Staff Profile

Current clinical studies:

- STRATIFYHF - Artificial intelligence-based decision support system for risk stratification and early detection of heart failure in primary and secondary care

- BeActive-HF - Feasibility of a theory-informed behavioural intervention to promote uptake of cardiac rehabilitation and increase habitual physical activity levels of heart failure patients

- Lifestyle behaviours of women newly diagnosed with heart failure: A quantitative and qualitative approach

- Neuromuscular fatigability in chronic heart failure with reduced ejection fraction

Previous clinical studies:

- SILICOFCM - In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy

- DIAGNOSE-HF

- Movement as Medicine for Type 2 Diabetes

- Movement as Medicine for Cardiovascular Disease Prevention

- Observational Prolonged Trial In myotonic dystrophy type 1 to Improve Quality of Life – Standards, a Target Identification Collaboration (OPTIMISTIC)

Area of expertise

- Clinical Research

- Heart Failure

- Physical Activity

- Physical Activity Measurement

- Exercise

Qualifications

- PhD Physical Activity and Health, University of Bedfordshire, UK

- MSc Physical Activity and Well-Being, University of Bedfordshire, UK

- BSc (Hons) Sports Studies, De Montfort University, UK

- AFHEA, Newcastle University, UK

Membership

- American Heart Association (AHA)

- Association for the Study of Obesity (ASO)

Google scholar:

https://scholar.google.co.uk/citations?user=5FiFImQAAAAJ&hl=en

ORCID:

https://orcid.org/0000-0002-3029-7672

• Articles

  • Charman SJ, Okwose NC, Groenewegen A, Del Franco A, Tafelmeier M, Preveden A, Garcia Sebastian C, Fuller AS, Sinclair D, Edwards D, Nelissen AP, Malitas P, Zisaki A, Darba J, Bosnic Z, Vracar P, Barlocco F, Fotiadis D, Banerjee P, MacGowan GA, Fernandez O, Zamorano J, Jimenez-Blanco Bravo M, Maier LS, Olivotto I, Rutten FH, Mant J, Velicki L, Seferovic PM, Filipovic N, Jakovljevic DG, Fatima B, Kate W, Alessandra F, Aleksandra M, Meritxell A, Ainoa A, Matej P, Borut F, Dimitrios B, Dimitris M, Manolis T, Thomas K, Tijana S, Bogdan M, Richard HF, Onno K. Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, multicentre longitudinal study. BMJ Open 2025, 15(1), e091793.
  • Seman S, Tesic M, Babic M, Mikic L, Velicki L, Okwose NC, Charman SJ, Tafelmeier M, Olivotto I, Filipovic N, Ristic A, Arena R, Guazzi M, Jakovljevic D, Allison TG, Popovic D. The ventilatory efficiency parameters outperform peak oxygen consumption in monitoring the therapy effects in patients with hypertrophic cardiomyopathy. Progress in Cardiovascular Diseases 2024, epub ahead of print.
  • Velicki L, Popovic D, Okwose NC, Preveden A, Tesic M, Tafelmeier M, Charman SJ, Barlocco F, MacGowan GA, Seferovic PM, Filipovic N, Ristic A, Olivotto I, Maier LS, Jakovljevic DG. Sacubitril/valsartan for the treatment of non-obstructive hypertrophic cardiomyopathy: An open label randomized controlled trial (SILICOFCM). European Journal of Heart Failure 2024, 26(6), 1361-1368.
  • Charman SJ, Blain AP, Okwose NC, Fuller AS, Alyahya AI, Hallsworth K, Eggett C, Luke P, Bailey K, MacGowan GA, Jakovljevic DG. Physical Activity, Inactivity and Sleep in Individuals with Hypertrophic Cardiomyopathy. International Journal of Sports Medicine 2024, 45(02), 149-154.
  • Alyahya AI, Charman SJ, Okwose NC, Fuller AS, Eggett C, Luke P, Bailey K, MacGowan GA, Jakovljevic DG. Lifestyle Intervention Improves Parasympathetic Activity in Hypertrophic Cardiomyopathy. American Journal of Lifestyle Medicine 2024, ePub ahead of Print.
  • Alyahya AI, Charman SJ, Okwose NC, Fuller AS, Eggett C, Luke P, Bailey K, MacGowan GA, Jakovljevic DG. Impact of age and sex on heart rate variability and cardiometabolic function in healthy adults. Experimental Gerontology 2024, 197, 112591.
  • Charman SJ, Blain AP, Trenell MI, Jakovljevic DG, Kunadian V. Physical activity, inactivity and sleep in older patients with coronary artery disease following percutaneous coronary intervention: a longitudinal, observational study. Coronary Artery Disease 2023, 34(6), 441-447.
  • Cassidy S, Trenell M, Stefanetti RJ, Charman SJ, Barnes AC, Brosnahan N, McCombie L, Thom G, Peters C, Zhyzhneuskaya S, Leslie WS, Catt C, Catt M, McConnachie A, Sattar N, Sniehotta FF, Lean MEJ, Taylor R. Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine 2023, 40(3), e15010.
  • Alyahya AI, Charman SJ, Okwose NC, Fuller AS, Eggett C, Luke P, Bailey K, MacGowan GA, Jakovljevic DG. Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy. Clinical Physiology and Functional Imaging 2023, 43(6), 421-430.
  • Okwose NC, Fuller AS, Alyahya AI, Charman SJ, Eggett C, Luke P, MacGowan GA, Jakovljevic DG. Application of non-invasive bioreactance to assess hemodynamic function in patients with hypertrophic cardiomyopathy. Physiological Reports 2023, 11(12), e15729.
  • Knittle K, Charman SJ, O'Connell S, Avery L, Catt M, Sniehotta FF, Trenell MI. Movement as Medicine for Cardiovascular Disease Prevention: Pilot Feasibility Study of a Physical Activity Promotion Intervention for At-Risk Patients in Primary Care. JMIR Cardio 2022, 6(1), e29035.
  • Cooper M, Chmelo J, Sinclair RCF, Charman S, Hallsworth K, Welford J, Phillips AW, Greystoke A, Avery L. Exploring factors influencing uptake and adherence to a home-based prehabilitation physical activity and exercise intervention for patients undergoing chemotherapy before major surgery (ChemoFit): a qualitative study. BMJ Open 2022, 12(9), e062526.
  • Chmelo J, Phillips AW, Greystoke A, Charman SJ, Avery L, Hallsworth K, Welford J, Cooper M, Sinclair RCF. A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study. Pilot and Feasibility Studies 2022, 8(1), 173.
  • Wibowo PG, Charman SJ, Okwose NC, Velicki L, Popovic D, Hollingsworth KG, Macgowan GA, Jakovljevic DG. Association between cardiac high-energy phosphate metabolism and whole body metabolism in healthy female adults. Physiological Research 2021, 70(3), 393-399.
  • Okwose NC, O'Brien N, Charman S, Cassidy S, Brodie D, Bailey K, Macgowan GA, Jakovljevic DG, Avery L. Overcoming barriers to engagement and adherence to a home-based physical activity intervention for patients with heart failure: A qualitative focus group study. BMJ Open 2020, 10(9), e036382.
  • Steele H, Gomez-Duran A, Pyle A, Hopton S, Newman J, Stefanetti RJ, Charman SJ, Parikh JD, He L, Viscomi C, Jakovljevic DG, Hollingsworth KG, Robinson AJ, Taylor RW, Bottolo L, Horvath R, Chinnery PF. Metabolic effects of bezafibrate in mitochondrial disease. EMBO Molecular Medicine 2020, 12(3), e11589.
  • Chmelo J, Phillips AW, Greystoke A, Charman SJ, Avery L, Hallsworth K, Welford J, Sinclair RCF. A feasibility study to investigate the utility of a home-based exercise intervention during and after neo-adjuvant chemotherapy for oesophago-gastric cancer-the ChemoFit study protocol. Pilot and Feasibility Studies 2020, 6(1), 50.
  • Charman S, Okwose N, Maniatopoulos G, Graziadio S, Metzler T, Banks H, Vale L, MacGowan GA, Seferovic PM, Fuat A, Deaton C, Mant J, Hobbs RFD, Jakovljevic DG. Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: Qualitative study. BMJ Open 2019, 9(4), e028122.
  • Jones C, Markovic M, Charman S, Okwose N, Ivkovic S, Ropret R, Markovic B, Mandaric S, Grbovic M, MacGowan GA, Jakovljevic DG. Cardiac function is not associated with glucose control in older women. Experimental Gerontology 2019, 116, 31-36.
  • Jimenez-Moreno AC, Charman SJ, Nikolenko N, Larweh M, Turner C, Gorman G, Lochmuller H, Catt M. Analyzing walking speeds with ankle and wrist worn accelerometers in a cohort with myotonic dystrophy. Disability and Rehabilitation 2019, 41(24), 2972-2978.
  • Okwose NC, Avery L, O'Brien N, Cassidy S, Charman SJ, Bailey K, Velicki L, Olivotto I, Brennan P, MacGowan GA, Jakovljevic DG. Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home-Based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): a Pilot Study. Sports Medicine Open 2019, 5, 45.
  • Kerr C, Smith L, Charman S, Harvey S, Savory L, Fairclough S, Govus A. Physical education contributes to total physical activity levels and predominantly in higher intensity physical activity categories. European Physical Education Review 2018, 24(2), 152-164.
  • Okkersen K, Jimenez-Moreno C, Wenninger S, Daidj F, Glennon J, Cumming S, Littleford R, Monckton DG, Lochmuller H, Catt M, Faber CG, Hapca A, Donnan PT, Gorman G, Bassez G, Schoser B, Knoop H, Treweek S, van Engelen BGM, Kierkegaard M, Okkersen K, Jimenez-Moreno C, Wenninger S, Daidj F, Glennon J, Cumming S, Littleford R, Monckton D, Lochmuller H, Catt M, Faber C, Hapca A, Donnan P, Gorman G, Bassez G, Schoser B, Knoop H, Treweek S, van Engelen B, Nikolaus S, Cornelissen Y, van Nimwegen M, Klerks E, Bouman S, Heskamp L, Heerschap A, Rahmadi R, Groot P, Heskes T, Kapusta K, Abghari S, Aschrafi A, Poelmans G, Raaphorst J, Trenell M, van Laar S, Wood L, Cassidy S, Newman J, Charman S, Steffaneti R, Taylor L, Brownrigg A, Day S, Atalaya A, Schuller A, Stahl K, Kunzel H, Wolf M, Jelinek A, Lignier B, Couppey F, Delmas S, Deux J-F, Hankiewicz K, Dogan C, Minier L, Chevalier P, Hamadouche A, Adam B, Hannah M, McKenzie E, Rauchhaus P, Van Hees V, Catt S, Schwalber A, Merkies I, Dittrich J. Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial. The Lancet Neurology 2018, 17(8), 671-680.
  • Charman SJ, Okwose NC, Stefanetti RJ, Bailey K, Skinner J, Ristic A, Seferovic PM, Scott M, Turley S, Fuat A, Mant J, Hobbs FDR, MacGowan GA, Jakovljevic DG. A novel cardiac output response to stress test developed to improve diagnosis and monitoring of heart failure in primary care. ESC Heart Failure 2018, 5(4), 703-712.
  • Jimenez-Moreno AC, Newman J, Charman SJ, Catt M, Trenell MI, Gorman GS, Hogrel JY, Lochmüller H. Measuring Habitual Physical Activity in Neuromuscular Disorders: A Systematic Review. Journal of Neuromuscular Diseases 2017, 4(1), 25-52.
  • Bailey DP, Charman SJ, Ploetz T, Savory LA, Kerr CJ. Associations between prolonged sedentary time and breaks in sedentary time with cardiometabolic risk in 10–14-year-old children: The HAPPY study. Journal of Sports Sciences 2017, 35(22), 2164-2171.
  • Charman SJ, van Hees VT, Quinn L, Dunford JR, Bawamia B, Veerasamy M, Trenell MI, Jakovljevic DG, Kunadian V. The effect of percutaneous coronary intervention on habitual physical activity in older patients. BMC Cardiovascular Disorders 2016, 16(1), 248.
  • Avery L, Charman SJ, Taylor L, Flynn D, Mosely K, Speight J, Lievesley M, Taylor R, Sniehotta FF, Trenell MI. Systematic development of a theory-informed multifaceted behavioural intervention to increase physical activity of adults with Type 2 diabetes in routine primary care: Movement as Medicine for Type 2 Diabetes. Implementation Science 2016, 11, 99.
  • Bailey DP, Savory LA, Denton SJ, Kerr CJ. The Association Between Cardiorespiratory Fitness and Cardiometabolic Risk in Children is Mediated by Abdominal Adiposity: The HAPPY Study. Journal of Physical Activity & Health 2015, 12(8), 1148-1152.
  • van Hees VT, Sabia S, Anderson KN, Denton SJ, Oliver J, Catt M, Abell JG, Kivimaki M, Trenell MI, Singh-Manoux A. A Novel, Open Access Method to Assess Sleep Duration Using a Wrist-Worn Accelerometer. PLOS One 2015, 10(11), e0142533.
  • Bailey DP, Savory LA, Denton SJ, Davies BR, Kerr CJ. The triglyceride to high-density lipoprotein ratio identifies children who may be at risk of developing cardiometabolic disease. Acta Paediatrica 2014, 1-5.
  • Avery L, Sniehotta FF, Denton SJ, Steen N, McColl E, Taylor R, Trenell MI. Movement as Medicine for Type 2 Diabetes: Protocol for an open pilot study and external pilot clustered randomised controlled trial to assess acceptability, feasibility and fidelity of a multifaceted behavioural intervention targeting physical activity in primary care. Trials 2014, 15(46), 1-18.
  • Bailey DP, Savory LA, Denton SJ, Davies BR, Kerr CJ. The hypertriglyceridemic waist, waist-to-height ratio and cardiometabolic risk. Journal of Pediatrics 2013, 162(4), 746-752.
  • Bailey DP, Boddy LM, Savory LA, Denton SJ, Kerr CJ. Choice of activity-intensity classification thresholds impacts upon accelerometer-assessed physical activity-health relationships in children. PLoS One 2013, 8(2), e57101.
  • Denton SJ, Trenell MI, Ploetz T, Savory LA, Bailey DP, Kerr CJ. Cardiorespiratory fitness is associated with hard and light intensity physical activity but not time spent sedentary in 10-14 year old schoolchildren: the HAPPY study. PLoS One 2013, 8(4), e61073.
  • Bailey DP, Boddy LM, Savory LA, Denton SJ, Kerr CJ. Associations between cardiorespiratory fitness, physical activity, and clustered cardiometabolic risk in children and adolescents: the HAPPY study. European Journal of Pediatrics 2012, 171(9), 1317-1323.
  • Bailey DP, Fairclough SJ, Savory LA, Denton SJ, Dong P, Deane CS, Kerr CJ. Accelerometry assessed sedentary behaviour and physical activity levels during the segmented school day in 10-14 year-old children: the HAPPY study. European Journal of Pediatrics 2012, 171(12), 1805-1813.

• Conference Proceedings (inc. Abstracts)

  • Jordan C, Charman SJ, Batterham AM, Flynn D, Ashley K, Cooper M, Houghton D, Errington L, Avery L. How physically active are adults with heart failure? A systematic review and meta-analysis. In: Heart Failure 2021 and the World Congress on Acute Heart Failure. 2021, Online: John Wiley and Sons Ltd.
  • Djordje J, Charman SJ, Okwose NC, Stefanetti RJ, Bailey K, Skinner J, Scott M, Mant J, Hobbs FDR, MacGowan GA. Reproducibility of a simple cardiac output response to stress test to diagnose and monitor heart failure in a primary care setting. In: BJGP Research Conference. 2018, London, UK: British Journal of General Practice.
  • Parovic M, Okwose NC, Charman SJ, Cassidy S, Doherty P, Bailey K, Skinner J, Seferovic PM, MacGowan GA, Jakovljevic DG. N-terminal prohormone brain natriuretic peptide is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure. In: Heart Failure 2018 & World Congress on Acute Heart Failure. 2018, Vienna, Austria: John Wiley & Sons Ltd.
  • Charman SJ, Brown E, Okwose NC, Markovic M, Ropret R, Cassidy S, MacGowan GA, Jakovljevic DG. Increased level of habitual physical activity improves body composition and exercise tolerance but has limited effect on cardio-metabolic function in middle-aged women. In: 5th UK Congress on Obesity. 2018, Newcastle upon Tyne, UK.
  • Avery L, Charman SJ, Catt M, Taylor R, Sniehotta FF, Trenell MI. Movement as medicine for type 2 diabetes: a clustered pilot randomised controlled trial of a theory-informed multifaceted behavioural intervention to increase physical activity of adults with type 2 diabetes in the primary care setting. In: International Conference of Behavioral Medicine. 2016, Melbourne, Australia: Springer.
  • Avery L, Mostafaee B, Charman S, Taylor R, Sniehotta F, Trenell M. Can a behavioural intervention targeting physical activity behaviour of adults with type 2 diabetes be delivered faithfully by healthcare professionals during routine primary care?. In: Diabetes UK Professional Conference 2016. 2016, Glasgow, UK: Wiley.
  • Avery L, Denton SJ, Lavender M, Sniehotta FF, Trenell MI. Barriers and enabling factors to use of a physical activity behavioural intervention for adults with Type 2 diabetes delivered in primary care: Qualitative findings from the Movement as Medicine Open Pilot Study. In: Diabetes UK Annual Professional Conference. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
  • Denton SJ, vanHees VT, Bawamia B, Veerasamy M, Quinn L, Dunford JR, Trenell MI, Jakovljevic DG, Kunadian V. Sedentary Behaviour and Physical Activity Among Older Patients Following Percutaneous Coronary Intervention Presented with Stable Angina versus Acute Coronary Syndrome. In: American Heart Association's 2014 Scientific Sessions and Resuscitation Science Symposium. 2014, Chicago, Illinois: American Heart Association , Inc.
  • Avery L, Denton SJ, Sniehotta FF, Steen N, McColl E, Taylor R, Trenell MI. Integrating an Evidence-Based Behaviour Change Intervention Targeting Physical Activity Behaviour into Routine Primary Care: Movement as Medicine for Type 2 Diabetes: An open pilot study. In: Diabetes UK Annual Professional Conference. 2014, Liverpool, UK: Wiley-Blackwell.
  • Bailey DP, Savory LA, Denton SJ, Davies BR, Kerr CJ. The hypertriglyceridemic waist, waist-to-height ratio and cardiometabolic risk in children and adolescents. In: 5th International Congress on Prediabetes and Metabolic Syndrome. 2013, Vienna, Austria.
  • Kerr CJ, Savory LA, Denton SJ, Pang D, Kozub SA, Davies B, Bailey DP. Body fat percentage, anthropometric obesity indices and cardiometabolic risk in children and adolescents. In: 5th International Congress on Prediabetes and Metabolic Syndrome. 2013, Vienna, Austria.

• Letter

  • Scragg J, Charman SJ, van Hees VT, Avery L, Taylor GS, Anstee QM, McPherson S, Cassidy S, Hallsworth K. Physical Activity, Inactivity and Sleep in Patients with Significant Non-Alcoholic Fatty Liver Disease. American Journal of the Medical Sciences 2022, 363(1), 80-83.

• Reviews

  • Jordan C, Charman SJ, Batterham AM, Flynn D, Houghton D, Errington L, MacGowan G, Avery L. Habitual physical activity levels of adults with heart failure: systematic review and meta-analysis. Heart 2023, 109(18), 1357-1362.
  • Charman SJ, Velicki L, Okwose NC, Harwood A, McGregor G, Ristic A, Banerjee P, Seferovic PM, MacGowan GA, Jakovljevic DG. Insights into heart failure hospitalizations, management, and services during and beyond COVID-19. ESC Heart Failure 2021, 8(1), 175-182.
  • Jimenez-Moreno AC, Newman J, Charman SJ, Catt M, Trenell MI, Gorman GS, Hogrel J-Y, Lochmuller H. Measuring Habitual Physical Activity in Neuromuscular Disorders: A Systematic Review. Journal of Neuromuscular Diseases 2017, 4(1), 25-52.