Staff Profile
Dr Rebecca Darlay
Research Associate
- Email: rebecca.darlay@ncl.ac.uk
- Telephone: +44 (0) 191 241 8692
- Address: Institute of Human Genetics
Newcastle University
International Centre for Life
Central Parkway
Newcastle upon Tyne
NE1 3BZ
Publications
- Darlow JM, Darlay R, Dobson MG, Stewart A, Charoen P, Southgate J, Baker SC, Xu Y, Hunziker M, Lambert HJ, Green AJ, Santibanez-Koref M, Sayer JA, Goodship THJ, Puri P, Woolf AS, Kenda RB, Barton DE, Cordell HJ. Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux. Scientific Reports 2017, 7, 14595.
- Liu W, Anstee QM, Wang X, Gawrieh S, Gamazon ER, Athinarayanan S, Liu Y-L, Darlay R, Cordell HJ, Daly AK, Day CP, Chalasani N. Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans. Aging 2017, 9(1), 26-40.
- Darlay R, Ayers KL, Mells GF, Money VA, Liu JZ, Almarri MA, Alexander GJ, Jones DE, Sandford RN, Anderson CA, Donaldson PT, Cordell HJ. Immunochip analysis identifies amino acid residues in five separate HLA genes driving the association between the MHC and primary biliary cirrhosis. In: 2015 Annual Meeting of the International Genetic Epidemiology Society. 2015, Maryland, USA: John Wiley & Sons, Inc.
- Mitchell AL, Bøe Wolff A, MacArthur K, Weaver JU, Vaidya B, Bensing S, Erichsen MM, Darlay R, Husebye ES, Cordell HJ, Pearce SHS. Linkage Analysis in Autoimmune Addison’s Disease: NFATC1 as a Potential Novel Susceptibility Locus. PLoS ONE 2015, 10(6), e0123550.
- Rushton MD, Reynard LN, Young DA, Shepherd C, Darlay R, Cordell HJ, Loughlin J. Methylation of cartilage DNA is a mediator of genetic risk at several OA susceptibility loci. In: 2015 Osteoarthritis Research Society International (OARSI) World Congress. 2015, Seattle, WA, USA: Elsevier.
- Rushton MD, Reynard LN, Young DA, Shepherd C, Aubourg G, Gee F, Darlay R, Deehan D, Cordell HJ, Loughlin J. Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk. Human Molecular Genetics 2015, 24(25), 7432-7444.
- Howey RAJ, Eu-Ahsunthornwattana J, Darlay R, Cordell HJ. Examination of previously identified associations within the Genetic Analysis Workshop 19 data. In: Genetic Analysis Workshop 19: Sequence, Blood Pressure and Expression Data. 2014, Vienna, Austria: BioMed Central Ltd.
- Darlay R, Stear MJ, Mason S, Smith J, Shaw MA. The heritability of abortion in pedigree Charollais flocks. Animal Reproduction Science 2014, 149(3-4), 297-304.
- Anstee QM, Darlay R, Leathart J, Liu YL, Tordjman J, Clement K, Aithal G, Valenti L, Van Gaal L, Stickel F, Alison M, Romero-Gomez M, Andrade R, Reeves H, Bedossa P, Pihlajamaki J, Kotronen A, Yki-Jarvinen H, Chalasani N, Kleiner DE, Rotter J, Burt A, Ratziu V, Cordell HJ, Daly AK, Day CP, FLIP Fatty Liver Inhibition, NASH CRN Investigators. A candidate-gene approach to validation of genetic modifier associations using a large cohort with histologically characterised non-alcoholic fatty liver disease. In: The International Liver Congress 2013 – 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam: Elsevier BV.
- Cordell HJ, Topf A, Mamasoula C, Postma AV, Bentham J, Zelenika D, Heath S, Blue G, Cosgrove C, Riveron JG, Darlay R, Soemedi R, Wilson IJ, Ayers KL, Rahman TJ, Hall D, Mulder BJM, Zwinderman AH, van Engelen K, Brook JD, Setchfield K, Bu'Lock FA, Thornborough C, O'Sullivan J, Stuart AG, Parsons J, Bhattacharya S, Winlaw D, Mital S, Gewillig M, Breckpot J, Devriendt K, Moorman AFM, Rauch A, Lathrop GM, Keavney BD, Goodship JA. Genome-wide association study identifies loci on 12q24 and 13q32 associated with Tetralogy of Fallot. Human Molecular Genetics 2013, 22(7), 1473-1481.
- Wilson V, Darlay R, Wong W, Wood KM, McFarlane J, Schejbel L, Schmidt IM, Harris CL, Tellez J, Hunze EM, Marchbank K, Goodship JA, Goodship THJ. Genotype/Phenotype Correlations in Complement Factor H Deficiency Arising From Uniparental Isodisomy. American Journal of Kidney Diseases 2013, 62(5), 978-983.
- Wang X, Onjiko RM, Anstee QM, Ratziu V, Liu YL, Cordell HJ, Darlay R, Day CP, Daly AK, Chalasani N, Liu W, FLIP Fatty Liver Inhibition Progression. Mapping Expression Quantitative Traits Loci (EQTL) for PNPLA3 Gene Identifies Additional SNPs Associated with Non-Alcoholic Fatty Liver Disease (NAFLD) Independent of rs738409. In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, Netherlands: Elsevier BV.
- Soemedi R, Wilson IJ, Bentham J, Darlay R, Topf A, Zelenika D, Cosgrove C, Setchfield K, Thornborough C, Granados-Riveron J, Blue GM, Breckpot J, Hellens S, Zwolinkski S, Glen E, Mamasoula C, Rahman TJ, Hall D, Rauch A, Devriendt K, Gewillig M, O' Sullivan J, Winlaw DS, Bu'Lock F, Brook JD, Bhattacharya S, Lathrop M, Santibanez-Koref M, Cordell HJ, Goodship JA, Keavney BD. Contribution of Global Rare Copy-Number Variants to the Risk of Sporadic Congenital Heart Disease. American Journal of Human Genetics 2012, 91(3), 489-501.
- Anstee QM, Darlay R, Leathart JB, Clement J, Clement K, Aithal GP, Valenti L, Van Gaal L, Stickel F, Allison ME, Romero-Gomez M, Andrade RJ, Reeves H, Pihlajamaki J, Bedossa P, Kotronen A, Yki-Jarvinen H, Chalasani NP, Kleiner DE, Rotter J, Burt AD, Ratziu V, Cordell HJ, Daly AK, Day CP. Genome-Wide Association Analysis Confirms Importance of PNPLA3 and Identifies Novel Variants Associated With Histologically Progressive Steatohepatitis in NAFLD. In: 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD). 2012, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
- Soemedi R, Topf A, Wilson IJ, Darlay R, Rahman T, Glen E, Hall D, Huang N, Bentham J, Bhattacharya S, Cosgrove C, Brook JD, Granados-Riveron J, Setchfield K, Bu'lock F, Thornborough C, Devreindt K, Breckpot J, Hofbeck M, Lathrop M, Rauch A, Blue G, Winlaw D, Hurles M, Santibanez-Koref M, Cordell H, Goodship J, Keavney B. Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. Human Molecular Genetics 2012, 21(7), 1513-1520.
- Darlay RJ, McCarthy AJ, Illot NE, Smith JE, Shaw MA. Novel polymorphisms in ovine immune response genes and their association with abortion. Animal Genetics 2011, 42(5), 535-543.
- Cordell HJ, Darlay R, Charoen P, Stewart A, Gullett AM, Lambert HJ, Malcolm S, Feather SA, Goodship THJ, Woolf AS, Kenda RB, Goodship JA, UK VUR Study Grp. Whole-Genome Linkage and Association Scan in Primary, Nonsyndromic Vesicoureteric Reflux. Journal of the American Society of Nephrology 2010, 21(1), 113-123.
- Goodship J, Darlay R, Charoen P, Stewart A, Gullett AS, Lambert HJ, Malcolm S, Feather SA, Woolf AS, Kenda RB, Cordell HJ. Whole-genome linkage and association scan in primary, non-syndromic vesicoureteric reflux (VUR) and reflux nephropathy. In: British Human Genetics Conference. 2009, University of Warwick, UK: Journal of Medical Genetics: BMJ Publishing Group.