos R, Rabinovich RA. 2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls. Respiratory Research 2017, 18, 81.
- Rabinovich RA, Drost E, Manning JR, Dunbar DR, Diaz-Ramos M, Lakhdar R, Bastos R, MacNee W. Genome-wide mRNA expression profiling in vastus lateralis of COPD patients with low and normal fat free mass index and healthy controls. Respiratory Research 2015, 16, 1.
- Kassab A, Msolly A, Lakhdar R, Gharbi O, Miled A. Polymorphisms of glutathione-S-transferases M1, T1, P1 and susceptibility to colorectal cancer in a sample of the Tunisian population. Medical Oncology 2014, 31(1), 760.
- Raffa M, Lakhdar R, Ghachem M, Barhoumi S, Safar MT, Bel Hadj Jrad B, Haj Khelil A, Kerkeni A, Mechri A. Relationship between GSTM1 and GSTT1 polymorphisms and schizophrenia: A case-control study in a Tunisian population. Gene 2013, 512(2), 282-285.
- Denden S, Lakhdar R, Boudawara Keskes N, Hamdaoui MH, Chibani JB, Khelil AH. PCR-based screening for the most prevalent alpha 1 antitrypsin deficiency mutations (PI S, Z, and Mmalton) in COPD patients from Eastern Tunisia. Biochemical Genetics 2013, 51(9-10), 677-685.
- Lakhdar R, Denden S, Kassab A, Leban N, Daimi H, Kahloun H, Hergli A, Knani J, Miled A, Khelil AH, Chibani JB. Oxidative stress and COPD: Polymorphism of glutathione S-transferase and contribution of clinical phytotherapy / Le stress oxydatif et la BPCO: Polymorphisme des glutathion- stransférases et apport de la phytothérapie clinique. Acta Horticulturae 2013, 997, 251-256.
- Mejrbi S, Lakhdar R, Chaieb L, Ben Chibani J, Miled A, Kassab A. Glycemia balance impact on oxidant-antioxidant status balance in Tunisian patients with type 2 diabetesL'impact de l'équilibre glycémique sur le statut oxydant-antioxydant dans un échantillon de diabétiques de type 2 tunisiens. Immuno-analyse & Biologie Spécialisée 2012, 27(6), 352-356.
- Lakhdar R, Denden S, Mouhamed MH, Chalgoum A, Leban N, Knani J, Lefranc G, Miled A, Chibani JB, Khelil AH. Correlation of EPHX1, GSTP1, GSTM1, and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic obstructive pulmonary disease. Experimental Lung Research 2011, 37(4), 195-204.
- Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Chibani JB, Khelil AH. Combined analysis of EPHX1, GSTP1, GSTM1 and GSTT1 gene polymorphisms in relation to chronic obstructive pulmonary disease risk and lung function impairment. Disease Markers 2011, 30(5), 253-263.
- Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Chibani JB, Khelil AH. Relationship between glutathione s-transferase p1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population. Genetics and Molecular Research 2010, 9(2), 897-907.
- Denden S, Lakhdar R, Leban N, Ben Chibani J, Haj Khelil A. Rapid genotyping of alpha 1 antitrypsin deletion mutation (PI*Mmalton) using Bi-directional PCR allele-specific amplification. Molecular Biotechnology 2010, 45(2), 111-115.
- Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Chibani JB, Khelil AH. Microsomal epoxide hydrolase gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in the Tunisian population. Genetic Testing and Molecular Biomarkers 2010, 14(6), 857-863.
- Denden S, Braham W, Gorcii Aloui S, Lakhdar R, Kahloun H, Mahdouani K, Knani J, Ben Chibani J, Haj Khelil A. Biological analysis and clinical phytotherapy of asthma in a population in Central Tunisia / Analyse biologique et phytothérapie clinique de l'asthme dans une population de la tunisie centrale. Acta Horticulturae 2010, 853, 391-396.
- Lakhdar R, Denden S, Knani J, Leban N, Daimi H, Hassine M, Lefranc G, Ben Chibani J, Haj Khelil A. Association of GSTM1 and GSTT1 polymorphisms with chronic obstructive pulmonary disease in a Tunisian population. Biochemical Genetics 2010, 48(7-8), 647-657.
- Denden S, Khelil AH, Knani J, Lakhdar R, Perrin P, Lefranc G, Chibani JB. Alpha-1 antitrypsin gene polymorphism in Chronic Obstructive Pulmonary Disease (COPD). Genetics and Molecular Biology 2010, 33(1), 23-26.
- Denden S, Braham W, Amri F, Lakhdar R, Lefranc G, Knani J, Ben Chibani J, Haj Khelil A. Biochemical and molecular diagnosis of alpha 1 antitrypsin deficiency in a Tunisian family / Diagnostic biochimique et moléculaire du déficit en alpha 1 antitrypsine dans une famille tunisienne. Annales de Biologie Clinique 2009, 67(4), 441-445.
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Book Chapter
- Dixey P, Abubakar-Waziri H, Raby K, Lakhdar R, Kermani N, Mumby S, Owen E, Adcock I, Bhavsar P, Chung KF. Adult Severe Asthma. In: Encyclopedia of Respiratory Medicine, Second Edition. Elsevier, 2021, pp.383-399.
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Note
- Hassayoune F, Lakhdar R, Mejbri S, Gharbi O, Ben Chibani J, Miled A, Kassab A. Glutathione-s-transferases GSTM1 and GSTT1 genetic polymorphisms and colorectal cancer onset in a sample of Tunisian population / Polymorphisme génétique des glutathion-s-transférases GSTM1 et GSTT1 et survenue d'un cancer colorectal dans un échantillon de la population tunisienne. Immuno-Analyse et Biologie Spécialisée 2012, 27(6), 325-331.
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Reviews
- Michaeloudes C, Abubakar-Waziri H, Lakhdar R, Raby K, Dixey P, Adcock IM, Mumby S, Bhavsar PK, Chung KF. Molecular mechanisms of oxidative stress in asthma. Molecular Aspects of Medicine 2022, 85, 101026.
- Lakhdar R, Mumby S, Abubakar-Waziri H, Porter A, Adcock IM, Chung KF. Lung toxicity of particulates and gaseous pollutants using ex-vivo airway epithelial cell culture systems. Environmental Pollution 2022, 305, 119323.
- Lakhdar R, Rabinovich RA. Can muscle protein metabolism be specifically targeted by nutritional support and exercise training in chronic obstructive pulmonary disease?. Journal of Thoracic Disease 2018, 10(Supplement 12), S1377-S1389.
- Lakhdar R, Denden S, Kassab A, Leban N, Knani J, Lefranc G, Miled A, Chibani JB, Khelil AH. Update in chronic obstructive pulmonary disease: Role of antioxidant and metabolizing gene polymorphisms. Experimental Lung Research 2011, 37(6), 364-375.