Staff Profile
Publications
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Articles
- Hallam TM, Cox TE, Smith-Jackson K, Brocklebank V, Baral AJ, Tzoumas N, Steel DH, Wong EKS, Shuttleworth VG, Lotery AJ, Harris CL, Marchbank KJ, Kavanagh D. A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in Age-related Macular Degeneration. Frontiers in Immunology 2022, 13, 1028760.
- McMahon O, Hallam TM, Patel S, Harris CL, Menny A, Zelek WM, Widjajahakim R, Java A, Cox TE, Tzoumas N, Steel DHW, Shuttleworth VG, Smith-Jackson K, Brocklebank V, Griffiths H, Cree AJ, Atkinson JP, Lotery AJ, Bubeck D, Morgan BP, Marchbank KJ, Seddon JM, Kavanagh D. The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade. Human Molecular Genetics 2021, 30(13), 1188–1199.
- Kamala O, Malik TH, Hallam TM, Cox TE, Yang Y, Vyas F, Luli S, Connelly C, Gibson B, Smith-Jackson K, Denton H, Pappworth IY, Huang L, Kavanagh D, Pickering MC, Marchbank KJ. Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice. Frontiers in Immunology 2021, 12, 752916.
- Wong EKS, Hallam T, Brocklebank V, Walsh P, Smith-Jackson K, Shuttleworth V, Cox T, Anderson H, Barlow PN, Marchbank KJ, Harris C, Kavanagh D. Functional characterisation of rare genetic variants in the N-terminus of complement factor H in aHUS, C3G and AMD. Frontiers in immunology 2021, 11, 602284.
- Gleeson PJ, Wilson V, Cox TE, Sharma SD, Smith-Jackson K, Strain L, Lappin D, McHale T, Kavanagh D, Goodship THJ. Chromosomal rearrangement – a rare cause of complement factor I associated atypical haemolytic uraemic syndrome. Immunobiology 2016, 221(10), 1124-1130.
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Review
- Gibson BG, Cox TE, Marchbank KJ. Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)-driven Complement-mediated Diseases. Immunological Reviews 2023, 313(1), 194-216.