Staff Profile

I am currently a post-doctoral research associate in the CRH Newcastle Drug Discovery Unit, with proficiency in structural biology and protein biochemistry. My position centres on construct generation, protein expression and purification, structural characterisation and biophysical validations in the scope of drug discovery programmes. 

Qualifications:

PhD in Biomolecular Science, University of East Anglia

BSc (Hons) Biochemistry, University of Aberdeen

Previous positions: 

2017-2018 Research technician, University of East Anglia

• Articles

  • George AL, Sidgwick FR, Watt JE, Martin MP, Trost M, Marin-Rubio JL, Duenas ME. Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling. Journal of Proteome Research 2023, 22(8), 2629–2640.
  • Uguen M, Davison G, Sprenger LJ, Hunter JH, Martin MP, Turberville S, Watt JE, Golding BT, Noble MEM, Stewart HL, Waring MJ. Build–Couple–Transform: A paradigm for lead-like library synthesis with scaffold diversity. Journal of Medicinal Chemistry 2022, 65(16), 11322-11339.
  • Marin-Rubio JL, Peltier-Heap RE, Duenas ME, Heunis T, Dannoura A, Inns J, Scott J, Simpson AJ, Blair HJ, Heidenreich O, Allan JM, Watt JE, Martin MP, Saxty B, Trost M. A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia. Journal of Medicinal Chemistry 2022, 65(18), 12014-12030.

• Review

  • Hope I, Endicott JA, Watt JE. Emerging approaches to CDK inhibitor development, a structural perspective. RSC Chemical Biology 2023, 4(2), 146-164.